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ENCODE cell lines, expression (Ernst 2011)

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Results for IRX6_IRX4

Z-value: 0.42

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Transcription factors associated with IRX6_IRX4

Gene Symbol Gene ID Gene Info
IRX6
ENSG00000159387.7 IRX6
IRX4
ENSG00000113430.5 IRX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
IRX4hg19_v2_chr5_-_1882858_1883003-0.263.3e-01Click!

Activity profile of IRX6_IRX4 motif

Sorted Z-values of IRX6_IRX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of IRX6_IRX4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_46716969 2.45 ENST00000435666.2
 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
chrX_+_49294472 2.30 ENST00000361446.5
 GAGE12B
 G antigen 12B
chr1_+_26644441 0.76 ENST00000374213.2
 CD52
 CD52 molecule
chr2_+_58655461 0.60 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
 AC007092.1
 long intergenic non-protein coding RNA 1122
chr12_+_32655048 0.49 ENST00000427716.2
ENST00000266482.3
 FGD4
 FYVE, RhoGEF and PH domain containing 4
chr15_+_41057818 0.42 ENST00000558467.1
 GCHFR
 GTP cyclohydrolase I feedback regulator
chr21_-_34185944 0.36 ENST00000479548.1
 C21orf62
 chromosome 21 open reading frame 62
chr21_-_34186006 0.34 ENST00000490358.1
 C21orf62
 chromosome 21 open reading frame 62
chr17_-_29641104 0.32 ENST00000577894.1
ENST00000330927.4
 EVI2B
 ecotropic viral integration site 2B
chr17_-_42327236 0.32 ENST00000399246.2
 AC003102.1
 AC003102.1
chr14_-_23623577 0.32 ENST00000422941.2
ENST00000453702.1
 SLC7A8
 solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr21_-_34185989 0.27 ENST00000487113.1
ENST00000382373.4
 C21orf62
 chromosome 21 open reading frame 62
chr14_-_21737551 0.27 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
 HNRNPC
 heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr15_+_66585879 0.27 ENST00000319212.4
 DIS3L
 DIS3 mitotic control homolog (S. cerevisiae)-like
chr17_-_29641084 0.25 ENST00000544462.1
 EVI2B
 ecotropic viral integration site 2B
chr17_-_47723943 0.24 ENST00000510476.1
ENST00000503676.1
 SPOP
 speckle-type POZ protein
chr15_+_66585555 0.20 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
 DIS3L
 DIS3 mitotic control homolog (S. cerevisiae)-like
chr3_-_9994021 0.19 ENST00000411976.2
ENST00000412055.1
 PRRT3
 proline-rich transmembrane protein 3
chr12_-_10282742 0.19 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A
 C-type lectin domain family 7, member A
chr2_-_183106641 0.18 ENST00000346717.4
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr8_+_12803176 0.17 ENST00000524591.2
 KIAA1456
 KIAA1456
chr14_-_106845789 0.16 ENST00000390617.2
 IGHV3-35
 immunoglobulin heavy variable 3-35 (non-functional)
chr4_-_153303658 0.16 ENST00000296555.5
 FBXW7
 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_+_158142750 0.16 ENST00000505888.1
ENST00000449365.1
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr8_+_67976593 0.15 ENST00000262210.5
ENST00000412460.1
 CSPP1
 centrosome and spindle pole associated protein 1
chr1_+_220267429 0.14 ENST00000366922.1
ENST00000302637.5
 IARS2
 isoleucyl-tRNA synthetase 2, mitochondrial
chr2_+_160590469 0.13 ENST00000409591.1
 MARCH7
 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr15_-_64665911 0.12 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
 CTD-2116N17.1
 Uncharacterized protein
chr4_-_104119528 0.12 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
 CENPE
 centromere protein E, 312kDa
chr8_-_67976509 0.11 ENST00000518747.1
 COPS5
 COP9 signalosome subunit 5
chrX_+_15767971 0.10 ENST00000479740.1
ENST00000454127.2
 CA5B
 carbonic anhydrase VB, mitochondrial
chr12_-_10282836 0.09 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
 CLEC7A
 C-type lectin domain family 7, member A
chr4_+_158141899 0.09 ENST00000264426.9
ENST00000506284.1
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr22_-_24096562 0.09 ENST00000398465.3
 VPREB3
 pre-B lymphocyte 3
chr7_-_80141328 0.09 ENST00000398291.3
 GNAT3
 guanine nucleotide binding protein, alpha transducing 3
chr8_+_84824920 0.09 ENST00000523678.1
 RP11-120I21.2
 RP11-120I21.2
chr5_+_54320078 0.09 ENST00000231009.2
 GZMK
 granzyme K (granzyme 3; tryptase II)
chr10_-_115904361 0.08 ENST00000428953.1
ENST00000543782.1
 C10orf118
 chromosome 10 open reading frame 118
chr3_-_168865522 0.07 ENST00000464456.1
 MECOM
 MDS1 and EVI1 complex locus
chr1_-_3566590 0.07 ENST00000424367.1
ENST00000378322.3
 WRAP73
 WD repeat containing, antisense to TP73
chrX_-_19988382 0.06 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
 CXorf23
 chromosome X open reading frame 23
chr3_+_171561127 0.06 ENST00000334567.5
ENST00000450693.1
 TMEM212
 transmembrane protein 212
chr1_+_53308398 0.05 ENST00000371528.1
 ZYG11A
 zyg-11 family member A, cell cycle regulator
chr19_-_22379753 0.05 ENST00000397121.2
 ZNF676
 zinc finger protein 676
chr1_-_152086556 0.04 ENST00000368804.1
 TCHH
 trichohyalin
chr12_-_76462713 0.04 ENST00000552056.1
 NAP1L1
 nucleosome assembly protein 1-like 1
chr10_+_118350522 0.04 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr10_+_118350468 0.03 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr3_+_53528659 0.03 ENST00000350061.5
 CACNA1D
 calcium channel, voltage-dependent, L type, alpha 1D subunit
chrX_-_15333736 0.03 ENST00000380470.3
 ASB11
 ankyrin repeat and SOCS box containing 11
chr1_+_67673297 0.02 ENST00000425614.1
ENST00000395227.1
 IL23R
 interleukin 23 receptor
chr6_-_49834209 0.02 ENST00000507853.1
 CRISP1
 cysteine-rich secretory protein 1
chr11_+_61891445 0.02 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
 INCENP
 inner centromere protein antigens 135/155kDa
chr15_-_51630772 0.02 ENST00000557858.1
ENST00000558328.1
ENST00000396404.4
ENST00000561075.1
ENST00000405011.2
ENST00000559980.1
ENST00000453807.2
ENST00000396402.1
 CYP19A1
 cytochrome P450, family 19, subfamily A, polypeptide 1
chr19_+_50691437 0.01 ENST00000598205.1
 MYH14
 myosin, heavy chain 14, non-muscle
chr12_+_5541267 0.01 ENST00000423158.3
 NTF3
 neurotrophin 3
chr6_-_49834240 0.01 ENST00000335847.4
 CRISP1
 cysteine-rich secretory protein 1
chr12_+_53848549 0.01 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
 PCBP2
 poly(rC) binding protein 2
chr7_-_16844611 0.01 ENST00000401412.1
ENST00000419304.2
 AGR2
 anterior gradient 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.4 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.2 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0 0.2 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.5 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.1 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.0 0.8 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.0 0.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.0 0.3 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.0 0.3 GO:0032211 negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.3 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.2 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.5 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.1 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 0.2 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.5 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.2 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)