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ENCODE cell lines, expression (Ernst 2011)

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Results for IRF9

Z-value: 1.44

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Transcription factors associated with IRF9

Gene Symbol Gene ID Gene Info
IRF9
ENSG00000213928.4 IRF9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRF9hg19_v2_chr14_+_24630465_246305310.902.1e-06Click!

Activity profile of IRF9 motif

Sorted Z-values of IRF9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRF9

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr21_+_42798094 9.76 ENST00000398598.3
ENST00000455164.2
ENST00000424365.1
 MX1
 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr12_+_113344582 4.55 ENST00000202917.5
ENST00000445409.2
ENST00000452357.2
 OAS1
 2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr1_+_79086088 4.39 ENST00000370751.5
ENST00000342282.3
 IFI44L
 interferon-induced protein 44-like
chr1_+_79115503 4.17 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44
 interferon-induced protein 44
chr1_+_948803 4.09 ENST00000379389.4
 ISG15
 ISG15 ubiquitin-like modifier
chr12_+_113344755 4.01 ENST00000550883.1
 OAS1
 2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr6_+_6588902 3.64 ENST00000230568.4
 LY86
 lymphocyte antigen 86
chr4_+_89378261 3.34 ENST00000264350.3
 HERC5
 HECT and RLD domain containing E3 ubiquitin protein ligase 5
chr14_+_24630465 3.22 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
 IRF9
 interferon regulatory factor 9
chr17_+_6659153 3.17 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
 XAF1
 XIAP associated factor 1
chr21_+_42733870 3.08 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
 MX2
 myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_158979792 3.06 ENST00000359709.3
ENST00000430894.2
 IFI16
 interferon, gamma-inducible protein 16
chr6_-_31324943 2.90 ENST00000412585.2
ENST00000434333.1
 HLA-B
 major histocompatibility complex, class I, B
chr1_+_158979680 2.90 ENST00000368131.4
ENST00000340979.6
 IFI16
 interferon, gamma-inducible protein 16
chr11_-_615570 2.90 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
 IRF7
 interferon regulatory factor 7
chr1_+_158979686 2.86 ENST00000368132.3
ENST00000295809.7
 IFI16
 interferon, gamma-inducible protein 16
chr12_+_113344811 2.80 ENST00000551241.1
ENST00000553185.1
ENST00000550689.1
 OAS1
 2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr11_-_615942 2.52 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
 IRF7
 interferon regulatory factor 7
chr2_-_163175133 2.49 ENST00000421365.2
ENST00000263642.2
 IFIH1
 interferon induced with helicase C domain 1
chr4_-_169239921 2.47 ENST00000514995.1
ENST00000393743.3
 DDX60
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr9_-_21995249 2.43 ENST00000494262.1
 CDKN2A
 cyclin-dependent kinase inhibitor 2A
chr9_-_21995300 2.34 ENST00000498628.2
 CDKN2A
 cyclin-dependent kinase inhibitor 2A
chr14_+_94577074 2.33 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
 IFI27
 interferon, alpha-inducible protein 27
chr10_-_91174215 2.28 ENST00000371837.1
 LIPA
 lipase A, lysosomal acid, cholesterol esterase
chr11_-_57335280 2.13 ENST00000287156.4
 UBE2L6
 ubiquitin-conjugating enzyme E2L 6
chr13_-_46961580 1.88 ENST00000378787.3
ENST00000378797.2
ENST00000429979.1
ENST00000378781.3
 KIAA0226L
 KIAA0226-like
chr9_-_32526184 1.69 ENST00000545044.1
ENST00000379868.1
 DDX58
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr18_-_67624160 1.66 ENST00000581982.1
ENST00000280200.4
 CD226
 CD226 molecule
chr4_+_146402925 1.66 ENST00000302085.4
 SMAD1
 SMAD family member 1
chr13_+_50070077 1.58 ENST00000378319.3
ENST00000426879.1
 PHF11
 PHD finger protein 11
chr13_+_50070491 1.50 ENST00000496612.1
ENST00000357596.3
ENST00000485919.1
ENST00000442195.1
 PHF11
 PHD finger protein 11
chr11_+_5646213 1.40 ENST00000429814.2
 TRIM34
 tripartite motif containing 34
chr4_-_76944621 1.33 ENST00000306602.1
 CXCL10
 chemokine (C-X-C motif) ligand 10
chr12_+_113376157 1.32 ENST00000228928.7
 OAS3
 2'-5'-oligoadenylate synthetase 3, 100kDa
chr10_-_95242044 1.13 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
 MYOF
 myoferlin
chr10_-_95241951 1.12 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
 MYOF
 myoferlin
chr1_-_150738261 1.11 ENST00000448301.2
ENST00000368985.3
 CTSS
 cathepsin S
chr10_+_91174314 1.03 ENST00000371795.4
 IFIT5
 interferon-induced protein with tetratricopeptide repeats 5
chr18_+_42260861 0.93 ENST00000282030.5
 SETBP1
 SET binding protein 1
chr3_-_121379739 0.87 ENST00000428394.2
ENST00000314583.3
 HCLS1
 hematopoietic cell-specific Lyn substrate 1
chr19_+_10196981 0.83 ENST00000591813.1
 C19orf66
 chromosome 19 open reading frame 66
chr1_-_154580616 0.79 ENST00000368474.4
 ADAR
 adenosine deaminase, RNA-specific
chr9_-_32526299 0.78 ENST00000379882.1
ENST00000379883.2
 DDX58
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr10_+_91092241 0.77 ENST00000371811.4
 IFIT3
 interferon-induced protein with tetratricopeptide repeats 3
chr2_-_152146385 0.70 ENST00000414946.1
ENST00000243346.5
 NMI
 N-myc (and STAT) interactor
chr10_+_115439699 0.69 ENST00000369315.1
 CASP7
 caspase 7, apoptosis-related cysteine peptidase
chr15_+_74287009 0.68 ENST00000395135.3
 PML
 promyelocytic leukemia
chr1_+_241695424 0.65 ENST00000366558.3
ENST00000366559.4
 KMO
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr10_+_115439282 0.64 ENST00000369321.2
ENST00000345633.4
 CASP7
 caspase 7, apoptosis-related cysteine peptidase
chr4_+_37892682 0.62 ENST00000508802.1
ENST00000261439.4
ENST00000402522.1
 TBC1D1
 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
chr10_+_115439630 0.61 ENST00000369318.3
 CASP7
 caspase 7, apoptosis-related cysteine peptidase
chr1_+_241695670 0.59 ENST00000366557.4
 KMO
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr11_-_4414880 0.58 ENST00000254436.7
ENST00000543625.1
 TRIM21
 tripartite motif containing 21
chr6_-_33282163 0.57 ENST00000434618.2
ENST00000456592.2
 TAPBP
 TAP binding protein (tapasin)
chr12_-_121477039 0.55 ENST00000257570.5
 OASL
 2'-5'-oligoadenylate synthetase-like
chrX_+_37639264 0.54 ENST00000378588.4
 CYBB
 cytochrome b-245, beta polypeptide
chr9_+_33265011 0.48 ENST00000419016.2
 CHMP5
 charged multivesicular body protein 5
chr22_+_18632666 0.47 ENST00000215794.7
 USP18
 ubiquitin specific peptidase 18
chr3_-_146262352 0.46 ENST00000462666.1
 PLSCR1
 phospholipid scramblase 1
chr17_-_40264692 0.46 ENST00000591220.1
ENST00000251642.3
 DHX58
 DEXH (Asp-Glu-X-His) box polypeptide 58
chr16_-_15736881 0.45 ENST00000540441.2
 KIAA0430
 KIAA0430
chr3_-_146262637 0.45 ENST00000472349.1
ENST00000342435.4
 PLSCR1
 phospholipid scramblase 1
chr17_+_7211656 0.44 ENST00000416016.2
 EIF5A
 eukaryotic translation initiation factor 5A
chr9_+_33264861 0.44 ENST00000223500.8
 CHMP5
 charged multivesicular body protein 5
chr6_+_106546808 0.41 ENST00000369089.3
 PRDM1
 PR domain containing 1, with ZNF domain
chr22_+_40297079 0.34 ENST00000344138.4
ENST00000543252.1
 GRAP2
 GRB2-related adaptor protein 2
chr10_+_91061712 0.32 ENST00000371826.3
 IFIT2
 interferon-induced protein with tetratricopeptide repeats 2
chr3_-_146262428 0.29 ENST00000486631.1
 PLSCR1
 phospholipid scramblase 1
chrX_-_63005405 0.27 ENST00000374878.1
ENST00000437457.2
 ARHGEF9
 Cdc42 guanine nucleotide exchange factor (GEF) 9
chr2_-_37384175 0.25 ENST00000411537.2
ENST00000233057.4
ENST00000395127.2
ENST00000390013.3
 EIF2AK2
 eukaryotic translation initiation factor 2-alpha kinase 2
chr3_-_146262488 0.25 ENST00000487389.1
 PLSCR1
 phospholipid scramblase 1
chr3_-_146262365 0.25 ENST00000448787.2
 PLSCR1
 phospholipid scramblase 1
chr12_+_6881678 0.24 ENST00000441671.2
ENST00000203629.2
 LAG3
 lymphocyte-activation gene 3
chr5_-_142783694 0.22 ENST00000394466.2
 NR3C1
 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr11_-_67141090 0.19 ENST00000312438.7
 CLCF1
 cardiotrophin-like cytokine factor 1
chrX_+_37639302 0.17 ENST00000545017.1
ENST00000536160.1
 CYBB
 cytochrome b-245, beta polypeptide
chr3_-_146262293 0.17 ENST00000448205.1
 PLSCR1
 phospholipid scramblase 1
chr5_-_142783175 0.16 ENST00000231509.3
ENST00000394464.2
 NR3C1
 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr5_-_95297678 0.15 ENST00000237853.4
 ELL2
 elongation factor, RNA polymerase II, 2
chr5_-_95297534 0.14 ENST00000513343.1
ENST00000431061.2
 ELL2
 elongation factor, RNA polymerase II, 2
chr22_+_40297105 0.13 ENST00000540310.1
 GRAP2
 GRB2-related adaptor protein 2
chr7_+_134832808 0.11 ENST00000275767.3
 TMEM140
 transmembrane protein 140
chr6_-_24936170 0.07 ENST00000538035.1
 FAM65B
 family with sequence similarity 65, member B
chr15_+_91643442 0.04 ENST00000394232.1
 SV2B
 synaptic vesicle glycoprotein 2B
chr12_-_27167233 0.03 ENST00000535819.1
ENST00000543803.1
ENST00000535423.1
ENST00000539741.1
ENST00000343028.4
ENST00000545600.1
ENST00000543088.1
 TM7SF3
 transmembrane 7 superfamily member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 9.6 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.2 12.8 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.1 4.4 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
1.1 5.4 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
0.7 2.9 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.6 1.7 GO:0002370 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.4 4.8 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.4 3.6 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.3 2.8 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.3 1.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.3 0.8 GO:1900368 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
0.2 1.2 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.2 19.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 1.9 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.2 0.7 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
0.2 1.7 GO:0002051 osteoblast fate commitment(GO:0002051)
0.2 2.2 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.6 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.1 0.7 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1 9.9 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.1 0.9 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
0.1 0.4 GO:0033078 extrathymic T cell differentiation(GO:0033078)
0.1 0.9 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.1 1.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.1 0.2 GO:0045085 negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1 2.3 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.0 0.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.2 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0 5.1 GO:0051607 defense response to virus(GO:0051607)
0.0 3.0 GO:0009615 response to virus(GO:0009615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 11.1 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.9 5.5 GO:0042296 ISG15 transferase activity(GO:0042296)
0.5 2.3 GO:0004771 sterol esterase activity(GO:0004771)
0.3 3.9 GO:0031386 protein tag(GO:0031386)
0.3 1.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 4.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 1.9 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.1 1.7 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 0.3 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.1 2.3 GO:0005521 lamin binding(GO:0005521)
0.1 1.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.4 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 2.7 GO:0042605 peptide antigen binding(GO:0042605)
0.1 7.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 1.9 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 17.5 GO:0001047 core promoter binding(GO:0001047)
0.1 0.7 GO:0050664 superoxide-generating NADPH oxidase activity(GO:0016175) oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664)
0.0 1.0 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.0 1.1 GO:0001968 fibronectin binding(GO:0001968)
0.0 12.8 GO:0008017 microtubule binding(GO:0008017)
0.0 0.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.4 GO:0017070 U6 snRNA binding(GO:0017070)
0.0 0.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.8 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.2 4.8 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 1.7 PID ALK2 PATHWAY ALK2 signaling events
0.1 1.9 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.1 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 5.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.3 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 2.2 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.5 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.7 PID RAC1 PATHWAY RAC1 signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.0 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.5 40.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 1.0 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 5.5 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 4.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.7 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.5 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 1.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 3.1 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 1.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.7 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 0.4 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.8 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.3 2.8 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 1.1 GO:0036021 endolysosome lumen(GO:0036021)
0.2 0.8 GO:0044530 supraspliceosomal complex(GO:0044530)
0.1 1.7 GO:0071141 SMAD protein complex(GO:0071141)
0.1 1.0 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 0.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.1 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.1 3.1 GO:0005643 nuclear pore(GO:0005643)
0.0 17.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 2.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 7.3 GO:0016607 nuclear speck(GO:0016607)
0.0 2.5 GO:0045111 intermediate filament cytoskeleton(GO:0045111)