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ENCODE cell lines, expression (Ernst 2011)

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Results for MEF2B

Z-value: 1.11

Motif logo

Transcription factors associated with MEF2B

Gene Symbol Gene ID Gene Info
ENSG00000213999.11 MEF2B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Bhg19_v2_chr19_-_19281054_192810980.322.3e-01Click!

Activity profile of MEF2B motif

Sorted Z-values of MEF2B motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2B

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_-_111091948 3.96 ENST00000447165.2
NREP
neuronal regeneration related protein
chr2_+_170366203 3.02 ENST00000284669.1
KLHL41
kelch-like family member 41
chr5_+_53751445 2.73 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr5_-_150521192 2.72 ENST00000523714.1
ENST00000521749.1
ANXA6
annexin A6
chr12_+_119616447 2.40 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr1_-_116311402 2.37 ENST00000261448.5
CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_211168332 2.26 ENST00000341685.4
MYL1
myosin, light chain 1, alkali; skeletal, fast
chr3_-_52486841 2.09 ENST00000496590.1
TNNC1
troponin C type 1 (slow)
chr1_-_201391149 2.04 ENST00000555948.1
ENST00000556362.1
TNNI1
troponin I type 1 (skeletal, slow)
chr9_+_100263912 1.92 ENST00000259365.4
TMOD1
tropomodulin 1
chr3_+_138067521 1.87 ENST00000494949.1
MRAS
muscle RAS oncogene homolog
chr10_-_75415825 1.55 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr3_+_138067666 1.53 ENST00000475711.1
ENST00000464896.1
MRAS
muscle RAS oncogene homolog
chr3_+_138067314 1.52 ENST00000423968.2
MRAS
muscle RAS oncogene homolog
chr2_-_86564776 1.49 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1
receptor accessory protein 1
chr16_-_88717423 1.45 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
CYBA
cytochrome b-245, alpha polypeptide
chr3_+_8543393 1.41 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
LMCD1
LIM and cysteine-rich domains 1
chr3_+_8543561 1.37 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr16_-_88717482 1.31 ENST00000261623.3
CYBA
cytochrome b-245, alpha polypeptide
chrX_-_11284095 1.17 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr2_+_33661382 1.16 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_+_8543533 1.15 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr4_+_41362796 1.14 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIMCH1
LIM and calponin homology domains 1
chr1_+_212782012 1.13 ENST00000341491.4
ENST00000366985.1
ATF3
activating transcription factor 3
chr16_+_12058961 1.11 ENST00000053243.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr12_+_25205568 1.10 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr16_+_12059050 1.09 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr17_-_34417479 1.09 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr12_-_111358372 1.08 ENST00000548438.1
ENST00000228841.8
MYL2
myosin, light chain 2, regulatory, cardiac, slow
chr2_-_190044480 1.05 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr8_+_11351876 1.02 ENST00000529894.1
BLK
B lymphoid tyrosine kinase
chr8_+_11351494 1.02 ENST00000259089.4
BLK
B lymphoid tyrosine kinase
chr12_+_25205666 1.01 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr11_+_7597639 0.99 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr4_+_120056939 0.97 ENST00000307128.5
MYOZ2
myozenin 2
chr3_+_179370517 0.94 ENST00000263966.3
USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr2_+_233497931 0.93 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr1_+_145524891 0.83 ENST00000369304.3
ITGA10
integrin, alpha 10
chr12_+_25205446 0.79 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr16_+_84328429 0.76 ENST00000568638.1
WFDC1
WAP four-disulfide core domain 1
chr16_+_84328252 0.74 ENST00000219454.5
WFDC1
WAP four-disulfide core domain 1
chr16_+_12059091 0.73 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr5_+_155753745 0.67 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
SGCD
sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr14_-_22005343 0.61 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr15_+_100106155 0.57 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
MEF2A
myocyte enhancer factor 2A
chr5_-_42811986 0.56 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chrX_+_70521584 0.56 ENST00000373829.3
ENST00000538820.1
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr15_+_100106126 0.53 ENST00000558812.1
ENST00000338042.6
MEF2A
myocyte enhancer factor 2A
chr8_+_1993152 0.53 ENST00000262113.4
MYOM2
myomesin 2
chr15_+_100106244 0.53 ENST00000557942.1
MEF2A
myocyte enhancer factor 2A
chr7_-_37488834 0.53 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr5_-_42812143 0.49 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr8_+_107282389 0.49 ENST00000577661.1
ENST00000445937.1
RP11-395G23.3
OXR1
RP11-395G23.3
oxidation resistance 1
chr8_+_1993173 0.47 ENST00000523438.1
MYOM2
myomesin 2
chr7_+_120629653 0.46 ENST00000450913.2
ENST00000340646.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr17_-_5322786 0.41 ENST00000225696.4
NUP88
nucleoporin 88kDa
chr22_-_30642782 0.40 ENST00000249075.3
LIF
leukemia inhibitory factor
chr17_+_80186908 0.37 ENST00000582743.1
ENST00000578684.1
ENST00000577650.1
ENST00000582715.1
SLC16A3
solute carrier family 16 (monocarboxylate transporter), member 3
chr14_-_102704783 0.36 ENST00000522534.1
MOK
MOK protein kinase
chr5_+_138609782 0.34 ENST00000361059.2
ENST00000514694.1
ENST00000504203.1
ENST00000502929.1
ENST00000394800.2
ENST00000509644.1
ENST00000505016.1
MATR3
matrin 3
chr4_-_25865159 0.34 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
SEL1L3
sel-1 suppressor of lin-12-like 3 (C. elegans)
chr6_+_139094657 0.34 ENST00000332797.6
CCDC28A
coiled-coil domain containing 28A
chr8_-_70745575 0.33 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr15_+_68346501 0.33 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr1_-_204329013 0.32 ENST00000272203.3
ENST00000414478.1
PLEKHA6
pleckstrin homology domain containing, family A member 6
chr6_+_42984723 0.27 ENST00000332245.8
KLHDC3
kelch domain containing 3
chr3_+_186739636 0.25 ENST00000440338.1
ENST00000448044.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr10_+_118350522 0.24 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1
pancreatic lipase-related protein 1
chr3_-_176914238 0.23 ENST00000430069.1
ENST00000428970.1
TBL1XR1
transducin (beta)-like 1 X-linked receptor 1
chr3_+_127634312 0.22 ENST00000407609.3
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr6_+_44194762 0.22 ENST00000371708.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr16_-_31439735 0.21 ENST00000287490.4
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr19_-_40324767 0.20 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr10_+_118350468 0.20 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1
pancreatic lipase-related protein 1
chr9_-_74980113 0.18 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
ZFAND5
zinc finger, AN1-type domain 5
chr7_+_143013198 0.18 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr3_+_54157480 0.18 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr19_+_56713670 0.17 ENST00000534327.1
ZSCAN5C
zinc finger and SCAN domain containing 5C
chr2_-_157198860 0.14 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_170633047 0.14 ENST00000239461.6
ENST00000497230.2
PRRX1
paired related homeobox 1
chr17_-_42200996 0.13 ENST00000587135.1
ENST00000225983.6
ENST00000393622.2
ENST00000588703.1
HDAC5
histone deacetylase 5
chr8_-_27115903 0.10 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
STMN4
stathmin-like 4
chr3_+_127634069 0.09 ENST00000405109.1
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr5_-_66492562 0.09 ENST00000256447.4
CD180
CD180 molecule
chr9_+_116327326 0.07 ENST00000342620.5
RGS3
regulator of G-protein signaling 3
chr7_+_30951461 0.07 ENST00000311813.4
AQP1
aquaporin 1 (Colton blood group)
chr4_+_44680429 0.06 ENST00000281543.5
GUF1
GUF1 GTPase homolog (S. cerevisiae)
chr3_+_46924829 0.04 ENST00000313049.5
PTH1R
parathyroid hormone 1 receptor
chr19_-_40324255 0.04 ENST00000593685.1
ENST00000600611.1
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr17_-_42200958 0.04 ENST00000336057.5
HDAC5
histone deacetylase 5
chr7_+_86781847 0.03 ENST00000432366.2
ENST00000423590.2
ENST00000394703.5
DMTF1
cyclin D binding myb-like transcription factor 1
chr8_-_27115931 0.02 ENST00000523048.1
STMN4
stathmin-like 4
chr8_+_95565947 0.01 ENST00000523011.1
RP11-267M23.4
RP11-267M23.4
chr11_-_47400078 0.01 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr12_+_15699286 0.00 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:1904288 BAT3 complex binding(GO:1904288)
0.2 1.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.2 1.0 GO:0051373 FATZ binding(GO:0051373)
0.2 0.8 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.2 1.8 GO:0031013 troponin I binding(GO:0031013)
0.1 4.9 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.1 2.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 1.9 GO:0005523 tropomyosin binding(GO:0005523)
0.1 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 1.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.3 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 5.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.9 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.0 0.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 0.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.4 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.6 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
0.0 2.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 4.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 2.0 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 4.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 2.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.2 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.5 PID NETRIN PATHWAY Netrin-mediated signaling events
0.0 1.1 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.8 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.5 2.1 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.4 1.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.3 1.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.3 1.6 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.3 1.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.3 1.1 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.2 2.4 GO:0071313 cellular response to caffeine(GO:0071313)
0.2 0.9 GO:0035523 protein K29-linked deubiquitination(GO:0035523) maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.2 3.0 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.2 3.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.2 1.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 2.0 GO:0014883 transition between fast and slow fiber(GO:0014883)
0.1 0.4 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.1 0.9 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 2.7 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 1.5 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.1 0.4 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.1 0.4 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.1 2.0 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.1 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 1.2 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 2.9 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.3 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 4.9 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 0.5 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.1 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 2.9 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.1 GO:0072229 carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
0.0 0.3 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 2.4 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 1.6 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.1 GO:0048664 neuron fate determination(GO:0048664)
0.0 1.5 GO:0061045 negative regulation of wound healing(GO:0061045)
0.0 0.9 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.5 GO:0016601 Rac protein signal transduction(GO:0016601)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 2.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 2.0 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 1.1 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.4 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.3 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.5 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.4 GO:0030314 junctional membrane complex(GO:0030314)
0.4 1.1 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.4 1.1 GO:0005588 collagen type V trimer(GO:0005588)
0.3 2.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.3 0.8 GO:0034680 integrin alpha10-beta1 complex(GO:0034680)
0.2 2.8 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 1.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 3.0 GO:0031143 pseudopodium(GO:0031143)
0.1 1.1 GO:0097512 cardiac myofibril(GO:0097512)
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 2.7 GO:0005859 muscle myosin complex(GO:0005859)
0.1 3.1 GO:0036379 myofilament(GO:0036379)
0.0 2.9 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.1 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.0 2.7 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.6 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 2.0 GO:0030018 Z disc(GO:0030018)
0.0 2.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)