ISMARA results: JUN

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ENCODE cell lines, expression (Ernst 2011)

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Results for JUN

Z-value: 1.76

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Transcription factors associated with JUN

Gene Symbol	Gene ID	Gene Info
JUN Ensembl NCBI GeneCards UniProt	ENSG00000177606.5	JUN

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
JUN	hg19_v2_chr1_-_59249732_59249785	0.79	2.7e-04	Click!

Activity profile of JUN motif

Sorted Z-values of JUN motif

Network of associatons between targets according to the STRING database.

First level regulatory network of JUN

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr5_-_54281407	5.66	ENST00000381403.4	ESM1	endothelial cell-specific molecule 1
chr6_+_139456226	5.42	ENST00000367658.2	HECA	headcase homolog (Drosophila)
chr11_+_117070037	4.47	ENST00000392951.4 ENST00000525531.1 ENST00000278968.6	TAGLN	transgelin
chr2_-_216300784	4.47	ENST00000421182.1 ENST00000432072.2 ENST00000323926.6 ENST00000336916.4 ENST00000357867.4 ENST00000359671.1 ENST00000346544.3 ENST00000345488.5 ENST00000357009.2 ENST00000446046.1 ENST00000356005.4 ENST00000443816.1 ENST00000426059.1 ENST00000354785.4	FN1	fibronectin 1
chr17_-_76899275	4.30	ENST00000322630.2 ENST00000586713.1	DDC8	Protein DDC8 homolog
chrX_-_101771645	4.26	ENST00000289373.4	TMSB15A	thymosin beta 15a
chr3_+_62304712	4.09	ENST00000494481.1	C3orf14	chromosome 3 open reading frame 14
chr22_+_38597889	4.07	ENST00000338483.2 ENST00000538320.1 ENST00000538999.1 ENST00000441709.1	MAFF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr3_+_62304648	3.86	ENST00000462069.1 ENST00000232519.5 ENST00000465142.1	C3orf14	chromosome 3 open reading frame 14
chr3_+_158991025	3.86	ENST00000337808.6	IQCJ-SCHIP1	IQCJ-SCHIP1 readthrough
chr2_-_216257849	3.73	ENST00000456923.1	FN1	fibronectin 1
chr6_+_121756809	3.65	ENST00000282561.3	GJA1	gap junction protein, alpha 1, 43kDa
chr3_-_99594948	3.60	ENST00000471562.1 ENST00000495625.2	FILIP1L	filamin A interacting protein 1-like
chr11_+_12696102	3.58	ENST00000527636.1 ENST00000527376.1	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr8_-_42065187	3.57	ENST00000270189.6 ENST00000352041.3 ENST00000220809.4	PLAT	plasminogen activator, tissue
chr3_-_99595037	3.51	ENST00000383694.2	FILIP1L	filamin A interacting protein 1-like
chr9_+_116298778	3.41	ENST00000462143.1	RGS3	regulator of G-protein signaling 3
chr6_-_112575912	3.37	ENST00000522006.1 ENST00000230538.7 ENST00000519932.1	LAMA4	laminin, alpha 4
chr12_+_75874984	3.34	ENST00000550491.1	GLIPR1	GLI pathogenesis-related 1
chr3_+_159570722	3.31	ENST00000482804.1	SCHIP1	schwannomin interacting protein 1
chr2_-_190044480	3.26	ENST00000374866.3	COL5A2	collagen, type V, alpha 2
chr5_-_111312622	3.22	ENST00000395634.3	NREP	neuronal regeneration related protein
chr8_-_42065075	3.06	ENST00000429089.2 ENST00000519510.1 ENST00000429710.2 ENST00000524009.1	PLAT	plasminogen activator, tissue
chr11_+_12695944	3.03	ENST00000361905.4	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr12_+_75874580	2.93	ENST00000456650.3	GLIPR1	GLI pathogenesis-related 1
chr2_-_238322770	2.80	ENST00000472056.1	COL6A3	collagen, type VI, alpha 3
chr11_-_104817919	2.80	ENST00000533252.1	CASP4	caspase 4, apoptosis-related cysteine peptidase
chr5_-_54281491	2.74	ENST00000381405.4	ESM1	endothelial cell-specific molecule 1
chr2_-_238322800	2.73	ENST00000392004.3 ENST00000433762.1 ENST00000347401.3 ENST00000353578.4 ENST00000346358.4 ENST00000392003.2	COL6A3	collagen, type VI, alpha 3
chr2_-_238323007	2.67	ENST00000295550.4	COL6A3	collagen, type VI, alpha 3
chr6_+_89791507	2.65	ENST00000354922.3	PNRC1	proline-rich nuclear receptor coactivator 1
chr4_-_186456766	2.60	ENST00000284771.6	PDLIM3	PDZ and LIM domain 3
chr4_-_186456652	2.56	ENST00000284767.5 ENST00000284770.5	PDLIM3	PDZ and LIM domain 3
chr7_-_129592471	2.50	ENST00000473814.2 ENST00000490974.1	UBE2H	ubiquitin-conjugating enzyme E2H
chr6_-_112575838	2.44	ENST00000455073.1	LAMA4	laminin, alpha 4
chr9_-_99381660	2.41	ENST00000375240.3 ENST00000463569.1	CDC14B	cell division cycle 14B
chr7_-_129592700	2.35	ENST00000472396.1 ENST00000355621.3	UBE2H	ubiquitin-conjugating enzyme E2H
chr9_+_97488939	2.32	ENST00000277198.2 ENST00000297979.5	C9orf3	chromosome 9 open reading frame 3
chr16_+_3068393	2.28	ENST00000573001.1	TNFRSF12A	tumor necrosis factor receptor superfamily, member 12A
chr8_+_79428539	2.27	ENST00000352966.5	PKIA	protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr10_+_123923105	2.25	ENST00000368999.1	TACC2	transforming, acidic coiled-coil containing protein 2
chr5_+_71403061	2.21	ENST00000512974.1 ENST00000296755.7	MAP1B	microtubule-associated protein 1B
chr12_+_10365404	2.21	ENST00000266458.5 ENST00000421801.2 ENST00000544284.1 ENST00000545047.1 ENST00000543602.1 ENST00000545887.1	GABARAPL1	GABA(A) receptor-associated protein like 1
chr19_+_16186903	2.11	ENST00000588507.1	TPM4	tropomyosin 4
chr5_-_139944196	2.10	ENST00000357560.4	APBB3	amyloid beta (A4) precursor protein-binding, family B, member 3
chr18_-_5540471	2.10	ENST00000581833.1 ENST00000544123.1 ENST00000342933.3 ENST00000400111.3 ENST00000585142.1	EPB41L3	erythrocyte membrane protein band 4.1-like 3
chr19_+_16187085	2.08	ENST00000300933.4	TPM4	tropomyosin 4
chr8_-_125740730	1.96	ENST00000354184.4	MTSS1	metastasis suppressor 1
chr17_-_63822563	1.96	ENST00000317442.8	CEP112	centrosomal protein 112kDa
chr5_-_172198190	1.96	ENST00000239223.3	DUSP1	dual specificity phosphatase 1
chr16_+_3115298	1.94	ENST00000325568.5 ENST00000534507.1	IL32	interleukin 32
chr2_+_37571717	1.93	ENST00000338415.3 ENST00000404976.1	QPCT	glutaminyl-peptide cyclotransferase
chr2_+_37571845	1.91	ENST00000537448.1	QPCT	glutaminyl-peptide cyclotransferase
chr4_-_7873981	1.90	ENST00000360265.4	AFAP1	actin filament associated protein 1
chr16_+_3115611	1.88	ENST00000530890.1 ENST00000444393.3 ENST00000533097.2 ENST00000008180.9 ENST00000396890.2 ENST00000525228.1 ENST00000548652.1 ENST00000525377.2 ENST00000530538.2 ENST00000549213.1 ENST00000552936.1 ENST00000548476.1 ENST00000552664.1 ENST00000552356.1 ENST00000551513.1 ENST00000382213.3 ENST00000548246.1	IL32	interleukin 32
chr10_+_123922941	1.88	ENST00000360561.3	TACC2	transforming, acidic coiled-coil containing protein 2
chr11_-_89224488	1.86	ENST00000534731.1 ENST00000527626.1	NOX4	NADPH oxidase 4
chr1_+_28099683	1.82	ENST00000373943.4	STX12	syntaxin 12
chr11_-_89224299	1.81	ENST00000343727.5 ENST00000531342.1 ENST00000375979.3	NOX4	NADPH oxidase 4
chr6_-_56819385	1.79	ENST00000370754.5 ENST00000449297.2	DST	dystonin
chr16_+_3115323	1.79	ENST00000531965.1 ENST00000396887.3 ENST00000529699.1 ENST00000526464.2 ENST00000440815.3	IL32	interleukin 32
chr10_+_123923205	1.78	ENST00000369004.3 ENST00000260733.3	TACC2	transforming, acidic coiled-coil containing protein 2
chr5_-_16916624	1.78	ENST00000513882.1	MYO10	myosin X
chr1_-_59249732	1.74	ENST00000371222.2	JUN	jun proto-oncogene
chr6_-_112575758	1.73	ENST00000431543.2 ENST00000453937.2 ENST00000368638.4 ENST00000389463.4	LAMA4	laminin, alpha 4
chr3_-_114343768	1.73	ENST00000393785.2	ZBTB20	zinc finger and BTB domain containing 20
chr11_-_63381925	1.72	ENST00000415826.1	PLA2G16	phospholipase A2, group XVI
chr16_+_3115378	1.71	ENST00000529550.1 ENST00000551122.1 ENST00000525643.2 ENST00000548807.1 ENST00000528163.2	IL32	interleukin 32
chr9_-_99382065	1.70	ENST00000265659.2 ENST00000375241.1 ENST00000375236.1	CDC14B	cell division cycle 14B
chr1_+_25071848	1.68	ENST00000374379.4	CLIC4	chloride intracellular channel 4
chr3_-_124774802	1.67	ENST00000311127.4	HEG1	heart development protein with EGF-like domains 1
chr19_+_42772659	1.67	ENST00000572681.2	CIC	capicua transcriptional repressor
chr3_+_8543393	1.66	ENST00000157600.3 ENST00000415597.1 ENST00000535732.1	LMCD1	LIM and cysteine-rich domains 1
chr11_-_89224139	1.66	ENST00000413594.2	NOX4	NADPH oxidase 4
chr8_+_40010989	1.63	ENST00000315792.3	C8orf4	chromosome 8 open reading frame 4
chr10_+_124134201	1.61	ENST00000368990.3 ENST00000368988.1 ENST00000368989.2 ENST00000463663.2	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr1_-_1293904	1.60	ENST00000309212.6 ENST00000342753.4 ENST00000445648.2	MXRA8	matrix-remodelling associated 8
chr14_+_104095514	1.59	ENST00000348520.6 ENST00000380038.3 ENST00000389744.4 ENST00000557575.1 ENST00000553286.1 ENST00000347839.6 ENST00000555836.1 ENST00000334553.6 ENST00000246489.7 ENST00000557450.1 ENST00000452929.2 ENST00000554280.1 ENST00000445352.4	KLC1	kinesin light chain 1
chr1_-_201476274	1.56	ENST00000340006.2	CSRP1	cysteine and glycine-rich protein 1
chr14_+_74003818	1.53	ENST00000311148.4	ACOT1	acyl-CoA thioesterase 1
chr1_-_16482554	1.50	ENST00000358432.5	EPHA2	EPH receptor A2
chr11_-_119187826	1.49	ENST00000264036.4	MCAM	melanoma cell adhesion molecule
chr2_+_5832799	1.49	ENST00000322002.3	SOX11	SRY (sex determining region Y)-box 11
chr4_+_124317940	1.49	ENST00000505319.1 ENST00000339241.1	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr11_-_2160180	1.46	ENST00000381406.4	IGF2	insulin-like growth factor 2 (somatomedin A)
chr2_+_241375069	1.43	ENST00000264039.2	GPC1	glypican 1
chrX_-_10645773	1.41	ENST00000453318.2	MID1	midline 1 (Opitz/BBB syndrome)
chr5_-_139943830	1.40	ENST00000412920.3 ENST00000511201.2 ENST00000356738.2 ENST00000354402.5 ENST00000358580.5 ENST00000508496.2	APBB3	amyloid beta (A4) precursor protein-binding, family B, member 3
chr1_+_66797687	1.39	ENST00000371045.5 ENST00000531025.1 ENST00000526197.1	PDE4B	phosphodiesterase 4B, cAMP-specific
chr9_-_129885010	1.33	ENST00000373425.3	ANGPTL2	angiopoietin-like 2
chr11_-_89223883	1.32	ENST00000528341.1	NOX4	NADPH oxidase 4
chr3_-_48130707	1.29	ENST00000360240.6 ENST00000383737.4	MAP4	microtubule-associated protein 4
chr22_-_36357671	1.27	ENST00000408983.2	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2
chr13_-_49018789	1.27	ENST00000378434.4	LPAR6	lysophosphatidic acid receptor 6
chr3_+_10068095	1.26	ENST00000287647.3 ENST00000383807.1 ENST00000383806.1 ENST00000419585.1	FANCD2	Fanconi anemia, complementation group D2
chr9_-_129884902	1.25	ENST00000373417.1	ANGPTL2	angiopoietin-like 2
chr4_+_668348	1.22	ENST00000511290.1	MYL5	myosin, light chain 5, regulatory
chr5_+_140864649	1.20	ENST00000306593.1	PCDHGC4	protocadherin gamma subfamily C, 4
chr9_-_113761720	1.19	ENST00000541779.1 ENST00000374430.2	LPAR1	lysophosphatidic acid receptor 1
chr6_-_46293378	1.17	ENST00000330430.6	RCAN2	regulator of calcineurin 2
chr1_+_163039143	1.17	ENST00000531057.1 ENST00000527809.1 ENST00000367908.4	RGS4	regulator of G-protein signaling 4
chr10_-_3827417	1.16	ENST00000497571.1 ENST00000542957.1	KLF6	Kruppel-like factor 6
chr8_-_119124045	1.16	ENST00000378204.2	EXT1	exostosin glycosyltransferase 1
chr19_-_48614033	1.15	ENST00000354276.3	PLA2G4C	phospholipase A2, group IVC (cytosolic, calcium-independent)
chr15_-_30113676	1.12	ENST00000400011.2	TJP1	tight junction protein 1
chr19_-_19051993	1.11	ENST00000594794.1 ENST00000355887.6 ENST00000392351.3 ENST00000596482.1	HOMER3	homer homolog 3 (Drosophila)
chr19_-_48614063	1.11	ENST00000599921.1 ENST00000599111.1	PLA2G4C	phospholipase A2, group IVC (cytosolic, calcium-independent)
chr7_-_142247606	1.10	ENST00000390361.3	TRBV7-3	T cell receptor beta variable 7-3
chr8_-_125740514	1.08	ENST00000325064.5 ENST00000518547.1	MTSS1	metastasis suppressor 1
chr2_+_54785485	1.08	ENST00000333896.5	SPTBN1	spectrin, beta, non-erythrocytic 1
chr14_-_103523745	1.05	ENST00000361246.2	CDC42BPB	CDC42 binding protein kinase beta (DMPK-like)
chr3_-_119182523	1.04	ENST00000319172.5	TMEM39A	transmembrane protein 39A
chrX_+_48432892	1.03	ENST00000376759.3 ENST00000430348.2	RBM3	RNA binding motif (RNP1, RRM) protein 3
chr11_-_8832182	1.02	ENST00000527510.1 ENST00000528527.1 ENST00000528523.1 ENST00000313726.6	ST5	suppression of tumorigenicity 5
chr6_-_116575226	1.01	ENST00000420283.1	TSPYL4	TSPY-like 4
chr1_+_151030234	1.00	ENST00000368921.3	MLLT11	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr14_+_96722152	1.00	ENST00000216629.6	BDKRB1	bradykinin receptor B1
chr12_+_6833237	0.99	ENST00000229251.3 ENST00000539735.1 ENST00000538410.1	COPS7A	COP9 signalosome subunit 7A
chr18_+_3262415	0.98	ENST00000581193.1 ENST00000400175.5	MYL12B	myosin, light chain 12B, regulatory
chr17_+_75084717	0.97	ENST00000561721.2 ENST00000589827.1 ENST00000392476.2	SEC14L1	SEC14-like 1 (S. cerevisiae)
chr8_-_13372395	0.97	ENST00000276297.4 ENST00000511869.1	DLC1	deleted in liver cancer 1
chr12_+_56552128	0.95	ENST00000548580.1 ENST00000293422.5 ENST00000348108.4 ENST00000549017.1 ENST00000549566.1 ENST00000536128.1 ENST00000547649.1 ENST00000547408.1 ENST00000551589.1 ENST00000549392.1 ENST00000548400.1 ENST00000548293.1	MYL6	myosin, light chain 6, alkali, smooth muscle and non-muscle
chr2_-_98280383	0.94	ENST00000289228.5	ACTR1B	ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr8_-_82754427	0.94	ENST00000353788.4 ENST00000520618.1 ENST00000518183.1 ENST00000396330.2 ENST00000519119.1 ENST00000345957.4	SNX16	sorting nexin 16
chrX_-_92928557	0.93	ENST00000373079.3 ENST00000475430.2	NAP1L3	nucleosome assembly protein 1-like 3
chr3_-_48130314	0.93	ENST00000439356.1 ENST00000395734.3 ENST00000426837.2	MAP4	microtubule-associated protein 4
chr18_+_3262954	0.92	ENST00000584539.1	MYL12B	myosin, light chain 12B, regulatory
chrX_-_77150985	0.91	ENST00000358075.6	MAGT1	magnesium transporter 1
chr20_+_43343886	0.90	ENST00000190983.4	WISP2	WNT1 inducible signaling pathway protein 2
chr2_+_242255297	0.90	ENST00000401990.1 ENST00000407971.1 ENST00000436795.1 ENST00000411484.1 ENST00000434955.1 ENST00000402092.2 ENST00000441533.1 ENST00000443492.1 ENST00000437066.1 ENST00000429791.1	SEPT2	septin 2
chr17_+_41476327	0.90	ENST00000320033.4	ARL4D	ADP-ribosylation factor-like 4D
chr1_-_242162375	0.89	ENST00000357246.3	MAP1LC3C	microtubule-associated protein 1 light chain 3 gamma
chr22_-_38713428	0.87	ENST00000403904.1 ENST00000405675.3	CSNK1E	casein kinase 1, epsilon
chr22_-_38669030	0.87	ENST00000361906.3	TMEM184B	transmembrane protein 184B
chr4_+_667686	0.87	ENST00000505477.1	MYL5	myosin, light chain 5, regulatory
chr16_-_4588469	0.86	ENST00000588381.1 ENST00000563332.2	CDIP1	cell death-inducing p53 target 1
chr8_-_21966893	0.85	ENST00000522405.1 ENST00000522379.1 ENST00000309188.6 ENST00000521807.2	NUDT18	nudix (nucleoside diphosphate linked moiety X)-type motif 18
chr22_-_38713394	0.84	ENST00000396832.1 ENST00000413574.2	CSNK1E	casein kinase 1, epsilon
chr7_+_22766766	0.83	ENST00000426291.1 ENST00000401651.1 ENST00000258743.5 ENST00000420258.2 ENST00000407492.1 ENST00000401630.3 ENST00000406575.1	IL6	interleukin 6 (interferon, beta 2)
chr18_+_76829385	0.82	ENST00000426216.2 ENST00000307671.7 ENST00000586672.1 ENST00000586722.1	ATP9B	ATPase, class II, type 9B
chr11_-_75201791	0.82	ENST00000529721.1	GDPD5	glycerophosphodiester phosphodiesterase domain containing 5
chr4_-_156298028	0.81	ENST00000433024.1 ENST00000379248.2	MAP9	microtubule-associated protein 9
chr4_-_111558135	0.81	ENST00000394598.2 ENST00000394595.3	PITX2	paired-like homeodomain 2
chr7_+_35840542	0.80	ENST00000435235.1 ENST00000399034.2 ENST00000350320.6 ENST00000469679.2	SEPT7	septin 7
chr14_+_77228532	0.80	ENST00000167106.4 ENST00000554237.1	VASH1	vasohibin 1
chr7_+_39663061	0.79	ENST00000005257.2	RALA	v-ral simian leukemia viral oncogene homolog A (ras related)
chr14_-_93651186	0.79	ENST00000556883.1 ENST00000298894.4	MOAP1	modulator of apoptosis 1
chr5_-_133304473	0.79	ENST00000231512.3	C5orf15	chromosome 5 open reading frame 15
chr3_-_52001448	0.79	ENST00000461554.1 ENST00000395013.3 ENST00000428823.2 ENST00000483411.1 ENST00000461544.1 ENST00000355852.2	PCBP4	poly(rC) binding protein 4
chr11_-_1593150	0.77	ENST00000397374.3	DUSP8	dual specificity phosphatase 8
chr15_+_44084040	0.76	ENST00000249786.4	SERF2	small EDRK-rich factor 2
chr19_+_17666403	0.76	ENST00000252599.4	COLGALT1	collagen beta(1-O)galactosyltransferase 1
chr12_-_6772303	0.76	ENST00000396807.4 ENST00000446105.2 ENST00000341550.4	ING4	inhibitor of growth family, member 4
chr3_+_8543533	0.75	ENST00000454244.1	LMCD1	LIM and cysteine-rich domains 1
chr14_+_88851874	0.75	ENST00000393545.4 ENST00000356583.5 ENST00000555401.1 ENST00000553885.1	SPATA7	spermatogenesis associated 7
chr10_+_134351319	0.74	ENST00000368594.3 ENST00000368593.3	INPP5A	inositol polyphosphate-5-phosphatase, 40kDa
chr16_+_2564254	0.74	ENST00000565223.1	ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr12_+_58138800	0.74	ENST00000547992.1 ENST00000552816.1 ENST00000547472.1	TSPAN31	tetraspanin 31
chr12_+_6833437	0.74	ENST00000534947.1 ENST00000541866.1 ENST00000534877.1 ENST00000538753.1	COPS7A	COP9 signalosome subunit 7A
chr7_+_100273736	0.72	ENST00000412215.1 ENST00000393924.1	GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2
chr15_+_68871569	0.72	ENST00000566799.1	CORO2B	coronin, actin binding protein, 2B
chr4_-_156297949	0.72	ENST00000515654.1	MAP9	microtubule-associated protein 9
chr9_+_34990219	0.71	ENST00000541010.1 ENST00000454002.2 ENST00000545841.1	DNAJB5	DnaJ (Hsp40) homolog, subfamily B, member 5
chr1_+_17866290	0.70	ENST00000361221.3 ENST00000452522.1 ENST00000434513.1	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like
chr11_-_14993819	0.70	ENST00000396372.2 ENST00000361010.3 ENST00000359642.3 ENST00000331587.4	CALCA	calcitonin-related polypeptide alpha
chr2_+_242255275	0.68	ENST00000391971.2	SEPT2	septin 2
chr7_+_35840819	0.68	ENST00000399035.3	SEPT7	septin 7
chr7_-_37956409	0.67	ENST00000436072.2	SFRP4	secreted frizzled-related protein 4
chrX_+_49832231	0.67	ENST00000376108.3	CLCN5	chloride channel, voltage-sensitive 5
chr5_-_95297534	0.66	ENST00000513343.1 ENST00000431061.2	ELL2	elongation factor, RNA polymerase II, 2
chr1_+_145293114	0.65	ENST00000369338.1	NBPF10	neuroblastoma breakpoint family, member 10
chrX_-_153602991	0.64	ENST00000369850.3 ENST00000422373.1	FLNA	filamin A, alpha
chr11_+_818902	0.63	ENST00000336615.4	PNPLA2	patatin-like phospholipase domain containing 2
chr7_-_45128472	0.63	ENST00000490531.2	NACAD	NAC alpha domain containing
chr2_-_242255117	0.62	ENST00000420451.1 ENST00000417540.1 ENST00000310931.4	HDLBP	high density lipoprotein binding protein
chr4_-_156298087	0.62	ENST00000311277.4	MAP9	microtubule-associated protein 9
chr12_+_58138664	0.61	ENST00000257910.3	TSPAN31	tetraspanin 31
chr20_+_43343517	0.61	ENST00000372865.4	WISP2	WNT1 inducible signaling pathway protein 2
chr11_+_57529234	0.60	ENST00000360682.6 ENST00000361796.4 ENST00000529526.1 ENST00000426142.2 ENST00000399050.4 ENST00000361391.6 ENST00000361332.4 ENST00000532463.1 ENST00000529986.1 ENST00000358694.6 ENST00000532787.1 ENST00000533667.1 ENST00000532649.1 ENST00000528621.1 ENST00000530748.1 ENST00000428599.2 ENST00000527467.1 ENST00000528232.1 ENST00000531014.1 ENST00000526772.1 ENST00000529873.1 ENST00000525902.1 ENST00000532844.1 ENST00000526357.1 ENST00000530094.1 ENST00000415361.2 ENST00000532245.1 ENST00000534579.1 ENST00000526938.1	CTNND1	catenin (cadherin-associated protein), delta 1
chr19_+_39214797	0.60	ENST00000440400.1	ACTN4	actinin, alpha 4
chr1_+_36023370	0.60	ENST00000356090.4 ENST00000373243.2	NCDN	neurochondrin
chr2_-_207082748	0.60	ENST00000407325.2 ENST00000411719.1	GPR1	G protein-coupled receptor 1
chr15_+_68871308	0.60	ENST00000261861.5	CORO2B	coronin, actin binding protein, 2B
chr9_+_34989638	0.60	ENST00000453597.3 ENST00000335998.3 ENST00000312316.5	DNAJB5	DnaJ (Hsp40) homolog, subfamily B, member 5
chr18_+_3412005	0.59	ENST00000401449.1	TGIF1	TGFB-induced factor homeobox 1
chrX_-_68385354	0.59	ENST00000361478.1	PJA1	praja ring finger 1, E3 ubiquitin protein ligase
chr16_+_31044413	0.59	ENST00000394998.1	STX4	syntaxin 4
chr12_+_54378923	0.59	ENST00000303460.4	HOXC10	homeobox C10
chr17_-_80231557	0.58	ENST00000392334.2 ENST00000314028.6	CSNK1D	casein kinase 1, delta
chr17_-_7155274	0.58	ENST00000318988.6 ENST00000575783.1 ENST00000573600.1	CTDNEP1	CTD nuclear envelope phosphatase 1
chrX_-_68385274	0.58	ENST00000374584.3 ENST00000590146.1	PJA1	praja ring finger 1, E3 ubiquitin protein ligase
chr2_-_89459813	0.57	ENST00000390256.2	IGKV6-21	immunoglobulin kappa variable 6-21 (non-functional)
chr8_-_141810634	0.56	ENST00000521986.1 ENST00000523539.1 ENST00000538769.1	PTK2	protein tyrosine kinase 2
chr16_-_5083917	0.56	ENST00000312251.3 ENST00000381955.3	NAGPA	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
chr22_+_51176624	0.56	ENST00000216139.5 ENST00000529621.1	ACR	acrosin
chr2_+_10183651	0.56	ENST00000305883.1	KLF11	Kruppel-like factor 11
chr19_-_59066452	0.56	ENST00000312547.2	CHMP2A	charged multivesicular body protein 2A
chr1_-_230850043	0.55	ENST00000366667.4	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr19_-_49622348	0.55	ENST00000408991.2	C19orf73	chromosome 19 open reading frame 73
chr20_+_8112824	0.55	ENST00000378641.3	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	3.2	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.9	5.3	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.9	2.7	GO:0004947	bradykinin receptor activity(GO:0004947)
0.9	18.5	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
0.6	3.6	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.6	1.7	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.5	3.3	GO:0019776	Atg8 ligase activity(GO:0019776)
0.4	1.3	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.3	5.8	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.3	1.7	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.3	0.3	GO:0001003	polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.3	0.8	GO:0016603	glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.3	0.8	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.2	1.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.2	9.7	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2	2.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.2	2.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.2	4.0	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2	9.6	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.2	0.6	GO:0016230	sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.2	2.0	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.1	8.0	GO:0016504	peptidase activator activity(GO:0016504)
0.1	2.2	GO:0045499	chemorepellent activity(GO:0045499)
0.1	13.3	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	1.8	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.1	3.1	GO:0031489	myosin V binding(GO:0031489)
0.1	1.0	GO:0030957	Tat protein binding(GO:0030957)
0.1	1.1	GO:0042731	PH domain binding(GO:0042731)
0.1	2.6	GO:0005523	tropomyosin binding(GO:0005523)
0.1	3.2	GO:0070064	proline-rich region binding(GO:0070064)
0.1	5.5	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	2.8	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	0.4	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1	0.8	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.1	1.5	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	0.4	GO:0050436	microfibril binding(GO:0050436)
0.1	0.6	GO:0004459	lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.1	2.0	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	1.1	GO:0030280	structural constituent of epidermis(GO:0030280)
0.1	1.9	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1	2.1	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1	8.6	GO:0051219	phosphoprotein binding(GO:0051219)
0.1	1.5	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.1	2.4	GO:0071889	14-3-3 protein binding(GO:0071889)
0.1	7.2	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	0.7	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.1	0.3	GO:0008384	IkappaB kinase activity(GO:0008384)
0.1	0.2	GO:0004040	amidase activity(GO:0004040) fucose binding(GO:0042806)
0.1	1.5	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	1.9	GO:0001190	transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1	1.5	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.1	0.4	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1	0.6	GO:0045159	myosin II binding(GO:0045159)
0.1	2.5	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	0.2	GO:0070984	SET domain binding(GO:0070984)
0.1	0.2	GO:0035473	lipase binding(GO:0035473)
0.1	0.2	GO:0051373	FATZ binding(GO:0051373)
0.1	0.2	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)
0.1	0.2	GO:0031716	calcitonin receptor binding(GO:0031716)
0.1	1.1	GO:0005003	ephrin receptor activity(GO:0005003)
0.0	0.4	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	0.1	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0	1.3	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0010465	nerve growth factor receptor activity(GO:0010465)
0.0	1.9	GO:0003774	motor activity(GO:0003774)
0.0	0.7	GO:0030506	ankyrin binding(GO:0030506)
0.0	6.7	GO:0051015	actin filament binding(GO:0051015)
0.0	0.7	GO:0005521	lamin binding(GO:0005521)
0.0	0.5	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.5	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	0.3	GO:0001042	RNA polymerase I core binding(GO:0001042)
0.0	0.5	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:1990932	5.8S rRNA binding(GO:1990932)
0.0	1.5	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.6	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	1.2	GO:0042056	chemoattractant activity(GO:0042056)
0.0	0.7	GO:0036041	long-chain fatty acid binding(GO:0036041)
0.0	0.2	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.0	0.6	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.7	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.7	GO:0005031	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.2	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.1	GO:0034617	tetrahydrobiopterin binding(GO:0034617)
0.0	0.7	GO:0019200	carbohydrate kinase activity(GO:0019200)
0.0	0.3	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.0	0.7	GO:0017022	myosin binding(GO:0017022)
0.0	1.1	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.0	GO:0098770	FBXO family protein binding(GO:0098770)
0.0	0.1	GO:0047179	platelet-activating factor acetyltransferase activity(GO:0047179)
0.0	0.8	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.7	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.1	GO:0031877	somatostatin receptor binding(GO:0031877)
0.0	0.5	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.6	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.2	GO:0036122	BMP binding(GO:0036122)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	4.2	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	0.1	GO:0022850	serotonin-gated cation channel activity(GO:0022850)
0.0	0.5	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	0.1	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	0.3	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.3	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.3	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.3	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.0	0.8	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0	0.2	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.6	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.2	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	1.8	GO:0008201	heparin binding(GO:0008201)
0.0	1.1	GO:0051117	ATPase binding(GO:0051117)
0.0	2.2	GO:0005516	calmodulin binding(GO:0005516)
0.0	0.9	GO:0003730	mRNA 3'-UTR binding(GO:0003730)
0.0	0.9	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.8	8.4	GO:0005171	hepatocyte growth factor receptor binding(GO:0005171)
1.3	3.8	GO:0016603	glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.8	3.8	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.7	6.7	GO:0019826	oxygen sensor activity(GO:0019826)
0.7	2.0	GO:0008330	protein tyrosine/threonine phosphatase activity(GO:0008330)
0.6	1.8	GO:0004947	bradykinin receptor activity(GO:0004947)
0.3	1.7	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.3	1.2	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.3	2.3	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.3	2.5	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.3	0.8	GO:0050211	procollagen galactosyltransferase activity(GO:0050211)
0.2	5.1	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
0.2	0.8	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.2	2.8	GO:0050700	CARD domain binding(GO:0050700)
0.2	1.8	GO:0060002	plus-end directed microfilament motor activity(GO:0060002)
0.2	1.9	GO:0032036	myosin heavy chain binding(GO:0032036)
0.2	0.6	GO:0004040	amidase activity(GO:0004040) fucose binding(GO:0042806)
0.2	1.5	GO:1990932	5.8S rRNA binding(GO:1990932)
0.2	0.2	GO:0001002	polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
0.2	0.7	GO:0031716	calcitonin receptor binding(GO:0031716)
0.2	7.9	GO:0003785	actin monomer binding(GO:0003785)
0.2	0.5	GO:0034353	RNA pyrophosphohydrolase activity(GO:0034353)
0.2	1.0	GO:0039552	RIG-I binding(GO:0039552)
0.2	0.6	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.2	0.5	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.2	2.2	GO:0030957	Tat protein binding(GO:0030957)
0.2	8.2	GO:0016504	peptidase activator activity(GO:0016504)
0.2	0.9	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)
0.1	0.6	GO:0016230	sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.1	0.9	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1	0.4	GO:0098770	FBXO family protein binding(GO:0098770)
0.1	0.4	GO:0004817	cysteine-tRNA ligase activity(GO:0004817)
0.1	0.4	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1	1.3	GO:1990380	Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.1	0.4	GO:0070699	type II activin receptor binding(GO:0070699)
0.1	11.4	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	2.3	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1	10.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	0.8	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.1	4.2	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	4.3	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
0.1	0.9	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1	0.6	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	8.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	1.6	GO:0005112	Notch binding(GO:0005112)
0.1	1.7	GO:0035497	cAMP response element binding(GO:0035497)
0.1	0.6	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.1	0.1	GO:0051430	corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1	0.7	GO:0042731	PH domain binding(GO:0042731)
0.1	0.4	GO:0071532	ankyrin repeat binding(GO:0071532)
0.1	0.2	GO:0016434	rRNA (cytosine) methyltransferase activity(GO:0016434)
0.1	0.4	GO:0019776	Atg8 ligase activity(GO:0019776)
0.1	1.5	GO:0005003	ephrin receptor activity(GO:0005003)
0.1	1.6	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	0.8	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.1	1.4	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	0.7	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1	0.4	GO:0008481	sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1	0.2	GO:0005137	interleukin-5 receptor binding(GO:0005137)
0.1	1.9	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.1	6.7	GO:0051219	phosphoprotein binding(GO:0051219)
0.1	0.1	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.1	0.3	GO:0003796	lysozyme activity(GO:0003796)
0.0	0.3	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	1.8	GO:0030552	cAMP binding(GO:0030552)
0.0	0.2	GO:0043891	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.0	1.2	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.2	GO:0035473	lipase binding(GO:0035473)
0.0	0.3	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.2	GO:0016402	pristanoyl-CoA oxidase activity(GO:0016402)
0.0	3.3	GO:0001540	beta-amyloid binding(GO:0001540)
0.0	0.4	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.8	GO:0030506	ankyrin binding(GO:0030506)
0.0	1.9	GO:0030546	receptor activator activity(GO:0030546)
0.0	0.9	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.2	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.5	GO:0005521	lamin binding(GO:0005521)
0.0	1.5	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	1.7	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.7	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.6	GO:0042923	neuropeptide binding(GO:0042923)
0.0	6.2	GO:0051015	actin filament binding(GO:0051015)
0.0	0.6	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.8	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.4	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.6	GO:0015929	hexosaminidase activity(GO:0015929)
0.0	0.5	GO:0043495	protein anchor(GO:0043495)
0.0	0.2	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.6	GO:0070410	co-SMAD binding(GO:0070410)
0.0	1.3	GO:0017022	myosin binding(GO:0017022)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.8	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
0.0	0.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.1	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.5	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.3	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	5.0	GO:0003779	actin binding(GO:0003779)
0.0	0.2	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.2	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	3.0	GO:0035257	nuclear hormone receptor binding(GO:0035257)
0.0	0.5	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	0.8	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.3	GO:0031210	phosphatidylcholine binding(GO:0031210)
0.0	1.0	GO:0004497	monooxygenase activity(GO:0004497)
0.0	1.5	GO:0008135	translation factor activity, RNA binding(GO:0008135)
0.0	0.8	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.9	GO:0051213	dioxygenase activity(GO:0051213)
0.0	0.4	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.1	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.2	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.0	6.1	GO:0008859	exoribonuclease II activity(GO:0008859)
1.2	3.7	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
0.9	3.7	GO:0019976	interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.7	4.6	GO:0004126	cytidine deaminase activity(GO:0004126)
0.3	1.3	GO:0035276	aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.3	2.0	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.3	0.9	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.2	0.9	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.2	0.6	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.1	1.9	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	0.6	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1	2.3	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.5	GO:0043515	kinetochore binding(GO:0043515)
0.1	1.3	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1	1.1	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.1	0.5	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1	2.8	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.1	0.4	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.1	0.6	GO:0015385	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.1	0.3	GO:0010858	calcium-dependent protein kinase regulator activity(GO:0010858)
0.0	2.4	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.4	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.4	GO:0000990	transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0	0.9	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.3	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.4	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.7	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.9	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.4	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0030343	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.1	GO:0047023	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.0	0.5	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	1.6	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.5	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.8	GO:0051183	vitamin transporter activity(GO:0051183)
0.0	1.3	GO:0030295	protein kinase activator activity(GO:0030295)
0.0	0.5	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.6	GO:0070034	telomerase RNA binding(GO:0070034)
0.0	0.9	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.4	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.5	GO:0015248	sterol transporter activity(GO:0015248)
0.0	1.1	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004)
0.0	0.3	GO:0070402	NADPH binding(GO:0070402)
0.0	0.3	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0008097	5S rRNA binding(GO:0008097)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	8.0	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2	3.8	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.2	4.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
0.2	11.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.2	6.6	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	8.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.7	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	0.2	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.1	1.3	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	4.5	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	2.4	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	1.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	0.4	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.1	1.1	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1	2.2	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.1	1.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	1.4	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	1.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	1.3	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.1	1.7	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.1	5.9	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	0.8	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	2.5	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.0	0.8	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	1.2	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.0	1.8	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.0	4.6	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.0	0.5	REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1	Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.0	0.4	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.9	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.4	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.4	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.5	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.5	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	Genes involved in Synthesis of bile acids and bile salts
0.0	1.6	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	1.1	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	4.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	0.3	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	2.5	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
0.0	0.3	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.4	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.1	REACTOME LATE PHASE OF HIV LIFE CYCLE	Genes involved in Late Phase of HIV Life Cycle
0.0	1.3	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	1.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.6	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.2	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	1.5	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	0.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.7	8.0	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.2	9.6	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
1.2	3.5	GO:0060460	subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
1.1	3.3	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
1.1	3.2	GO:0061386	closure of optic fissure(GO:0061386)
1.0	5.8	GO:0055064	chloride ion homeostasis(GO:0055064)
1.0	8.6	GO:1902412	regulation of mitotic cytokinesis(GO:1902412)
0.9	3.5	GO:0032792	negative regulation of CREB transcription factor activity(GO:0032792)
0.9	5.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.8	2.5	GO:1901350	cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.8	8.1	GO:0051612	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.6	11.8	GO:0071850	mitotic cell cycle arrest(GO:0071850)
0.6	1.1	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.5	1.5	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.5	1.4	GO:2000681	negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.4	4.8	GO:0033327	Leydig cell differentiation(GO:0033327)
0.4	15.6	GO:1902895	positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.4	1.9	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.4	1.8	GO:0030200	heparan sulfate proteoglycan catabolic process(GO:0030200)
0.4	0.7	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.3	1.0	GO:1903722	regulation of centriole elongation(GO:1903722)
0.3	1.0	GO:1901877	regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.3	1.5	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.3	5.3	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.3	0.9	GO:1901842	negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.3	9.0	GO:0042730	fibrinolysis(GO:0042730)
0.3	1.3	GO:0035617	stress granule disassembly(GO:0035617)
0.3	0.8	GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.3	0.8	GO:0043400	cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462)
0.2	1.7	GO:0006655	phosphatidylglycerol biosynthetic process(GO:0006655)
0.2	2.2	GO:0003344	pericardium morphogenesis(GO:0003344)
0.2	0.7	GO:0006014	D-ribose metabolic process(GO:0006014)
0.2	0.7	GO:0097156	fasciculation of motor neuron axon(GO:0097156)
0.2	2.1	GO:0007042	lysosomal lumen acidification(GO:0007042)
0.2	1.3	GO:0051012	microtubule sliding(GO:0051012)
0.2	2.6	GO:0035372	protein localization to microtubule(GO:0035372)
0.2	1.1	GO:2000035	positive regulation of somatic stem cell population maintenance(GO:1904674) regulation of stem cell division(GO:2000035)
0.2	0.6	GO:0043311	positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.2	1.9	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.2	0.6	GO:0033140	negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
0.2	4.0	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.2	1.2	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.2	1.6	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.2	0.6	GO:0002318	myeloid progenitor cell differentiation(GO:0002318)
0.2	0.6	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.2	2.6	GO:0061000	negative regulation of dendritic spine development(GO:0061000)
0.2	1.3	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.2	0.7	GO:1903644	regulation of chaperone-mediated protein folding(GO:1903644)
0.2	0.7	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.2	1.6	GO:0008090	retrograde axonal transport(GO:0008090)
0.2	2.3	GO:0043562	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2	0.5	GO:0046066	dGDP metabolic process(GO:0046066)
0.1	3.8	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1	2.6	GO:0007021	tubulin complex assembly(GO:0007021)
0.1	1.3	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
0.1	0.4	GO:0001544	initiation of primordial ovarian follicle growth(GO:0001544)
0.1	1.3	GO:0070836	caveola assembly(GO:0070836)
0.1	0.4	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.1	0.7	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.1	2.0	GO:0031268	pseudopodium organization(GO:0031268)
0.1	0.4	GO:1903028	positive regulation of opsonization(GO:1903028)
0.1	0.4	GO:1901899	dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.1	1.8	GO:0090168	Golgi reassembly(GO:0090168)
0.1	2.1	GO:0060856	establishment of blood-brain barrier(GO:0060856)
0.1	1.8	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.1	1.7	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1	0.6	GO:0044856	plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.1	0.5	GO:0070317	negative regulation of G0 to G1 transition(GO:0070317)
0.1	2.3	GO:0006853	carnitine shuttle(GO:0006853)
0.1	0.7	GO:0019060	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1	1.7	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1	2.5	GO:0045109	intermediate filament organization(GO:0045109)
0.1	1.5	GO:0046325	negative regulation of glucose import(GO:0046325)
0.1	0.6	GO:2000348	regulation of CD40 signaling pathway(GO:2000348)
0.1	1.1	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.1	1.2	GO:0031573	intra-S DNA damage checkpoint(GO:0031573)
0.1	0.5	GO:0018125	peptidyl-cysteine methylation(GO:0018125) minus-end-directed organelle transport along microtubule(GO:0072385)
0.1	0.3	GO:1903347	negative regulation of bicellular tight junction assembly(GO:1903347)
0.1	0.3	GO:0001983	regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.1	0.3	GO:1902963	regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1	0.3	GO:0051754	meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.1	0.2	GO:0021577	hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1	1.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.8	GO:0051546	keratinocyte migration(GO:0051546)
0.1	0.1	GO:1900158	negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1	0.3	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.1	0.9	GO:0033138	positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1	0.9	GO:2001135	regulation of endocytic recycling(GO:2001135)
0.1	1.1	GO:0048245	eosinophil chemotaxis(GO:0048245)
0.1	5.2	GO:0030574	collagen catabolic process(GO:0030574)
0.1	0.3	GO:0021797	forebrain anterior/posterior pattern specification(GO:0021797)
0.1	1.4	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1	0.9	GO:0051412	response to corticosterone(GO:0051412)
0.1	0.3	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
0.1	0.3	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.1	0.2	GO:0043932	ossification involved in bone remodeling(GO:0043932)
0.1	0.5	GO:0003190	atrioventricular valve formation(GO:0003190)
0.1	0.5	GO:0035754	B cell chemotaxis(GO:0035754)
0.1	0.1	GO:0035751	regulation of lysosomal lumen pH(GO:0035751)
0.1	0.5	GO:0001842	neural fold formation(GO:0001842)
0.1	0.2	GO:0045229	cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1	1.7	GO:0070306	lens fiber cell differentiation(GO:0070306)
0.1	0.7	GO:1901673	regulation of mitotic spindle assembly(GO:1901673)
0.1	4.5	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1	0.2	GO:0072717	cellular response to actinomycin D(GO:0072717)
0.1	0.5	GO:0070365	hepatocyte differentiation(GO:0070365)
0.1	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0	0.3	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.5	GO:0036155	acylglycerol acyl-chain remodeling(GO:0036155)
0.0	0.4	GO:0035583	sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0	0.8	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0	0.2	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.0	0.4	GO:0016191	synaptic vesicle uncoating(GO:0016191)
0.0	2.9	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.0	0.4	GO:0038007	netrin-activated signaling pathway(GO:0038007)
0.0	0.7	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.9	GO:0007567	parturition(GO:0007567)
0.0	0.3	GO:0046604	positive regulation of mitotic centrosome separation(GO:0046604)
0.0	0.3	GO:0042797	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	0.4	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.3	GO:0033523	nucleosome positioning(GO:0016584) histone H2B ubiquitination(GO:0033523)
0.0	0.1	GO:0021785	branchiomotor neuron axon guidance(GO:0021785)
0.0	0.4	GO:0022615	protein to membrane docking(GO:0022615)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.4	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0033484	nitric oxide homeostasis(GO:0033484)
0.0	0.5	GO:0006089	lactate metabolic process(GO:0006089)
0.0	0.5	GO:0000338	protein deneddylation(GO:0000338)
0.0	1.5	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0060734	regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0	0.4	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0	0.1	GO:1990108	protein linear deubiquitination(GO:1990108)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.3	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.3	GO:0001865	NK T cell differentiation(GO:0001865)
0.0	1.1	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol(GO:0051281)
0.0	0.1	GO:0032414	positive regulation of ion transmembrane transporter activity(GO:0032414)
0.0	0.2	GO:0007341	penetration of zona pellucida(GO:0007341)
0.0	2.7	GO:0007588	excretion(GO:0007588)
0.0	0.8	GO:0043616	keratinocyte proliferation(GO:0043616)
0.0	0.1	GO:1990637	response to prolactin(GO:1990637)
0.0	0.5	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.0	2.9	GO:0006024	aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
0.0	3.5	GO:0021987	cerebral cortex development(GO:0021987)
0.0	0.3	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.6	GO:0097120	receptor localization to synapse(GO:0097120)
0.0	0.1	GO:0045903	positive regulation of translational fidelity(GO:0045903)
0.0	0.1	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.4	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.0	0.6	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:0090063	positive regulation of microtubule nucleation(GO:0090063)
0.0	0.2	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.6	GO:0032402	melanosome transport(GO:0032402)
0.0	0.1	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0	0.3	GO:0061003	positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0	0.0	GO:0033686	positive regulation of luteinizing hormone secretion(GO:0033686)
0.0	0.3	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.7	GO:0051291	protein heterooligomerization(GO:0051291)
0.0	0.0	GO:0046122	purine deoxyribonucleoside metabolic process(GO:0046122)
0.0	0.2	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.2	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0	0.1	GO:0046959	habituation(GO:0046959) determination of affect(GO:0050894)
0.0	1.0	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	1.3	GO:0042795	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	0.8	GO:2000144	positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0	0.4	GO:0030517	negative regulation of axon extension(GO:0030517)
0.0	0.1	GO:0060965	negative regulation of gene silencing by miRNA(GO:0060965)
0.0	0.1	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.0	0.1	GO:0014827	intestine smooth muscle contraction(GO:0014827)
0.0	0.2	GO:0044458	motile cilium assembly(GO:0044458)
0.0	0.3	GO:0006970	response to osmotic stress(GO:0006970)
0.0	4.5	GO:0007507	heart development(GO:0007507)
0.0	0.2	GO:0030728	ovulation(GO:0030728)
0.0	0.4	GO:0071480	cellular response to gamma radiation(GO:0071480)
0.0	0.8	GO:0007368	determination of left/right symmetry(GO:0007368)
0.0	0.2	GO:0035635	entry of bacterium into host cell(GO:0035635)
0.0	0.4	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.0	0.3	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.0	GO:0015871	choline transport(GO:0015871)
0.0	0.2	GO:0060765	regulation of androgen receptor signaling pathway(GO:0060765)
0.0	0.1	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0	0.0	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0	2.1	GO:0030323	respiratory tube development(GO:0030323)
0.0	0.0	GO:0019287	isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	1.7	GO:0000187	activation of MAPK activity(GO:0000187)
0.0	0.8	GO:0070527	platelet aggregation(GO:0070527)
0.0	0.2	GO:0090083	regulation of inclusion body assembly(GO:0090083)
0.0	0.0	GO:0070494	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.0	0.1	GO:0038180	nerve growth factor signaling pathway(GO:0038180)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.3	8.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	8.4	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	6.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	3.3	NABA COLLAGENS	Genes encoding collagen proteins
0.1	5.7	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.1	1.5	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.1	2.5	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	3.6	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.1	4.0	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	2.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.1	3.4	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	1.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.6	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	2.8	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	2.8	PID PLK1 PATHWAY	PLK1 signaling events
0.0	2.6	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	1.2	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	1.3	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	1.5	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.5	ST G ALPHA S PATHWAY	G alpha s Pathway
0.0	0.5	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	1.9	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	1.1	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	1.1	PID BARD1 PATHWAY	BARD1 signaling events
0.0	1.5	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.5	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.5	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.8	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	0.6	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.9	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.5	PID CDC42 PATHWAY	CDC42 signaling events
0.0	0.4	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	1.1	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.0	1.1	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.4	PID MYC PATHWAY	C-MYC pathway
0.0	0.5	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.5	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.9	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.4	3.5	GO:0070652	HAUS complex(GO:0070652)
0.3	2.0	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.2	2.4	GO:0005577	fibrinogen complex(GO:0005577)
0.2	4.3	GO:0000178	exosome (RNase complex)(GO:0000178)
0.1	1.3	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.1	6.6	GO:0015030	Cajal body(GO:0015030)
0.1	1.3	GO:0031209	SCAR complex(GO:0031209)
0.1	7.7	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	0.7	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.3	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.4	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.4	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.5	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	2.4	GO:0034707	chloride channel complex(GO:0034707)
0.0	2.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	0.3	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.4	GO:0032059	bleb(GO:0032059)
0.0	1.0	GO:0008305	integrin complex(GO:0008305)
0.0	0.2	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.3	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	2.3	GO:0005643	nuclear pore(GO:0005643)
0.0	0.9	GO:0044215	other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0	0.3	GO:0097342	ripoptosome(GO:0097342)
0.0	1.0	GO:0005801	cis-Golgi network(GO:0005801)
0.0	1.1	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.5	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0	0.6	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.3	GO:0042599	lamellar body(GO:0042599)
0.0	0.4	GO:0005771	multivesicular body(GO:0005771)
0.0	0.2	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.5	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	6.6	GO:0071148	TEAD-1-YAP complex(GO:0071148)
1.1	3.3	GO:0005588	collagen type V trimer(GO:0005588)
0.6	8.2	GO:0005577	fibrinogen complex(GO:0005577)
0.6	8.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.5	2.8	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.4	1.8	GO:0031673	H zone(GO:0031673)
0.4	6.7	GO:0043020	NADPH oxidase complex(GO:0043020)
0.3	0.8	GO:0071595	Nem1-Spo7 phosphatase complex(GO:0071595)
0.3	2.1	GO:0000235	astral microtubule(GO:0000235) aster(GO:0005818)
0.2	3.7	GO:0005916	fascia adherens(GO:0005916)
0.2	4.3	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.2	1.8	GO:0035976	AP1 complex(GO:0035976)
0.2	3.1	GO:0097227	sperm annulus(GO:0097227)
0.2	0.6	GO:0043224	nuclear SCF ubiquitin ligase complex(GO:0043224)
0.2	0.8	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.2	7.2	GO:0005605	basal lamina(GO:0005605)
0.2	2.0	GO:0060077	inhibitory synapse(GO:0060077)
0.2	0.9	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.2	1.1	GO:0032437	cuticular plate(GO:0032437)
0.1	0.6	GO:0043219	lateral loop(GO:0043219)
0.1	0.4	GO:0071159	NF-kappaB complex(GO:0071159)
0.1	0.9	GO:0098560	cytoplasmic side of late endosome membrane(GO:0098560)
0.1	0.4	GO:0043511	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1	2.1	GO:0033270	paranode region of axon(GO:0033270)
0.1	0.5	GO:0036449	microtubule minus-end(GO:0036449)
0.1	2.1	GO:0031083	BLOC-1 complex(GO:0031083)
0.1	7.9	GO:0035577	azurophil granule membrane(GO:0035577)
0.1	1.3	GO:0000815	ESCRT III complex(GO:0000815)
0.1	3.1	GO:0000421	autophagosome membrane(GO:0000421)
0.1	0.6	GO:0005854	nascent polypeptide-associated complex(GO:0005854)
0.1	1.8	GO:0032433	filopodium tip(GO:0032433)
0.1	1.3	GO:0005869	dynactin complex(GO:0005869)
0.1	0.4	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.1	4.0	GO:0016460	myosin II complex(GO:0016460)
0.1	0.4	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.1	2.0	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.1	3.2	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.1	0.6	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1	0.4	GO:0001741	XY body(GO:0001741)
0.1	0.6	GO:0005915	zonula adherens(GO:0005915)
0.1	0.6	GO:0016461	unconventional myosin complex(GO:0016461)
0.1	0.5	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1	0.8	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.0	0.3	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	1.2	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	1.3	GO:0005921	gap junction(GO:0005921)
0.0	3.8	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	0.4	GO:0000125	PCAF complex(GO:0000125)
0.0	0.3	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	0.5	GO:0044292	dendrite terminus(GO:0044292)
0.0	1.6	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.3	GO:0005874	microtubule(GO:0005874)
0.0	1.0	GO:0005871	kinesin complex(GO:0005871)
0.0	1.5	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.7	GO:0036020	endolysosome membrane(GO:0036020)
0.0	0.5	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	19.3	GO:0015629	actin cytoskeleton(GO:0015629)
0.0	2.6	GO:0072686	mitotic spindle(GO:0072686)
0.0	0.3	GO:0031045	dense core granule(GO:0031045)
0.0	0.3	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.2	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0043196	varicosity(GO:0043196)
0.0	0.2	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	2.2	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	0.4	GO:0042583	chromaffin granule(GO:0042583)
0.0	1.7	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	1.6	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	0.6	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	9.9	GO:0031012	extracellular matrix(GO:0031012)
0.0	0.2	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	1.4	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	1.8	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.2	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	1.8	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.5	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	1.4	GO:0008076	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0	0.4	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.6	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	1.4	GO:0001726	ruffle(GO:0001726)
0.0	2.5	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	0.7	GO:0036064	ciliary basal body(GO:0036064)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	3.7	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	3.4	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	4.3	PID IL4 2PATHWAY	IL4-mediated signaling events
0.0	1.6	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	2.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	1.0	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	0.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.9	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.9	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	0.9	PID FOXO PATHWAY	FoxO family signaling
0.0	0.3	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.4	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	2.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	9.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.3	8.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2	3.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.2	7.4	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.1	8.2	PID PLK1 PATHWAY	PLK1 signaling events
0.1	5.2	NABA COLLAGENS	Genes encoding collagen proteins
0.1	3.9	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	5.9	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	3.3	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1	1.9	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	3.1	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.1	0.8	PID IL5 PATHWAY	IL5-mediated signaling events
0.1	1.9	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	1.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	2.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	1.3	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.8	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.6	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	1.7	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	0.3	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	1.9	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	1.7	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	1.4	PID AURORA B PATHWAY	Aurora B signaling
0.0	2.9	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	0.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.5	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	5.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.7	PID ATM PATHWAY	ATM pathway
0.0	0.4	PID RHOA PATHWAY	RhoA signaling pathway
0.0	0.5	PID MYC PATHWAY	C-MYC pathway
0.0	1.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.5	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	1.1	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	0.5	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	1.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.7	8.2	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.3	3.8	GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
1.2	3.7	GO:0010645	regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
1.2	8.4	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.8	3.3	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.8	2.3	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.6	0.6	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.5	1.5	GO:0061386	closure of optic fissure(GO:0061386)
0.5	1.5	GO:0060940	epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.4	1.7	GO:0035026	leading edge cell differentiation(GO:0035026)
0.4	2.6	GO:0051012	microtubule sliding(GO:0051012)
0.4	1.3	GO:0046066	dGDP metabolic process(GO:0046066)
0.4	1.3	GO:1990108	protein linear deubiquitination(GO:1990108)
0.4	2.3	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.4	1.1	GO:1901350	cell-cell signaling involved in cell-cell junction organization(GO:1901350)
0.4	1.1	GO:1903722	regulation of centriole elongation(GO:1903722)
0.4	1.1	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.3	1.0	GO:0090427	activation of meiosis(GO:0090427)
0.3	2.7	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3	1.9	GO:0030035	microspike assembly(GO:0030035)
0.3	6.1	GO:0071850	mitotic cell cycle arrest(GO:0071850)
0.3	1.6	GO:0035617	stress granule disassembly(GO:0035617)
0.3	3.3	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.3	2.1	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.3	1.2	GO:1904565	response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.3	1.5	GO:0016476	regulation of embryonic cell shape(GO:0016476)
0.3	1.4	GO:0030200	proteoglycan catabolic process(GO:0030167) heparan sulfate proteoglycan catabolic process(GO:0030200)
0.3	0.8	GO:0002384	hepatic immune response(GO:0002384) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.3	0.8	GO:0060577	subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.2	6.5	GO:0007567	parturition(GO:0007567)
0.2	1.7	GO:0046485	ether lipid metabolic process(GO:0046485)
0.2	1.5	GO:0045903	positive regulation of translational fidelity(GO:0045903)
0.2	2.1	GO:1902412	regulation of mitotic cytokinesis(GO:1902412)
0.2	0.7	GO:0001983	regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.2	1.6	GO:1900020	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.2	0.7	GO:2000118	regulation of sodium-dependent phosphate transport(GO:2000118)
0.2	7.1	GO:0042730	fibrinolysis(GO:0042730)
0.2	1.5	GO:0061042	vascular wound healing(GO:0061042)
0.2	1.3	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.2	1.3	GO:2000348	regulation of CD40 signaling pathway(GO:2000348)
0.2	3.5	GO:0043562	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.2	0.6	GO:1902396	protein localization to bicellular tight junction(GO:1902396)
0.2	1.8	GO:0008090	retrograde axonal transport(GO:0008090)
0.2	0.6	GO:0043311	positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.2	0.8	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.2	6.7	GO:0050667	homocysteine metabolic process(GO:0050667)
0.2	2.5	GO:2000052	positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.2	1.9	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.2	6.1	GO:1902895	positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.2	1.5	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2	0.5	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.1	2.2	GO:0061162	establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.1	1.6	GO:0033327	Leydig cell differentiation(GO:0033327)
0.1	0.7	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
0.1	0.4	GO:1902523	positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1	2.3	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1	0.4	GO:0006423	cysteinyl-tRNA aminoacylation(GO:0006423)
0.1	0.5	GO:1903597	negative regulation of gap junction assembly(GO:1903597)
0.1	0.4	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1	0.4	GO:1901899	dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.1	0.4	GO:0060278	negative regulation of B cell differentiation(GO:0045578) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1	1.7	GO:0000338	protein deneddylation(GO:0000338)
0.1	0.5	GO:0033123	positive regulation of cyclic nucleotide catabolic process(GO:0030807) positive regulation of cAMP catabolic process(GO:0030822) positive regulation of purine nucleotide catabolic process(GO:0033123)
0.1	2.5	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1	0.5	GO:0008298	intracellular mRNA localization(GO:0008298)
0.1	0.4	GO:0006669	sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.1	1.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	1.4	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1	4.6	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.1	0.9	GO:0015693	magnesium ion transport(GO:0015693)
0.1	8.2	GO:0030574	collagen catabolic process(GO:0030574)
0.1	0.6	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479) formation of radial glial scaffolds(GO:0021943)
0.1	0.9	GO:0007042	lysosomal lumen acidification(GO:0007042)
0.1	1.6	GO:0060856	establishment of blood-brain barrier(GO:0060856)
0.1	1.1	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.1	1.0	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.1	0.3	GO:1901253	negative regulation of intracellular transport of viral material(GO:1901253)
0.1	0.5	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.1	0.5	GO:0051708	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1	1.0	GO:0035372	protein localization to microtubule(GO:0035372)
0.1	0.6	GO:0007341	penetration of zona pellucida(GO:0007341)
0.1	0.5	GO:0010761	fibroblast migration(GO:0010761)
0.1	0.7	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.1	5.0	GO:0070936	protein K48-linked ubiquitination(GO:0070936)
0.1	0.6	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.1	0.8	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1	0.1	GO:0086053	SA node cell to atrial cardiac muscle cell communication by electrical coupling(GO:0086021) AV node cell to bundle of His cell communication by electrical coupling(GO:0086053)
0.1	0.7	GO:0045054	constitutive secretory pathway(GO:0045054)
0.1	0.8	GO:0051665	membrane raft localization(GO:0051665)
0.1	2.0	GO:0097120	receptor localization to synapse(GO:0097120)
0.1	0.6	GO:0021520	spinal cord motor neuron cell fate specification(GO:0021520)
0.1	0.2	GO:1901877	regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.1	0.3	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.1	0.2	GO:0060313	negative regulation of neutrophil degranulation(GO:0043314) negative regulation of blood vessel remodeling(GO:0060313)
0.1	0.5	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.2	GO:0097091	synaptic vesicle clustering(GO:0097091)
0.1	0.2	GO:0045645	regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.1	0.3	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.1	0.6	GO:0033299	secretion of lysosomal enzymes(GO:0033299)
0.1	0.5	GO:0035754	B cell chemotaxis(GO:0035754)
0.1	0.5	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
0.1	0.5	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.1	0.5	GO:0003094	glomerular filtration(GO:0003094)
0.1	1.0	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901)
0.0	4.1	GO:0033275	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0	0.9	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0	0.2	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0	1.1	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	1.5	GO:0000038	very long-chain fatty acid metabolic process(GO:0000038)
0.0	0.2	GO:0045053	protein retention in Golgi apparatus(GO:0045053) asymmetric Golgi ribbon formation(GO:0090164)
0.0	0.1	GO:0032792	negative regulation of CREB transcription factor activity(GO:0032792)
0.0	0.4	GO:0070365	hepatocyte differentiation(GO:0070365)
0.0	0.6	GO:0051775	response to redox state(GO:0051775)
0.0	0.3	GO:0090063	positive regulation of microtubule nucleation(GO:0090063)
0.0	0.6	GO:0034384	high-density lipoprotein particle clearance(GO:0034384)
0.0	0.5	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.0	0.2	GO:0090520	sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.0	0.9	GO:0045332	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	1.0	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	1.4	GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0	0.5	GO:0001842	neural fold formation(GO:0001842)
0.0	1.6	GO:0033344	cholesterol efflux(GO:0033344)
0.0	0.3	GO:1902219	negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress(GO:1902219)
0.0	0.8	GO:0021522	spinal cord motor neuron differentiation(GO:0021522)
0.0	0.5	GO:0035902	response to immobilization stress(GO:0035902)
0.0	0.5	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	1.7	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	1.8	GO:0051489	regulation of filopodium assembly(GO:0051489)
0.0	0.5	GO:0071027	nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0	0.4	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	3.9	GO:0021987	cerebral cortex development(GO:0021987)
0.0	0.5	GO:0060972	left/right pattern formation(GO:0060972)
0.0	0.4	GO:2000291	regulation of myoblast proliferation(GO:2000291)
0.0	0.9	GO:0045022	early endosome to late endosome transport(GO:0045022)
0.0	0.4	GO:0023019	signal transduction involved in regulation of gene expression(GO:0023019)
0.0	0.2	GO:0001711	endodermal cell fate commitment(GO:0001711) nucleosome positioning(GO:0016584)
0.0	0.2	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.2	GO:0098914	membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.0	0.2	GO:0042791	5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.0	1.1	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.5	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.3	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.0	0.3	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.3	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.2	GO:1901673	regulation of mitotic spindle assembly(GO:1901673)
0.0	0.5	GO:0030517	negative regulation of axon extension(GO:0030517)
0.0	0.1	GO:0046604	positive regulation of mitotic centrosome separation(GO:0046604)
0.0	0.3	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	1.6	GO:0070527	platelet aggregation(GO:0070527)
0.0	1.0	GO:0045453	bone resorption(GO:0045453)
0.0	0.7	GO:0071377	cellular response to glucagon stimulus(GO:0071377)
0.0	0.0	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0	1.9	GO:0045995	regulation of embryonic development(GO:0045995)
0.0	0.1	GO:0001970	positive regulation of activation of membrane attack complex(GO:0001970)
0.0	0.2	GO:0002052	positive regulation of neuroblast proliferation(GO:0002052)
0.0	0.1	GO:0033227	dsRNA transport(GO:0033227)
0.0	0.0	GO:0001544	initiation of primordial ovarian follicle growth(GO:0001544)
0.0	5.8	GO:0007015	actin filament organization(GO:0007015)
0.0	0.4	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.1	GO:0070307	lens fiber cell development(GO:0070307)
0.0	0.5	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.3	GO:0006744	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0	0.1	GO:0009146	purine nucleoside triphosphate catabolic process(GO:0009146)
0.0	0.1	GO:1902527	positive regulation of protein monoubiquitination(GO:1902527)
0.0	1.4	GO:0002181	cytoplasmic translation(GO:0002181)
0.0	0.2	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0	0.0	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.3	GO:0030513	positive regulation of BMP signaling pathway(GO:0030513)
0.0	0.5	GO:0010107	potassium ion import(GO:0010107)
0.0	0.1	GO:0002879	positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0	4.3	GO:0045930	negative regulation of mitotic cell cycle(GO:0045930)
0.0	1.5	GO:0006937	regulation of muscle contraction(GO:0006937)
0.0	0.3	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.0	1.2	GO:0030183	B cell differentiation(GO:0030183)
0.0	0.3	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0	0.3	GO:0001937	negative regulation of endothelial cell proliferation(GO:0001937)
0.0	0.2	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0	0.3	GO:0060071	Wnt signaling pathway, planar cell polarity pathway(GO:0060071) regulation of establishment of planar polarity(GO:0090175)
0.0	0.0	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity(GO:0035509) negative regulation of bicellular tight junction assembly(GO:1903347)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.3	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	3.7	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1	2.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	2.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	7.8	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	3.4	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.1	0.9	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	1.6	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	2.0	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.6	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	0.9	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.0	0.4	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.3	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.9	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.6	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.0	0.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.5	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.0	1.1	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.0	0.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.5	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.7	18.4	GO:0071148	TEAD-1-YAP complex(GO:0071148)
1.1	9.1	GO:0000235	astral microtubule(GO:0000235) aster(GO:0005818)
0.6	8.0	GO:0005577	fibrinogen complex(GO:0005577)
0.5	3.3	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.4	5.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.3	1.5	GO:0045323	interleukin-1 receptor complex(GO:0045323)
0.3	4.2	GO:0097512	cardiac myofibril(GO:0097512)
0.2	4.5	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.2	2.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2	2.0	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.2	3.2	GO:0030478	actin cap(GO:0030478)
0.2	1.9	GO:0000439	core TFIIH complex(GO:0000439)
0.2	4.0	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.2	0.5	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.2	3.5	GO:0044295	axonal growth cone(GO:0044295)
0.2	0.6	GO:0031673	H zone(GO:0031673)
0.1	0.8	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.1	0.8	GO:0098560	cytoplasmic side of late endosome membrane(GO:0098560)
0.1	0.6	GO:0044292	dendrite terminus(GO:0044292)
0.1	0.9	GO:0035976	AP1 complex(GO:0035976)
0.1	1.5	GO:0000815	ESCRT III complex(GO:0000815)
0.1	9.0	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.1	0.3	GO:0034271	phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
0.1	0.7	GO:0032437	cuticular plate(GO:0032437)
0.1	2.5	GO:0031143	pseudopodium(GO:0031143)
0.1	2.5	GO:0005921	gap junction(GO:0005921)
0.1	0.4	GO:0020018	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1	6.6	GO:0072686	mitotic spindle(GO:0072686)
0.1	0.6	GO:0072546	ER membrane protein complex(GO:0072546)
0.1	0.4	GO:0000813	ESCRT I complex(GO:0000813)
0.1	0.6	GO:0035749	myelin sheath adaxonal region(GO:0035749) lateral loop(GO:0043219)
0.1	1.1	GO:0031045	dense core granule(GO:0031045)
0.1	2.0	GO:0000421	autophagosome membrane(GO:0000421)
0.1	0.5	GO:1990909	Wnt signalosome(GO:1990909)
0.1	2.9	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.1	0.5	GO:0000125	PCAF complex(GO:0000125)
0.1	0.4	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.1	0.6	GO:0060077	inhibitory synapse(GO:0060077)
0.0	6.7	GO:0032587	ruffle membrane(GO:0032587)
0.0	2.7	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	0.4	GO:0034464	BBSome(GO:0034464)
0.0	0.7	GO:0005869	dynactin complex(GO:0005869)
0.0	0.3	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.0	0.4	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.3	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0001520	outer dense fiber(GO:0001520)
0.0	5.7	GO:0030018	Z disc(GO:0030018)
0.0	1.1	GO:0005859	muscle myosin complex(GO:0005859)
0.0	0.4	GO:0042583	chromaffin granule(GO:0042583)
0.0	1.3	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.6	GO:0031082	BLOC complex(GO:0031082)
0.0	1.0	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	1.2	GO:0009986	cell surface(GO:0009986)
0.0	1.3	GO:0001533	cornified envelope(GO:0001533)
0.0	3.2	GO:0031091	platelet alpha granule(GO:0031091)
0.0	8.9	GO:0045121	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	2.2	GO:0005814	centriole(GO:0005814)
0.0	9.0	GO:0045177	apical part of cell(GO:0045177)
0.0	0.2	GO:0044232	organelle membrane contact site(GO:0044232)
0.0	0.8	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.4	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	0.2	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.1	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.0	1.3	GO:0012505	endomembrane system(GO:0012505)
0.0	0.1	GO:0005854	nascent polypeptide-associated complex(GO:0005854)
0.0	0.5	GO:0005811	lipid particle(GO:0005811)
0.0	0.2	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	0.1	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.4	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0	0.2	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.4	GO:0016591	DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0	1.7	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.0	0.2	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)
0.0	1.0	GO:1904724	tertiary granule lumen(GO:1904724)
0.0	0.5	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.4	GO:0016592	mediator complex(GO:0016592)
0.0	0.2	GO:0000974	Prp19 complex(GO:0000974)
0.0	1.1	GO:0005882	intermediate filament(GO:0005882)
0.0	0.1	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.4	GO:0016459	myosin complex(GO:0016459)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	17.7	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4	5.8	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.3	5.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.3	7.5	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2	4.1	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	2.5	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1	8.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	4.4	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	2.3	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1	1.5	REACTOME GABA RECEPTOR ACTIVATION	Genes involved in GABA receptor activation
0.1	5.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	2.1	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.1	1.8	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.1	1.9	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.1	0.6	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	3.4	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	1.8	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.1	0.6	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.1	0.7	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	1.0	REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT	Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0	1.8	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	5.3	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.0	0.7	REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	Genes involved in NCAM signaling for neurite out-growth
0.0	0.9	REACTOME HYALURONAN METABOLISM	Genes involved in Hyaluronan metabolism
0.0	0.9	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.4	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.3	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.8	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.6	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.5	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	2.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.7	REACTOME CIRCADIAN CLOCK	Genes involved in Circadian Clock
0.0	0.3	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	1.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.6	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.5	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS	Genes involved in Synthesis of bile acids and bile salts
0.0	0.4	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.6	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.3	REACTOME HOST INTERACTIONS OF HIV FACTORS	Genes involved in Host Interactions of HIV factors
0.0	0.6	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	1.3	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis
0.0	0.2	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.0	6.1	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
1.2	3.7	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
0.7	4.6	GO:0090308	regulation of methylation-dependent chromatin silencing(GO:0090308)
0.5	3.7	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
0.4	1.3	GO:0010430	fatty acid omega-oxidation(GO:0010430)
0.4	7.7	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.4	1.1	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.3	1.3	GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
0.3	1.9	GO:0051342	regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.3	2.8	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.2	0.6	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.2	0.6	GO:0032203	telomere formation via telomerase(GO:0032203)
0.2	2.4	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.2	1.7	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.2	0.8	GO:0061143	alveolar primary septum development(GO:0061143)
0.1	0.4	GO:0051097	negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
0.1	1.6	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1	0.9	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.1	0.9	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1	2.3	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1	0.7	GO:0061517	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1	0.5	GO:0015862	uridine transport(GO:0015862)
0.1	0.9	GO:1903027	regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.1	0.4	GO:0035992	tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1	0.3	GO:0097368	histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.1	0.3	GO:0002424	plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.1	0.5	GO:1903385	regulation of homophilic cell adhesion(GO:1903385)
0.1	1.3	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.1	0.8	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1	0.7	GO:0045078	positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1	0.5	GO:0007079	mitotic chromosome movement towards spindle pole(GO:0007079)
0.1	0.3	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.1	0.4	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1	4.9	GO:0042267	natural killer cell mediated cytotoxicity(GO:0042267)
0.1	0.4	GO:0051414	response to cortisol(GO:0051414)
0.1	0.7	GO:0042118	endothelial cell activation(GO:0042118)
0.1	0.3	GO:1904977	lymphatic endothelial cell migration(GO:1904977)
0.1	1.9	GO:0050873	brown fat cell differentiation(GO:0050873)
0.0	0.5	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.5	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.9	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.3	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0	0.1	GO:0007538	primary sex determination(GO:0007538)
0.0	0.2	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.8	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	2.0	GO:0061621	NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0	0.4	GO:0051660	establishment of centrosome localization(GO:0051660)
0.0	0.6	GO:0098719	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0	0.4	GO:0015671	oxygen transport(GO:0015671)
0.0	0.2	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.0	0.1	GO:0036378	calcitriol biosynthetic process from calciol(GO:0036378)
0.0	0.3	GO:1903944	negative regulation of myoblast fusion(GO:1901740) regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0	0.1	GO:1902715	positive regulation of interferon-gamma secretion(GO:1902715)
0.0	0.5	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.3	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.9	GO:0002385	mucosal immune response(GO:0002385)
0.0	3.5	GO:0051225	spindle assembly(GO:0051225)
0.0	0.3	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:1900133	regulation of renin secretion into blood stream(GO:1900133)
0.0	0.4	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.0	1.1	GO:0010501	RNA secondary structure unwinding(GO:0010501)
0.0	0.1	GO:0009753	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.0	2.0	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	0.8	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.6	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)
0.0	0.1	GO:0060133	somatotropin secreting cell development(GO:0060133)
0.0	1.0	GO:0034113	heterotypic cell-cell adhesion(GO:0034113)
0.0	0.6	GO:0006656	phosphatidylcholine biosynthetic process(GO:0006656)
0.0	0.3	GO:0034142	toll-like receptor 4 signaling pathway(GO:0034142)

Results for JUN

Z-value: 1.76

Motif logo

Transcription factors associated with JUN

Activity-expression correlation:

Activity profile of JUN motif

Sorted Z-values of JUN motif

Network of associatons between targets according to the STRING database.

First level regulatory network of JUN

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category: