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ENCODE cell lines, expression (Ernst 2011)

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Results for LHX2

Z-value: 0.39

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Transcription factors associated with LHX2

Gene Symbol Gene ID Gene Info
LHX2
ENSG00000106689.6 LHX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX2hg19_v2_chr9_+_126777676_126777700,
hg19_v2_chr9_+_126773880_126773895		0.533.6e-02Click!

Activity profile of LHX2 motif

Sorted Z-values of LHX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of LHX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr18_+_29027696 1.14 ENST00000257189.4
 DSG3
 desmoglein 3
chr13_-_99959641 1.03 ENST00000376414.4
 GPR183
 G protein-coupled receptor 183
chr12_+_6309517 0.69 ENST00000382519.4
ENST00000009180.4
 CD9
 CD9 molecule
chr11_-_104972158 0.67 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
 CASP1
CARD16
CARD17
 caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr14_-_106926724 0.61 ENST00000434710.1
 IGHV3-43
 immunoglobulin heavy variable 3-43
chr2_-_89157161 0.60 ENST00000390237.2
 IGKC
 immunoglobulin kappa constant
chr1_+_160709055 0.58 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
 SLAMF7
 SLAM family member 7
chr12_+_6554021 0.52 ENST00000266557.3
 CD27
 CD27 molecule
chr1_+_160709029 0.51 ENST00000444090.2
ENST00000441662.2
 SLAMF7
 SLAM family member 7
chr13_-_99910673 0.39 ENST00000397473.2
ENST00000397470.2
 GPR18
 G protein-coupled receptor 18
chr4_-_90756769 0.38 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
 SNCA
 synuclein, alpha (non A4 component of amyloid precursor)
chr1_-_183560011 0.34 ENST00000367536.1
 NCF2
 neutrophil cytosolic factor 2
chr2_+_234627424 0.34 ENST00000373409.3
 UGT1A4
 UDP glucuronosyltransferase 1 family, polypeptide A4
chr4_-_153332886 0.29 ENST00000603841.1
 FBXW7
 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_-_105416039 0.27 ENST00000394767.2
 CXXC4
 CXXC finger protein 4
chr2_-_231084617 0.26 ENST00000409815.2
 SP110
 SP110 nuclear body protein
chr6_+_30848557 0.25 ENST00000460944.2
ENST00000324771.8
 DDR1
 discoidin domain receptor tyrosine kinase 1
chr2_+_68961905 0.24 ENST00000295381.3
 ARHGAP25
 Rho GTPase activating protein 25
chr18_+_34124507 0.24 ENST00000591635.1
 FHOD3
 formin homology 2 domain containing 3
chr2_+_68961934 0.24 ENST00000409202.3
 ARHGAP25
 Rho GTPase activating protein 25
chr7_-_5998714 0.23 ENST00000539903.1
 RSPH10B
 radial spoke head 10 homolog B (Chlamydomonas)
chr11_-_104827425 0.23 ENST00000393150.3
 CASP4
 caspase 4, apoptosis-related cysteine peptidase
chr6_+_125524785 0.22 ENST00000392482.2
 TPD52L1
 tumor protein D52-like 1
chr13_+_73632897 0.21 ENST00000377687.4
 KLF5
 Kruppel-like factor 5 (intestinal)
chr2_-_231084659 0.20 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
 SP110
 SP110 nuclear body protein
chr15_-_72563585 0.19 ENST00000287196.9
ENST00000260376.7
 PARP6
 poly (ADP-ribose) polymerase family, member 6
chr10_-_14372870 0.18 ENST00000357447.2
 FRMD4A
 FERM domain containing 4A
chr16_+_31271274 0.18 ENST00000287497.8
ENST00000544665.3
 ITGAM
 integrin, alpha M (complement component 3 receptor 3 subunit)
chr4_-_120243545 0.17 ENST00000274024.3
 FABP2
 fatty acid binding protein 2, intestinal
chr2_-_10587897 0.17 ENST00000405333.1
ENST00000443218.1
 ODC1
 ornithine decarboxylase 1
chr12_-_118797475 0.15 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
 TAOK3
 TAO kinase 3
chr11_+_64001962 0.14 ENST00000309422.2
 VEGFB
 vascular endothelial growth factor B
chr18_+_3247779 0.14 ENST00000578611.1
ENST00000583449.1
 MYL12A
 myosin, light chain 12A, regulatory, non-sarcomeric
chr21_+_34619079 0.13 ENST00000433395.2
 AP000295.9
 AP000295.9
chr9_+_116207007 0.13 ENST00000374140.2
 RGS3
 regulator of G-protein signaling 3
chr4_+_69313145 0.12 ENST00000305363.4
 TMPRSS11E
 transmembrane protease, serine 11E
chr14_+_69865401 0.12 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
 SLC39A9
 solute carrier family 39, member 9
chr8_-_109260897 0.11 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
 EIF3E
 eukaryotic translation initiation factor 3, subunit E
chr10_+_96443204 0.11 ENST00000339022.5
 CYP2C18
 cytochrome P450, family 2, subfamily C, polypeptide 18
chr7_-_54826920 0.11 ENST00000395535.3
ENST00000352861.4
 SEC61G
 Sec61 gamma subunit
chr12_-_11548496 0.11 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
 PRB2
PRB1
 proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr5_+_179921344 0.10 ENST00000261951.4
 CNOT6
 CCR4-NOT transcription complex, subunit 6
chr17_-_38859996 0.10 ENST00000264651.2
 KRT24
 keratin 24
chr12_+_16064106 0.10 ENST00000428559.2
 DERA
 deoxyribose-phosphate aldolase (putative)
chr1_-_147142557 0.10 ENST00000369238.6
 ACP6
 acid phosphatase 6, lysophosphatidic
chr14_-_51027838 0.08 ENST00000555216.1
 MAP4K5
 mitogen-activated protein kinase kinase kinase kinase 5
chr7_-_103848405 0.08 ENST00000447452.2
ENST00000545943.1
ENST00000297431.4
 ORC5
 origin recognition complex, subunit 5
chr3_+_108541545 0.08 ENST00000295756.6
 TRAT1
 T cell receptor associated transmembrane adaptor 1
chr7_-_54826869 0.07 ENST00000450622.1
 SEC61G
 Sec61 gamma subunit
chr2_+_90139056 0.07 ENST00000492446.1
 IGKV1D-16
 immunoglobulin kappa variable 1D-16
chr11_+_31391381 0.07 ENST00000465995.1
ENST00000536040.1
 DNAJC24
 DnaJ (Hsp40) homolog, subfamily C, member 24
chr11_+_27076764 0.07 ENST00000525090.1
 BBOX1
 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr12_+_64173583 0.07 ENST00000261234.6
 TMEM5
 transmembrane protein 5
chr9_-_100854838 0.07 ENST00000538344.1
 TRIM14
 tripartite motif containing 14
chr7_-_122840015 0.06 ENST00000194130.2
 SLC13A1
 solute carrier family 13 (sodium/sulfate symporter), member 1
chr2_+_210517895 0.06 ENST00000447185.1
 MAP2
 microtubule-associated protein 2
chr17_-_39222131 0.06 ENST00000394015.2
 KRTAP2-4
 keratin associated protein 2-4
chr3_+_108541608 0.06 ENST00000426646.1
 TRAT1
 T cell receptor associated transmembrane adaptor 1
chr13_+_33160553 0.06 ENST00000315596.10
 PDS5B
 PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr10_-_61900762 0.05 ENST00000355288.2
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr14_-_107211459 0.05 ENST00000390636.2
 IGHV3-73
 immunoglobulin heavy variable 3-73
chr9_+_108320392 0.05 ENST00000602661.1
ENST00000223528.2
ENST00000448551.2
ENST00000540160.1
 FKTN
 fukutin
chr2_+_145780767 0.05 ENST00000599358.1
ENST00000596278.1
ENST00000596747.1
ENST00000608652.1
ENST00000609705.1
ENST00000608432.1
ENST00000596970.1
ENST00000602041.1
ENST00000601578.1
ENST00000596034.1
ENST00000414195.2
ENST00000594837.1
 TEX41
 testis expressed 41 (non-protein coding)
chr15_+_58430567 0.05 ENST00000536493.1
 AQP9
 aquaporin 9
chr4_+_88532028 0.05 ENST00000282478.7
 DSPP
 dentin sialophosphoprotein
chr15_+_58430368 0.05 ENST00000558772.1
ENST00000219919.4
 AQP9
 aquaporin 9
chr18_+_66465302 0.05 ENST00000360242.5
ENST00000358653.5
 CCDC102B
 coiled-coil domain containing 102B
chr21_-_35014027 0.04 ENST00000399442.1
ENST00000413017.2
ENST00000445393.1
ENST00000417979.1
ENST00000426935.1
ENST00000381540.3
ENST00000361534.2
ENST00000381554.3
 CRYZL1
 crystallin, zeta (quinone reductase)-like 1
chr2_+_45168875 0.04 ENST00000260653.3
 SIX3
 SIX homeobox 3
chr6_-_26027480 0.04 ENST00000377364.3
 HIST1H4B
 histone cluster 1, H4b
chr16_+_24266874 0.04 ENST00000005284.3
 CACNG3
 calcium channel, voltage-dependent, gamma subunit 3
chr1_-_89591749 0.04 ENST00000370466.3
 GBP2
 guanylate binding protein 2, interferon-inducible
chrX_+_99839799 0.04 ENST00000373031.4
 TNMD
 tenomodulin
chr8_+_76452097 0.03 ENST00000396423.2
 HNF4G
 hepatocyte nuclear factor 4, gamma
chr9_+_105757590 0.03 ENST00000374798.3
ENST00000487798.1
 CYLC2
 cylicin, basic protein of sperm head cytoskeleton 2
chr19_+_22235310 0.03 ENST00000600162.1
 ZNF257
 zinc finger protein 257
chr6_+_26199737 0.03 ENST00000359985.1
 HIST1H2BF
 histone cluster 1, H2bf
chr19_+_42212526 0.02 ENST00000598976.1
ENST00000435837.2
ENST00000221992.6
ENST00000405816.1
 CEA
CEACAM5
 Uncharacterized protein
carcinoembryonic antigen-related cell adhesion molecule 5
chr2_+_145780739 0.02 ENST00000597173.1
ENST00000602108.1
ENST00000420472.1
 TEX41
 testis expressed 41 (non-protein coding)
chr12_-_25348007 0.02 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1
 cancer susceptibility candidate 1
chr11_+_24518723 0.02 ENST00000336930.6
ENST00000529015.1
ENST00000533227.1
 LUZP2
 leucine zipper protein 2
chr12_-_10955226 0.02 ENST00000240687.2
 TAS2R7
 taste receptor, type 2, member 7
chr3_-_131221790 0.02 ENST00000512877.1
ENST00000264995.3
ENST00000511168.1
ENST00000425847.2
 MRPL3
 mitochondrial ribosomal protein L3
chr4_+_128554081 0.02 ENST00000335251.6
ENST00000296461.5
 INTU
 inturned planar cell polarity protein
chr3_+_119187785 0.02 ENST00000295588.4
ENST00000476573.1
 POGLUT1
 protein O-glucosyltransferase 1
chr13_-_19755975 0.02 ENST00000400113.3
 TUBA3C
 tubulin, alpha 3c
chr4_+_70796784 0.02 ENST00000246891.4
ENST00000444405.3
 CSN1S1
 casein alpha s1
chr7_-_14880892 0.02 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
 DGKB
 diacylglycerol kinase, beta 90kDa
chr2_-_208989225 0.02 ENST00000264376.4
 CRYGD
 crystallin, gamma D
chr18_-_19994830 0.01 ENST00000525417.1
 CTAGE1
 cutaneous T-cell lymphoma-associated antigen 1
chr14_+_22694606 0.01 ENST00000390463.3
 TRAV36DV7
 T cell receptor alpha variable 36/delta variable 7
chr10_-_90712520 0.01 ENST00000224784.6
 ACTA2
 actin, alpha 2, smooth muscle, aorta
chr7_+_156433573 0.01 ENST00000311822.8
 RNF32
 ring finger protein 32
chr2_+_173686303 0.01 ENST00000397087.3
 RAPGEF4
 Rap guanine nucleotide exchange factor (GEF) 4
chr14_+_56078695 0.00 ENST00000416613.1
 KTN1
 kinectin 1 (kinesin receptor)
chrX_-_138724677 0.00 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
 MCF2
 MCF.2 cell line derived transforming sequence
chr17_+_17082842 0.00 ENST00000579361.1
 MPRIP
 myosin phosphatase Rho interacting protein
chr12_+_122688090 0.00 ENST00000324189.4
ENST00000546192.1
 B3GNT4
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr9_+_21440440 0.00 ENST00000276927.1
 IFNA1
 interferon, alpha 1
chr12_+_94071129 0.00 ENST00000552983.1
ENST00000332896.3
ENST00000552033.1
ENST00000548483.1
 CRADD
 CASP2 and RIPK1 domain containing adaptor with death domain

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.0 0.3 GO:0032010 phagolysosome(GO:0032010)
0.0 0.3 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.2 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 1.1 GO:0030057 desmosome(GO:0030057)
0.0 1.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 1.3 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.0 GO:0033150 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.2 0.7 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1 0.5 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.4 GO:2000468 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
0.1 0.7 GO:0009414 response to water deprivation(GO:0009414)
0.1 0.3 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.3 GO:0006789 bilirubin conjugation(GO:0006789)
0.0 0.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.0 0.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.4 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.2 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
0.0 1.3 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.0 0.1 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.0 0.1 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.0 0.2 GO:0051639 actin filament network formation(GO:0051639)
0.0 1.0 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.1 GO:0072660 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 0.0 GO:0021798 neuroblast differentiation(GO:0014016) forebrain dorsal/ventral pattern formation(GO:0021798) regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
0.0 0.2 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.1 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.1 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.3 GO:0045730 respiratory burst(GO:0045730)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.4 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.9 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.3 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0015254 glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.0 1.3 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 0.2 GO:0001851 complement component C3b binding(GO:0001851)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.5 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.6 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation