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ENCODE cell lines, expression (Ernst 2011)

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Results for IRX5

Z-value: 0.66

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Transcription factors associated with IRX5

Gene Symbol Gene ID Gene Info
IRX5
ENSG00000176842.10 IRX5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX5hg19_v2_chr16_+_54964740_54964789-0.039.2e-01Click!

Activity profile of IRX5 motif

Sorted Z-values of IRX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_46716969 4.10 ENST00000435666.2
 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
chrX_+_49294472 3.34 ENST00000361446.5
 GAGE12B
 G antigen 12B
chrX_-_52258669 2.47 ENST00000441417.1
 XAGE1A
 X antigen family, member 1A
chrX_+_52513455 2.36 ENST00000446098.1
 XAGE1C
 X antigen family, member 1C
chr8_-_108510224 1.88 ENST00000517746.1
ENST00000297450.3
 ANGPT1
 angiopoietin 1
chrX_+_52240504 1.57 ENST00000399805.2
 XAGE1B
 X antigen family, member 1B
chr1_+_26644441 1.47 ENST00000374213.2
 CD52
 CD52 molecule
chr6_-_26216872 1.38 ENST00000244601.3
 HIST1H2BG
 histone cluster 1, H2bg
chr7_-_87856280 1.20 ENST00000490437.1
ENST00000431660.1
 SRI
 sorcin
chr7_-_87856303 1.14 ENST00000394641.3
 SRI
 sorcin
chr11_+_60223225 0.95 ENST00000524807.1
ENST00000345732.4
 MS4A1
 membrane-spanning 4-domains, subfamily A, member 1
chr16_+_31539197 0.92 ENST00000564707.1
 AHSP
 alpha hemoglobin stabilizing protein
chr15_+_49170083 0.84 ENST00000530028.2
 EID1
 EP300 interacting inhibitor of differentiation 1
chr17_-_29641104 0.82 ENST00000577894.1
ENST00000330927.4
 EVI2B
 ecotropic viral integration site 2B
chrX_+_12809463 0.80 ENST00000380663.3
ENST00000380668.5
ENST00000398491.2
ENST00000489404.1
 PRPS2
 phosphoribosyl pyrophosphate synthetase 2
chr16_+_31539183 0.78 ENST00000302312.4
 AHSP
 alpha hemoglobin stabilizing protein
chr15_+_41057818 0.77 ENST00000558467.1
 GCHFR
 GTP cyclohydrolase I feedback regulator
chr11_+_60048053 0.73 ENST00000337908.4
 MS4A4A
 membrane-spanning 4-domains, subfamily A, member 4A
chr1_-_241683001 0.63 ENST00000366560.3
 FH
 fumarate hydratase
chr17_-_29641084 0.62 ENST00000544462.1
 EVI2B
 ecotropic viral integration site 2B
chr2_-_183106641 0.60 ENST00000346717.4
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr3_-_168865522 0.59 ENST00000464456.1
 MECOM
 MDS1 and EVI1 complex locus
chr12_+_32655048 0.56 ENST00000427716.2
ENST00000266482.3
 FGD4
 FYVE, RhoGEF and PH domain containing 4
chr17_+_18380051 0.54 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
 LGALS9C
 lectin, galactoside-binding, soluble, 9C
chr14_-_23623577 0.54 ENST00000422941.2
ENST00000453702.1
 SLC7A8
 solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr14_-_106471723 0.53 ENST00000390595.2
 IGHV1-3
 immunoglobulin heavy variable 1-3
chr2_+_58655461 0.53 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
 AC007092.1
 long intergenic non-protein coding RNA 1122
chr11_+_31531291 0.52 ENST00000350638.5
ENST00000379163.5
ENST00000395934.2
 ELP4
 elongator acetyltransferase complex subunit 4
chr12_-_25102252 0.51 ENST00000261192.7
 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
chr2_+_160590469 0.51 ENST00000409591.1
 MARCH7
 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr8_-_101962777 0.50 ENST00000395951.3
 YWHAZ
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr14_-_106963409 0.49 ENST00000390621.2
 IGHV1-45
 immunoglobulin heavy variable 1-45
chr6_+_42584847 0.49 ENST00000372883.3
 UBR2
 ubiquitin protein ligase E3 component n-recognin 2
chr6_+_26217159 0.48 ENST00000303910.2
 HIST1H2AE
 histone cluster 1, H2ae
chr8_+_27947746 0.46 ENST00000521015.1
ENST00000521570.1
 ELP3
 elongator acetyltransferase complex subunit 3
chr8_+_125463048 0.45 ENST00000328599.3
 TRMT12
 tRNA methyltransferase 12 homolog (S. cerevisiae)
chr16_+_87636474 0.45 ENST00000284262.2
 JPH3
 junctophilin 3
chr4_+_122722466 0.45 ENST00000243498.5
ENST00000379663.3
ENST00000509800.1
 EXOSC9
 exosome component 9
chr14_-_106845789 0.44 ENST00000390617.2
 IGHV3-35
 immunoglobulin heavy variable 3-35 (non-functional)
chr8_-_67976509 0.43 ENST00000518747.1
 COPS5
 COP9 signalosome subunit 5
chr3_+_173116225 0.40 ENST00000457714.1
 NLGN1
 neuroligin 1
chr21_-_34185944 0.39 ENST00000479548.1
 C21orf62
 chromosome 21 open reading frame 62
chr4_+_17616253 0.39 ENST00000237380.7
 MED28
 mediator complex subunit 28
chr15_-_64665911 0.38 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
 CTD-2116N17.1
 Uncharacterized protein
chr17_-_47723943 0.38 ENST00000510476.1
ENST00000503676.1
 SPOP
 speckle-type POZ protein
chr17_+_25958174 0.37 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
 LGALS9
 lectin, galactoside-binding, soluble, 9
chr8_+_84824920 0.37 ENST00000523678.1
 RP11-120I21.2
 RP11-120I21.2
chr4_-_104119528 0.37 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
 CENPE
 centromere protein E, 312kDa
chr2_+_169757750 0.37 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
 G6PC2
 glucose-6-phosphatase, catalytic, 2
chr14_-_23877474 0.36 ENST00000405093.3
 MYH6
 myosin, heavy chain 6, cardiac muscle, alpha
chr10_-_14050522 0.35 ENST00000342409.2
 FRMD4A
 FERM domain containing 4A
chrX_-_15353629 0.35 ENST00000333590.4
ENST00000428964.1
ENST00000542278.1
 PIGA
 phosphatidylinositol glycan anchor biosynthesis, class A
chr7_+_77469439 0.35 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
 PHTF2
 putative homeodomain transcription factor 2
chr5_+_169010638 0.34 ENST00000265295.4
ENST00000506574.1
ENST00000515224.1
ENST00000508247.1
ENST00000513941.1
 SPDL1
 spindle apparatus coiled-coil protein 1
chr15_-_44116873 0.34 ENST00000267812.3
 MFAP1
 microfibrillar-associated protein 1
chr4_-_100356844 0.33 ENST00000437033.2
 ADH7
 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr1_-_197115818 0.32 ENST00000367409.4
ENST00000294732.7
 ASPM
 asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr1_-_114355083 0.32 ENST00000261441.5
 RSBN1
 round spermatid basic protein 1
chr3_+_52245458 0.32 ENST00000459884.1
 ALAS1
 aminolevulinate, delta-, synthase 1
chr10_-_96829246 0.32 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
 CYP2C8
 cytochrome P450, family 2, subfamily C, polypeptide 8
chr4_+_80584903 0.31 ENST00000506460.1
 RP11-452C8.1
 RP11-452C8.1
chr17_+_58018269 0.31 ENST00000591035.1
 RP11-178C3.1
 Uncharacterized protein
chr5_-_64064508 0.31 ENST00000513458.4
 SREK1IP1
 SREK1-interacting protein 1
chr19_-_12992244 0.31 ENST00000538460.1
 DNASE2
 deoxyribonuclease II, lysosomal
chr6_+_37012607 0.29 ENST00000423336.1
 COX6A1P2
 cytochrome c oxidase subunit VIa polypeptide 1 pseudogene 2
chr3_+_186383741 0.27 ENST00000232003.4
 HRG
 histidine-rich glycoprotein
chr13_-_88323218 0.27 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
 MIR4500HG
 MIR4500 host gene (non-protein coding)
chr14_-_21737551 0.26 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
 HNRNPC
 heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr16_-_58585513 0.26 ENST00000245138.4
ENST00000567285.1
 CNOT1
 CCR4-NOT transcription complex, subunit 1
chr1_-_115124257 0.26 ENST00000369541.3
 BCAS2
 breast carcinoma amplified sequence 2
chr9_+_42704004 0.25 ENST00000457288.1
 CBWD7
 COBW domain containing 7
chr3_-_3221358 0.25 ENST00000424814.1
ENST00000450014.1
ENST00000231948.4
ENST00000432408.2
 CRBN
 cereblon
chr16_+_19467772 0.25 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
 TMC5
 transmembrane channel-like 5
chr1_+_155579979 0.25 ENST00000452804.2
ENST00000538143.1
ENST00000245564.2
ENST00000368341.4
 MSTO1
 misato 1, mitochondrial distribution and morphology regulator
chr8_+_67976593 0.24 ENST00000262210.5
ENST00000412460.1
 CSPP1
 centrosome and spindle pole associated protein 1
chr21_-_34186006 0.24 ENST00000490358.1
 C21orf62
 chromosome 21 open reading frame 62
chr3_+_46395219 0.24 ENST00000445132.2
ENST00000292301.4
 CCR2
 chemokine (C-C motif) receptor 2
chrX_+_108779004 0.23 ENST00000218004.1
 NXT2
 nuclear transport factor 2-like export factor 2
chr9_-_21202204 0.23 ENST00000239347.3
 IFNA7
 interferon, alpha 7
chr9_-_21166659 0.22 ENST00000380225.1
 IFNA21
 interferon, alpha 21
chr19_-_22379753 0.22 ENST00000397121.2
 ZNF676
 zinc finger protein 676
chrX_+_15767971 0.22 ENST00000479740.1
ENST00000454127.2
 CA5B
 carbonic anhydrase VB, mitochondrial
chr17_+_75447326 0.22 ENST00000591088.1
 SEPT9
 septin 9
chr17_-_42327236 0.22 ENST00000399246.2
 AC003102.1
 AC003102.1
chr2_-_40657397 0.22 ENST00000408028.2
ENST00000332839.4
ENST00000406391.2
ENST00000542024.1
ENST00000542756.1
ENST00000405901.3
 SLC8A1
 solute carrier family 8 (sodium/calcium exchanger), member 1
chr14_-_106967788 0.21 ENST00000390622.2
 IGHV1-46
 immunoglobulin heavy variable 1-46
chr1_-_145826450 0.21 ENST00000462900.2
 GPR89A
 G protein-coupled receptor 89A
chr19_-_12992274 0.20 ENST00000592506.1
ENST00000222219.3
 DNASE2
 deoxyribonuclease II, lysosomal
chr1_+_196857144 0.19 ENST00000367416.2
ENST00000251424.4
ENST00000367418.2
 CFHR4
 complement factor H-related 4
chr1_+_196788887 0.18 ENST00000320493.5
ENST00000367424.4
ENST00000367421.3
 CFHR1
CFHR2
 complement factor H-related 1
complement factor H-related 2
chr22_-_24096562 0.18 ENST00000398465.3
 VPREB3
 pre-B lymphocyte 3
chr6_-_154677900 0.18 ENST00000265198.4
ENST00000520261.1
 IPCEF1
 interaction protein for cytohesin exchange factors 1
chr12_-_100486668 0.18 ENST00000550544.1
ENST00000551980.1
ENST00000548045.1
ENST00000545232.2
ENST00000551973.1
 UHRF1BP1L
 UHRF1 binding protein 1-like
chr21_-_34185989 0.18 ENST00000487113.1
ENST00000382373.4
 C21orf62
 chromosome 21 open reading frame 62
chr7_+_116502527 0.18 ENST00000361183.3
 CAPZA2
 capping protein (actin filament) muscle Z-line, alpha 2
chr3_-_9994021 0.17 ENST00000411976.2
ENST00000412055.1
 PRRT3
 proline-rich transmembrane protein 3
chr6_+_26204825 0.17 ENST00000360441.4
 HIST1H4E
 histone cluster 1, H4e
chr12_-_76462713 0.16 ENST00000552056.1
 NAP1L1
 nucleosome assembly protein 1-like 1
chr14_+_51706886 0.16 ENST00000457354.2
 TMX1
 thioredoxin-related transmembrane protein 1
chr15_+_66585879 0.15 ENST00000319212.4
 DIS3L
 DIS3 mitotic control homolog (S. cerevisiae)-like
chr3_+_180586536 0.15 ENST00000465551.1
 FXR1
 fragile X mental retardation, autosomal homolog 1
chr11_-_89653576 0.14 ENST00000420869.1
 TRIM49D1
 tripartite motif containing 49D1
chr12_+_106751436 0.14 ENST00000228347.4
 POLR3B
 polymerase (RNA) III (DNA directed) polypeptide B
chr6_+_27925019 0.14 ENST00000244623.1
 OR2B6
 olfactory receptor, family 2, subfamily B, member 6
chr9_+_105757590 0.14 ENST00000374798.3
ENST00000487798.1
 CYLC2
 cylicin, basic protein of sperm head cytoskeleton 2
chr1_+_196743912 0.14 ENST00000367425.4
 CFHR3
 complement factor H-related 3
chr14_+_73563735 0.14 ENST00000532192.1
 RBM25
 RNA binding motif protein 25
chr10_-_35379524 0.13 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
 CUL2
 cullin 2
chr7_+_66386204 0.13 ENST00000341567.4
ENST00000607045.1
 TMEM248
 transmembrane protein 248
chr11_-_22647350 0.12 ENST00000327470.3
 FANCF
 Fanconi anemia, complementation group F
chr12_-_4553385 0.12 ENST00000543077.1
 FGF6
 fibroblast growth factor 6
chr19_-_50266580 0.11 ENST00000246801.3
 TSKS
 testis-specific serine kinase substrate
chr12_-_10282836 0.11 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
 CLEC7A
 C-type lectin domain family 7, member A
chr9_-_37465396 0.10 ENST00000307750.4
 ZBTB5
 zinc finger and BTB domain containing 5
chr21_-_43816052 0.10 ENST00000398405.1
 TMPRSS3
 transmembrane protease, serine 3
chr4_+_76995855 0.09 ENST00000355810.4
ENST00000349321.3
 ART3
 ADP-ribosyltransferase 3
chr8_+_12803176 0.09 ENST00000524591.2
 KIAA1456
 KIAA1456
chr3_-_72897545 0.09 ENST00000325599.8
 SHQ1
 SHQ1, H/ACA ribonucleoprotein assembly factor
chr12_-_10282742 0.09 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A
 C-type lectin domain family 7, member A
chr2_+_113816215 0.09 ENST00000346807.3
 IL36RN
 interleukin 36 receptor antagonist
chr1_+_196912902 0.09 ENST00000476712.2
ENST00000367415.5
 CFHR2
 complement factor H-related 2
chr1_+_22778337 0.08 ENST00000404138.1
ENST00000400239.2
ENST00000375647.4
ENST00000374651.4
 ZBTB40
 zinc finger and BTB domain containing 40
chr12_-_21757774 0.08 ENST00000261195.2
 GYS2
 glycogen synthase 2 (liver)
chr7_+_20686946 0.08 ENST00000443026.2
ENST00000406935.1
 ABCB5
 ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr18_-_32924372 0.08 ENST00000261332.6
ENST00000399061.3
 ZNF24
 zinc finger protein 24
chr1_-_152086556 0.07 ENST00000368804.1
 TCHH
 trichohyalin
chr17_+_3379284 0.07 ENST00000263080.2
 ASPA
 aspartoacylase
chr18_+_6729725 0.07 ENST00000400091.2
ENST00000583410.1
ENST00000584387.1
 ARHGAP28
 Rho GTPase activating protein 28
chr11_-_118305921 0.06 ENST00000532619.1
 RP11-770J1.4
 RP11-770J1.4
chr11_+_61891445 0.06 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
 INCENP
 inner centromere protein antigens 135/155kDa
chr13_+_96085847 0.06 ENST00000376873.3
 CLDN10
 claudin 10
chr10_+_118350468 0.06 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr3_-_50378235 0.05 ENST00000357043.2
 RASSF1
 Ras association (RalGDS/AF-6) domain family member 1
chr1_-_3566590 0.05 ENST00000424367.1
ENST00000378322.3
 WRAP73
 WD repeat containing, antisense to TP73
chr1_+_10509971 0.05 ENST00000320498.4
 CORT
 cortistatin
chr21_+_38792602 0.05 ENST00000398960.2
ENST00000398956.2
 DYRK1A
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr10_+_118350522 0.05 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr1_+_220267429 0.05 ENST00000366922.1
ENST00000302637.5
 IARS2
 isoleucyl-tRNA synthetase 2, mitochondrial
chr6_-_111804905 0.05 ENST00000358835.3
ENST00000435970.1
 REV3L
 REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr1_+_67632083 0.04 ENST00000347310.5
ENST00000371002.1
 IL23R
 interleukin 23 receptor
chr6_+_146920116 0.04 ENST00000367493.3
 ADGB
 androglobin
chr2_+_191792376 0.04 ENST00000409428.1
ENST00000409215.1
 GLS
 glutaminase
chr3_+_53528659 0.04 ENST00000350061.5
 CACNA1D
 calcium channel, voltage-dependent, L type, alpha 1D subunit
chr2_-_127963343 0.04 ENST00000335247.7
 CYP27C1
 cytochrome P450, family 27, subfamily C, polypeptide 1
chr1_-_116383738 0.03 ENST00000320238.3
 NHLH2
 nescient helix loop helix 2
chr6_+_29364416 0.03 ENST00000383555.2
 OR12D2
 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
chr5_+_128300810 0.03 ENST00000262462.4
 SLC27A6
 solute carrier family 27 (fatty acid transporter), member 6
chr6_-_111804393 0.03 ENST00000368802.3
ENST00000368805.1
 REV3L
 REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr14_+_50291993 0.03 ENST00000595378.1
 AL627171.2
 HCG1786899; PRO2610; Uncharacterized protein
chr2_+_173686303 0.03 ENST00000397087.3
 RAPGEF4
 Rap guanine nucleotide exchange factor (GEF) 4
chr1_+_196743943 0.03 ENST00000471440.2
ENST00000391985.3
 CFHR3
 complement factor H-related 3
chr10_-_115904361 0.03 ENST00000428953.1
ENST00000543782.1
 C10orf118
 chromosome 10 open reading frame 118
chr1_+_158969752 0.03 ENST00000566111.1
 IFI16
 interferon, gamma-inducible protein 16
chr12_+_21679220 0.03 ENST00000256969.2
 C12orf39
 chromosome 12 open reading frame 39
chr6_+_146920097 0.02 ENST00000397944.3
ENST00000522242.1
 ADGB
 androglobin
chr1_+_113010056 0.02 ENST00000369686.5
 WNT2B
 wingless-type MMTV integration site family, member 2B
chr5_+_54455946 0.02 ENST00000503787.1
ENST00000296734.6
ENST00000515370.1
 GPX8
 glutathione peroxidase 8 (putative)
chr3_+_155838337 0.02 ENST00000490337.1
ENST00000389636.5
 KCNAB1
 potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr3_-_46068969 0.02 ENST00000542109.1
ENST00000395946.2
 XCR1
 chemokine (C motif) receptor 1
chrX_-_33229636 0.02 ENST00000357033.4
 DMD
 dystrophin
chr14_+_22386325 0.02 ENST00000390439.2
 TRAV13-2
 T cell receptor alpha variable 13-2
chr14_-_23876801 0.02 ENST00000356287.3
 MYH6
 myosin, heavy chain 6, cardiac muscle, alpha
chrY_+_23698778 0.01 ENST00000303902.5
 RBMY1A1
 RNA binding motif protein, Y-linked, family 1, member A1
chr20_+_10199468 0.01 ENST00000254976.2
ENST00000304886.2
 SNAP25
 synaptosomal-associated protein, 25kDa
chr12_+_5541267 0.01 ENST00000423158.3
 NTF3
 neurotrophin 3
chrY_-_24038660 0.01 ENST00000382677.3
 RBMY1D
 RNA binding motif protein, Y-linked, family 1, member D
chr4_+_56212270 0.01 ENST00000264228.4
 SRD5A3
 steroid 5 alpha-reductase 3
chr6_+_29429217 0.01 ENST00000396792.2
 OR2H1
 olfactory receptor, family 2, subfamily H, member 1
chr15_+_66585555 0.01 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
 DIS3L
 DIS3 mitotic control homolog (S. cerevisiae)-like
chr3_+_171561127 0.01 ENST00000334567.5
ENST00000450693.1
 TMEM212
 transmembrane protein 212
chr7_-_80141328 0.01 ENST00000398291.3
 GNAT3
 guanine nucleotide binding protein, alpha transducing 3
chr12_-_11036844 0.00 ENST00000428168.2
 PRH1
 proline-rich protein HaeIII subfamily 1
chr16_+_19535133 0.00 ENST00000396212.2
ENST00000381396.5
 CCP110
 centriolar coiled coil protein 110kDa
chr4_+_159131630 0.00 ENST00000504569.1
ENST00000509278.1
ENST00000514558.1
ENST00000503200.1
 TMEM144
 transmembrane protein 144

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0044326 dendritic spine neck(GO:0044326)
0.2 4.1 GO:0001891 phagocytic cup(GO:0001891)
0.2 0.8 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.1 1.7 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.5 GO:0030314 junctional membrane complex(GO:0030314)
0.1 1.0 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.1 0.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.1 GO:0033011 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.0 0.6 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.5 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0 1.5 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.3 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.0 0.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.3 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0 1.9 GO:0005902 microvillus(GO:0005902)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.3 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.4 GO:0032982 myosin filament(GO:0032982)
0.0 0.1 GO:0000801 central element(GO:0000801)
0.0 0.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.3 GO:0036019 endolysosome(GO:0036019)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 0.5 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 2.0 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.5 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.2 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 0.3 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.5 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.5 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0030492 hemoglobin binding(GO:0030492)
0.3 0.8 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.2 0.7 GO:0043515 kinetochore binding(GO:0043515)
0.2 0.5 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.1 0.8 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.1 0.3 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 1.0 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.1 0.4 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.6 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 0.5 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.3 GO:0035276 aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.1 0.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.2 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1 0.4 GO:0017018 myosin phosphatase activity(GO:0017018)
0.1 2.4 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 0.3 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 0.4 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.5 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.5 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 1.0 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.4 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 1.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 1.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.5 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 4.1 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.0 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.2 GO:0002151 G-quadruplex RNA binding(GO:0002151) RNA strand annealing activity(GO:0033592)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.6 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.5 GO:0017091 AU-rich element binding(GO:0017091)
0.0 0.6 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.9 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.6 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.3 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.3 1.9 GO:0048014 Tie signaling pathway(GO:0048014)
0.3 4.1 GO:0051639 actin filament network formation(GO:0051639)
0.3 0.8 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.2 0.6 GO:0006106 fumarate metabolic process(GO:0006106)
0.2 0.8 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.1 0.4 GO:0099543 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 0.4 GO:0032831 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1 0.5 GO:0034473 U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1 0.3 GO:0010430 fatty acid omega-oxidation(GO:0010430)
0.1 0.5 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1 0.5 GO:0071233 cellular response to leucine(GO:0071233)
0.1 0.2 GO:2000439 negative regulation of eosinophil activation(GO:1902567) positive regulation of monocyte extravasation(GO:2000439)
0.1 1.4 GO:0020027 hemoglobin metabolic process(GO:0020027)
0.1 0.3 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1 0.1 GO:0006533 aspartate catabolic process(GO:0006533)
0.1 0.4 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.4 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.3 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.3 GO:0002933 lipid hydroxylation(GO:0002933)
0.0 1.5 GO:0045730 respiratory burst(GO:0045730)
0.0 0.3 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.4 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.4 GO:0055009 atrial cardiac muscle tissue development(GO:0003228) cardiac muscle fiber development(GO:0048739) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0 0.5 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.2 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.0 0.3 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.4 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.3 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.5 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:2000232 regulation of rRNA processing(GO:2000232)
0.0 0.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.0 0.3 GO:0090073 positive regulation of protein homodimerization activity(GO:0090073)
0.0 0.3 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.5 GO:0002643 regulation of tolerance induction(GO:0002643)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.8 GO:0035065 regulation of histone acetylation(GO:0035065)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.6 GO:0071425 hematopoietic stem cell proliferation(GO:0071425)
0.0 0.5 GO:0015695 organic cation transport(GO:0015695)
0.0 0.0 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.1 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.0 0.2 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.5 GO:0035640 exploration behavior(GO:0035640)
0.0 0.2 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 0.3 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.2 GO:0015671 oxygen transport(GO:0015671)
0.0 0.4 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 1.0 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 1.0 GO:0042100 B cell proliferation(GO:0042100)
0.0 0.4 GO:0051156 glucose 6-phosphate metabolic process(GO:0051156)