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ENCODE cell lines, expression (Ernst 2011)

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Results for IRX2

Z-value: 0.67

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Transcription factors associated with IRX2

Gene Symbol Gene ID Gene Info
IRX2
ENSG00000170561.8 IRX2

Activity profile of IRX2 motif

Sorted Z-values of IRX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_88896819 2.26 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
 SPP1
 secreted phosphoprotein 1
chr13_-_46679185 2.06 ENST00000439329.3
 CPB2
 carboxypeptidase B2 (plasma)
chr13_-_46679144 2.03 ENST00000181383.4
 CPB2
 carboxypeptidase B2 (plasma)
chr1_-_92371839 1.51 ENST00000370399.2
 TGFBR3
 transforming growth factor, beta receptor III
chr4_+_69681710 1.42 ENST00000265403.7
ENST00000458688.2
 UGT2B10
 UDP glucuronosyltransferase 2 family, polypeptide B10
chr1_-_111506562 1.25 ENST00000485275.2
ENST00000369763.4
 LRIF1
 ligand dependent nuclear receptor interacting factor 1
chr20_+_56136136 1.23 ENST00000319441.4
ENST00000543666.1
 PCK1
 phosphoenolpyruvate carboxykinase 1 (soluble)
chr7_+_150065278 1.12 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
 REPIN1
 replication initiator 1
chr16_+_82068830 1.08 ENST00000199936.4
 HSD17B2
 hydroxysteroid (17-beta) dehydrogenase 2
chr1_+_10292308 0.96 ENST00000377081.1
 KIF1B
 kinesin family member 1B
chrX_-_70331298 0.94 ENST00000456850.2
ENST00000473378.1
ENST00000487883.1
ENST00000374202.2
 IL2RG
 interleukin 2 receptor, gamma
chr3_+_193853927 0.86 ENST00000232424.3
 HES1
 hes family bHLH transcription factor 1
chr15_-_80263506 0.83 ENST00000335661.6
 BCL2A1
 BCL2-related protein A1
chr2_+_196313239 0.76 ENST00000413290.1
 AC064834.1
 AC064834.1
chr8_-_124428569 0.76 ENST00000521903.1
 ATAD2
 ATPase family, AAA domain containing 2
chr6_+_24775153 0.66 ENST00000356509.3
ENST00000230056.3
 GMNN
 geminin, DNA replication inhibitor
chrX_+_9431324 0.65 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X
 transducin (beta)-like 1X-linked
chr15_-_45670924 0.62 ENST00000396659.3
 GATM
 glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr6_-_31620455 0.61 ENST00000437771.1
ENST00000404765.2
ENST00000375964.6
ENST00000211379.5
 BAG6
 BCL2-associated athanogene 6
chr3_-_194072019 0.58 ENST00000429275.1
ENST00000323830.3
 CPN2
 carboxypeptidase N, polypeptide 2
chr6_-_31620403 0.56 ENST00000451898.1
ENST00000439687.2
ENST00000362049.6
ENST00000424480.1
 BAG6
 BCL2-associated athanogene 6
chr8_+_81397876 0.54 ENST00000430430.1
 ZBTB10
 zinc finger and BTB domain containing 10
chr1_+_215747118 0.54 ENST00000448333.1
 KCTD3
 potassium channel tetramerization domain containing 3
chr10_-_61122220 0.50 ENST00000422313.2
ENST00000435852.2
ENST00000442566.3
ENST00000373868.2
ENST00000277705.6
ENST00000373867.3
ENST00000419214.2
 FAM13C
 family with sequence similarity 13, member C
chr5_+_156696362 0.49 ENST00000377576.3
 CYFIP2
 cytoplasmic FMR1 interacting protein 2
chr1_-_149783914 0.43 ENST00000369167.1
ENST00000427880.2
ENST00000545683.1
 HIST2H2BF
 histone cluster 2, H2bf
chr3_+_46616017 0.42 ENST00000542931.1
 TDGF1
 teratocarcinoma-derived growth factor 1
chrX_+_30261847 0.41 ENST00000378981.3
ENST00000397550.1
 MAGEB1
 melanoma antigen family B, 1
chr6_+_13272904 0.40 ENST00000379335.3
ENST00000379329.1
 PHACTR1
 phosphatase and actin regulator 1
chr12_+_66218598 0.40 ENST00000541363.1
 HMGA2
 high mobility group AT-hook 2
chr7_+_95115210 0.37 ENST00000428113.1
ENST00000325885.5
 ASB4
 ankyrin repeat and SOCS box containing 4
chr4_-_38806404 0.37 ENST00000308979.2
ENST00000505940.1
ENST00000515861.1
 TLR1
 toll-like receptor 1
chr15_-_20193370 0.35 ENST00000558565.2
 IGHV3OR15-7
 immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr14_+_23790655 0.35 ENST00000397276.2
 PABPN1
 poly(A) binding protein, nuclear 1
chr5_-_138210977 0.35 ENST00000274711.6
ENST00000521094.2
 LRRTM2
 leucine rich repeat transmembrane neuronal 2
chr4_+_119606523 0.34 ENST00000388822.5
ENST00000506780.1
ENST00000508801.1
 METTL14
 methyltransferase like 14
chr4_+_158142750 0.32 ENST00000505888.1
ENST00000449365.1
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr16_+_69373323 0.30 ENST00000254940.5
 NIP7
 NIP7, nucleolar pre-rRNA processing protein
chr16_-_25026641 0.30 ENST00000289968.6
ENST00000303665.5
ENST00000455311.2
ENST00000441763.2
 ARHGAP17
 Rho GTPase activating protein 17
chr1_-_173793458 0.29 ENST00000356198.2
 CENPL
 centromere protein L
chr4_+_158141899 0.29 ENST00000264426.9
ENST00000506284.1
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr19_-_40336969 0.28 ENST00000599134.1
ENST00000597634.1
ENST00000598417.1
ENST00000601274.1
ENST00000594309.1
ENST00000221801.3
 FBL
 fibrillarin
chr9_+_79792410 0.28 ENST00000357409.5
 VPS13A
 vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr16_-_5083917 0.28 ENST00000312251.3
ENST00000381955.3
 NAGPA
 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr5_+_54320078 0.27 ENST00000231009.2
 GZMK
 granzyme K (granzyme 3; tryptase II)
chr2_+_171034646 0.26 ENST00000409044.3
ENST00000408978.4
 MYO3B
 myosin IIIB
chr4_-_153332886 0.26 ENST00000603841.1
 FBXW7
 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chrX_-_118739835 0.26 ENST00000542113.1
ENST00000304449.5
 NKRF
 NFKB repressing factor
chr8_-_86253888 0.25 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
 CA1
 carbonic anhydrase I
chr17_+_34842473 0.25 ENST00000490126.2
ENST00000225410.4
 ZNHIT3
 zinc finger, HIT-type containing 3
chr17_+_34842512 0.25 ENST00000588253.1
ENST00000592616.1
ENST00000590858.1
ENST00000588357.1
 ZNHIT3
 zinc finger, HIT-type containing 3
chr1_+_74701062 0.24 ENST00000326637.3
 TNNI3K
 TNNI3 interacting kinase
chr17_+_37856299 0.24 ENST00000269571.5
 ERBB2
 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
chr11_+_59824127 0.23 ENST00000278865.3
 MS4A3
 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
chr2_-_70520539 0.23 ENST00000482975.2
ENST00000438261.1
 SNRPG
 small nuclear ribonucleoprotein polypeptide G
chr14_+_75536280 0.22 ENST00000238686.8
 ZC2HC1C
 zinc finger, C2HC-type containing 1C
chr1_+_16083154 0.22 ENST00000375771.1
 FBLIM1
 filamin binding LIM protein 1
chr4_+_187187098 0.21 ENST00000403665.2
ENST00000264692.4
 F11
 coagulation factor XI
chrX_+_19373700 0.20 ENST00000379804.1
 PDHA1
 pyruvate dehydrogenase (lipoamide) alpha 1
chr11_-_118305921 0.20 ENST00000532619.1
 RP11-770J1.4
 RP11-770J1.4
chr2_+_138721850 0.20 ENST00000329366.4
ENST00000280097.3
 HNMT
 histamine N-methyltransferase
chr4_-_70505358 0.19 ENST00000457664.2
ENST00000604629.1
ENST00000604021.1
 UGT2A2
 UDP glucuronosyltransferase 2 family, polypeptide A2
chr1_-_190446759 0.19 ENST00000367462.3
 BRINP3
 bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr1_+_67673297 0.18 ENST00000425614.1
ENST00000395227.1
 IL23R
 interleukin 23 receptor
chr14_+_75536335 0.18 ENST00000554763.1
ENST00000439583.2
ENST00000526130.1
ENST00000525046.1
 ZC2HC1C
 zinc finger, C2HC-type containing 1C
chr2_+_242577097 0.18 ENST00000419606.1
ENST00000474739.2
ENST00000396411.3
ENST00000425239.1
ENST00000400771.3
ENST00000430617.2
 ATG4B
 autophagy related 4B, cysteine peptidase
chr6_-_27841289 0.17 ENST00000355981.2
 HIST1H4L
 histone cluster 1, H4l
chr2_+_168675182 0.16 ENST00000305861.1
 B3GALT1
 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr1_+_110527308 0.16 ENST00000369799.5
 AHCYL1
 adenosylhomocysteinase-like 1
chr16_-_20367584 0.15 ENST00000570689.1
 UMOD
 uromodulin
chr14_+_29236269 0.15 ENST00000313071.4
 FOXG1
 forkhead box G1
chr4_+_114214125 0.15 ENST00000509550.1
 ANK2
 ankyrin 2, neuronal
chr5_-_142814241 0.14 ENST00000504572.1
 NR3C1
 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr4_-_80247162 0.14 ENST00000286794.4
 NAA11
 N(alpha)-acetyltransferase 11, NatA catalytic subunit
chr1_+_206516200 0.13 ENST00000295713.5
 SRGAP2
 SLIT-ROBO Rho GTPase activating protein 2
chr1_-_207095324 0.13 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
 FAIM3
 Fas apoptotic inhibitory molecule 3
chr12_+_53773944 0.12 ENST00000551969.1
ENST00000327443.4
 SP1
 Sp1 transcription factor
chr21_+_43823983 0.11 ENST00000291535.6
ENST00000450356.1
ENST00000319294.6
ENST00000398367.1
 UBASH3A
 ubiquitin associated and SH3 domain containing A
chr19_-_38720294 0.11 ENST00000412732.1
ENST00000456296.1
 DPF1
 D4, zinc and double PHD fingers family 1
chr3_+_108541545 0.11 ENST00000295756.6
 TRAT1
 T cell receptor associated transmembrane adaptor 1
chr4_+_158141843 0.11 ENST00000509417.1
ENST00000296526.7
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr14_+_22931924 0.10 ENST00000390477.2
 TRDC
 T cell receptor delta constant
chr12_+_32655048 0.10 ENST00000427716.2
ENST00000266482.3
 FGD4
 FYVE, RhoGEF and PH domain containing 4
chr2_-_109605663 0.10 ENST00000409271.1
ENST00000258443.2
ENST00000376651.1
 EDAR
 ectodysplasin A receptor
chr2_-_166060552 0.10 ENST00000283254.7
ENST00000453007.1
 SCN3A
 sodium channel, voltage-gated, type III, alpha subunit
chr3_-_15140629 0.09 ENST00000507357.1
ENST00000449050.1
ENST00000253699.3
ENST00000435849.3
ENST00000476527.2
 ZFYVE20
 zinc finger, FYVE domain containing 20
chr17_-_2614927 0.09 ENST00000435359.1
 CLUH
 clustered mitochondria (cluA/CLU1) homolog
chr6_-_53013620 0.09 ENST00000259803.7
 GCM1
 glial cells missing homolog 1 (Drosophila)
chr17_-_26127525 0.09 ENST00000313735.6
 NOS2
 nitric oxide synthase 2, inducible
chr22_-_36013368 0.08 ENST00000442617.1
ENST00000397326.2
ENST00000397328.1
ENST00000451685.1
 MB
 myoglobin
chr8_+_24151553 0.08 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
 ADAM28
 ADAM metallopeptidase domain 28
chr4_-_168155417 0.08 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
 SPOCK3
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr16_-_4401258 0.07 ENST00000577031.1
 PAM16
 presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr11_+_98891797 0.07 ENST00000527185.1
ENST00000528682.1
ENST00000524871.1
 CNTN5
 contactin 5
chr3_-_58419537 0.06 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
 PDHB
 pyruvate dehydrogenase (lipoamide) beta
chr21_-_31538971 0.06 ENST00000286808.3
 CLDN17
 claudin 17
chr1_-_156698181 0.05 ENST00000313146.6
 ISG20L2
 interferon stimulated exonuclease gene 20kDa-like 2
chrX_-_100129320 0.05 ENST00000372966.3
 NOX1
 NADPH oxidase 1
chr1_+_113010056 0.05 ENST00000369686.5
 WNT2B
 wingless-type MMTV integration site family, member 2B
chr6_-_136847610 0.05 ENST00000454590.1
ENST00000432797.2
 MAP7
 microtubule-associated protein 7
chr17_+_44590076 0.05 ENST00000333412.3
 LRRC37A2
 leucine rich repeat containing 37, member A2
chr19_+_13134772 0.04 ENST00000587760.1
ENST00000585575.1
 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
chr19_-_38720354 0.03 ENST00000416611.1
 DPF1
 D4, zinc and double PHD fingers family 1
chr7_-_150020578 0.03 ENST00000478393.1
 ACTR3C
 ARP3 actin-related protein 3 homolog C (yeast)
chr12_-_102513843 0.02 ENST00000551744.2
ENST00000552283.1
 NUP37
 nucleoporin 37kDa
chr7_-_107770794 0.02 ENST00000205386.4
ENST00000418464.1
ENST00000388781.3
ENST00000388780.3
ENST00000414450.2
 LAMB4
 laminin, beta 4
chr12_+_66218212 0.01 ENST00000393578.3
ENST00000425208.2
ENST00000536545.1
ENST00000354636.3
 HMGA2
 high mobility group AT-hook 2
chr3_+_148457585 0.01 ENST00000402260.1
 AGTR1
 angiotensin II receptor, type 1
chr14_-_75536182 0.01 ENST00000555463.1
 ACYP1
 acylphosphatase 1, erythrocyte (common) type
chr15_+_57998923 0.01 ENST00000380557.4
 POLR2M
 polymerase (RNA) II (DNA directed) polypeptide M
chr3_-_81792780 0.01 ENST00000489715.1
 GBE1
 glucan (1,4-alpha-), branching enzyme 1
chr4_-_120243545 0.01 ENST00000274024.3
 FABP2
 fatty acid binding protein 2, intestinal
chr4_-_71705060 0.01 ENST00000514161.1
 GRSF1
 G-rich RNA sequence binding factor 1
chr10_+_96522361 0.01 ENST00000371321.3
 CYP2C19
 cytochrome P450, family 2, subfamily C, polypeptide 19
chr10_+_46997926 0.01 ENST00000374314.4
 GPRIN2
 G protein regulated inducer of neurite outgrowth 2
chr3_-_113160334 0.01 ENST00000393845.2
ENST00000295868.2
 WDR52
 WD repeat domain 52
chr1_-_157811588 0.01 ENST00000368174.4
 CD5L
 CD5 molecule-like
chr14_-_106312010 0.00 ENST00000390556.2
 IGHD
 immunoglobulin heavy constant delta
chr3_-_11645925 0.00 ENST00000413604.1
 VGLL4
 vestigial like 4 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.8 2.3 GO:2000864 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.5 1.5 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.3 1.0 GO:1904647 response to rotenone(GO:1904647)
0.3 1.2 GO:0006114 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
0.3 1.2 GO:1904327 maintenance of unfolded protein(GO:0036506) protein localization to cytosolic proteasome complex(GO:1904327) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.3 0.9 GO:0021558 midbrain-hindbrain boundary morphogenesis(GO:0021555) trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164)
0.1 0.4 GO:0031049 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.1 0.9 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.1 0.4 GO:0042495 detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.1 0.4 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.1 0.7 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
0.1 1.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 0.8 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.3 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
0.1 0.3 GO:0080009 mRNA methylation(GO:0080009)
0.1 0.5 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1 0.2 GO:0051697 protein delipidation(GO:0051697)
0.1 0.6 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.3 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.2 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.1 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.2 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.1 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.0 0.1 GO:0018002 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
0.0 0.2 GO:0001692 histamine metabolic process(GO:0001692)
0.0 0.8 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.2 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0 0.2 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0 0.4 GO:0002091 negative regulation of receptor internalization(GO:0002091)
0.0 0.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:0060018 astrocyte fate commitment(GO:0060018)
0.0 0.4 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.4 GO:0008595 tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595)
0.0 0.3 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.2 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.7 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.2 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.1 GO:0021815 modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.3 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.2 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.7 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
0.0 0.7 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.0 0.2 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.0 0.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 2.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.2 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.0 0.2 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.9 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.8 PID BCR 5PATHWAY BCR signaling pathway
0.0 0.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.5 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.3 1.2 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 0.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.1 0.3 GO:0036396 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.1 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.1 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.4 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.2 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.0 0.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.3 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.0 1.0 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.1 GO:0031415 NatA complex(GO:0031415)
0.0 0.1 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.0 0.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.1 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.3 0.9 GO:0004913 interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.3 1.1 GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.2 4.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 1.5 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 0.4 GO:0035501 MH1 domain binding(GO:0035501)
0.1 0.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.1 0.3 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.1 1.2 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.3 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.2 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0 0.2 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.8 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
0.0 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.3 GO:0004064 arylesterase activity(GO:0004064)
0.0 0.1 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.3 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 0.6 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.0 0.3 GO:0008649 rRNA methyltransferase activity(GO:0008649)
0.0 1.0 GO:1990939 ATP-dependent microtubule motor activity(GO:1990939)
0.0 0.2 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.5 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.3 GO:0015929 hexosaminidase activity(GO:0015929)
0.0 1.7 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.2 GO:0031005 filamin binding(GO:0031005)