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ENCODE cell lines, expression (Ernst 2011)

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Results for IRF3

Z-value: 1.33

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Transcription factors associated with IRF3

Gene Symbol Gene ID Gene Info
IRF3
ENSG00000126456.11 IRF3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF3hg19_v2_chr19_-_50169064_501691320.126.6e-01Click!

Activity profile of IRF3 motif

Sorted Z-values of IRF3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_127413677 4.22 ENST00000356887.7
 GYPC
 glycophorin C (Gerbich blood group)
chr2_+_127413704 4.20 ENST00000409836.3
 GYPC
 glycophorin C (Gerbich blood group)
chr2_+_127413481 4.14 ENST00000259254.4
 GYPC
 glycophorin C (Gerbich blood group)
chr5_-_95158644 2.94 ENST00000237858.6
 GLRX
 glutaredoxin (thioltransferase)
chr1_+_948803 2.77 ENST00000379389.4
 ISG15
 ISG15 ubiquitin-like modifier
chr19_+_18284477 2.48 ENST00000407280.3
 IFI30
 interferon, gamma-inducible protein 30
chr6_+_32821924 2.08 ENST00000374859.2
ENST00000453265.2
 PSMB9
 proteasome (prosome, macropain) subunit, beta type, 9
chr5_-_95158375 2.01 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
 GLRX
 glutaredoxin (thioltransferase)
chr21_+_42792442 2.00 ENST00000398600.2
 MX1
 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr11_-_57335280 1.94 ENST00000287156.4
 UBE2L6
 ubiquitin-conjugating enzyme E2L 6
chr6_+_31540056 1.39 ENST00000418386.2
 LTA
 lymphotoxin alpha
chr1_-_159046617 1.32 ENST00000368130.4
 AIM2
 absent in melanoma 2
chr16_-_67970990 1.25 ENST00000358514.4
 PSMB10
 proteasome (prosome, macropain) subunit, beta type, 10
chr16_-_11350036 1.22 ENST00000332029.2
 SOCS1
 suppressor of cytokine signaling 1
chr4_+_89378261 1.18 ENST00000264350.3
 HERC5
 HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr1_+_79115503 1.06 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44
 interferon-induced protein 44
chr19_-_17516449 0.96 ENST00000252593.6
 BST2
 bone marrow stromal cell antigen 2
chr19_+_50431959 0.96 ENST00000595125.1
 ATF5
 activating transcription factor 5
chr10_+_91087651 0.95 ENST00000371818.4
 IFIT3
 interferon-induced protein with tetratricopeptide repeats 3
chr2_-_231084617 0.92 ENST00000409815.2
 SP110
 SP110 nuclear body protein
chr14_+_24605361 0.90 ENST00000206451.6
ENST00000559123.1
 PSME1
 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr2_-_163175133 0.88 ENST00000421365.2
ENST00000263642.2
 IFIH1
 interferon induced with helicase C domain 1
chr14_+_24605389 0.86 ENST00000382708.3
ENST00000561435.1
 PSME1
 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr19_+_50432400 0.86 ENST00000423777.2
ENST00000600336.1
ENST00000597227.1
 ATF5
 activating transcription factor 5
chr17_+_6659153 0.83 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
 XAF1
 XIAP associated factor 1
chr4_-_156875003 0.77 ENST00000433477.3
 CTSO
 cathepsin O
chr22_+_18632666 0.75 ENST00000215794.7
 USP18
 ubiquitin specific peptidase 18
chr1_+_76190357 0.73 ENST00000370834.5
ENST00000541113.1
ENST00000543667.1
ENST00000420607.2
 ACADM
 acyl-CoA dehydrogenase, C-4 to C-12 straight chain
chr10_+_91061712 0.73 ENST00000371826.3
 IFIT2
 interferon-induced protein with tetratricopeptide repeats 2
chr17_-_40264692 0.68 ENST00000591220.1
ENST00000251642.3
 DHX58
 DEXH (Asp-Glu-X-His) box polypeptide 58
chr6_-_28226984 0.68 ENST00000423974.2
 ZKSCAN4
 zinc finger with KRAB and SCAN domains 4
chr16_+_75681650 0.66 ENST00000300086.4
 TERF2IP
 telomeric repeat binding factor 2, interacting protein
chr10_+_35415978 0.66 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
 CREM
 cAMP responsive element modulator
chr2_-_231084820 0.63 ENST00000258382.5
ENST00000338556.3
 SP110
 SP110 nuclear body protein
chr2_+_201981527 0.63 ENST00000441224.1
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr2_-_231084659 0.62 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
 SP110
 SP110 nuclear body protein
chr6_+_26440700 0.61 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
 BTN3A3
 butyrophilin, subfamily 3, member A3
chr6_-_32821599 0.59 ENST00000354258.4
 TAP1
 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr15_-_55611306 0.59 ENST00000563262.1
 RAB27A
 RAB27A, member RAS oncogene family
chr12_+_113416191 0.54 ENST00000342315.4
ENST00000392583.2
 OAS2
 2'-5'-oligoadenylate synthetase 2, 69/71kDa
chr11_-_615570 0.52 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
 IRF7
 interferon regulatory factor 7
chr17_+_36861735 0.52 ENST00000378137.5
ENST00000325718.7
 MLLT6
 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr22_+_36649056 0.50 ENST00000397278.3
ENST00000422706.1
ENST00000426053.1
ENST00000319136.4
 APOL1
 apolipoprotein L, 1
chr22_+_36044411 0.48 ENST00000409652.4
 APOL6
 apolipoprotein L, 6
chr3_+_187086120 0.46 ENST00000259030.2
 RTP4
 receptor (chemosensory) transporter protein 4
chr2_-_157198860 0.45 ENST00000409572.1
 NR4A2
 nuclear receptor subfamily 4, group A, member 2
chr2_+_69240302 0.45 ENST00000303714.4
 ANTXR1
 anthrax toxin receptor 1
chr1_+_25598989 0.44 ENST00000454452.2
 RHD
 Rh blood group, D antigen
chr2_+_69240415 0.43 ENST00000409829.3
 ANTXR1
 anthrax toxin receptor 1
chr3_-_53079281 0.43 ENST00000394750.1
 SFMBT1
 Scm-like with four mbt domains 1
chr20_-_20033052 0.42 ENST00000536226.1
 CRNKL1
 crooked neck pre-mRNA splicing factor 1
chr17_+_25958174 0.41 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
 LGALS9
 lectin, galactoside-binding, soluble, 9
chr2_-_145275228 0.41 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
 ZEB2
 zinc finger E-box binding homeobox 2
chr11_-_615942 0.41 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
 IRF7
 interferon regulatory factor 7
chr19_+_10196781 0.40 ENST00000253110.11
 C19orf66
 chromosome 19 open reading frame 66
chr2_+_163175394 0.40 ENST00000446271.1
ENST00000429691.2
 GCA
 grancalcin, EF-hand calcium binding protein
chr2_+_99771418 0.39 ENST00000393473.2
ENST00000393477.3
ENST00000393474.3
ENST00000340066.1
ENST00000393471.2
ENST00000449211.1
ENST00000434566.1
ENST00000410042.1
 LIPT1
MRPL30
 lipoyltransferase 1
39S ribosomal protein L30, mitochondrial
chr16_-_29874211 0.38 ENST00000563415.1
 CDIPT
 CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr4_+_156588350 0.38 ENST00000296518.7
 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3
chr2_-_231989808 0.38 ENST00000258400.3
 HTR2B
 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr4_+_156588249 0.38 ENST00000393832.3
 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3
chr5_-_96143602 0.38 ENST00000443439.2
ENST00000503921.1
ENST00000508227.1
ENST00000507154.1
 ERAP1
 endoplasmic reticulum aminopeptidase 1
chr11_+_5646213 0.36 ENST00000429814.2
 TRIM34
 tripartite motif containing 34
chr3_+_159706537 0.35 ENST00000305579.2
ENST00000480787.1
ENST00000466512.1
 IL12A
 interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr14_-_75518129 0.35 ENST00000556257.1
ENST00000557648.1
ENST00000553263.1
ENST00000355774.2
ENST00000380968.2
ENST00000238662.7
 MLH3
 mutL homolog 3
chr10_+_35416223 0.35 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
 CREM
 cAMP responsive element modulator
chr12_+_6561190 0.35 ENST00000544021.1
ENST00000266556.7
 TAPBPL
 TAP binding protein-like
chr20_-_47894936 0.35 ENST00000371754.4
 ZNFX1
 zinc finger, NFX1-type containing 1
chr7_-_92747269 0.34 ENST00000446617.1
ENST00000379958.2
 SAMD9
 sterile alpha motif domain containing 9
chr8_-_7274385 0.34 ENST00000318157.2
 DEFB4B
 defensin, beta 4B
chr6_+_26365443 0.34 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
 BTN3A2
 butyrophilin, subfamily 3, member A2
chr14_-_24615805 0.34 ENST00000560410.1
 PSME2
 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr2_+_201981119 0.34 ENST00000395148.2
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr14_-_24615523 0.33 ENST00000559056.1
 PSME2
 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr22_-_36556821 0.33 ENST00000531095.1
ENST00000397293.2
ENST00000349314.2
 APOL3
 apolipoprotein L, 3
chr2_-_220252603 0.32 ENST00000322176.7
ENST00000273075.4
 DNPEP
 aspartyl aminopeptidase
chr15_-_62352570 0.31 ENST00000261517.5
ENST00000395896.4
ENST00000395898.3
 VPS13C
 vacuolar protein sorting 13 homolog C (S. cerevisiae)
chr19_+_50887585 0.31 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
 POLD1
 polymerase (DNA directed), delta 1, catalytic subunit
chr4_+_100495864 0.30 ENST00000265517.5
ENST00000422897.2
 MTTP
 microsomal triglyceride transfer protein
chr7_+_134832808 0.30 ENST00000275767.3
 TMEM140
 transmembrane protein 140
chr10_-_14996017 0.30 ENST00000378241.1
ENST00000456122.1
ENST00000418843.1
ENST00000378249.1
ENST00000396817.2
ENST00000378255.1
ENST00000378254.1
ENST00000378278.2
ENST00000357717.2
 DCLRE1C
 DNA cross-link repair 1C
chr4_+_156588115 0.29 ENST00000455639.2
 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3
chr1_+_210502238 0.29 ENST00000545154.1
ENST00000537898.1
ENST00000391905.3
ENST00000545781.1
ENST00000261458.3
ENST00000308852.6
 HHAT
 hedgehog acyltransferase
chr14_-_91976794 0.28 ENST00000555462.1
 SMEK1
 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr20_+_388791 0.27 ENST00000441733.1
ENST00000353660.3
 RBCK1
 RanBP-type and C3HC4-type zinc finger containing 1
chr6_-_41039567 0.27 ENST00000468811.1
 OARD1
 O-acyl-ADP-ribose deacylase 1
chr10_-_70231639 0.25 ENST00000551118.2
ENST00000358410.3
ENST00000399180.2
ENST00000399179.2
 DNA2
 DNA replication helicase/nuclease 2
chr8_+_145438870 0.24 ENST00000527931.1
 FAM203B
 family with sequence similarity 203, member B
chr6_+_26402465 0.23 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
 BTN3A1
 butyrophilin, subfamily 3, member A1
chr1_-_89664595 0.22 ENST00000355754.6
 GBP4
 guanylate binding protein 4
chr16_-_28223166 0.21 ENST00000304658.5
 XPO6
 exportin 6
chr1_-_25747283 0.21 ENST00000346452.4
ENST00000340849.4
ENST00000349438.4
ENST00000294413.7
ENST00000413854.1
ENST00000455194.1
ENST00000243186.6
ENST00000425135.1
 RHCE
 Rh blood group, CcEe antigens
chr1_+_25598872 0.21 ENST00000328664.4
 RHD
 Rh blood group, D antigen
chr4_+_87856129 0.20 ENST00000395146.4
ENST00000507468.1
 AFF1
 AF4/FMR2 family, member 1
chr10_-_14996070 0.20 ENST00000378258.1
ENST00000453695.2
ENST00000378246.2
 DCLRE1C
 DNA cross-link repair 1C
chr7_+_142829162 0.20 ENST00000291009.3
 PIP
 prolactin-induced protein
chr22_+_31892261 0.19 ENST00000432498.1
ENST00000540643.1
ENST00000443326.1
ENST00000414585.1
 SFI1
 Sfi1 homolog, spindle assembly associated (yeast)
chr15_+_64428529 0.19 ENST00000560861.1
 SNX1
 sorting nexin 1
chr22_+_31892373 0.19 ENST00000443011.1
ENST00000400289.1
ENST00000444859.1
ENST00000400288.2
 SFI1
 Sfi1 homolog, spindle assembly associated (yeast)
chr3_-_125803105 0.18 ENST00000346785.5
ENST00000315891.6
 SLC41A3
 solute carrier family 41, member 3
chr19_+_49977466 0.18 ENST00000596435.1
ENST00000344019.3
ENST00000597551.1
ENST00000204637.2
ENST00000600429.1
 FLT3LG
 fms-related tyrosine kinase 3 ligand
chr5_-_96143796 0.16 ENST00000296754.3
 ERAP1
 endoplasmic reticulum aminopeptidase 1
chr12_+_133614119 0.16 ENST00000327668.7
 ZNF84
 zinc finger protein 84
chr10_+_91092241 0.15 ENST00000371811.4
 IFIT3
 interferon-induced protein with tetratricopeptide repeats 3
chr14_-_20881579 0.15 ENST00000556935.1
ENST00000262715.5
ENST00000556549.1
 TEP1
 telomerase-associated protein 1
chr2_-_119605253 0.15 ENST00000295206.6
 EN1
 engrailed homeobox 1
chr4_+_156587853 0.15 ENST00000506455.1
ENST00000511108.1
 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3
chr3_-_125802765 0.14 ENST00000514891.1
ENST00000512470.1
ENST00000504035.1
ENST00000360370.4
ENST00000513723.1
ENST00000510651.1
ENST00000514333.1
 SLC41A3
 solute carrier family 41, member 3
chr4_+_156587979 0.14 ENST00000511507.1
 GUCY1A3
 guanylate cyclase 1, soluble, alpha 3
chr1_+_25599018 0.14 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
 RHD
 Rh blood group, D antigen
chr16_-_29874462 0.13 ENST00000566113.1
ENST00000569956.1
ENST00000570016.1
 CDIPT
 CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr1_+_150480576 0.13 ENST00000346569.6
 ECM1
 extracellular matrix protein 1
chr1_+_150480551 0.13 ENST00000369049.4
ENST00000369047.4
 ECM1
 extracellular matrix protein 1
chr22_+_39436862 0.13 ENST00000381565.2
ENST00000452957.2
 APOBEC3F
APOBEC3G
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr12_+_12224331 0.12 ENST00000396367.1
ENST00000266434.4
ENST00000396369.1
 BCL2L14
 BCL2-like 14 (apoptosis facilitator)
chr8_+_7752151 0.12 ENST00000302247.2
 DEFB4A
 defensin, beta 4A
chr12_-_322821 0.12 ENST00000359674.4
 SLC6A12
 solute carrier family 6 (neurotransmitter transporter), member 12
chr20_+_388679 0.12 ENST00000356286.5
ENST00000475269.1
 RBCK1
 RanBP-type and C3HC4-type zinc finger containing 1
chr17_+_21729899 0.12 ENST00000583708.1
 UBBP4
 ubiquitin B pseudogene 4
chr9_-_95087604 0.12 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
 NOL8
 nucleolar protein 8
chr6_+_134758827 0.11 ENST00000431422.1
 LINC01010
 long intergenic non-protein coding RNA 1010
chr17_+_21730180 0.11 ENST00000584398.1
 UBBP4
 ubiquitin B pseudogene 4
chr4_+_118955500 0.11 ENST00000296499.5
 NDST3
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3
chr12_+_133613878 0.11 ENST00000392319.2
ENST00000543758.1
 ZNF84
 zinc finger protein 84
chr9_-_135282195 0.11 ENST00000334270.2
 TTF1
 transcription termination factor, RNA polymerase I
chr14_+_73525229 0.10 ENST00000527432.1
ENST00000531500.1
ENST00000525321.1
ENST00000526754.1
 RBM25
 RNA binding motif protein 25
chr11_+_118230287 0.10 ENST00000252108.3
ENST00000431736.2
 UBE4A
 ubiquitination factor E4A
chr6_+_28193037 0.10 ENST00000531981.1
ENST00000425468.2
ENST00000252207.5
ENST00000531979.1
ENST00000527436.1
 ZSCAN9
 zinc finger and SCAN domain containing 9
chr6_-_36355513 0.10 ENST00000340181.4
ENST00000373737.4
 ETV7
 ets variant 7
chr12_-_54582655 0.09 ENST00000504338.1
ENST00000514685.1
ENST00000504797.1
ENST00000513838.1
ENST00000505128.1
ENST00000337581.3
ENST00000503306.1
ENST00000243112.5
ENST00000514196.1
ENST00000506169.1
ENST00000507904.1
ENST00000508394.2
 SMUG1
 single-strand-selective monofunctional uracil-DNA glycosylase 1
chr12_-_48963829 0.09 ENST00000301046.2
ENST00000549817.1
 LALBA
 lactalbumin, alpha-
chr4_+_87928140 0.09 ENST00000307808.6
 AFF1
 AF4/FMR2 family, member 1
chr14_+_77790901 0.09 ENST00000553586.1
ENST00000555583.1
 GSTZ1
 glutathione S-transferase zeta 1
chr14_+_73525265 0.09 ENST00000525161.1
 RBM25
 RNA binding motif protein 25
chr14_+_73525144 0.09 ENST00000261973.7
ENST00000540173.1
 RBM25
 RNA binding motif protein 25
chr9_-_95087838 0.09 ENST00000442668.2
ENST00000421075.2
ENST00000536624.1
 NOL8
 nucleolar protein 8
chrX_+_77154935 0.09 ENST00000481445.1
 COX7B
 cytochrome c oxidase subunit VIIb
chr1_-_146644122 0.08 ENST00000254101.3
 PRKAB2
 protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr5_-_77656175 0.07 ENST00000513755.1
ENST00000421004.3
 CTD-2037K23.2
 CTD-2037K23.2
chr16_-_29875057 0.07 ENST00000219789.6
 CDIPT
 CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr17_-_30669138 0.06 ENST00000225805.4
ENST00000577809.1
 C17orf75
 chromosome 17 open reading frame 75
chr12_+_133613937 0.05 ENST00000539354.1
ENST00000542874.1
ENST00000438628.2
 ZNF84
 zinc finger protein 84
chr7_-_138794081 0.05 ENST00000464606.1
 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
chr2_-_37384175 0.05 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
 EIF2AK2
 eukaryotic translation initiation factor 2-alpha kinase 2
chr4_-_74847800 0.05 ENST00000296029.3
 PF4
 platelet factor 4
chr16_-_75681522 0.05 ENST00000568378.1
ENST00000568682.1
ENST00000570215.1
ENST00000319410.5
ENST00000302445.3
 KARS
 lysyl-tRNA synthetase
chr17_-_63052929 0.03 ENST00000439174.2
 GNA13
 guanine nucleotide binding protein (G protein), alpha 13
chr1_-_146644036 0.03 ENST00000425272.2
 PRKAB2
 protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr12_+_12223867 0.02 ENST00000308721.5
 BCL2L14
 BCL2-like 14 (apoptosis facilitator)
chr12_+_4758264 0.02 ENST00000266544.5
 NDUFA9
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr2_-_175629135 0.01 ENST00000409542.1
ENST00000409219.1
 CHRNA1
 cholinergic receptor, nicotinic, alpha 1 (muscle)
chr19_+_10196981 0.01 ENST00000591813.1
 C19orf66
 chromosome 19 open reading frame 66
chr20_+_388935 0.00 ENST00000382181.2
ENST00000400247.3
 RBCK1
 RanBP-type and C3HC4-type zinc finger containing 1
chr1_+_151129135 0.00 ENST00000602841.1
 SCNM1
 sodium channel modifier 1
chr15_+_55611128 0.00 ENST00000164305.5
ENST00000539642.1
 PIGB
 phosphatidylinositol glycan anchor biosynthesis, class B

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 0.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.4 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.7 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.2 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 0.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 1.0 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.5 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.4 PID IL27 PATHWAY IL27-mediated signaling events
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.5 5.0 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.3 2.4 GO:0061133 endopeptidase activator activity(GO:0061133)
0.2 2.8 GO:0031386 protein tag(GO:0031386)
0.2 0.6 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.1 0.5 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
0.1 3.3 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.6 GO:0046979 TAP2 binding(GO:0046979)
0.1 0.4 GO:0016979 lipoate-protein ligase activity(GO:0016979)
0.1 0.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 1.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 0.7 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.1 0.4 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 1.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 2.5 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.0 0.4 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.7 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.0 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.1 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.0 1.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.4 GO:0019237 satellite DNA binding(GO:0003696) centromeric DNA binding(GO:0019237)
0.0 0.4 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.0 1.0 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 1.2 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.3 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.1 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.1 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.6 GO:0031489 myosin V binding(GO:0031489)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.1 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.0 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 11.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 0.4 GO:0019902 phosphatase binding(GO:0019902)
0.0 0.9 GO:0005518 collagen binding(GO:0005518)
0.0 0.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.3 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 5.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.5 1.4 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.4 0.4 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.3 1.0 GO:1901253 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
0.3 0.9 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.3 5.0 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.2 0.7 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.2 1.3 GO:0052551 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.2 12.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.3 GO:0070269 pyroptosis(GO:0070269)
0.2 0.9 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
0.2 2.0 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.2 0.4 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.2 1.2 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.2 0.7 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
0.2 1.8 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.2 1.8 GO:0021891 olfactory bulb interneuron development(GO:0021891)
0.2 0.5 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.4 GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 1.2 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 0.3 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.6 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.1 0.2 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.1 0.5 GO:0018377 protein myristoylation(GO:0018377)
0.1 0.4 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.1 7.8 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.1 0.3 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 0.2 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.1 0.3 GO:0034196 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0 0.4 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.0 0.5 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.4 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.4 GO:0007144 female meiosis I(GO:0007144)
0.0 0.6 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.0 0.1 GO:0005988 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.0 1.0 GO:0015695 organic cation transport(GO:0015695)
0.0 0.2 GO:1902570 protein localization to nucleolus(GO:1902570)
0.0 0.7 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.8 GO:0035456 response to interferon-beta(GO:0035456)
0.0 0.1 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 1.0 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.0 GO:0002276 basophil activation involved in immune response(GO:0002276)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.1 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 0.5 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 0.0 GO:0045918 negative regulation of cytolysis(GO:0045918)
0.0 0.3 GO:2000404 regulation of T cell migration(GO:2000404)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.1 9.7 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 5.8 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 1.0 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.4 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.3 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 1.3 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.0 0.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.1 REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G Genes involved in Vif-mediated degradation of APOBEC3G
0.0 0.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.3 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 2.4 GO:0008537 proteasome activator complex(GO:0008537)
0.2 1.3 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 12.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 0.7 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.4 GO:0005712 chiasma(GO:0005712)
0.1 0.4 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.1 0.4 GO:0071797 LUBAC complex(GO:0071797)
0.1 0.3 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.5 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.4 GO:0031906 late endosome lumen(GO:0031906)
0.0 0.9 GO:0031527 filopodium membrane(GO:0031527)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.5 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 1.0 GO:0005771 multivesicular body(GO:0005771)
0.0 0.0 GO:0097679 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
0.0 1.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)