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ENCODE cell lines, expression (Ernst 2011)
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Results for KLF8
Z-value: 1.21
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Transcription factors associated with KLF8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| KLF8 | hg19_v2_chrX_+_56258844_56258882 | 0.07 | 7.9e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of KLF8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_29910301 | 2.86 |
ENST00000376809.5 ENST00000376802.2 |
HLA-A |
major histocompatibility complex, class I, A |
| chr6_+_31865552 | 2.86 |
ENST00000469372.1 ENST00000497706.1 |
C2 |
complement component 2 |
| chr2_-_20425158 | 2.44 |
ENST00000381150.1 |
SDC1 |
syndecan 1 |
| chr2_-_20424844 | 2.26 |
ENST00000403076.1 ENST00000254351.4 |
SDC1 |
syndecan 1 |
| chr17_-_7080227 | 1.88 |
ENST00000574330.1 |
ASGR1 |
asialoglycoprotein receptor 1 |
| chr16_-_11681316 | 1.69 |
ENST00000571688.1 |
LITAF |
lipopolysaccharide-induced TNF factor |
| chr15_+_45926919 | 1.61 |
ENST00000561735.1 ENST00000260324.7 |
SQRDL |
sulfide quinone reductase-like (yeast) |
| chr2_+_235860616 | 1.57 |
ENST00000392011.2 |
SH3BP4 |
SH3-domain binding protein 4 |
| chr16_-_11680759 | 1.49 |
ENST00000571459.1 ENST00000570798.1 ENST00000572255.1 ENST00000574763.1 ENST00000574703.1 ENST00000571277.1 ENST00000381810.3 |
LITAF |
lipopolysaccharide-induced TNF factor |
| chr9_-_6645628 | 1.47 |
ENST00000321612.6 |
GLDC |
glycine dehydrogenase (decarboxylating) |
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.9 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 5.9 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.5 | 5.5 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.1 | 5.2 | GO:0042347 | negative regulation of NF-kappaB import into nucleus(GO:0042347) |
| 1.6 | 4.7 | GO:0048627 | myoblast development(GO:0048627) |
| 0.4 | 3.5 | GO:2000664 | positive regulation of interleukin-5 secretion(GO:2000664) |
| 0.0 | 3.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.5 | 2.9 | GO:0061517 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.2 | 2.9 | GO:2000427 | positive regulation of apoptotic cell clearance(GO:2000427) |
| 0.2 | 2.8 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.2 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.5 | 5.1 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 5.0 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 4.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 3.6 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.1 | 3.2 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 0.0 | 3.0 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.1 | 2.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 2.1 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.1 | 2.1 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 6.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 6.4 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.7 | 5.4 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.1 | 5.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 5.3 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 3.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 3.0 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.2 | 2.8 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.0 | 2.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 6.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.5 | 5.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.9 | 5.1 | GO:0098560 | cytoplasmic side of late endosome membrane(GO:0098560) |
| 0.6 | 4.4 | GO:0034363 | intermediate-density lipoprotein particle(GO:0034363) |
| 0.1 | 4.4 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.4 | 3.6 | GO:0045179 | apical cortex(GO:0045179) |
| 0.6 | 3.2 | GO:0032449 | CBM complex(GO:0032449) |
| 0.1 | 3.0 | GO:0042611 | MHC protein complex(GO:0042611) |
| 0.3 | 2.8 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 4.5 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.1 | 4.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 3.7 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.1 | 3.6 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.0 | 3.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 2.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 2.4 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.1 | 2.3 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 2.3 | PID BCR 5PATHWAY | BCR signaling pathway |