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ENCODE cell lines, expression (Ernst 2011)

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Results for MSX2

Z-value: 0.43

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Transcription factors associated with MSX2

Gene Symbol Gene ID Gene Info
MSX2
ENSG00000120149.7 MSX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MSX2hg19_v2_chr5_+_174151536_1741516100.591.5e-02Click!

Activity profile of MSX2 motif

Sorted Z-values of MSX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of MSX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_-_151965048 1.78 ENST00000368809.1
 S100A10
 S100 calcium binding protein A10
chr1_-_68698222 1.12 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
 WLS
 wntless Wnt ligand secretion mediator
chr6_-_167040731 1.02 ENST00000265678.4
 RPS6KA2
 ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_94050668 0.89 ENST00000539242.1
 BCAR3
 breast cancer anti-estrogen resistance 3
chr3_-_151034734 0.78 ENST00000260843.4
 GPR87
 G protein-coupled receptor 87
chr1_-_68698197 0.66 ENST00000370973.2
ENST00000370971.1
 WLS
 wntless Wnt ligand secretion mediator
chr12_-_10022735 0.60 ENST00000228438.2
 CLEC2B
 C-type lectin domain family 2, member B
chrX_-_48931648 0.48 ENST00000376386.3
ENST00000376390.4
 PRAF2
 PRA1 domain family, member 2
chr12_+_9102632 0.47 ENST00000539240.1
 KLRG1
 killer cell lectin-like receptor subfamily G, member 1
chr3_-_112127981 0.47 ENST00000486726.2
 RP11-231E6.1
 RP11-231E6.1
chr5_+_95997918 0.47 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
 CAST
 calpastatin
chr7_+_134331550 0.45 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
 BPGM
 2,3-bisphosphoglycerate mutase
chr6_-_111927449 0.40 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
 TRAF3IP2
 TRAF3 interacting protein 2
chr5_+_66254698 0.38 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
 MAST4
 microtubule associated serine/threonine kinase family member 4
chr5_+_95998070 0.37 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
 CAST
 calpastatin
chr5_+_140797296 0.35 ENST00000398594.2
 PCDHGB7
 protocadherin gamma subfamily B, 7
chr10_-_99447024 0.35 ENST00000370626.3
 AVPI1
 arginine vasopressin-induced 1
chr15_+_41245160 0.35 ENST00000444189.2
ENST00000446533.3
 CHAC1
 ChaC, cation transport regulator homolog 1 (E. coli)
chr7_-_2883928 0.33 ENST00000275364.3
 GNA12
 guanine nucleotide binding protein (G protein) alpha 12
chr6_-_111927062 0.33 ENST00000359831.4
 TRAF3IP2
 TRAF3 interacting protein 2
chr7_+_100210133 0.31 ENST00000393950.2
ENST00000424091.2
 MOSPD3
 motile sperm domain containing 3
chr7_+_100209725 0.29 ENST00000223054.4
 MOSPD3
 motile sperm domain containing 3
chr7_+_100209979 0.29 ENST00000493970.1
ENST00000379527.2
 MOSPD3
 motile sperm domain containing 3
chr1_+_44115814 0.21 ENST00000372396.3
 KDM4A
 lysine (K)-specific demethylase 4A
chr12_+_54718904 0.21 ENST00000262061.2
ENST00000549043.1
ENST00000552218.1
ENST00000553231.1
ENST00000552362.1
ENST00000455864.2
ENST00000416254.2
ENST00000549116.1
ENST00000551779.1
 COPZ1
 coatomer protein complex, subunit zeta 1
chr12_-_9102549 0.20 ENST00000000412.3
 M6PR
 mannose-6-phosphate receptor (cation dependent)
chr1_-_21377383 0.19 ENST00000374935.3
 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
chr4_-_69536346 0.19 ENST00000338206.5
 UGT2B15
 UDP glucuronosyltransferase 2 family, polypeptide B15
chr1_-_151762943 0.18 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
 TDRKH
 tudor and KH domain containing
chr9_+_34646651 0.18 ENST00000378842.3
 GALT
 galactose-1-phosphate uridylyltransferase
chr1_+_151735431 0.17 ENST00000321531.5
ENST00000315067.8
 OAZ3
 ornithine decarboxylase antizyme 3
chr9_+_34646624 0.17 ENST00000450095.2
ENST00000556278.1
 GALT
GALT
 galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr4_+_71587669 0.16 ENST00000381006.3
ENST00000226328.4
 RUFY3
 RUN and FYVE domain containing 3
chr7_-_100183742 0.16 ENST00000310300.6
 LRCH4
 leucine-rich repeats and calponin homology (CH) domain containing 4
chr10_-_28571015 0.14 ENST00000375719.3
ENST00000375732.1
 MPP7
 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr8_+_9413410 0.12 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
 TNKS
 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr20_+_54967409 0.12 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
 CSTF1
 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chrX_-_139587225 0.10 ENST00000370536.2
 SOX3
 SRY (sex determining region Y)-box 3
chr7_+_100183927 0.10 ENST00000241071.6
ENST00000360609.2
 FBXO24
 F-box protein 24
chr11_-_71823266 0.10 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15
 anaphase promoting complex subunit 15
chr4_-_69434245 0.09 ENST00000317746.2
 UGT2B17
 UDP glucuronosyltransferase 2 family, polypeptide B17
chr20_+_56964169 0.09 ENST00000475243.1
 VAPB
 VAMP (vesicle-associated membrane protein)-associated protein B and C
chr19_+_17378278 0.09 ENST00000596335.1
ENST00000601436.1
ENST00000595632.1
 BABAM1
 BRISC and BRCA1 A complex member 1
chr5_-_132200477 0.09 ENST00000296875.2
 GDF9
 growth differentiation factor 9
chr7_-_99716952 0.09 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_+_202317815 0.09 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
 PPP1R12B
 protein phosphatase 1, regulatory subunit 12B
chr9_-_95056010 0.08 ENST00000443024.2
 IARS
 isoleucyl-tRNA synthetase
chr14_-_23504337 0.08 ENST00000361611.6
 PSMB5
 proteasome (prosome, macropain) subunit, beta type, 5
chr17_-_43045439 0.08 ENST00000253407.3
 C1QL1
 complement component 1, q subcomponent-like 1
chr5_+_150639360 0.08 ENST00000523004.1
 GM2A
 GM2 ganglioside activator
chr3_-_114866084 0.07 ENST00000357258.3
 ZBTB20
 zinc finger and BTB domain containing 20
chr11_+_17298297 0.07 ENST00000529010.1
 NUCB2
 nucleobindin 2
chr3_-_11685345 0.07 ENST00000430365.2
 VGLL4
 vestigial like 4 (Drosophila)
chr19_+_17378159 0.06 ENST00000598188.1
ENST00000359435.4
ENST00000599474.1
ENST00000599057.1
ENST00000601043.1
ENST00000447614.2
 BABAM1
 BRISC and BRCA1 A complex member 1
chr11_-_71823796 0.06 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
 ANAPC15
 anaphase promoting complex subunit 15
chr11_-_71823715 0.06 ENST00000545944.1
ENST00000502597.2
 ANAPC15
 anaphase promoting complex subunit 15
chr14_-_23504432 0.05 ENST00000425762.2
 PSMB5
 proteasome (prosome, macropain) subunit, beta type, 5
chr11_-_13517565 0.05 ENST00000282091.1
ENST00000529816.1
 PTH
 parathyroid hormone
chr12_-_10955226 0.05 ENST00000240687.2
 TAS2R7
 taste receptor, type 2, member 7
chr12_-_57039739 0.05 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
 ATP5B
 ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr2_-_98280383 0.05 ENST00000289228.5
 ACTR1B
 ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr11_+_17298255 0.03 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
 NUCB2
 nucleobindin 2
chrX_+_113818545 0.03 ENST00000371951.1
ENST00000276198.1
ENST00000371950.3
 HTR2C
 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
chr19_-_10121144 0.03 ENST00000264828.3
 COL5A3
 collagen, type V, alpha 3
chr4_-_46996424 0.03 ENST00000264318.3
 GABRA4
 gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr8_+_1993173 0.02 ENST00000523438.1
 MYOM2
 myomesin 2
chr9_-_5339873 0.02 ENST00000223862.1
ENST00000223858.4
 RLN1
 relaxin 1
chr1_-_228613026 0.01 ENST00000366696.1
 HIST3H3
 histone cluster 3, H3
chr8_+_1993152 0.01 ENST00000262113.4
 MYOM2
 myomesin 2
chr16_+_69345243 0.01 ENST00000254950.11
 VPS4A
 vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr3_+_129247479 0.01 ENST00000296271.3
 RHO
 rhodopsin
chr18_+_39535152 0.00 ENST00000262039.4
ENST00000398870.3
ENST00000586545.1
 PIK3C3
 phosphatidylinositol 3-kinase, catalytic subunit type 3
chr19_+_42817527 0.00 ENST00000598766.1
 TMEM145
 transmembrane protein 145

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.1 0.3 GO:0006258 UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499)
0.1 0.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 1.8 GO:0001765 membrane raft assembly(GO:0001765)
0.1 0.8 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.0 0.8 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0 0.2 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.7 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.0 0.1 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544) negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.3 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.0 0.1 GO:0061743 motor learning(GO:0061743)
0.0 0.2 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
0.0 0.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.0 0.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.5 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.3 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 0.2 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 1.8 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.8 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.3 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.2 GO:0071546 pi-body(GO:0071546)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.0 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport