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ENCODE cell lines, expression (Ernst 2011)

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Results for ISL1

Z-value: 1.16

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Transcription factors associated with ISL1

Gene Symbol Gene ID Gene Info
ISL1
ENSG00000016082.10 ISL1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ISL1hg19_v2_chr5_+_50678921_506789210.029.5e-01Click!

Activity profile of ISL1 motif

Sorted Z-values of ISL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ISL1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_175711133 5.21 ENST00000409597.1
ENST00000413882.1
 CHN1
 chimerin 1
chr4_+_169418195 4.61 ENST00000261509.6
ENST00000335742.7
 PALLD
 palladin, cytoskeletal associated protein
chr19_-_50143452 4.14 ENST00000246792.3
 RRAS
 related RAS viral (r-ras) oncogene homolog
chr10_-_95242044 3.61 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
 MYOF
 myoferlin
chr10_-_95241951 3.59 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
 MYOF
 myoferlin
chr1_-_95391315 3.33 ENST00000545882.1
ENST00000415017.1
 CNN3
 calponin 3, acidic
chr3_+_157154578 3.09 ENST00000295927.3
 PTX3
 pentraxin 3, long
chr3_+_158787041 2.57 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
chr1_-_79472365 2.48 ENST00000370742.3
 ELTD1
 EGF, latrophilin and seven transmembrane domain containing 1
chr11_-_102668879 2.31 ENST00000315274.6
 MMP1
 matrix metallopeptidase 1 (interstitial collagenase)
chr4_-_186877806 2.25 ENST00000355634.5
 SORBS2
 sorbin and SH3 domain containing 2
chr4_+_169418255 2.07 ENST00000505667.1
ENST00000511948.1
 PALLD
 palladin, cytoskeletal associated protein
chrX_+_135251783 1.97 ENST00000394153.2
 FHL1
 four and a half LIM domains 1
chr5_+_34757309 1.93 ENST00000397449.1
 RAI14
 retinoic acid induced 14
chr3_-_149095652 1.84 ENST00000305366.3
 TM4SF1
 transmembrane 4 L six family member 1
chrX_+_135252050 1.81 ENST00000449474.1
ENST00000345434.3
 FHL1
 four and a half LIM domains 1
chr4_-_186877502 1.79 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
 SORBS2
 sorbin and SH3 domain containing 2
chr5_-_94417339 1.75 ENST00000429576.2
ENST00000508509.1
ENST00000510732.1
 MCTP1
 multiple C2 domains, transmembrane 1
chr10_-_17659357 1.72 ENST00000326961.6
ENST00000361271.3
 PTPLA
 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr10_+_17270214 1.69 ENST00000544301.1
 VIM
 vimentin
chr1_+_100111479 1.68 ENST00000263174.4
 PALMD
 palmdelphin
chr8_+_70404996 1.65 ENST00000402687.4
ENST00000419716.3
 SULF1
 sulfatase 1
chr8_+_26371763 1.57 ENST00000521913.1
 DPYSL2
 dihydropyrimidinase-like 2
chr14_+_22458631 1.53 ENST00000390444.1
 TRAV16
 T cell receptor alpha variable 16
chr18_-_21977748 1.49 ENST00000399441.4
ENST00000319481.3
 OSBPL1A
 oxysterol binding protein-like 1A
chr12_+_81110684 1.31 ENST00000228644.3
 MYF5
 myogenic factor 5
chr18_-_53177984 1.30 ENST00000543082.1
 TCF4
 transcription factor 4
chr18_-_52989217 1.21 ENST00000570287.2
 TCF4
 transcription factor 4
chr10_-_116444371 1.20 ENST00000533213.2
ENST00000369252.4
 ABLIM1
 actin binding LIM protein 1
chr12_-_10251576 1.19 ENST00000315330.4
 CLEC1A
 C-type lectin domain family 1, member A
chr18_-_5544241 1.18 ENST00000341928.2
ENST00000540638.2
 EPB41L3
 erythrocyte membrane protein band 4.1-like 3
chr2_-_208030647 1.18 ENST00000309446.6
 KLF7
 Kruppel-like factor 7 (ubiquitous)
chr12_-_30887948 1.17 ENST00000433722.2
 CAPRIN2
 caprin family member 2
chrX_+_135251835 1.16 ENST00000456445.1
 FHL1
 four and a half LIM domains 1
chr5_+_140772381 1.14 ENST00000398604.2
 PCDHGA8
 protocadherin gamma subfamily A, 8
chr18_-_52989525 1.13 ENST00000457482.3
 TCF4
 transcription factor 4
chr10_+_123923205 1.11 ENST00000369004.3
ENST00000260733.3
 TACC2
 transforming, acidic coiled-coil containing protein 2
chr12_-_10251603 1.09 ENST00000457018.2
 CLEC1A
 C-type lectin domain family 1, member A
chr3_-_185538849 1.01 ENST00000421047.2
 IGF2BP2
 insulin-like growth factor 2 mRNA binding protein 2
chr10_-_17659234 1.01 ENST00000466335.1
 PTPLA
 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr12_-_10251539 0.98 ENST00000420265.2
 CLEC1A
 C-type lectin domain family 1, member A
chr9_-_113761720 0.97 ENST00000541779.1
ENST00000374430.2
 LPAR1
 lysophosphatidic acid receptor 1
chr22_-_36784035 0.96 ENST00000216181.5
 MYH9
 myosin, heavy chain 9, non-muscle
chr2_+_170366203 0.94 ENST00000284669.1
 KLHL41
 kelch-like family member 41
chr7_+_129932974 0.93 ENST00000445470.2
ENST00000222482.4
ENST00000492072.1
ENST00000473956.1
ENST00000493259.1
ENST00000486598.1
 CPA4
 carboxypeptidase A4
chr6_-_116575226 0.90 ENST00000420283.1
 TSPYL4
 TSPY-like 4
chr1_+_82266053 0.75 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
 LPHN2
 latrophilin 2
chr7_+_90338712 0.66 ENST00000265741.3
ENST00000406263.1
 CDK14
 cyclin-dependent kinase 14
chrX_+_55478538 0.65 ENST00000342972.1
 MAGEH1
 melanoma antigen family H, 1
chr20_+_60174827 0.62 ENST00000543233.1
 CDH4
 cadherin 4, type 1, R-cadherin (retinal)
chr8_+_26247878 0.60 ENST00000518611.1
 BNIP3L
 BCL2/adenovirus E1B 19kDa interacting protein 3-like
chrX_-_102941596 0.58 ENST00000441076.2
ENST00000422355.1
ENST00000442614.1
ENST00000422154.2
ENST00000451301.1
 MORF4L2
 mortality factor 4 like 2
chr9_+_27109133 0.58 ENST00000519097.1
ENST00000380036.4
 TEK
 TEK tyrosine kinase, endothelial
chr5_+_140593509 0.56 ENST00000341948.4
 PCDHB13
 protocadherin beta 13
chr5_+_32788945 0.56 ENST00000326958.1
 AC026703.1
 AC026703.1
chr3_+_35721106 0.49 ENST00000474696.1
ENST00000412048.1
ENST00000396482.2
ENST00000432682.1
 ARPP21
 cAMP-regulated phosphoprotein, 21kDa
chr4_+_8201091 0.47 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
 SH3TC1
 SH3 domain and tetratricopeptide repeats 1
chr13_+_115000556 0.47 ENST00000252458.6
 CDC16
 cell division cycle 16
chr3_-_27498235 0.47 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
 SLC4A7
 solute carrier family 4, sodium bicarbonate cotransporter, member 7
chrX_-_92928557 0.47 ENST00000373079.3
ENST00000475430.2
 NAP1L3
 nucleosome assembly protein 1-like 3
chr1_+_156024552 0.45 ENST00000368304.5
ENST00000368302.3
 LAMTOR2
 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr6_+_90272027 0.45 ENST00000522441.1
 ANKRD6
 ankyrin repeat domain 6
chr2_+_172543919 0.44 ENST00000452242.1
ENST00000340296.4
 DYNC1I2
 dynein, cytoplasmic 1, intermediate chain 2
chr19_+_13842559 0.39 ENST00000586600.1
 CCDC130
 coiled-coil domain containing 130
chr1_+_156024525 0.38 ENST00000368305.4
 LAMTOR2
 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
chr17_+_1933404 0.37 ENST00000263083.6
ENST00000571418.1
 DPH1
 diphthamide biosynthesis 1
chr17_-_15501932 0.37 ENST00000583965.1
 CDRT1
 CMT1A duplicated region transcript 1
chr8_-_19540266 0.36 ENST00000311540.4
 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
chrX_+_49832231 0.35 ENST00000376108.3
 CLCN5
 chloride channel, voltage-sensitive 5
chr15_+_59279851 0.34 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
 RNF111
 ring finger protein 111
chr5_+_32710736 0.33 ENST00000415685.2
 NPR3
 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr18_+_21529811 0.32 ENST00000588004.1
 LAMA3
 laminin, alpha 3
chr5_+_137203465 0.31 ENST00000239926.4
 MYOT
 myotilin
chr12_-_53012343 0.30 ENST00000305748.3
 KRT73
 keratin 73
chr8_-_59412717 0.29 ENST00000301645.3
 CYP7A1
 cytochrome P450, family 7, subfamily A, polypeptide 1
chr8_-_19540086 0.29 ENST00000332246.6
 CSGALNACT1
 chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr5_+_32711419 0.28 ENST00000265074.8
 NPR3
 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr4_+_74347400 0.28 ENST00000226355.3
 AFM
 afamin
chr12_-_50290839 0.27 ENST00000552863.1
 FAIM2
 Fas apoptotic inhibitory molecule 2
chr18_+_616672 0.27 ENST00000338387.7
 CLUL1
 clusterin-like 1 (retinal)
chr6_-_100912785 0.27 ENST00000369208.3
 SIM1
 single-minded family bHLH transcription factor 1
chr7_-_107880508 0.27 ENST00000425651.2
 NRCAM
 neuronal cell adhesion molecule
chr4_-_72649763 0.26 ENST00000513476.1
 GC
 group-specific component (vitamin D binding protein)
chr17_+_66521936 0.25 ENST00000592800.1
 PRKAR1A
 protein kinase, cAMP-dependent, regulatory, type I, alpha
chr16_+_3493611 0.25 ENST00000407558.4
ENST00000572169.1
ENST00000572757.1
ENST00000573593.1
ENST00000570372.1
ENST00000424546.2
ENST00000575733.1
ENST00000573201.1
ENST00000574950.1
ENST00000573580.1
ENST00000608722.1
 NAA60
NAA60
 N(alpha)-acetyltransferase 60, NatF catalytic subunit
N-alpha-acetyltransferase 60
chr18_+_46065393 0.25 ENST00000256413.3
 CTIF
 CBP80/20-dependent translation initiation factor
chr10_+_114710211 0.24 ENST00000349937.2
ENST00000369397.4
 TCF7L2
 transcription factor 7-like 2 (T-cell specific, HMG-box)
chr13_+_115000521 0.23 ENST00000252457.5
ENST00000375308.1
 CDC16
 cell division cycle 16
chr13_-_108870623 0.23 ENST00000405925.1
 LIG4
 ligase IV, DNA, ATP-dependent
chr2_+_234216454 0.23 ENST00000447536.1
ENST00000409110.1
 SAG
 S-antigen; retina and pineal gland (arrestin)
chr1_+_161736072 0.22 ENST00000367942.3
 ATF6
 activating transcription factor 6
chr19_-_49622348 0.22 ENST00000408991.2
 C19orf73
 chromosome 19 open reading frame 73
chr22_-_32651326 0.21 ENST00000266086.4
 SLC5A4
 solute carrier family 5 (glucose activated ion channel), member 4
chr10_+_135340859 0.20 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
 CYP2E1
 cytochrome P450, family 2, subfamily E, polypeptide 1
chr7_+_16793160 0.20 ENST00000262067.4
 TSPAN13
 tetraspanin 13
chrX_-_30327495 0.19 ENST00000453287.1
 NR0B1
 nuclear receptor subfamily 0, group B, member 1
chr18_+_616711 0.19 ENST00000579494.1
 CLUL1
 clusterin-like 1 (retinal)
chr2_-_224467093 0.18 ENST00000305409.2
 SCG2
 secretogranin II
chr14_+_22963806 0.16 ENST00000390493.1
 TRAJ44
 T cell receptor alpha joining 44
chr3_+_179322481 0.16 ENST00000259037.3
 NDUFB5
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr1_+_104159999 0.15 ENST00000414303.2
ENST00000423678.1
 AMY2A
 amylase, alpha 2A (pancreatic)
chr1_+_206972215 0.15 ENST00000340758.2
 IL19
 interleukin 19
chr6_+_167704798 0.15 ENST00000230256.3
 UNC93A
 unc-93 homolog A (C. elegans)
chr2_-_217560248 0.14 ENST00000233813.4
 IGFBP5
 insulin-like growth factor binding protein 5
chr1_+_196621156 0.14 ENST00000359637.2
 CFH
 complement factor H
chr18_+_46065483 0.13 ENST00000382998.4
 CTIF
 CBP80/20-dependent translation initiation factor
chr6_+_31707725 0.13 ENST00000375755.3
ENST00000375742.3
ENST00000375750.3
ENST00000425703.1
ENST00000534153.4
ENST00000375703.3
ENST00000375740.3
 MSH5
 mutS homolog 5
chr3_+_38307293 0.12 ENST00000311856.4
 SLC22A13
 solute carrier family 22 (organic anion/urate transporter), member 13
chr1_+_221054584 0.12 ENST00000549319.1
 HLX
 H2.0-like homeobox
chr8_-_133637624 0.12 ENST00000522789.1
 LRRC6
 leucine rich repeat containing 6
chr1_+_35734562 0.11 ENST00000314607.6
ENST00000373297.2
 ZMYM4
 zinc finger, MYM-type 4
chr12_-_6484715 0.09 ENST00000228916.2
 SCNN1A
 sodium channel, non-voltage-gated 1 alpha subunit
chr14_-_92198403 0.09 ENST00000553329.1
ENST00000256343.3
 CATSPERB
 catsper channel auxiliary subunit beta
chr13_-_103719196 0.08 ENST00000245312.3
 SLC10A2
 solute carrier family 10 (sodium/bile acid cotransporter), member 2
chr12_+_14572070 0.08 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
 ATF7IP
 activating transcription factor 7 interacting protein
chr8_+_110098850 0.08 ENST00000518632.1
 TRHR
 thyrotropin-releasing hormone receptor
chr4_+_88754113 0.07 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
 MEPE
 matrix extracellular phosphoglycoprotein
chr2_+_171034646 0.07 ENST00000409044.3
ENST00000408978.4
 MYO3B
 myosin IIIB
chr9_+_136325089 0.07 ENST00000291722.7
ENST00000316948.4
ENST00000540581.1
 CACFD1
 calcium channel flower domain containing 1
chr8_+_119294456 0.07 ENST00000366457.2
 AC023590.1
 Uncharacterized protein
chr6_+_168418553 0.05 ENST00000354419.2
ENST00000351261.3
 KIF25
 kinesin family member 25
chr12_-_121454148 0.05 ENST00000535367.1
ENST00000538296.1
ENST00000445832.3
ENST00000536407.2
ENST00000366211.2
ENST00000539736.1
ENST00000288757.3
ENST00000537817.1
 C12orf43
 chromosome 12 open reading frame 43
chr5_+_140248518 0.04 ENST00000398640.2
 PCDHA11
 protocadherin alpha 11
chr4_+_4861385 0.04 ENST00000382723.4
 MSX1
 msh homeobox 1
chrX_+_144908928 0.03 ENST00000408967.2
 TMEM257
 transmembrane protein 257
chr10_+_114710425 0.03 ENST00000352065.5
ENST00000369395.1
 TCF7L2
 transcription factor 7-like 2 (T-cell specific, HMG-box)
chr5_+_52856456 0.03 ENST00000296684.5
ENST00000506765.1
 NDUFS4
 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
chr13_+_25670268 0.03 ENST00000281589.3
 PABPC3
 poly(A) binding protein, cytoplasmic 3
chr16_+_47496023 0.02 ENST00000567200.1
 PHKB
 phosphorylase kinase, beta
chrX_-_100129128 0.02 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
 NOX1
 NADPH oxidase 1
chr7_-_31380502 0.02 ENST00000297142.3
 NEUROD6
 neuronal differentiation 6
chr6_+_108977520 0.02 ENST00000540898.1
 FOXO3
 forkhead box O3
chr6_+_42123141 0.02 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
 GUCA1A
RP1-139D8.6
 guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr8_-_25281747 0.01 ENST00000421054.2
 GNRH1
 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chrX_-_100129320 0.01 ENST00000372966.3
 NOX1
 NADPH oxidase 1
chr11_-_62783276 0.01 ENST00000535878.1
ENST00000545207.1
 SLC22A8
 solute carrier family 22 (organic anion transporter), member 8
chr3_-_62359180 0.01 ENST00000283268.3
 FEZF2
 FEZ family zinc finger 2
chr1_-_93257951 0.01 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
 EVI5
 ecotropic viral integration site 5
chr2_-_89247338 0.01 ENST00000496168.1
 IGKV1-5
 immunoglobulin kappa variable 1-5
chr6_+_36853607 0.00 ENST00000480824.2
ENST00000355190.3
ENST00000373685.1
 C6orf89
 chromosome 6 open reading frame 89
chr22_+_40390930 0.00 ENST00000333407.6
 FAM83F
 family with sequence similarity 83, member F
chr3_-_146262637 0.00 ENST00000472349.1
ENST00000342435.4
 PLSCR1
 phospholipid scramblase 1

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.4 1.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.4 3.1 GO:0001849 complement component C1q binding(GO:0001849)
0.3 6.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.3 1.7 GO:1990254 keratin filament binding(GO:1990254)
0.3 3.6 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 0.6 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.2 4.0 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 3.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.3 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 5.2 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 1.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 0.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.3 GO:0008431 vitamin E binding(GO:0008431)
0.1 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 1.0 GO:0043495 protein anchor(GO:0043495)
0.0 0.2 GO:0002046 opsin binding(GO:0002046)
0.0 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 1.5 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.2 GO:0016160 amylase activity(GO:0016160)
0.0 1.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.6 GO:0019003 GDP binding(GO:0019003)
0.0 0.5 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 1.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.6 GO:0005521 lamin binding(GO:0005521)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 3.7 GO:0044325 ion channel binding(GO:0044325)
0.0 0.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 2.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.8 GO:0070888 E-box binding(GO:0070888)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.0 0.7 GO:0030332 cyclin binding(GO:0030332)
0.0 5.5 GO:0005543 phospholipid binding(GO:0005543)
0.0 0.3 GO:0070016 gamma-catenin binding(GO:0045295) armadillo repeat domain binding(GO:0070016)
0.0 0.1 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.3 GO:0008603 cAMP-dependent protein kinase inhibitor activity(GO:0004862) cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0 0.2 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.2 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 3.3 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.8 GO:0032947 protein complex scaffold(GO:0032947)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.1 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.1 1.6 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 5.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 1.2 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 4.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.7 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 1.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.3 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 0.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.3 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 0.7 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.2 0.8 GO:0071986 Ragulator complex(GO:0071986)
0.1 6.7 GO:0002102 podosome(GO:0002102)
0.1 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 7.1 GO:0005901 caveola(GO:0005901)
0.1 0.9 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.2 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.3 GO:0005610 laminin-5 complex(GO:0005610)
0.0 0.9 GO:0031143 pseudopodium(GO:0031143)
0.0 0.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0 3.1 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 18.4 GO:0005925 focal adhesion(GO:0005925)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 1.0 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.2 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.6 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.0 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.1 GO:0036128 CatSper complex(GO:0036128)
0.0 3.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.1 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.5 GO:0032420 stereocilium(GO:0032420)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 1.2 GO:0043235 receptor complex(GO:0043235)
0.0 0.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.2 GO:0031045 dense core granule(GO:0031045)
0.0 1.6 GO:0005795 Golgi stack(GO:0005795)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.6 7.2 GO:0001778 plasma membrane repair(GO:0001778)
0.3 1.0 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
0.3 6.5 GO:0003334 keratinocyte development(GO:0003334)
0.2 1.0 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 1.6 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.2 1.2 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 0.6 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.2 1.7 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.1 5.2 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 3.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 0.4 GO:0009615 response to virus(GO:0009615)
0.1 4.0 GO:0060325 face morphogenesis(GO:0060325)
0.1 4.0 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.3 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.1 0.6 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.1 0.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.1 0.9 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.1 0.2 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.1 0.1 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.1 2.3 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.1 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 4.2 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.0 0.2 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.4 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.3 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.4 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.2 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.3 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.2 GO:0010193 response to ozone(GO:0010193)
0.0 0.6 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.4 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.0 1.8 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 1.2 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.5 GO:0060117 auditory receptor cell development(GO:0060117)
0.0 0.2 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.8 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 2.0 GO:0030516 regulation of axon extension(GO:0030516)
0.0 0.3 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.1 GO:0051026 chiasma assembly(GO:0051026)
0.0 5.1 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 0.3 GO:2000480 negative regulation of meiotic nuclear division(GO:0045835) negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0 0.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 0.1 GO:0015747 urate transport(GO:0015747)
0.0 0.5 GO:0051180 vitamin transport(GO:0051180)
0.0 0.2 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.0 0.1 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0 0.0 GO:0045113 regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 PID RAS PATHWAY Regulation of Ras family activation
0.1 3.1 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 4.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 6.8 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 2.3 PID ENDOTHELIN PATHWAY Endothelins
0.0 5.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.7 PID AURORA B PATHWAY Aurora B signaling
0.0 1.0 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.6 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network