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ENCODE cell lines, expression (Ernst 2011)

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Results for MAFA

Z-value: 0.81

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Transcription factors associated with MAFA

Gene Symbol Gene ID Gene Info
MAFA
ENSG00000182759.3 MAFA

Activity profile of MAFA motif

Sorted Z-values of MAFA motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MAFA

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_+_124221036 2.52 ENST00000368984.3
 HTRA1
 HtrA serine peptidase 1
chr11_-_104817919 2.18 ENST00000533252.1
 CASP4
 caspase 4, apoptosis-related cysteine peptidase
chr2_+_85811525 2.15 ENST00000306384.4
 VAMP5
 vesicle-associated membrane protein 5
chr1_-_153517473 1.99 ENST00000368715.1
 S100A4
 S100 calcium binding protein A4
chr17_-_10325261 1.74 ENST00000403437.2
 MYH8
 myosin, heavy chain 8, skeletal muscle, perinatal
chr10_-_79397391 1.47 ENST00000286628.8
ENST00000406533.3
ENST00000354353.5
ENST00000404857.1
 KCNMA1
 potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr1_-_57045228 1.41 ENST00000371250.3
 PPAP2B
 phosphatidic acid phosphatase type 2B
chr7_-_151433342 1.35 ENST00000433631.2
 PRKAG2
 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr7_-_30029574 1.34 ENST00000426154.1
ENST00000421434.1
ENST00000434476.2
 SCRN1
 secernin 1
chr16_+_56598961 1.33 ENST00000219162.3
 MT4
 metallothionein 4
chr10_+_120967072 1.24 ENST00000392870.2
 GRK5
 G protein-coupled receptor kinase 5
chr7_-_30029367 1.23 ENST00000242059.5
 SCRN1
 secernin 1
chr6_+_116692102 1.23 ENST00000359564.2
 DSE
 dermatan sulfate epimerase
chr6_+_89791507 1.21 ENST00000354922.3
 PNRC1
 proline-rich nuclear receptor coactivator 1
chr9_+_97488939 1.19 ENST00000277198.2
ENST00000297979.5
 C9orf3
 chromosome 9 open reading frame 3
chr12_-_21654479 1.11 ENST00000421138.2
ENST00000444129.2
ENST00000539672.1
ENST00000542432.1
ENST00000536964.1
ENST00000536240.1
ENST00000396093.3
ENST00000314748.6
 RECQL
 RecQ protein-like (DNA helicase Q1-like)
chr4_-_22517620 1.05 ENST00000502482.1
ENST00000334304.5
 GPR125
 G protein-coupled receptor 125
chr12_+_79258444 0.89 ENST00000261205.4
 SYT1
 synaptotagmin I
chr1_+_163039143 0.87 ENST00000531057.1
ENST00000527809.1
ENST00000367908.4
 RGS4
 regulator of G-protein signaling 4
chr12_+_21654714 0.87 ENST00000542038.1
ENST00000540141.1
ENST00000229314.5
 GOLT1B
 golgi transport 1B
chr1_-_203144941 0.83 ENST00000255416.4
 MYBPH
 myosin binding protein H
chr7_-_86849883 0.79 ENST00000433078.1
 TMEM243
 transmembrane protein 243, mitochondrial
chr2_+_191745535 0.74 ENST00000320717.3
 GLS
 glutaminase
chr3_+_107241783 0.72 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
 BBX
 bobby sox homolog (Drosophila)
chr15_+_80696666 0.71 ENST00000303329.4
 ARNT2
 aryl-hydrocarbon receptor nuclear translocator 2
chr12_+_79258547 0.62 ENST00000457153.2
 SYT1
 synaptotagmin I
chr16_-_29517141 0.62 ENST00000550665.1
 RP11-231C14.4
 Uncharacterized protein
chr5_-_94620239 0.61 ENST00000515393.1
 MCTP1
 multiple C2 domains, transmembrane 1
chr2_+_118846008 0.55 ENST00000245787.4
 INSIG2
 insulin induced gene 2
chr12_+_56546363 0.53 ENST00000551834.1
ENST00000552568.1
 MYL6B
 myosin, light chain 6B, alkali, smooth muscle and non-muscle
chrX_-_153141302 0.53 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
 L1CAM
 L1 cell adhesion molecule
chrX_-_92928557 0.52 ENST00000373079.3
ENST00000475430.2
 NAP1L3
 nucleosome assembly protein 1-like 3
chr4_-_10118348 0.47 ENST00000502702.1
 WDR1
 WD repeat domain 1
chr16_-_21436459 0.42 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
 NPIPB3
 nuclear pore complex interacting protein family, member B3
chr6_+_7727030 0.38 ENST00000283147.6
 BMP6
 bone morphogenetic protein 6
chr10_-_79397479 0.38 ENST00000404771.3
 KCNMA1
 potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chrX_-_106959631 0.36 ENST00000486554.1
ENST00000372390.4
 TSC22D3
 TSC22 domain family, member 3
chr11_-_66103867 0.36 ENST00000424433.2
 RIN1
 Ras and Rab interactor 1
chr14_+_24605389 0.34 ENST00000382708.3
ENST00000561435.1
 PSME1
 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr16_+_22524844 0.30 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
 NPIPB5
 nuclear pore complex interacting protein family, member B5
chr16_-_21868739 0.30 ENST00000415645.2
 NPIPB4
 nuclear pore complex interacting protein family, member B4
chr2_+_191745560 0.29 ENST00000338435.4
 GLS
 glutaminase
chr7_-_100860851 0.28 ENST00000223127.3
 PLOD3
 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr11_-_2182388 0.28 ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
ENST00000397270.1
 INS
INS-IGF2
 insulin
INS-IGF2 readthrough
chr10_-_29811456 0.27 ENST00000535393.1
 SVIL
 supervillin
chr20_-_23066953 0.26 ENST00000246006.4
 CD93
 CD93 molecule
chr9_+_2622085 0.25 ENST00000382099.2
 VLDLR
 very low density lipoprotein receptor
chr3_-_48754599 0.23 ENST00000413654.1
ENST00000454335.1
ENST00000440424.1
ENST00000449610.1
ENST00000443964.1
ENST00000417896.1
ENST00000413298.1
ENST00000449563.1
ENST00000443853.1
ENST00000437427.1
ENST00000446860.1
ENST00000412850.1
ENST00000424035.1
ENST00000340879.4
ENST00000431721.2
ENST00000434860.1
ENST00000328631.5
ENST00000432678.2
 IP6K2
 inositol hexakisphosphate kinase 2
chr16_-_29415350 0.23 ENST00000524087.1
 NPIPB11
 nuclear pore complex interacting protein family, member B11
chr22_-_28197486 0.23 ENST00000302326.4
 MN1
 meningioma (disrupted in balanced translocation) 1
chr1_+_90286562 0.22 ENST00000525774.1
ENST00000337338.5
 LRRC8D
 leucine rich repeat containing 8 family, member D
chr5_-_114505624 0.22 ENST00000513154.1
 TRIM36
 tripartite motif containing 36
chr2_+_33172221 0.22 ENST00000354476.3
 LTBP1
 latent transforming growth factor beta binding protein 1
chr2_+_102624977 0.19 ENST00000441002.1
 IL1R2
 interleukin 1 receptor, type II
chr4_+_2470664 0.18 ENST00000314289.8
ENST00000541204.1
ENST00000502316.1
ENST00000507247.1
ENST00000509258.1
ENST00000511859.1
 RNF4
 ring finger protein 4
chrY_-_1461617 0.17 ENSTR0000381401.5
 SLC25A6
 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr11_+_33563821 0.16 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
 KIAA1549L
 KIAA1549-like
chr5_-_118324200 0.16 ENST00000515439.3
ENST00000510708.1
 DTWD2
 DTW domain containing 2
chr10_-_102289611 0.15 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
 NDUFB8
SEC31B
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr4_+_74606223 0.15 ENST00000307407.3
ENST00000401931.1
 IL8
 interleukin 8
chrX_-_43741594 0.15 ENST00000536181.1
ENST00000378069.4
 MAOB
 monoamine oxidase B
chr8_+_85095553 0.15 ENST00000521268.1
 RALYL
 RALY RNA binding protein-like
chr5_+_138629389 0.12 ENST00000504045.1
ENST00000504311.1
ENST00000502499.1
 MATR3
 matrin 3
chr9_+_2621798 0.11 ENST00000382100.3
 VLDLR
 very low density lipoprotein receptor
chr11_+_72929319 0.11 ENST00000393597.2
ENST00000311131.2
 P2RY2
 purinergic receptor P2Y, G-protein coupled, 2
chr5_+_138629337 0.11 ENST00000394805.3
ENST00000512876.1
ENST00000513678.1
 MATR3
 matrin 3
chr19_+_12949251 0.11 ENST00000251472.4
 MAST1
 microtubule associated serine/threonine kinase 1
chr8_+_85095497 0.11 ENST00000522455.1
ENST00000521695.1
 RALYL
 RALY RNA binding protein-like
chr7_-_73133959 0.10 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
 STX1A
 syntaxin 1A (brain)
chr8_+_85095769 0.09 ENST00000518566.1
 RALYL
 RALY RNA binding protein-like
chr22_+_23161491 0.09 ENST00000390316.2
 IGLV3-9
 immunoglobulin lambda variable 3-9 (gene/pseudogene)
chr17_-_42019836 0.09 ENST00000225992.3
 PPY
 pancreatic polypeptide
chr11_-_66103932 0.08 ENST00000311320.4
 RIN1
 Ras and Rab interactor 1
chr18_+_77623668 0.08 ENST00000316249.3
 KCNG2
 potassium voltage-gated channel, subfamily G, member 2
chrX_-_65859096 0.08 ENST00000456230.2
 EDA2R
 ectodysplasin A2 receptor
chr10_-_49701686 0.08 ENST00000417247.2
 ARHGAP22
 Rho GTPase activating protein 22
chrX_-_1511617 0.07 ENST00000381401.5
 SLC25A6
 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr11_+_72929402 0.07 ENST00000393596.2
 P2RY2
 purinergic receptor P2Y, G-protein coupled, 2
chr19_-_43099070 0.06 ENST00000244336.5
 CEACAM8
 carcinoembryonic antigen-related cell adhesion molecule 8
chr5_-_179285848 0.06 ENST00000403396.2
ENST00000292586.6
 C5orf45
 chromosome 5 open reading frame 45
chr4_+_72052964 0.05 ENST00000264485.5
ENST00000425175.1
 SLC4A4
 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chr19_+_33182823 0.04 ENST00000397061.3
 NUDT19
 nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr1_-_216978709 0.04 ENST00000360012.3
 ESRRG
 estrogen-related receptor gamma
chr5_-_179285785 0.04 ENST00000520698.1
ENST00000518235.1
ENST00000376931.2
ENST00000518219.1
ENST00000521333.1
ENST00000523084.1
 C5orf45
 chromosome 5 open reading frame 45
chr1_+_66458072 0.04 ENST00000423207.2
 PDE4B
 phosphodiesterase 4B, cAMP-specific
chrX_-_65858865 0.04 ENST00000374719.3
ENST00000450752.1
ENST00000451436.2
 EDA2R
 ectodysplasin A2 receptor
chr3_-_196439065 0.03 ENST00000399942.4
ENST00000409690.3
 CEP19
 centrosomal protein 19kDa
chr21_+_19617140 0.03 ENST00000299295.2
ENST00000338326.3
 CHODL
 chondrolectin
chr1_+_156124162 0.03 ENST00000368282.1
 SEMA4A
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr21_+_41239243 0.02 ENST00000328619.5
 PCP4
 Purkinje cell protein 4
chr17_+_25936862 0.01 ENST00000582410.1
 KSR1
 kinase suppressor of ras 1
chr20_+_306177 0.01 ENST00000544632.1
 SOX12
 SRY (sex determining region Y)-box 12
chr12_-_123215306 0.01 ENST00000356987.2
ENST00000436083.2
 HCAR1
 hydroxycarboxylic acid receptor 1
chr11_-_62783276 0.00 ENST00000535878.1
ENST00000545207.1
 SLC22A8
 solute carrier family 22 (organic anion transporter), member 8

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.3 1.5 GO:0030348 syntaxin-3 binding(GO:0030348)
0.3 1.7 GO:0017018 myosin phosphatase activity(GO:0017018)
0.3 0.8 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.3 1.9 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 1.0 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.1 GO:0009378 four-way junction helicase activity(GO:0009378)
0.2 2.2 GO:0050700 CARD domain binding(GO:0050700)
0.1 1.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 2.0 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 2.6 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.1 0.4 GO:0038025 glycoprotein transporter activity(GO:0034437) reelin receptor activity(GO:0038025)
0.1 2.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.2 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.1 0.7 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 2.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.2 GO:0050436 microfibril binding(GO:0050436)
0.0 0.4 GO:0043426 MRF binding(GO:0043426)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.8 GO:0051371 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.0 1.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 2.2 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.5 1.5 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.2 1.0 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 2.2 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.2 1.9 GO:0034465 response to carbon monoxide(GO:0034465)
0.2 1.2 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 1.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 0.5 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.1 1.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 0.4 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 0.3 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.1 0.2 GO:0044416 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.1 0.4 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 1.3 GO:0006853 carnitine shuttle(GO:0006853)
0.1 0.8 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.1 0.6 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.1 2.1 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 1.2 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.2 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 0.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 0.2 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.0 0.4 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 2.3 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.2 GO:0010269 response to selenium ion(GO:0010269)
0.0 0.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.0 3.0 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 1.3 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 2.2 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 1.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 1.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.2 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.3 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.9 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.3 1.5 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 0.6 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 2.6 GO:0032982 myosin filament(GO:0032982)
0.1 0.5 GO:0042643 actomyosin, actin portion(GO:0042643)
0.1 1.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.3 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.2 GO:0031201 SNARE complex(GO:0031201)
0.0 0.5 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.5 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 1.9 GO:0005901 caveola(GO:0005901)
0.0 0.4 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)