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ENCODE cell lines, expression (Ernst 2011)

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Results for IRF6_IRF4_IRF5

Z-value: 1.47

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Transcription factors associated with IRF6_IRF4_IRF5

Gene Symbol Gene ID Gene Info
IRF6
ENSG00000117595.6 IRF6
IRF4
ENSG00000137265.10 IRF4
IRF5
ENSG00000128604.14 IRF5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF6hg19_v2_chr1_-_209979375_2099793890.621.1e-02Click!
IRF5hg19_v2_chr7_+_128577972_1285780470.312.5e-01Click!
IRF4hg19_v2_chr6_+_391739_3917590.292.7e-01Click!

Activity profile of IRF6_IRF4_IRF5 motif

Sorted Z-values of IRF6_IRF4_IRF5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF6_IRF4_IRF5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr21_+_42792442 5.88 ENST00000398600.2
 MX1
 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344582 5.15 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
 OAS1
 2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr21_+_42798094 4.27 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
 MX1
 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344755 4.27 ENST00000550883.1
 OAS1
 2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr9_-_32526184 4.18 ENST00000545044.1
ENST00000379868.1
 DDX58
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr9_-_32526299 4.14 ENST00000379882.1
ENST00000379883.2
 DDX58
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr1_-_59043166 3.89 ENST00000371225.2
 TACSTD2
 tumor-associated calcium signal transducer 2
chr11_-_615942 3.81 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
 IRF7
 interferon regulatory factor 7
chr11_-_104817919 3.12 ENST00000533252.1
 CASP4
 caspase 4, apoptosis-related cysteine peptidase
chr11_-_118134997 3.07 ENST00000278937.2
 MPZL2
 myelin protein zero-like 2
chr12_+_113344811 3.05 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
 OAS1
 2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_+_5710919 2.62 ENST00000379965.3
ENST00000425490.1
 TRIM22
 tripartite motif containing 22
chr9_-_21995249 2.34 ENST00000494262.1
 CDKN2A
 cyclin-dependent kinase inhibitor 2A
chr11_-_57335280 2.21 ENST00000287156.4
 UBE2L6
 ubiquitin-conjugating enzyme E2L 6
chr10_-_91174215 1.85 ENST00000371837.1
 LIPA
 lipase A, lysosomal acid, cholesterol esterase
chr12_+_113376157 1.79 ENST00000228928.7
 OAS3
 2'-5'-oligoadenylate synthetase 3, 100kDa
chr15_-_45670924 1.68 ENST00000396659.3
 GATM
 glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr1_+_948803 1.64 ENST00000379389.4
 ISG15
 ISG15 ubiquitin-like modifier
chr14_+_94577074 1.59 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
 IFI27
 interferon, alpha-inducible protein 27
chr4_+_89378261 1.53 ENST00000264350.3
 HERC5
 HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr13_-_46961580 1.51 ENST00000378787.3
ENST00000378797.2
ENST00000429979.1
ENST00000378781.3
 KIAA0226L
 KIAA0226-like
chr17_+_18380051 1.48 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
 LGALS9C
 lectin, galactoside-binding, soluble, 9C
chr3_-_146262352 1.48 ENST00000462666.1
 PLSCR1
 phospholipid scramblase 1
chr17_-_39677971 1.46 ENST00000393976.2
 KRT15
 keratin 15
chr11_-_615570 1.46 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
 IRF7
 interferon regulatory factor 7
chr17_+_6659153 1.44 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
 XAF1
 XIAP associated factor 1
chr3_-_146262637 1.40 ENST00000472349.1
ENST00000342435.4
 PLSCR1
 phospholipid scramblase 1
chr3_-_146262428 1.36 ENST00000486631.1
 PLSCR1
 phospholipid scramblase 1
chr9_+_112542572 1.31 ENST00000374530.3
 PALM2-AKAP2
 PALM2-AKAP2 readthrough
chr9_-_21995300 1.15 ENST00000498628.2
 CDKN2A
 cyclin-dependent kinase inhibitor 2A
chr1_-_169680745 1.15 ENST00000236147.4
 SELL
 selectin L
chr9_+_112542591 1.11 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
 PALM2
PALM2-AKAP2
AKAP2
 paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr3_+_118892362 1.06 ENST00000497685.1
ENST00000264234.3
 UPK1B
 uroplakin 1B
chr3_-_182880541 1.06 ENST00000470251.1
ENST00000265598.3
 LAMP3
 lysosomal-associated membrane protein 3
chr3_-_146262488 1.04 ENST00000487389.1
 PLSCR1
 phospholipid scramblase 1
chr19_+_10196981 1.02 ENST00000591813.1
 C19orf66
 chromosome 19 open reading frame 66
chr15_+_41136586 1.01 ENST00000431806.1
 SPINT1
 serine peptidase inhibitor, Kunitz type 1
chr2_-_163175133 0.98 ENST00000421365.2
ENST00000263642.2
 IFIH1
 interferon induced with helicase C domain 1
chr3_-_146262365 0.97 ENST00000448787.2
 PLSCR1
 phospholipid scramblase 1
chr3_-_146262293 0.96 ENST00000448205.1
 PLSCR1
 phospholipid scramblase 1
chr1_+_86889769 0.95 ENST00000370565.4
 CLCA2
 chloride channel accessory 2
chr6_+_89791507 0.94 ENST00000354922.3
 PNRC1
 proline-rich nuclear receptor coactivator 1
chrX_+_23801280 0.91 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
 SAT1
 spermidine/spermine N1-acetyltransferase 1
chr22_+_23247030 0.86 ENST00000390324.2
 IGLJ3
 immunoglobulin lambda joining 3
chr1_+_179262905 0.85 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
 SOAT1
 sterol O-acyltransferase 1
chr15_+_74287009 0.84 ENST00000395135.3
 PML
 promyelocytic leukemia
chr17_+_25958174 0.84 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
 LGALS9
 lectin, galactoside-binding, soluble, 9
chr21_+_42733870 0.75 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
 MX2
 myxovirus (influenza virus) resistance 2 (mouse)
chr2_-_191878874 0.68 ENST00000392322.3
ENST00000392323.2
ENST00000424722.1
ENST00000361099.3
 STAT1
 signal transducer and activator of transcription 1, 91kDa
chr12_-_50616382 0.66 ENST00000552783.1
 LIMA1
 LIM domain and actin binding 1
chr11_+_32851487 0.66 ENST00000257836.3
 PRRG4
 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr17_-_20370847 0.66 ENST00000423676.3
ENST00000324290.5
 LGALS9B
 lectin, galactoside-binding, soluble, 9B
chrX_+_49028265 0.64 ENST00000376322.3
ENST00000376327.5
 PLP2
 proteolipid protein 2 (colonic epithelium-enriched)
chr16_+_12059050 0.61 ENST00000396495.3
 TNFRSF17
 tumor necrosis factor receptor superfamily, member 17
chr16_+_12058961 0.61 ENST00000053243.1
 TNFRSF17
 tumor necrosis factor receptor superfamily, member 17
chr19_+_10196781 0.60 ENST00000253110.11
 C19orf66
 chromosome 19 open reading frame 66
chr10_+_91174314 0.55 ENST00000371795.4
 IFIT5
 interferon-induced protein with tetratricopeptide repeats 5
chr18_+_42260861 0.52 ENST00000282030.5
 SETBP1
 SET binding protein 1
chr11_+_130029457 0.52 ENST00000278742.5
 ST14
 suppression of tumorigenicity 14 (colon carcinoma)
chr2_-_37384175 0.52 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
 EIF2AK2
 eukaryotic translation initiation factor 2-alpha kinase 2
chr2_-_191878681 0.49 ENST00000409465.1
 STAT1
 signal transducer and activator of transcription 1, 91kDa
chr6_+_32605195 0.47 ENST00000374949.2
 HLA-DQA1
 major histocompatibility complex, class II, DQ alpha 1
chrX_-_110655391 0.46 ENST00000356915.2
ENST00000356220.3
 DCX
 doublecortin
chr4_-_48782259 0.44 ENST00000507711.1
ENST00000358350.4
ENST00000537810.1
ENST00000264319.7
 FRYL
 FRY-like
chr6_+_32605134 0.43 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
 HLA-DQA1
 major histocompatibility complex, class II, DQ alpha 1
chrX_-_139587225 0.41 ENST00000370536.2
 SOX3
 SRY (sex determining region Y)-box 3
chr8_-_101962777 0.41 ENST00000395951.3
 YWHAZ
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr11_+_128563652 0.40 ENST00000527786.2
 FLI1
 Fli-1 proto-oncogene, ETS transcription factor
chr5_+_140772381 0.39 ENST00000398604.2
 PCDHGA8
 protocadherin gamma subfamily A, 8
chr12_+_79258547 0.39 ENST00000457153.2
 SYT1
 synaptotagmin I
chr16_+_28962128 0.38 ENST00000564978.1
ENST00000320805.4
 NFATC2IP
 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
chr16_+_12059091 0.37 ENST00000562385.1
 TNFRSF17
 tumor necrosis factor receptor superfamily, member 17
chr7_-_138794394 0.36 ENST00000242351.5
ENST00000471652.1
 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
chr12_+_79258444 0.36 ENST00000261205.4
 SYT1
 synaptotagmin I
chr11_+_126173647 0.35 ENST00000263579.4
 DCPS
 decapping enzyme, scavenger
chr17_-_36981556 0.35 ENST00000536127.1
ENST00000225428.5
 CWC25
 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
chr17_-_7164410 0.34 ENST00000574070.1
 CLDN7
 claudin 7
chr12_-_27167233 0.33 ENST00000535819.1
ENST00000543803.1
ENST00000535423.1
ENST00000539741.1
ENST00000343028.4
ENST00000545600.1
ENST00000543088.1
 TM7SF3
 transmembrane 7 superfamily member 3
chr11_+_695787 0.33 ENST00000526170.1
ENST00000488769.1
 TMEM80
 transmembrane protein 80
chr19_+_7600584 0.32 ENST00000600737.1
 PNPLA6
 patatin-like phospholipase domain containing 6
chr18_-_67624160 0.32 ENST00000581982.1
ENST00000280200.4
 CD226
 CD226 molecule
chr8_-_22926623 0.31 ENST00000276431.4
 TNFRSF10B
 tumor necrosis factor receptor superfamily, member 10b
chr1_-_151319710 0.31 ENST00000290524.4
ENST00000437327.1
ENST00000452513.2
ENST00000368870.2
ENST00000452671.2
 RFX5
 regulatory factor X, 5 (influences HLA class II expression)
chr2_+_68961934 0.31 ENST00000409202.3
 ARHGAP25
 Rho GTPase activating protein 25
chr2_+_68961905 0.31 ENST00000295381.3
 ARHGAP25
 Rho GTPase activating protein 25
chr14_-_70883708 0.29 ENST00000256366.4
 SYNJ2BP
 synaptojanin 2 binding protein
chr12_+_54402790 0.29 ENST00000040584.4
 HOXC8
 homeobox C8
chr1_+_241695670 0.29 ENST00000366557.4
 KMO
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr22_-_31688431 0.28 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
 PIK3IP1
 phosphoinositide-3-kinase interacting protein 1
chr3_-_15374033 0.27 ENST00000253688.5
ENST00000383791.3
 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
chr2_-_160473114 0.26 ENST00000392783.2
 BAZ2B
 bromodomain adjacent to zinc finger domain, 2B
chr11_+_695614 0.26 ENST00000608174.1
ENST00000397512.3
 TMEM80
 transmembrane protein 80
chr1_-_154580616 0.26 ENST00000368474.4
 ADAR
 adenosine deaminase, RNA-specific
chr10_+_71561649 0.26 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
 COL13A1
 collagen, type XIII, alpha 1
chr10_+_15139394 0.26 ENST00000441850.1
 RPP38
 ribonuclease P/MRP 38kDa subunit
chr8_-_22926526 0.25 ENST00000347739.3
ENST00000542226.1
 TNFRSF10B
 tumor necrosis factor receptor superfamily, member 10b
chr16_+_30751953 0.25 ENST00000483578.1
 RP11-2C24.4
 RP11-2C24.4
chr2_-_70780572 0.24 ENST00000450929.1
 TGFA
 transforming growth factor, alpha
chr3_-_15374659 0.24 ENST00000426925.1
 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
chr1_-_160990886 0.24 ENST00000537746.1
 F11R
 F11 receptor
chr1_+_19923454 0.21 ENST00000602662.1
ENST00000602293.1
ENST00000322753.6
 MINOS1-NBL1
MINOS1
 MINOS1-NBL1 readthrough
mitochondrial inner membrane organizing system 1
chr17_-_76778339 0.21 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
 CYTH1
 cytohesin 1
chrY_-_6742068 0.20 ENST00000215479.5
 AMELY
 amelogenin, Y-linked
chr11_-_71823715 0.20 ENST00000545944.1
ENST00000502597.2
 ANAPC15
 anaphase promoting complex subunit 15
chr5_-_139943830 0.20 ENST00000412920.3
ENST00000511201.2
ENST00000356738.2
ENST00000354402.5
ENST00000358580.5
ENST00000508496.2
 APBB3
 amyloid beta (A4) precursor protein-binding, family B, member 3
chr11_-_71823796 0.19 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
 ANAPC15
 anaphase promoting complex subunit 15
chr16_+_89642120 0.19 ENST00000268720.5
ENST00000319518.8
 CPNE7
 copine VII
chr12_+_14518598 0.19 ENST00000261168.4
ENST00000538511.1
ENST00000545723.1
ENST00000543189.1
ENST00000536444.1
 ATF7IP
 activating transcription factor 7 interacting protein
chr6_-_100016678 0.18 ENST00000523799.1
ENST00000520429.1
 CCNC
 cyclin C
chr4_+_190992387 0.17 ENST00000554906.2
ENST00000553820.2
 DUX4L7
 double homeobox 4 like 7
chr6_+_126070726 0.17 ENST00000368364.3
 HEY2
 hes-related family bHLH transcription factor with YRPW motif 2
chr11_-_71823266 0.17 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15
 anaphase promoting complex subunit 15
chr12_+_6881678 0.16 ENST00000441671.2
ENST00000203629.2
 LAG3
 lymphocyte-activation gene 3
chr12_-_12837423 0.16 ENST00000540510.1
 GPR19
 G protein-coupled receptor 19
chr1_+_241695424 0.16 ENST00000366558.3
ENST00000366559.4
 KMO
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr4_-_11431188 0.15 ENST00000510712.1
 HS3ST1
 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
chr15_+_23810853 0.14 ENST00000568252.1
 MKRN3
 makorin ring finger protein 3
chr10_+_15139330 0.14 ENST00000378202.5
ENST00000378197.4
 RPP38
 ribonuclease P/MRP 38kDa subunit
chrX_-_77041685 0.14 ENST00000373344.5
ENST00000395603.3
 ATRX
 alpha thalassemia/mental retardation syndrome X-linked
chr10_+_71561630 0.14 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
 COL13A1
 collagen, type XIII, alpha 1
chr4_-_89080003 0.13 ENST00000237612.3
 ABCG2
 ATP-binding cassette, sub-family G (WHITE), member 2
chr3_-_149095652 0.13 ENST00000305366.3
 TM4SF1
 transmembrane 4 L six family member 1
chr10_+_71561704 0.12 ENST00000520267.1
 COL13A1
 collagen, type XIII, alpha 1
chr7_-_138794081 0.12 ENST00000464606.1
 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
chr10_+_15139176 0.12 ENST00000378203.1
ENST00000378201.2
 RPP38
 ribonuclease P/MRP 38kDa subunit
chr19_+_41222998 0.12 ENST00000263370.2
 ITPKC
 inositol-trisphosphate 3-kinase C
chr11_-_67141090 0.12 ENST00000312438.7
 CLCF1
 cardiotrophin-like cytokine factor 1
chr17_+_7387677 0.12 ENST00000322644.6
 POLR2A
 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr19_-_57183114 0.11 ENST00000537055.2
ENST00000601659.1
 ZNF835
 zinc finger protein 835
chr14_+_90528109 0.11 ENST00000282146.4
 KCNK13
 potassium channel, subfamily K, member 13
chr3_-_155572164 0.10 ENST00000392845.3
ENST00000359479.3
 SLC33A1
 solute carrier family 33 (acetyl-CoA transporter), member 1
chr11_-_47736896 0.10 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
 AGBL2
 ATP/GTP binding protein-like 2
chr2_+_68962014 0.10 ENST00000467265.1
 ARHGAP25
 Rho GTPase activating protein 25
chr22_+_23487513 0.10 ENST00000263116.2
ENST00000341989.4
 RAB36
 RAB36, member RAS oncogene family
chr16_+_3068393 0.10 ENST00000573001.1
 TNFRSF12A
 tumor necrosis factor receptor superfamily, member 12A
chr1_+_207669495 0.09 ENST00000367052.1
ENST00000367051.1
ENST00000367053.1
 CR1
 complement component (3b/4b) receptor 1 (Knops blood group)
chrX_+_47420516 0.09 ENST00000377045.4
ENST00000290277.6
ENST00000377039.2
 ARAF
 v-raf murine sarcoma 3611 viral oncogene homolog
chr2_+_201980827 0.09 ENST00000309955.3
ENST00000443227.1
ENST00000341222.6
ENST00000355558.4
ENST00000340870.5
ENST00000341582.6
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr11_-_321340 0.09 ENST00000526811.1
 IFITM3
 interferon induced transmembrane protein 3
chr2_+_217277137 0.09 ENST00000430374.1
ENST00000357276.4
ENST00000444508.1
 SMARCAL1
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr7_-_14880892 0.09 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
 DGKB
 diacylglycerol kinase, beta 90kDa
chr5_-_156569754 0.08 ENST00000420343.1
 MED7
 mediator complex subunit 7
chr11_+_809647 0.08 ENST00000321153.4
 RPLP2
 ribosomal protein, large, P2
chr2_-_32390801 0.08 ENST00000608489.1
 RP11-563N4.1
 RP11-563N4.1
chr10_+_123923205 0.08 ENST00000369004.3
ENST00000260733.3
 TACC2
 transforming, acidic coiled-coil containing protein 2
chr9_+_33265011 0.08 ENST00000419016.2
 CHMP5
 charged multivesicular body protein 5
chr19_-_9649303 0.08 ENST00000253115.2
 ZNF426
 zinc finger protein 426
chr5_+_178286925 0.08 ENST00000322434.3
 ZNF354B
 zinc finger protein 354B
chr19_-_9649253 0.08 ENST00000593003.1
 ZNF426
 zinc finger protein 426
chr11_+_809961 0.08 ENST00000530797.1
 RPLP2
 ribosomal protein, large, P2
chr15_+_74287035 0.08 ENST00000395132.2
ENST00000268059.6
ENST00000354026.6
ENST00000268058.3
ENST00000565898.1
ENST00000569477.1
ENST00000569965.1
ENST00000567543.1
ENST00000436891.3
ENST00000435786.2
ENST00000564428.1
ENST00000359928.4
 PML
 promyelocytic leukemia
chr4_-_88141615 0.08 ENST00000545252.1
ENST00000425278.2
ENST00000498875.2
 KLHL8
 kelch-like family member 8
chr2_+_187454749 0.08 ENST00000261023.3
ENST00000374907.3
 ITGAV
 integrin, alpha V
chr1_+_46016703 0.07 ENST00000481885.1
ENST00000351829.4
ENST00000471651.1
 AKR1A1
 aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr17_+_41363854 0.07 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
 TMEM106A
 transmembrane protein 106A
chr1_-_153514241 0.07 ENST00000368718.1
ENST00000359215.1
 S100A5
 S100 calcium binding protein A5
chr19_-_49339915 0.07 ENST00000263278.4
 HSD17B14
 hydroxysteroid (17-beta) dehydrogenase 14
chr7_-_20256965 0.07 ENST00000400331.5
ENST00000332878.4
 MACC1
 metastasis associated in colon cancer 1
chr17_-_59668550 0.07 ENST00000521764.1
 NACA2
 nascent polypeptide-associated complex alpha subunit 2
chr14_-_45603657 0.07 ENST00000396062.3
 FKBP3
 FK506 binding protein 3, 25kDa
chr9_+_33264861 0.07 ENST00000223500.8
 CHMP5
 charged multivesicular body protein 5
chr17_-_40264692 0.06 ENST00000591220.1
ENST00000251642.3
 DHX58
 DEXH (Asp-Glu-X-His) box polypeptide 58
chr10_+_71562180 0.06 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
 COL13A1
 collagen, type XIII, alpha 1
chr1_+_177140633 0.06 ENST00000361539.4
 BRINP2
 bone morphogenetic protein/retinoic acid inducible neural-specific 2
chr19_-_4723761 0.06 ENST00000597849.1
ENST00000598800.1
ENST00000602161.1
ENST00000597726.1
ENST00000601130.1
ENST00000262960.9
 DPP9
 dipeptidyl-peptidase 9
chr5_-_95297534 0.06 ENST00000513343.1
ENST00000431061.2
 ELL2
 elongation factor, RNA polymerase II, 2
chr17_+_78965624 0.06 ENST00000325167.5
 CHMP6
 charged multivesicular body protein 6
chr13_-_76056250 0.06 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
 TBC1D4
 TBC1 domain family, member 4
chr5_-_95297678 0.05 ENST00000237853.4
 ELL2
 elongation factor, RNA polymerase II, 2
chrX_+_54834791 0.05 ENST00000218439.4
ENST00000375058.1
ENST00000375060.1
 MAGED2
 melanoma antigen family D, 2
chr1_-_54355430 0.05 ENST00000371399.1
ENST00000072644.1
ENST00000412288.1
 YIPF1
 Yip1 domain family, member 1
chr18_+_22006580 0.05 ENST00000284202.4
 IMPACT
 impact RWD domain protein
chr4_-_88141755 0.05 ENST00000273963.5
 KLHL8
 kelch-like family member 8
chr9_+_33629119 0.05 ENST00000331828.4
 TRBV21OR9-2
 T cell receptor beta variable 21/OR9-2 (pseudogene)
chr12_+_70133152 0.05 ENST00000550536.1
ENST00000362025.5
 RAB3IP
 RAB3A interacting protein
chr9_-_90589402 0.05 ENST00000375871.4
ENST00000605159.1
ENST00000336654.5
 CDK20
 cyclin-dependent kinase 20
chr7_+_141478242 0.05 ENST00000247881.2
 TAS2R4
 taste receptor, type 2, member 4
chr5_-_11904152 0.04 ENST00000304623.8
ENST00000458100.2
 CTNND2
 catenin (cadherin-associated protein), delta 2
chr13_+_51483814 0.04 ENST00000336617.3
ENST00000422660.1
 RNASEH2B
 ribonuclease H2, subunit B
chrX_-_85302531 0.04 ENST00000537751.1
ENST00000358786.4
ENST00000357749.2
 CHM
 choroideremia (Rab escort protein 1)
chr16_-_3068171 0.04 ENST00000572154.1
ENST00000328796.4
 CLDN6
 claudin 6
chr14_-_23564320 0.04 ENST00000605057.1
 ACIN1
 apoptotic chromatin condensation inducer 1
chr3_-_15140629 0.04 ENST00000507357.1
ENST00000449050.1
ENST00000253699.3
ENST00000435849.3
ENST00000476527.2
 ZFYVE20
 zinc finger, FYVE domain containing 20
chr10_+_135192782 0.04 ENST00000480071.2
 PAOX
 polyamine oxidase (exo-N4-amino)
chr22_-_31688381 0.04 ENST00000487265.2
 PIK3IP1
 phosphoinositide-3-kinase interacting protein 1
chr11_-_66056596 0.03 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
 YIF1A
 Yip1 interacting factor homolog A (S. cerevisiae)
chr18_-_33647487 0.03 ENST00000590898.1
ENST00000357384.4
ENST00000319040.6
ENST00000588737.1
ENST00000399022.4
 RPRD1A
 regulation of nuclear pre-mRNA domain containing 1A
chr7_-_100895414 0.03 ENST00000435848.1
ENST00000474120.1
 FIS1
 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
chr1_-_44497024 0.03 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
 SLC6A9
 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr19_-_15544099 0.03 ENST00000599910.2
 WIZ
 widely interspaced zinc finger motifs
chr12_+_121131970 0.03 ENST00000535656.1
 MLEC
 malectin
chr5_+_133706865 0.03 ENST00000265339.2
 UBE2B
 ubiquitin-conjugating enzyme E2B
chr12_-_51664058 0.03 ENST00000605627.1
 SMAGP
 small cell adhesion glycoprotein
chr14_+_89029336 0.03 ENST00000556945.1
ENST00000556158.1
ENST00000557607.1
 ZC3H14
 zinc finger CCCH-type containing 14
chr6_+_106546808 0.02 ENST00000369089.3
 PRDM1
 PR domain containing 1, with ZNF domain
chr22_-_31885727 0.02 ENST00000330125.5
ENST00000344710.5
ENST00000397518.1
 EIF4ENIF1
 eukaryotic translation initiation factor 4E nuclear import factor 1
chr2_-_127977654 0.02 ENST00000409327.1
 CYP27C1
 cytochrome P450, family 27, subfamily C, polypeptide 1
chr15_+_90544532 0.02 ENST00000268154.4
 ZNF710
 zinc finger protein 710
chr19_+_55897297 0.02 ENST00000431533.2
ENST00000428193.2
ENST00000558815.1
ENST00000560583.1
ENST00000560055.1
ENST00000559463.1
 RPL28
 ribosomal protein L28
chr10_+_135192695 0.02 ENST00000368539.4
ENST00000278060.5
ENST00000357296.3
 PAOX
 polyamine oxidase (exo-N4-amino)

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 14.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.3 29.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 3.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.7 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.9 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0 1.0 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.4 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 3.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 3.3 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.9 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 0.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.7 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.3 PID NECTIN PATHWAY Nectin adhesion pathway

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.1 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.3 3.5 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.7 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 0.6 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.1 1.1 GO:0097208 alveolar lamellar body(GO:0097208)
0.1 0.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 4.8 GO:0009925 basal plasma membrane(GO:0009925)
0.1 8.1 GO:0032587 ruffle membrane(GO:0032587)
0.1 0.5 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.0 0.9 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.0 2.6 GO:0015030 Cajal body(GO:0015030)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 0.2 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 10.8 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.4 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 6.0 GO:0045121 membrane raft(GO:0045121)
0.0 0.3 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.4 GO:0005882 intermediate filament(GO:0005882)
0.0 0.8 GO:0005643 nuclear pore(GO:0005643)
0.0 0.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.3 GO:0034343 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
1.1 5.3 GO:2000110 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
1.0 10.9 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.9 7.2 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.7 5.4 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.5 3.9 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.3 1.0 GO:0009447 putrescine catabolic process(GO:0009447)
0.3 3.5 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.3 1.2 GO:2000697 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.3 3.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.3 0.8 GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.2 0.7 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.2 0.9 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.2 12.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 1.7 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.5 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.1 0.9 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.3 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.1 0.3 GO:0060369 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1 0.7 GO:0050713 PML body organization(GO:0030578) negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 0.4 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.1 0.2 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1 1.0 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 1.1 GO:0035455 response to interferon-alpha(GO:0035455)
0.1 0.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.2 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621) negative regulation of vascular smooth muscle cell differentiation(GO:1905064)
0.0 0.3 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 1.9 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.6 GO:0035456 response to interferon-beta(GO:0035456)
0.0 0.1 GO:0001172 transcription, RNA-templated(GO:0001172)
0.0 0.1 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.0 0.1 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.0 1.3 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 0.6 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.0 0.5 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.0 3.4 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.0 1.1 GO:0033198 response to ATP(GO:0033198)
0.0 0.4 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.1 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
0.0 0.4 GO:0090527 actin filament reorganization(GO:0090527)
0.0 1.6 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.4 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.6 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.4 GO:0007250 activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.0 3.1 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.1 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 0.1 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534) positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.0 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.4 GO:0007530 sex determination(GO:0007530)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.7 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.0 0.1 GO:0015886 heme transport(GO:0015886)
0.0 0.0 GO:0032058 positive regulation of translational initiation in response to stress(GO:0032058)
0.0 0.1 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.0 1.4 GO:0070268 cornification(GO:0070268)
0.0 0.0 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.0 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 12.8 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.7 7.2 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.6 3.7 GO:0042296 ISG15 transferase activity(GO:0042296)
0.4 1.9 GO:0004771 sterol esterase activity(GO:0004771)
0.2 3.1 GO:0050700 CARD domain binding(GO:0050700)
0.2 3.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 0.5 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 0.8 GO:0070492 oligosaccharide binding(GO:0070492)
0.2 2.0 GO:0031386 protein tag(GO:0031386)
0.2 1.1 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 0.7 GO:0030348 syntaxin-3 binding(GO:0030348)
0.1 0.6 GO:0045569 TRAIL binding(GO:0045569)
0.1 9.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 0.2 GO:0035939 microsatellite binding(GO:0035939)
0.1 1.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.7 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.1 0.3 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1 0.9 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 6.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 1.6 GO:0005521 lamin binding(GO:0005521)
0.0 0.1 GO:0015616 DNA translocase activity(GO:0015616)
0.0 0.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 0.1 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 11.2 GO:0008017 microtubule binding(GO:0008017)
0.0 0.1 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 0.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.7 GO:0032183 SUMO binding(GO:0032183)
0.0 0.5 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 0.1 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.0 0.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.2 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0 0.2 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0 0.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0 0.1 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.7 GO:0019956 chemokine binding(GO:0019956)
0.0 0.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.1 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 1.3 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.7 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.0 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0 0.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 0.1 GO:0052901 polyamine oxidase activity(GO:0046592) spermine:oxygen oxidoreductase (spermidine-forming) activity(GO:0052901)
0.0 0.0 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)