ENCODE cell lines, expression (Ernst 2011)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Download the whole report

Gene Symbol	Gene ID	Gene Info
MEF2C Links Ensembl NCBI GeneCards UniProt	ENSG00000081189.9	MEF2C

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MEF2C	hg19_v2_chr5_-_88119580_88119605	0.15	5.7e-01	Click!

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Promoter	Score	Transcript	Gene	Gene Info
chr4_-_143226979	15.36	ENST00000514525.1	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa
chr4_-_143227088	11.00	ENST00000511838.1	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa
chr4_+_169418195	9.44	ENST00000261509.6 ENST00000335742.7	PALLD	palladin, cytoskeletal associated protein
chr1_-_201391149	9.14	ENST00000555948.1 ENST00000556362.1	TNNI1	troponin I type 1 (skeletal, slow)
chr4_+_169418255	6.97	ENST00000505667.1 ENST00000511948.1	PALLD	palladin, cytoskeletal associated protein
chr2_-_151344172	6.95	ENST00000375734.2 ENST00000263895.4 ENST00000454202.1	RND3	Rho family GTPase 3
chr8_-_49834299	6.52	ENST00000396822.1	SNAI2	snail family zinc finger 2
chr3_+_8543393	6.32	ENST00000157600.3 ENST00000415597.1 ENST00000535732.1	LMCD1	LIM and cysteine-rich domains 1
chr8_-_49833978	6.13	ENST00000020945.1	SNAI2	snail family zinc finger 2
chr10_-_75410771	6.11	ENST00000372873.4	SYNPO2L	synaptopodin 2-like
chr3_+_8543561	6.08	ENST00000397386.3	LMCD1	LIM and cysteine-rich domains 1
chr4_-_143767428	5.98	ENST00000513000.1 ENST00000509777.1 ENST00000503927.1	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa
chr10_-_75415825	5.65	ENST00000394810.2	SYNPO2L	synaptopodin 2-like
chr3_+_138067521	5.63	ENST00000494949.1	MRAS	muscle RAS oncogene homolog
chr2_-_211168332	5.32	ENST00000341685.4	MYL1	myosin, light chain 1, alkali; skeletal, fast
chr3_+_135741576	5.11	ENST00000334546.2	PPP2R3A	protein phosphatase 2, regulatory subunit B'', alpha
chr2_+_170366203	5.06	ENST00000284669.1	KLHL41	kelch-like family member 41
chr3_+_8543533	4.94	ENST00000454244.1	LMCD1	LIM and cysteine-rich domains 1
chr3_-_52486841	4.83	ENST00000496590.1	TNNC1	troponin C type 1 (slow)
chrX_+_135278908	4.67	ENST00000539015.1 ENST00000370683.1	FHL1	four and a half LIM domains 1
chr5_+_53751445	4.48	ENST00000302005.1	HSPB3	heat shock 27kDa protein 3
chr1_-_201390846	4.45	ENST00000367312.1 ENST00000555340.2 ENST00000361379.4	TNNI1	troponin I type 1 (skeletal, slow)
chr1_-_116311402	4.42	ENST00000261448.5	CASQ2	calsequestrin 2 (cardiac muscle)
chrX_+_135279179	4.34	ENST00000370676.3	FHL1	four and a half LIM domains 1
chr5_-_111091948	3.90	ENST00000447165.2	NREP	neuronal regeneration related protein
chr3_+_159570722	3.83	ENST00000482804.1	SCHIP1	schwannomin interacting protein 1
chr3_+_138067314	3.67	ENST00000423968.2	MRAS	muscle RAS oncogene homolog
chr13_+_76334567	3.60	ENST00000321797.8	LMO7	LIM domain 7
chr3_+_138067666	3.60	ENST00000475711.1 ENST00000464896.1	MRAS	muscle RAS oncogene homolog
chr2_-_190044480	3.50	ENST00000374866.3	COL5A2	collagen, type V, alpha 2
chr6_-_169654139	3.28	ENST00000366787.3	THBS2	thrombospondin 2
chr11_+_12766583	3.18	ENST00000361985.2	TEAD1	TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr4_-_186697044	3.11	ENST00000437304.2	SORBS2	sorbin and SH3 domain containing 2
chr3_+_154797877	3.10	ENST00000462745.1 ENST00000493237.1	MME	membrane metallo-endopeptidase
chr1_-_31845914	3.05	ENST00000373713.2	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr13_+_76334795	3.01	ENST00000526202.1 ENST00000465261.2	LMO7	LIM domain 7
chr1_-_201346761	2.96	ENST00000455702.1 ENST00000422165.1 ENST00000367318.5 ENST00000367320.2 ENST00000438742.1 ENST00000412633.1 ENST00000458432.2 ENST00000421663.2 ENST00000367322.1 ENST00000509001.1	TNNT2	troponin T type 2 (cardiac)
chr1_-_173174681	2.94	ENST00000367718.1	TNFSF4	tumor necrosis factor (ligand) superfamily, member 4
chr17_+_4855053	2.89	ENST00000518175.1	ENO3	enolase 3 (beta, muscle)
chr9_-_21995249	2.85	ENST00000494262.1	CDKN2A	cyclin-dependent kinase inhibitor 2A
chr2_-_235405679	2.78	ENST00000390645.2	ARL4C	ADP-ribosylation factor-like 4C
chr11_+_1942580	2.54	ENST00000381558.1	TNNT3	troponin T type 3 (skeletal, fast)
chr11_+_1860200	2.50	ENST00000381911.1	TNNI2	troponin I type 2 (skeletal, fast)
chr12_-_111358372	2.49	ENST00000548438.1 ENST00000228841.8	MYL2	myosin, light chain 2, regulatory, cardiac, slow
chr7_-_150946015	2.42	ENST00000262188.8	SMARCD3	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr17_+_80186908	2.37	ENST00000582743.1 ENST00000578684.1 ENST00000577650.1 ENST00000582715.1	SLC16A3	solute carrier family 16 (monocarboxylate transporter), member 3
chr4_+_41362796	2.28	ENST00000508501.1 ENST00000512946.1 ENST00000313860.7 ENST00000512632.1 ENST00000512820.1	LIMCH1	LIM and calponin homology domains 1
chr10_+_63661053	2.10	ENST00000279873.7	ARID5B	AT rich interactive domain 5B (MRF1-like)
chr13_-_67802549	1.89	ENST00000328454.5 ENST00000377865.2	PCDH9	protocadherin 9
chr16_+_6069072	1.85	ENST00000547605.1 ENST00000550418.1 ENST00000553186.1	RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_+_19799327	1.83	ENST00000540292.1	NAV2	neuron navigator 2
chr11_+_1860832	1.78	ENST00000252898.7	TNNI2	troponin I type 2 (skeletal, fast)
chrX_+_153046456	1.68	ENST00000393786.3 ENST00000370104.1 ENST00000370108.3 ENST00000370101.3 ENST00000430541.1 ENST00000370100.1	SRPK3	SRSF protein kinase 3
chr9_+_116327326	1.64	ENST00000342620.5	RGS3	regulator of G-protein signaling 3
chr21_+_27011584	1.64	ENST00000400532.1 ENST00000480456.1 ENST00000312957.5	JAM2	junctional adhesion molecule 2
chr16_+_84328252	1.62	ENST00000219454.5	WFDC1	WAP four-disulfide core domain 1
chr21_+_39628852	1.58	ENST00000398938.2	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15
chr1_-_59249732	1.57	ENST00000371222.2	JUN	jun proto-oncogene
chr16_+_7382745	1.56	ENST00000436368.2 ENST00000311745.5 ENST00000355637.4 ENST00000340209.4	RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1
chr11_+_1940925	1.53	ENST00000453458.1 ENST00000381557.2 ENST00000381589.3 ENST00000381579.3 ENST00000381563.4 ENST00000344578.4	TNNT3	troponin T type 3 (skeletal, fast)
chr1_+_145524891	1.48	ENST00000369304.3	ITGA10	integrin, alpha 10
chr8_-_62602327	1.48	ENST00000445642.3 ENST00000517847.2 ENST00000389204.4 ENST00000517661.1 ENST00000517903.1 ENST00000522603.1 ENST00000522349.1 ENST00000522835.1 ENST00000541428.1 ENST00000518306.1	ASPH	aspartate beta-hydroxylase
chr10_+_124134201	1.48	ENST00000368990.3 ENST00000368988.1 ENST00000368989.2 ENST00000463663.2	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr16_+_84328429	1.46	ENST00000568638.1	WFDC1	WAP four-disulfide core domain 1
chr1_+_156095951	1.45	ENST00000448611.2 ENST00000368297.1	LMNA	lamin A/C
chr11_+_1940786	1.45	ENST00000278317.6 ENST00000381561.4 ENST00000381548.3 ENST00000360603.3 ENST00000381549.3	TNNT3	troponin T type 3 (skeletal, fast)
chr2_+_233497931	1.44	ENST00000264059.3	EFHD1	EF-hand domain family, member D1
chr11_+_1860682	1.43	ENST00000381906.1	TNNI2	troponin I type 2 (skeletal, fast)
chr17_-_1389419	1.42	ENST00000575158.1	MYO1C	myosin IC
chr4_+_55095264	1.42	ENST00000257290.5	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide
chr5_+_140749803	1.42	ENST00000576222.1	PCDHGB3	protocadherin gamma subfamily B, 3
chr3_+_99357319	1.40	ENST00000452013.1 ENST00000261037.3 ENST00000273342.4	COL8A1	collagen, type VIII, alpha 1
chr4_+_41614909	1.36	ENST00000509454.1 ENST00000396595.3 ENST00000381753.4	LIMCH1	LIM and calponin homology domains 1
chr2_-_208030647	1.34	ENST00000309446.6	KLF7	Kruppel-like factor 7 (ubiquitous)
chr17_-_1389228	1.31	ENST00000438665.2	MYO1C	myosin IC
chr21_+_39628655	1.28	ENST00000398925.1 ENST00000398928.1 ENST00000328656.4 ENST00000443341.1	KCNJ15	potassium inwardly-rectifying channel, subfamily J, member 15
chr4_-_186696425	1.28	ENST00000430503.1 ENST00000319454.6 ENST00000450341.1	SORBS2	sorbin and SH3 domain containing 2
chr10_+_88428206	1.21	ENST00000429277.2 ENST00000458213.2 ENST00000352360.5	LDB3	LIM domain binding 3
chr10_-_62704005	1.17	ENST00000337910.5	RHOBTB1	Rho-related BTB domain containing 1
chr1_-_230513367	1.15	ENST00000321327.2 ENST00000525115.1	PGBD5	piggyBac transposable element derived 5
chr4_+_120056939	1.10	ENST00000307128.5	MYOZ2	myozenin 2
chr8_+_132952112	1.10	ENST00000520362.1 ENST00000519656.1	EFR3A	EFR3 homolog A (S. cerevisiae)
chr7_+_18535346	1.09	ENST00000405010.3 ENST00000406451.4 ENST00000428307.2	HDAC9	histone deacetylase 9
chr5_-_142065223	1.09	ENST00000378046.1	FGF1	fibroblast growth factor 1 (acidic)
chr10_-_3827417	1.08	ENST00000497571.1 ENST00000542957.1	KLF6	Kruppel-like factor 6
chr9_-_110251836	1.08	ENST00000374672.4	KLF4	Kruppel-like factor 4 (gut)
chr5_-_150521192	1.03	ENST00000523714.1 ENST00000521749.1	ANXA6	annexin A6
chr15_+_100106126	1.03	ENST00000558812.1 ENST00000338042.6	MEF2A	myocyte enhancer factor 2A
chr17_+_65040678	0.96	ENST00000226021.3	CACNG1	calcium channel, voltage-dependent, gamma subunit 1
chr3_+_36421826	0.86	ENST00000273183.3	STAC	SH3 and cysteine rich domain
chr15_+_100106244	0.85	ENST00000557942.1	MEF2A	myocyte enhancer factor 2A
chr7_-_151217166	0.82	ENST00000496004.1	RHEB	Ras homolog enriched in brain
chr1_+_68150744	0.75	ENST00000370986.4 ENST00000370985.3	GADD45A	growth arrest and DNA-damage-inducible, alpha
chr1_-_154164534	0.74	ENST00000271850.7 ENST00000368530.2	TPM3	tropomyosin 3
chr16_-_31439735	0.74	ENST00000287490.4	COX6A2	cytochrome c oxidase subunit VIa polypeptide 2
chr14_+_78870030	0.74	ENST00000553631.1 ENST00000554719.1	NRXN3	neurexin 3
chr20_+_48807351	0.73	ENST00000303004.3	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta
chr8_+_1993173	0.71	ENST00000523438.1	MYOM2	myomesin 2
chr11_+_69924639	0.71	ENST00000538023.1 ENST00000398543.2	ANO1	anoctamin 1, calcium activated chloride channel
chr3_+_54157480	0.70	ENST00000490478.1	CACNA2D3	calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr14_-_61748550	0.69	ENST00000555868.1	TMEM30B	transmembrane protein 30B
chr8_+_1993152	0.68	ENST00000262113.4	MYOM2	myomesin 2
chr2_+_220143989	0.68	ENST00000336576.5	DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2
chr14_+_74003818	0.68	ENST00000311148.4	ACOT1	acyl-CoA thioesterase 1
chr7_+_80267973	0.67	ENST00000394788.3 ENST00000447544.2	CD36	CD36 molecule (thrombospondin receptor)
chr15_+_100106155	0.63	ENST00000557785.1 ENST00000558049.1 ENST00000449277.2	MEF2A	myocyte enhancer factor 2A
chr7_-_151217001	0.60	ENST00000262187.5	RHEB	Ras homolog enriched in brain
chr15_+_67418047	0.55	ENST00000540846.2	SMAD3	SMAD family member 3
chr6_+_132129151	0.54	ENST00000360971.2	ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1
chr3_+_46924829	0.53	ENST00000313049.5	PTH1R	parathyroid hormone 1 receptor
chr18_+_9708162	0.48	ENST00000578921.1	RAB31	RAB31, member RAS oncogene family
chr3_+_179370517	0.47	ENST00000263966.3	USP13	ubiquitin specific peptidase 13 (isopeptidase T-3)
chr2_+_220144052	0.43	ENST00000425450.1 ENST00000392086.4 ENST00000421532.1	DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2
chr1_-_204329013	0.43	ENST00000272203.3 ENST00000414478.1	PLEKHA6	pleckstrin homology domain containing, family A member 6
chr1_+_156096336	0.40	ENST00000504687.1 ENST00000473598.2	LMNA	lamin A/C
chr18_+_3252206	0.38	ENST00000578562.2	MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric
chr2_+_109204909	0.38	ENST00000393310.1	LIMS1	LIM and senescent cell antigen-like domains 1
chr10_+_88428370	0.38	ENST00000372066.3 ENST00000263066.6 ENST00000372056.4 ENST00000310944.6 ENST00000361373.4 ENST00000542786.1	LDB3	LIM domain binding 3
chr1_+_170633047	0.37	ENST00000239461.6 ENST00000497230.2	PRRX1	paired related homeobox 1
chr10_+_52751010	0.36	ENST00000373985.1	PRKG1	protein kinase, cGMP-dependent, type I
chr9_+_130565147	0.36	ENST00000373247.2 ENST00000373245.1 ENST00000393706.2 ENST00000373228.1	FPGS	folylpolyglutamate synthase
chr2_+_109204743	0.35	ENST00000332345.6	LIMS1	LIM and senescent cell antigen-like domains 1
chr9_-_74980113	0.32	ENST00000376962.5 ENST00000376960.4 ENST00000237937.3	ZFAND5	zinc finger, AN1-type domain 5
chr7_-_56160625	0.29	ENST00000446428.1 ENST00000432123.1 ENST00000452681.2 ENST00000537360.1	PHKG1	phosphorylase kinase, gamma 1 (muscle)
chr22_+_41487711	0.28	ENST00000263253.7	EP300	E1A binding protein p300
chr7_+_142457315	0.26	ENST00000486171.1 ENST00000311737.7	PRSS1	protease, serine, 1 (trypsin 1)
chr7_+_75931861	0.26	ENST00000248553.6	HSPB1	heat shock 27kDa protein 1
chr15_+_80364901	0.22	ENST00000560228.1 ENST00000559835.1 ENST00000559775.1 ENST00000558688.1 ENST00000560392.1 ENST00000560976.1 ENST00000558272.1 ENST00000558390.1	ZFAND6	zinc finger, AN1-type domain 6
chr18_+_29027696	0.18	ENST00000257189.4	DSG3	desmoglein 3
chr3_-_3151664	0.16	ENST00000256452.3 ENST00000311981.8 ENST00000430514.2 ENST00000456302.1	IL5RA	interleukin 5 receptor, alpha
chr7_-_56160666	0.15	ENST00000297373.2	PHKG1	phosphorylase kinase, gamma 1 (muscle)
chr11_-_85780853	0.15	ENST00000531930.1 ENST00000528398.1	PICALM	phosphatidylinositol binding clathrin assembly protein
chr17_-_79604075	0.14	ENST00000374747.5 ENST00000539314.1 ENST00000331134.6	NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)
chr20_+_44519948	0.14	ENST00000354880.5 ENST00000191018.5	CTSA	cathepsin A
chr1_+_201979645	0.13	ENST00000367284.5 ENST00000367283.3	ELF3	E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chrX_-_109683446	0.11	ENST00000372057.1	AMMECR1	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr17_-_10276319	0.11	ENST00000252172.4 ENST00000418404.3	MYH13	myosin, heavy chain 13, skeletal muscle
chr4_+_41614720	0.10	ENST00000509277.1	LIMCH1	LIM and calponin homology domains 1
chr11_+_75110530	0.08	ENST00000531188.1 ENST00000530164.1 ENST00000422465.2 ENST00000278572.6 ENST00000534440.1 ENST00000527446.1 ENST00000526608.1 ENST00000527273.1 ENST00000524851.1	RPS3	ribosomal protein S3
chr9_-_215744	0.08	ENST00000382387.2	C9orf66	chromosome 9 open reading frame 66
chr18_+_3252265	0.06	ENST00000580887.1 ENST00000536605.1	MYL12A	myosin, light chain 12A, regulatory, non-sarcomeric
chr10_+_95517660	0.05	ENST00000371413.3	LGI1	leucine-rich, glioma inactivated 1
chr15_+_68582544	0.05	ENST00000566008.1	FEM1B	fem-1 homolog b (C. elegans)
chr8_-_7309887	0.05	ENST00000458665.1 ENST00000528168.1	SPAG11B	sperm associated antigen 11B
chr5_-_66492562	0.05	ENST00000256447.4	CD180	CD180 molecule
chr1_-_713985	0.04	ENST00000428504.1	RP11-206L10.2	RP11-206L10.2
chr6_-_161085291	0.03	ENST00000316300.5	LPA	lipoprotein, Lp(a)
chr20_+_44520009	0.03	ENST00000607482.1 ENST00000372459.2	CTSA	cathepsin A
chr4_-_88450612	0.03	ENST00000418378.1 ENST00000282470.6	SPARCL1	SPARC-like 1 (hevin)
chr10_+_121652204	0.03	ENST00000369075.3 ENST00000543134.1	SEC23IP	SEC23 interacting protein
chr1_+_24018269	0.03	ENST00000374550.3	RPL11	ribosomal protein L11
chr4_-_57547870	0.01	ENST00000381260.3 ENST00000420433.1 ENST00000554144.1 ENST00000557328.1	HOPX	HOP homeobox
chr4_-_57547454	0.01	ENST00000556376.2	HOPX	HOP homeobox
chr1_+_92632542	0.00	ENST00000409154.4 ENST00000370378.4	KIAA1107	KIAA1107

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.1	3.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.1	2.9	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	2.9	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	13.4	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.1	9.7	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	8.4	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.0	1.6	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	1.0	PID IFNG PATHWAY	IFN-gamma pathway
0.0	1.4	PID MTOR 4PATHWAY	mTOR signaling pathway
0.0	1.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.7	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.8	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	1.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.0	0.5	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.3	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.0	0.8	PID FGF PATHWAY	FGF signaling pathway
0.0	0.7	PID ILK PATHWAY	Integrin-linked kinase signaling

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	32.6	GO:0005861	troponin complex(GO:0005861)
1.2	3.5	GO:0005588	collagen type V trimer(GO:0005588)
1.1	4.4	GO:0030314	junctional membrane complex(GO:0030314)
0.7	2.7	GO:0045160	myosin I complex(GO:0045160)
0.6	3.2	GO:0071148	TEAD-1-YAP complex(GO:0071148)
0.5	1.5	GO:0034680	integrin alpha10-beta1 complex(GO:0034680)
0.5	2.9	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.3	16.2	GO:0002102	podosome(GO:0002102)
0.2	1.5	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.2	6.7	GO:0031143	pseudopodium(GO:0031143)
0.2	1.9	GO:0005638	lamin filament(GO:0005638)
0.2	2.4	GO:0097512	cardiac myofibril(GO:0097512)
0.2	1.6	GO:0035976	AP1 complex(GO:0035976)
0.2	1.8	GO:0005614	interstitial matrix(GO:0005614)
0.2	1.8	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.2	1.4	GO:0098645	network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.1	4.6	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.1	2.4	GO:0071564	npBAF complex(GO:0071564)
0.1	0.2	GO:0098575	lumenal side of lysosomal membrane(GO:0098575)
0.1	1.2	GO:0044291	cell-cell contact zone(GO:0044291)
0.1	12.4	GO:0030018	Z disc(GO:0030018)
0.1	2.7	GO:0005859	muscle myosin complex(GO:0005859)
0.1	0.5	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.1	0.7	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.7	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.4	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	21.7	GO:0031012	extracellular matrix(GO:0031012)
0.0	24.3	GO:0005925	focal adhesion(GO:0005925)
0.0	13.0	GO:0000790	nuclear chromatin(GO:0000790)
0.0	2.8	GO:0030175	filopodium(GO:0030175)
0.0	1.4	GO:0005902	microvillus(GO:0005902)
0.0	0.1	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.0	0.6	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.8	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	1.1	GO:0035097	histone methyltransferase complex(GO:0035097)
0.0	3.9	GO:0005802	trans-Golgi network(GO:0005802)
0.0	3.6	GO:0016607	nuclear speck(GO:0016607)
0.0	0.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	1.6	GO:0005923	bicellular tight junction(GO:0005923)
0.0	0.4	GO:0031526	brush border membrane(GO:0031526)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
4.2	12.7	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.9	7.8	GO:0032972	regulation of muscle filament sliding speed(GO:0032972)
1.0	3.1	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
1.0	2.9	GO:2000523	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.9	13.6	GO:0014883	transition between fast and slow fiber(GO:0014883)
0.9	3.5	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.8	3.1	GO:0071492	cellular response to UV-A(GO:0071492)
0.7	16.4	GO:0003334	keratinocyte development(GO:0003334)
0.6	16.5	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.6	2.4	GO:0035879	plasma membrane lactate transport(GO:0035879)
0.5	1.5	GO:0042264	peptidyl-aspartic acid hydroxylation(GO:0042264)
0.5	2.9	GO:0071313	cellular response to caffeine(GO:0071313)
0.5	2.4	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.5	1.4	GO:0072276	metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.5	5.1	GO:0031272	regulation of pseudopodium assembly(GO:0031272)
0.5	1.8	GO:0021564	vagus nerve development(GO:0021564)
0.5	2.7	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.4	32.6	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.4	2.5	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.4	2.5	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.4	1.6	GO:0035026	leading edge cell differentiation(GO:0035026)
0.4	1.9	GO:0035105	sterol regulatory element binding protein import into nucleus(GO:0035105)
0.4	1.1	GO:0071409	negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409)
0.3	1.1	GO:1903644	regulation of chaperone-mediated protein folding(GO:1903644)
0.2	2.9	GO:2000111	positive regulation of macrophage apoptotic process(GO:2000111)
0.2	9.6	GO:0003009	skeletal muscle contraction(GO:0003009)
0.2	1.4	GO:2000074	regulation of type B pancreatic cell development(GO:2000074)
0.1	8.2	GO:0043268	positive regulation of potassium ion transport(GO:0043268)
0.1	1.3	GO:0033327	Leydig cell differentiation(GO:0033327)
0.1	11.3	GO:0032233	positive regulation of actin filament bundle assembly(GO:0032233)
0.1	3.2	GO:0003301	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1	1.1	GO:0090050	peptidyl-lysine deacetylation(GO:0034983) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1	0.4	GO:0046900	tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1	0.5	GO:0035523	protein K29-linked deubiquitination(GO:0035523) maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1	12.9	GO:1990823	response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1	0.3	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.1	0.5	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1	0.7	GO:0015705	iodide transport(GO:0015705)
0.1	0.6	GO:2000334	lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1	0.7	GO:0070863	positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.1	2.5	GO:0010107	potassium ion import(GO:0010107)
0.1	3.2	GO:0035329	hippo signaling(GO:0035329)
0.1	2.1	GO:0016577	histone demethylation(GO:0016577)
0.1	5.1	GO:0061053	somite development(GO:0061053)
0.1	0.3	GO:0099640	axo-dendritic protein transport(GO:0099640)
0.1	2.8	GO:0032456	endocytic recycling(GO:0032456)
0.1	0.7	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1	2.7	GO:0043403	skeletal muscle tissue regeneration(GO:0043403)
0.1	0.2	GO:0038043	interleukin-5-mediated signaling pathway(GO:0038043)
0.1	3.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1	4.0	GO:0051965	positive regulation of synapse assembly(GO:0051965)
0.0	1.0	GO:0051560	mitochondrial calcium ion homeostasis(GO:0051560)
0.0	0.7	GO:0071850	mitotic cell cycle arrest(GO:0071850)
0.0	1.6	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	3.4	GO:0061045	negative regulation of wound healing(GO:0061045)
0.0	0.1	GO:1902962	regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.0	0.7	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.7	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894)
0.0	1.0	GO:0070296	sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.0	1.4	GO:0035987	endodermal cell differentiation(GO:0035987)
0.0	1.7	GO:0000245	spliceosomal complex assembly(GO:0000245)
0.0	0.1	GO:1902544	positive regulation of endodeoxyribonuclease activity(GO:0032079) regulation of DNA N-glycosylase activity(GO:1902544)
0.0	3.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0	0.4	GO:0045880	positive regulation of smoothened signaling pathway(GO:0045880)
0.0	0.7	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)
0.0	0.5	GO:0002076	osteoblast development(GO:0002076)
0.0	0.2	GO:1904715	negative regulation of chaperone-mediated autophagy(GO:1904715)
0.0	3.6	GO:0006986	response to unfolded protein(GO:0006986)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.3	GO:0003016	respiratory system process(GO:0003016)
0.0	5.7	GO:0000209	protein polyubiquitination(GO:0000209)
0.0	0.1	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.1	GO:0060056	mammary gland involution(GO:0060056)
0.0	0.5	GO:0090382	phagosome maturation(GO:0090382)
0.0	1.5	GO:0007229	integrin-mediated signaling pathway(GO:0007229)
0.0	0.4	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.3	GO:0009235	cobalamin metabolic process(GO:0009235)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
6.5	32.3	GO:0016316	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
1.4	5.5	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
1.0	3.1	GO:0070538	oleic acid binding(GO:0070538)
0.9	6.5	GO:0031013	troponin I binding(GO:0031013)
0.8	17.5	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.5	2.9	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.5	5.7	GO:0031014	troponin T binding(GO:0031014)
0.5	1.4	GO:0005017	platelet-derived growth factor-activated receptor activity(GO:0005017)
0.3	1.5	GO:0098639	collagen binding involved in cell-matrix adhesion(GO:0098639)
0.3	2.4	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.2	8.7	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.2	1.1	GO:0001010	transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.2	3.2	GO:0001134	transcription factor activity, transcription factor recruiting(GO:0001134)
0.2	0.5	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.2	4.4	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.2	2.7	GO:0017160	Ral GTPase binding(GO:0017160)
0.2	2.9	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2	0.5	GO:1904288	BAT3 complex binding(GO:1904288)
0.1	0.7	GO:0015111	iodide transmembrane transporter activity(GO:0015111)
0.1	2.5	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1	0.5	GO:0031962	mineralocorticoid receptor binding(GO:0031962)
0.1	0.5	GO:0004991	parathyroid hormone receptor activity(GO:0004991)
0.1	14.8	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1	0.6	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.1	1.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.1	0.3	GO:0008426	protein kinase C inhibitor activity(GO:0008426)
0.1	1.2	GO:0032036	myosin heavy chain binding(GO:0032036)
0.1	1.1	GO:0044548	S100 protein binding(GO:0044548)
0.1	0.4	GO:0004692	cGMP-dependent protein kinase activity(GO:0004692)
0.1	0.3	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1	5.5	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.1	2.1	GO:0032452	histone demethylase activity(GO:0032452)
0.1	0.7	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.1	4.8	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	1.5	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	17.2	GO:0003714	transcription corepressor activity(GO:0003714)
0.1	0.2	GO:0004914	interleukin-5 receptor activity(GO:0004914)
0.1	2.5	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.4	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.7	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	4.6	GO:0019888	protein phosphatase regulator activity(GO:0019888)
0.0	1.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	12.8	GO:0003924	GTPase activity(GO:0003924)
0.0	3.5	GO:0046332	SMAD binding(GO:0046332)
0.0	17.1	GO:0003779	actin binding(GO:0003779)
0.0	5.1	GO:0044325	ion channel binding(GO:0044325)
0.0	3.1	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	0.4	GO:0071837	HMG box domain binding(GO:0071837)
0.0	0.7	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	2.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.8	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.2	GO:0016997	exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
0.0	8.5	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
0.0	0.4	GO:0016881	acid-amino acid ligase activity(GO:0016881)
0.0	2.7	GO:0008201	heparin binding(GO:0008201)
0.0	0.7	GO:0005262	calcium channel activity(GO:0005262)
0.0	3.5	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0	0.1	GO:0035615	clathrin heavy chain binding(GO:0032050) clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.2	32.3	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.4	28.6	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.2	2.4	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	4.9	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1	1.8	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	1.1	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.1	1.4	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1	2.5	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1	2.5	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	1.1	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1	0.7	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	3.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	2.9	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	1.6	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.7	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	2.0	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	2.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.4	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.5	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.4	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	1.7	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.0	0.9	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.3	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)