ENCODE cell lines, expression (Ernst 2011)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Download the whole report

Gene Symbol	Gene ID	Gene Info
NFKB1 Links Ensembl NCBI GeneCards UniProt	ENSG00000109320.7	NFKB1

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFKB1	hg19_v2_chr4_+_103423055_103423112	0.68	3.9e-03	Click!

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Promoter	Score	Transcript	Gene	Gene Info
chr5_-_149792295	9.70	ENST00000518797.1 ENST00000524315.1 ENST00000009530.7 ENST00000377795.3	CD74	CD74 molecule, major histocompatibility complex, class II invariant chain
chr19_-_6591113	6.93	ENST00000423145.3 ENST00000245903.3	CD70	CD70 molecule
chr14_+_75988851	6.56	ENST00000555504.1	BATF	basic leucine zipper transcription factor, ATF-like
chr6_+_14117872	6.08	ENST00000379153.3	CD83	CD83 molecule
chr6_+_32605134	5.70	ENST00000343139.5 ENST00000395363.1 ENST00000496318.1	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1
chr6_+_138188551	5.70	ENST00000237289.4 ENST00000433680.1	TNFAIP3	tumor necrosis factor, alpha-induced protein 3
chr6_+_32605195	5.70	ENST00000374949.2	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1
chr11_+_102188272	5.65	ENST00000532808.1	BIRC3	baculoviral IAP repeat containing 3
chr6_-_29527702	5.64	ENST00000377050.4	UBD	ubiquitin D
chr11_+_102188224	5.62	ENST00000263464.3	BIRC3	baculoviral IAP repeat containing 3
chr1_+_111770278	4.89	ENST00000369748.4	CHI3L2	chitinase 3-like 2
chr19_+_42381337	4.85	ENST00000597454.1 ENST00000444740.2	CD79A	CD79a molecule, immunoglobulin-associated alpha
chr19_+_42381173	4.63	ENST00000221972.3	CD79A	CD79a molecule, immunoglobulin-associated alpha
chr12_-_9913489	4.54	ENST00000228434.3 ENST00000536709.1	CD69	CD69 molecule
chr19_+_1067492	3.94	ENST00000586866.1	HMHA1	histocompatibility (minor) HA-1
chr19_+_1067144	3.90	ENST00000313093.2	HMHA1	histocompatibility (minor) HA-1
chr14_-_35873856	3.90	ENST00000553342.1 ENST00000216797.5 ENST00000557140.1	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
chr19_+_1067271	3.88	ENST00000536472.1 ENST00000590214.1	HMHA1	histocompatibility (minor) HA-1
chr20_+_57430162	3.71	ENST00000450130.1 ENST00000349036.3 ENST00000423897.1	GNAS	GNAS complex locus
chr19_+_50922187	3.50	ENST00000595883.1 ENST00000597855.1 ENST00000596074.1 ENST00000439922.2 ENST00000594685.1 ENST00000270632.7	SPIB	Spi-B transcription factor (Spi-1/PU.1 related)
chr22_-_37640456	3.40	ENST00000405484.1 ENST00000441619.1 ENST00000406508.1	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr10_+_30722866	3.38	ENST00000263056.1	MAP3K8	mitogen-activated protein kinase kinase kinase 8
chr6_+_31540056	3.37	ENST00000418386.2	LTA	lymphotoxin alpha
chr10_+_12391481	3.33	ENST00000378847.3	CAMK1D	calcium/calmodulin-dependent protein kinase ID
chr7_+_69064300	3.27	ENST00000342771.4	AUTS2	autism susceptibility candidate 2
chr1_+_111770232	3.26	ENST00000369744.2	CHI3L2	chitinase 3-like 2
chr14_+_75988768	3.23	ENST00000286639.6	BATF	basic leucine zipper transcription factor, ATF-like
chr6_-_31550192	3.12	ENST00000429299.2 ENST00000446745.2	LTB	lymphotoxin beta (TNF superfamily, member 3)
chr6_+_29691198	3.08	ENST00000440587.2 ENST00000434407.2	HLA-F	major histocompatibility complex, class I, F
chr20_+_44746885	3.04	ENST00000372285.3	CD40	CD40 molecule, TNF receptor superfamily member 5
chr6_+_29691056	3.03	ENST00000414333.1 ENST00000334668.4 ENST00000259951.7	HLA-F	major histocompatibility complex, class I, F
chr4_-_40631859	3.03	ENST00000295971.7 ENST00000319592.4	RBM47	RNA binding motif protein 47
chr22_-_37640277	2.94	ENST00000401529.3 ENST00000249071.6	RAC2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr9_-_123691047	2.88	ENST00000373887.3	TRAF1	TNF receptor-associated factor 1
chr6_+_135502466	2.85	ENST00000367814.4	MYB	v-myb avian myeloblastosis viral oncogene homolog
chr16_+_50776021	2.76	ENST00000566679.2 ENST00000564634.1 ENST00000398568.2	CYLD	cylindromatosis (turban tumor syndrome)
chr15_+_85923797	2.74	ENST00000559362.1	AKAP13	A kinase (PRKA) anchor protein 13
chr14_+_61789382	2.68	ENST00000555082.1	PRKCH	protein kinase C, eta
chr6_+_32821924	2.66	ENST00000374859.2 ENST00000453265.2	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9
chr4_+_103422471	2.62	ENST00000226574.4 ENST00000394820.4	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr11_+_128562372	2.60	ENST00000344954.6	FLI1	Fli-1 proto-oncogene, ETS transcription factor
chr15_+_85923856	2.59	ENST00000560302.1 ENST00000394518.2 ENST00000361243.2 ENST00000560256.1	AKAP13	A kinase (PRKA) anchor protein 13
chr2_+_61108650	2.58	ENST00000295025.8	REL	v-rel avian reticuloendotheliosis viral oncogene homolog
chr20_+_9494987	2.57	ENST00000427562.2 ENST00000246070.2	LAMP5	lysosomal-associated membrane protein family, member 5
chr2_-_163175133	2.40	ENST00000421365.2 ENST00000263642.2	IFIH1	interferon induced with helicase C domain 1
chr3_+_53195136	2.36	ENST00000394729.2 ENST00000330452.3	PRKCD	protein kinase C, delta
chr16_+_50730910	2.32	ENST00000300589.2	NOD2	nucleotide-binding oligomerization domain containing 2
chr20_+_44746939	2.30	ENST00000372276.3	CD40	CD40 molecule, TNF receptor superfamily member 5
chr1_-_202130702	2.30	ENST00000309017.3 ENST00000477554.1 ENST00000492451.1	PTPN7	protein tyrosine phosphatase, non-receptor type 7
chr6_-_44233361	2.25	ENST00000275015.5	NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
chr2_-_191885686	2.22	ENST00000432058.1	STAT1	signal transducer and activator of transcription 1, 91kDa
chr2_+_228678550	2.20	ENST00000409189.3 ENST00000358813.4	CCL20	chemokine (C-C motif) ligand 20
chr16_+_50775971	2.17	ENST00000311559.9 ENST00000564326.1 ENST00000566206.1	CYLD	cylindromatosis (turban tumor syndrome)
chr2_+_61108771	2.10	ENST00000394479.3	REL	v-rel avian reticuloendotheliosis viral oncogene homolog
chr1_+_156123359	2.09	ENST00000368284.1 ENST00000368286.2 ENST00000438830.1	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_-_76944621	2.07	ENST00000306602.1	CXCL10	chemokine (C-X-C motif) ligand 10
chr6_-_32821599	2.05	ENST00000354258.4	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr5_-_150466692	2.04	ENST00000315050.7 ENST00000523338.1 ENST00000522100.1	TNIP1	TNFAIP3 interacting protein 1
chr6_+_106534192	2.02	ENST00000369091.2 ENST00000369096.4	PRDM1	PR domain containing 1, with ZNF domain
chr1_+_156123318	1.99	ENST00000368285.3	SEMA4A	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr11_-_58345569	1.95	ENST00000528954.1 ENST00000528489.1	LPXN	leupaxin
chr6_+_29910301	1.92	ENST00000376809.5 ENST00000376802.2	HLA-A	major histocompatibility complex, class I, A
chr5_-_150460539	1.71	ENST00000520931.1 ENST00000520695.1 ENST00000521591.1 ENST00000518977.1	TNIP1	TNFAIP3 interacting protein 1
chr12_+_11802753	1.70	ENST00000396373.4	ETV6	ets variant 6
chr14_+_66975213	1.68	ENST00000543237.1 ENST00000305960.9	GPHN	gephyrin
chr2_+_163175394	1.63	ENST00000446271.1 ENST00000429691.2	GCA	grancalcin, EF-hand calcium binding protein
chr16_+_50775948	1.60	ENST00000569681.1 ENST00000569418.1 ENST00000540145.1	CYLD	cylindromatosis (turban tumor syndrome)
chrX_-_73072534	1.57	ENST00000429829.1	XIST	X inactive specific transcript (non-protein coding)
chr19_+_2476116	1.57	ENST00000215631.4 ENST00000587345.1	GADD45B	growth arrest and DNA-damage-inducible, beta
chr10_+_104154229	1.55	ENST00000428099.1 ENST00000369966.3	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
chr11_-_46142948	1.54	ENST00000257821.4	PHF21A	PHD finger protein 21A
chr17_-_7590745	1.53	ENST00000514944.1 ENST00000503591.1 ENST00000455263.2 ENST00000420246.2 ENST00000445888.2 ENST00000509690.1 ENST00000604348.1 ENST00000269305.4	TP53	tumor protein p53
chr2_+_208394658	1.53	ENST00000421139.1	CREB1	cAMP responsive element binding protein 1
chr19_-_46234119	1.47	ENST00000317683.3	FBXO46	F-box protein 46
chrX_-_30595959	1.45	ENST00000378962.3	CXorf21	chromosome X open reading frame 21
chr19_+_496454	1.44	ENST00000346144.4 ENST00000215637.3 ENST00000382683.4	MADCAM1	mucosal vascular addressin cell adhesion molecule 1
chr4_-_76928641	1.44	ENST00000264888.5	CXCL9	chemokine (C-X-C motif) ligand 9
chr11_-_72853091	1.43	ENST00000311172.7 ENST00000409314.1	FCHSD2	FCH and double SH3 domains 2
chr2_+_97203082	1.41	ENST00000454558.2	ARID5A	AT rich interactive domain 5A (MRF1-like)
chr2_-_152955213	1.41	ENST00000427385.1	CACNB4	calcium channel, voltage-dependent, beta 4 subunit
chr6_+_292051	1.38	ENST00000344450.5	DUSP22	dual specificity phosphatase 22
chr9_-_115480303	1.33	ENST00000374234.1 ENST00000374238.1 ENST00000374236.1 ENST00000374242.4	INIP	INTS3 and NABP interacting protein
chr5_-_150460914	1.33	ENST00000389378.2	TNIP1	TNFAIP3 interacting protein 1
chr4_-_185395672	1.33	ENST00000393593.3	IRF2	interferon regulatory factor 2
chr2_-_152955537	1.32	ENST00000201943.5 ENST00000539935.1	CACNB4	calcium channel, voltage-dependent, beta 4 subunit
chr2_+_208394616	1.30	ENST00000432329.2 ENST00000353267.3 ENST00000445803.1	CREB1	cAMP responsive element binding protein 1
chr5_-_150521192	1.27	ENST00000523714.1 ENST00000521749.1	ANXA6	annexin A6
chr3_-_4793274	1.23	ENST00000414938.1	EGOT	eosinophil granule ontogeny transcript (non-protein coding)
chr19_-_2050852	1.22	ENST00000541165.1 ENST00000591601.1	MKNK2	MAP kinase interacting serine/threonine kinase 2
chr2_+_38893047	1.21	ENST00000272252.5	GALM	galactose mutarotase (aldose 1-epimerase)
chr19_+_45504688	1.21	ENST00000221452.8 ENST00000540120.1 ENST00000505236.1	RELB	v-rel avian reticuloendotheliosis viral oncogene homolog B
chr2_+_97202480	1.18	ENST00000357485.3	ARID5A	AT rich interactive domain 5A (MRF1-like)
chr11_-_77185094	1.17	ENST00000278568.4 ENST00000356341.3	PAK1	p21 protein (Cdc42/Rac)-activated kinase 1
chr4_+_142558078	1.11	ENST00000529613.1	IL15	interleukin 15
chr14_-_64970494	1.09	ENST00000608382.1	ZBTB25	zinc finger and BTB domain containing 25
chr15_-_66084428	1.07	ENST00000443035.3 ENST00000431932.2	DENND4A	DENN/MADD domain containing 4A
chr1_+_211432593	1.05	ENST00000367006.4	RCOR3	REST corepressor 3
chr14_+_64970662	1.04	ENST00000556965.1 ENST00000554015.1	ZBTB1	zinc finger and BTB domain containing 1
chr4_+_142557771	1.04	ENST00000514653.1	IL15	interleukin 15
chr4_+_142557717	1.03	ENST00000320650.4 ENST00000296545.7	IL15	interleukin 15
chr12_-_12849073	1.03	ENST00000332427.2 ENST00000540796.1	GPR19	G protein-coupled receptor 19
chr14_+_103243813	1.03	ENST00000560371.1 ENST00000347662.4 ENST00000392745.2 ENST00000539721.1 ENST00000560463.1	TRAF3	TNF receptor-associated factor 3
chr15_-_71055878	1.00	ENST00000322954.6	UACA	uveal autoantigen with coiled-coil domains and ankyrin repeats
chr11_-_46142615	1.00	ENST00000529734.1 ENST00000323180.6	PHF21A	PHD finger protein 21A
chr19_-_2042065	0.99	ENST00000591588.1 ENST00000591142.1	MKNK2	MAP kinase interacting serine/threonine kinase 2
chr1_-_202129105	0.95	ENST00000367279.4	PTPN7	protein tyrosine phosphatase, non-receptor type 7
chrX_-_112084043	0.95	ENST00000304758.1	AMOT	angiomotin
chr2_+_208394455	0.93	ENST00000430624.1	CREB1	cAMP responsive element binding protein 1
chr12_+_52445191	0.90	ENST00000243050.1 ENST00000394825.1 ENST00000550763.1 ENST00000394824.2 ENST00000548232.1 ENST00000562373.1	NR4A1	nuclear receptor subfamily 4, group A, member 1
chr14_-_24616426	0.88	ENST00000216802.5	PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr1_-_202129704	0.86	ENST00000476061.1 ENST00000544762.1 ENST00000467283.1 ENST00000464870.1 ENST00000435759.2 ENST00000486116.1 ENST00000543735.1 ENST00000308986.5 ENST00000477625.1	PTPN7	protein tyrosine phosphatase, non-receptor type 7
chr10_-_97050777	0.85	ENST00000329399.6	PDLIM1	PDZ and LIM domain 1
chr10_+_12391685	0.85	ENST00000378845.1	CAMK1D	calcium/calmodulin-dependent protein kinase ID
chr6_+_144471643	0.84	ENST00000367568.4	STX11	syntaxin 11
chr1_+_37940153	0.84	ENST00000373087.6	ZC3H12A	zinc finger CCCH-type containing 12A
chr5_-_96143602	0.79	ENST00000443439.2 ENST00000503921.1 ENST00000508227.1 ENST00000507154.1	ERAP1	endoplasmic reticulum aminopeptidase 1
chr14_-_24615805	0.74	ENST00000560410.1	PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr15_+_89346699	0.74	ENST00000558207.1	ACAN	aggrecan
chr8_-_9008206	0.73	ENST00000310455.3	PPP1R3B	protein phosphatase 1, regulatory subunit 3B
chr4_-_140098339	0.73	ENST00000394235.2	ELF2	E74-like factor 2 (ets domain transcription factor)
chr1_-_54304212	0.72	ENST00000540001.1	NDC1	NDC1 transmembrane nucleoporin
chr11_+_63997750	0.71	ENST00000321685.3	DNAJC4	DnaJ (Hsp40) homolog, subfamily C, member 4
chr19_-_39330818	0.69	ENST00000594769.1 ENST00000602021.1	AC104534.3	Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
chrX_-_15872914	0.68	ENST00000380291.1 ENST00000545766.1 ENST00000421527.2 ENST00000329235.2	AP1S2	adaptor-related protein complex 1, sigma 2 subunit
chr3_+_57261743	0.66	ENST00000288266.3	APPL1	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr12_-_49259643	0.66	ENST00000309739.5	RND1	Rho family GTPase 1
chr1_-_54303949	0.66	ENST00000234725.8	NDC1	NDC1 transmembrane nucleoporin
chr19_-_13617037	0.66	ENST00000360228.5	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr5_+_139781445	0.65	ENST00000532219.1 ENST00000394722.3	ANKHD1-EIF4EBP3 ANKHD1	ANKHD1-EIF4EBP3 readthrough ankyrin repeat and KH domain containing 1
chr5_+_139781393	0.65	ENST00000360839.2 ENST00000297183.6 ENST00000421134.1 ENST00000394723.3 ENST00000511151.1	ANKHD1	ankyrin repeat and KH domain containing 1
chr4_-_103748696	0.64	ENST00000321805.7	UBE2D3	ubiquitin-conjugating enzyme E2D 3
chr17_+_7590734	0.63	ENST00000457584.2	WRAP53	WD repeat containing, antisense to TP53
chr1_-_41950342	0.62	ENST00000372587.4	EDN2	endothelin 2
chr2_+_208394794	0.60	ENST00000536726.1 ENST00000374397.4 ENST00000452474.1	CREB1	cAMP responsive element binding protein 1
chr6_-_111804905	0.58	ENST00000358835.3 ENST00000435970.1	REV3L	REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr1_+_62417957	0.58	ENST00000307297.7 ENST00000543708.1	INADL	InaD-like (Drosophila)
chr14_+_76618242	0.58	ENST00000557542.1 ENST00000557263.1 ENST00000557207.1 ENST00000312858.5 ENST00000261530.7	GPATCH2L	G patch domain containing 2-like
chr1_-_161168834	0.58	ENST00000367995.3 ENST00000367996.5	ADAMTS4	ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr1_-_155658085	0.57	ENST00000311573.5 ENST00000438245.2	YY1AP1	YY1 associated protein 1
chr1_-_173886491	0.57	ENST00000367698.3	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1
chr5_-_135231516	0.54	ENST00000274520.1	IL9	interleukin 9
chr2_-_136743169	0.54	ENST00000264161.4	DARS	aspartyl-tRNA synthetase
chr1_-_54303934	0.53	ENST00000537333.1	NDC1	NDC1 transmembrane nucleoporin
chr12_+_49761224	0.53	ENST00000553127.1 ENST00000321898.6	SPATS2	spermatogenesis associated, serine-rich 2
chr17_+_40440481	0.53	ENST00000590726.2 ENST00000452307.2 ENST00000444283.1 ENST00000588868.1	STAT5A	signal transducer and activator of transcription 5A
chr2_-_100721178	0.52	ENST00000409236.2	AFF3	AF4/FMR2 family, member 3
chr11_-_3862206	0.51	ENST00000351018.4	RHOG	ras homolog family member G
chr19_-_47734448	0.50	ENST00000439096.2	BBC3	BCL2 binding component 3
chr21_+_34775698	0.49	ENST00000381995.1	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)
chr2_-_100721923	0.49	ENST00000356421.2	AFF3	AF4/FMR2 family, member 3
chr12_+_57624119	0.48	ENST00000555773.1 ENST00000554975.1 ENST00000449049.3 ENST00000393827.4	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)
chr7_-_100881109	0.47	ENST00000308344.5	CLDN15	claudin 15
chr8_+_104831554	0.45	ENST00000408894.2	RIMS2	regulating synaptic membrane exocytosis 2
chr3_+_9439400	0.43	ENST00000450326.1 ENST00000402198.1 ENST00000402466.1	SETD5	SET domain containing 5
chr4_-_103748271	0.43	ENST00000343106.5	UBE2D3	ubiquitin-conjugating enzyme E2D 3
chr14_+_24439148	0.42	ENST00000543805.1 ENST00000534993.1	DHRS4L2	dehydrogenase/reductase (SDR family) member 4 like 2
chr8_+_73449625	0.41	ENST00000523207.1	KCNB2	potassium voltage-gated channel, Shab-related subfamily, member 2
chr12_+_57624085	0.41	ENST00000553474.1	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_43205811	0.40	ENST00000372539.3 ENST00000296387.1 ENST00000539749.1	CLDN19	claudin 19
chr16_-_10276611	0.40	ENST00000396573.2	GRIN2A	glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr12_+_57623869	0.39	ENST00000414700.3 ENST00000557703.1	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)
chr20_-_62103862	0.39	ENST00000344462.4 ENST00000357249.2 ENST00000359125.2 ENST00000360480.3 ENST00000370224.1 ENST00000344425.5 ENST00000354587.3 ENST00000359689.1	KCNQ2	potassium voltage-gated channel, KQT-like subfamily, member 2
chrX_+_147582228	0.39	ENST00000342251.3	AFF2	AF4/FMR2 family, member 2
chr6_+_149068464	0.39	ENST00000367463.4	UST	uronyl-2-sulfotransferase
chr2_+_64681641	0.38	ENST00000409537.2	LGALSL	lectin, galactoside-binding-like
chr17_+_8924837	0.38	ENST00000173229.2	NTN1	netrin 1
chr12_-_118810688	0.38	ENST00000542532.1 ENST00000392533.3	TAOK3	TAO kinase 3
chr21_+_34775772	0.37	ENST00000405436.1	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)
chr10_+_21823079	0.37	ENST00000377100.3 ENST00000377072.3 ENST00000446906.2	MLLT10	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr11_-_133826852	0.37	ENST00000533871.2 ENST00000321016.8	IGSF9B	immunoglobulin superfamily, member 9B
chr21_+_34775181	0.36	ENST00000290219.6	IFNGR2	interferon gamma receptor 2 (interferon gamma transducer 1)
chr6_+_31949801	0.36	ENST00000428956.2 ENST00000498271.1	C4A	complement component 4A (Rodgers blood group)
chr11_+_118307179	0.36	ENST00000534358.1 ENST00000531904.2 ENST00000389506.5 ENST00000354520.4	KMT2A	lysine (K)-specific methyltransferase 2A
chr8_-_70747205	0.36	ENST00000260126.4	SLCO5A1	solute carrier organic anion transporter family, member 5A1
chr12_+_57623477	0.36	ENST00000557487.1 ENST00000555634.1 ENST00000556689.1	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)
chr4_-_122085469	0.35	ENST00000057513.3	TNIP3	TNFAIP3 interacting protein 3
chr17_-_7154984	0.35	ENST00000574322.1	CTDNEP1	CTD nuclear envelope phosphatase 1
chr12_-_24103954	0.34	ENST00000441133.2 ENST00000545921.1	SOX5	SRY (sex determining region Y)-box 5
chr1_+_54359854	0.34	ENST00000361921.3 ENST00000322679.6 ENST00000532493.1 ENST00000525202.1 ENST00000524406.1 ENST00000388876.3	DIO1	deiodinase, iodothyronine, type I
chr19_-_13617247	0.34	ENST00000573710.2	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
chr9_+_82188077	0.34	ENST00000425506.1	TLE4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr17_+_40996590	0.34	ENST00000253799.3 ENST00000452774.2	AOC2	amine oxidase, copper containing 2 (retina-specific)
chr11_-_44331679	0.33	ENST00000329255.3	ALX4	ALX homeobox 4
chr12_+_56732658	0.33	ENST00000228534.4	IL23A	interleukin 23, alpha subunit p19
chr1_-_205744574	0.33	ENST00000367139.3 ENST00000235932.4 ENST00000437324.2 ENST00000414729.1	RAB7L1	RAB7, member RAS oncogene family-like 1
chr19_+_42364460	0.32	ENST00000593863.1	RPS19	ribosomal protein S19
chr3_+_9439579	0.32	ENST00000406341.1	SETD5	SET domain containing 5
chr17_+_38465441	0.29	ENST00000577646.1 ENST00000254066.5	RARA	retinoic acid receptor, alpha
chr19_-_49149553	0.29	ENST00000084798.4	CA11	carbonic anhydrase XI
chr12_-_6716569	0.29	ENST00000544040.1 ENST00000545942.1	CHD4	chromodomain helicase DNA binding protein 4
chr11_-_64570706	0.27	ENST00000294066.2 ENST00000377350.3	MAP4K2	mitogen-activated protein kinase kinase kinase kinase 2
chr8_+_104831472	0.27	ENST00000262231.10 ENST00000507740.1	RIMS2	regulating synaptic membrane exocytosis 2
chr7_+_143013198	0.27	ENST00000343257.2	CLCN1	chloride channel, voltage-sensitive 1
chr4_+_114214125	0.26	ENST00000509550.1	ANK2	ankyrin 2, neuronal
chr12_-_57824739	0.26	ENST00000347140.3 ENST00000402412.1	R3HDM2	R3H domain containing 2
chrX_-_119709637	0.26	ENST00000404115.3	CUL4B	cullin 4B
chr1_-_57889687	0.26	ENST00000371236.2 ENST00000371230.1	DAB1	Dab, reelin signal transducer, homolog 1 (Drosophila)
chr4_-_5891918	0.25	ENST00000512574.1	CRMP1	collapsin response mediator protein 1
chr1_-_161279749	0.25	ENST00000533357.1 ENST00000360451.6 ENST00000336559.4	MPZ	myelin protein zero
chr1_-_205744205	0.24	ENST00000446390.2	RAB7L1	RAB7, member RAS oncogene family-like 1

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.4	9.7	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
1.4	9.5	GO:0019815	B cell receptor complex(GO:0019815)
1.2	14.0	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.8	5.3	GO:0043196	varicosity(GO:0043196)
0.7	7.4	GO:0042612	MHC class I protein complex(GO:0042612)
0.6	1.9	GO:0070762	nuclear pore transmembrane ring(GO:0070762)
0.6	4.4	GO:1990589	ATF4-CREB1 transcription factor complex(GO:1990589)
0.6	11.4	GO:0042611	MHC protein complex(GO:0042611)
0.4	2.6	GO:0032584	growth cone membrane(GO:0032584)
0.3	2.1	GO:0042825	TAP complex(GO:0042825)
0.3	2.7	GO:1990111	spermatoproteasome complex(GO:1990111)
0.3	1.3	GO:0070876	SOSS complex(GO:0070876)
0.3	0.9	GO:0005667	transcription factor complex(GO:0005667)
0.3	1.6	GO:0008537	proteasome activator complex(GO:0008537)
0.2	1.6	GO:0070552	BRISC complex(GO:0070552)
0.1	6.5	GO:0097542	ciliary tip(GO:0097542)
0.1	0.8	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	0.3	GO:0071595	Nem1-Spo7 phosphatase complex(GO:0071595)
0.1	5.6	GO:0016235	aggresome(GO:0016235)
0.1	1.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.1	0.7	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.1	0.6	GO:0042575	DNA polymerase complex(GO:0042575)
0.1	0.7	GO:0042587	glycogen granule(GO:0042587)
0.1	5.4	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.1	3.9	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.1	3.3	GO:0008180	COP9 signalosome(GO:0008180)
0.0	2.7	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	2.5	GO:1990391	DNA repair complex(GO:1990391)
0.0	6.7	GO:0016363	nuclear matrix(GO:0016363)
0.0	4.1	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.0	0.2	GO:0031501	mannosyltransferase complex(GO:0031501)
0.0	1.2	GO:0090545	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0	1.7	GO:0002102	podosome(GO:0002102)
0.0	0.6	GO:0031011	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0	0.2	GO:0072536	interleukin-23 receptor complex(GO:0072536)
0.0	0.2	GO:1990393	3M complex(GO:1990393)
0.0	0.3	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.4	GO:0060077	inhibitory synapse(GO:0060077)
0.0	0.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.8	GO:0071437	invadopodium(GO:0071437)
0.0	0.4	GO:0043194	axon initial segment(GO:0043194)
0.0	9.1	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	0.5	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.3	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	3.5	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.0	6.7	GO:0098857	membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0	1.4	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.4	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	1.6	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.8	GO:0031201	SNARE complex(GO:0031201)
0.0	1.6	GO:0016605	PML body(GO:0016605)
0.0	2.0	GO:0001650	fibrillar center(GO:0001650)
0.0	0.7	GO:0030119	AP-type membrane coat adaptor complex(GO:0030119)
0.0	0.4	GO:0071339	MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0	0.6	GO:0015030	Cajal body(GO:0015030)
0.0	0.3	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	7.4	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.5	25.8	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.5	1.5	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.5	11.4	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.4	3.9	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.2	9.5	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.2	3.4	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.2	4.8	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.2	3.4	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.2	1.5	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.2	4.1	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.2	6.9	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.2	2.1	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.1	0.4	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.1	3.5	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.1	7.8	REACTOME G ALPHA Z SIGNALLING EVENTS	Genes involved in G alpha (z) signalling events
0.1	9.5	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells
0.1	5.2	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.1	1.6	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.1	10.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	0.7	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.1	9.2	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.1	5.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1	1.3	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.1	0.9	REACTOME PIP3 ACTIVATES AKT SIGNALING	Genes involved in PIP3 activates AKT signaling
0.0	0.7	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	2.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	1.5	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.7	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.5	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.8	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.5	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.8	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	2.9	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.0	1.7	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	0.1	REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	Genes involved in Signaling by the B Cell Receptor (BCR)
0.0	0.6	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.0	1.0	REACTOME REGULATION OF INSULIN SECRETION	Genes involved in Regulation of Insulin Secretion
0.0	0.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.3	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.7	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	32.7	PID CD40 PATHWAY	CD40/CD40L signaling
0.3	7.6	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	8.4	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.2	7.7	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.2	4.4	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.2	1.2	PID S1P S1P2 PATHWAY	S1P2 pathway
0.2	4.7	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.2	2.3	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.2	3.8	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.1	2.9	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	5.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.1	8.0	PID BCR 5PATHWAY	BCR signaling pathway
0.1	3.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	3.2	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.1	2.2	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.1	2.5	PID ENDOTHELIN PATHWAY	Endothelins
0.1	2.1	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.1	1.5	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.0	1.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.2	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	1.8	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	0.7	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	0.6	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.5	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	0.6	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.9	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.9	9.7	GO:0042289	MHC class II protein binding(GO:0042289)
1.4	8.2	GO:0046979	TAP2 binding(GO:0046979)
1.2	12.2	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
1.0	5.0	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.9	11.4	GO:0032395	MHC class II receptor activity(GO:0032395)
0.7	3.7	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.7	8.2	GO:0004568	chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.7	2.2	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
0.5	4.4	GO:1990763	arrestin family protein binding(GO:1990763)
0.5	1.4	GO:0098640	integrin binding involved in cell-matrix adhesion(GO:0098640)
0.4	5.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.4	1.7	GO:0008940	nitrate reductase activity(GO:0008940)
0.4	18.8	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.3	3.7	GO:0051430	corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.3	1.6	GO:0061133	endopeptidase activator activity(GO:0061133)
0.3	5.4	GO:0070628	proteasome binding(GO:0070628)
0.3	2.9	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2	1.2	GO:0004906	interferon-gamma receptor activity(GO:0004906)
0.2	4.1	GO:0038191	neuropilin binding(GO:0038191)
0.2	10.6	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2	1.6	GO:0004793	glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.2	2.3	GO:0042834	peptidoglycan binding(GO:0042834)
0.2	10.9	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2	3.7	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.2	5.2	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2	1.5	GO:0000990	transcription factor activity, core RNA polymerase binding(GO:0000990)
0.2	0.2	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2	1.0	GO:0043532	angiostatin binding(GO:0043532)
0.1	6.4	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.1	5.1	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.1	0.6	GO:0031708	endothelin B receptor binding(GO:0031708)
0.1	0.4	GO:0045322	unmethylated CpG binding(GO:0045322)
0.1	3.9	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.1	1.9	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.1	0.4	GO:0005151	interleukin-1, Type II receptor binding(GO:0005151)
0.1	0.3	GO:0052593	tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596)
0.1	3.9	GO:0051059	NF-kappaB binding(GO:0051059)
0.1	0.5	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.1	1.2	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1	2.7	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	2.4	GO:0046965	retinoid X receptor binding(GO:0046965)
0.1	0.4	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.1	1.0	GO:0043422	protein kinase B binding(GO:0043422)
0.1	0.3	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.1	0.8	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.2	GO:0004376	glycolipid mannosyltransferase activity(GO:0004376)
0.0	1.3	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	1.7	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.0	1.6	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.2	GO:0042020	interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0	2.5	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0	0.4	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.0	4.2	GO:0004725	protein tyrosine phosphatase activity(GO:0004725)
0.0	0.9	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0	0.1	GO:0042015	interleukin-20 binding(GO:0042015)
0.0	0.2	GO:0023025	MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.0	0.5	GO:0071837	HMG box domain binding(GO:0071837)
0.0	1.3	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	10.0	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	2.4	GO:0003727	single-stranded RNA binding(GO:0003727)
0.0	0.1	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0	0.6	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	0.3	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.8	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.2	GO:0001164	RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0	0.1	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.3	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0016781	selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.0	0.4	GO:0005251	delayed rectifier potassium channel activity(GO:0005251)
0.0	0.2	GO:0022851	GABA-gated chloride ion channel activity(GO:0022851)
0.0	0.7	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0	0.4	GO:0030506	ankyrin binding(GO:0030506)
0.0	0.1	GO:0023029	MHC class Ib protein binding(GO:0023029)
0.0	0.2	GO:0043495	protein anchor(GO:0043495)
0.0	0.3	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.7	GO:0044325	ion channel binding(GO:0044325)
0.0	0.2	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	1.0	GO:0004721	phosphoprotein phosphatase activity(GO:0004721)
0.0	0.1	GO:0035198	miRNA binding(GO:0035198)
0.0	0.4	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.0	0.4	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.2	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.3	2.3	GO:1902523	positive regulation of protein K63-linked ubiquitination(GO:1902523)
2.2	6.5	GO:1990108	protein linear deubiquitination(GO:1990108)
1.9	9.7	GO:0002901	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.9	5.7	GO:0034146	B-1 B cell homeostasis(GO:0001922) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
1.8	5.3	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
1.7	5.1	GO:0085032	modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
1.3	3.9	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
1.3	11.3	GO:0070424	regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
1.1	5.6	GO:0070842	aggresome assembly(GO:0070842)
1.1	3.4	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
1.1	3.2	GO:0045062	extrathymic T cell selection(GO:0045062)
1.0	2.0	GO:0033078	extrathymic T cell differentiation(GO:0033078)
1.0	2.9	GO:1904897	regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.8	5.7	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.8	3.3	GO:2000620	positive regulation of histone H4-K16 acetylation(GO:2000620)
0.8	5.3	GO:0033590	response to cobalamin(GO:0033590)
0.8	6.1	GO:0032713	negative regulation of interleukin-4 production(GO:0032713)
0.7	8.2	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.7	7.4	GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.7	2.2	GO:0045360	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.7	4.4	GO:0034670	chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.7	10.7	GO:0060263	regulation of respiratory burst(GO:0060263)
0.6	1.9	GO:0051300	spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.6	2.4	GO:0034343	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.6	2.4	GO:0060697	positive regulation of phospholipid catabolic process(GO:0060697)
0.6	1.7	GO:0097112	gamma-aminobutyric acid receptor clustering(GO:0097112)
0.6	2.2	GO:0072183	negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.5	10.3	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
0.5	3.7	GO:0040032	post-embryonic body morphogenesis(GO:0040032)
0.5	2.1	GO:0046967	cytosol to ER transport(GO:0046967)
0.5	1.5	GO:0051097	negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
0.5	3.0	GO:0016554	cytidine to uridine editing(GO:0016554)
0.4	2.1	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.4	1.6	GO:0002268	follicular dendritic cell differentiation(GO:0002268)
0.4	1.2	GO:0033499	galactose catabolic process via UDP-galactose(GO:0033499)
0.4	2.7	GO:0034351	regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.3	5.9	GO:0032688	negative regulation of interferon-beta production(GO:0032688)
0.3	0.6	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.3	1.7	GO:0007296	vitellogenesis(GO:0007296)
0.3	0.8	GO:0000294	nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294) negative regulation by host of viral genome replication(GO:0044828)
0.3	1.0	GO:0002572	pro-T cell differentiation(GO:0002572)
0.3	1.0	GO:0008063	Toll signaling pathway(GO:0008063)
0.2	1.9	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2	1.6	GO:0019264	glycine biosynthetic process from serine(GO:0019264)
0.2	2.2	GO:0042940	D-amino acid transport(GO:0042940)
0.2	0.6	GO:0032203	telomere formation via telomerase(GO:0032203)
0.2	1.6	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)
0.2	0.5	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.2	1.2	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.2	1.4	GO:0002710	negative regulation of T cell mediated immunity(GO:0002710)
0.1	1.0	GO:0038061	NIK/NF-kappaB signaling(GO:0038061)
0.1	2.6	GO:0035855	megakaryocyte development(GO:0035855)
0.1	0.5	GO:0000255	allantoin metabolic process(GO:0000255)
0.1	2.8	GO:0045063	T-helper 1 cell differentiation(GO:0045063)
0.1	14.8	GO:0031295	T cell costimulation(GO:0031295)
0.1	0.4	GO:1901674	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.1	0.4	GO:0021577	hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.1	2.2	GO:0071243	cellular response to arsenic-containing substance(GO:0071243)
0.1	8.9	GO:0042100	B cell proliferation(GO:0042100)
0.1	0.9	GO:0061469	regulation of type B pancreatic cell proliferation(GO:0061469)
0.1	0.3	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1	0.5	GO:0072553	terminal button organization(GO:0072553)
0.1	0.7	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.1	0.7	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1	0.4	GO:0035063	nuclear speck organization(GO:0035063)
0.1	0.4	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.1	0.4	GO:0002483	antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.1	0.3	GO:0060010	Sertoli cell fate commitment(GO:0060010)
0.1	1.0	GO:0042074	cell migration involved in gastrulation(GO:0042074)
0.1	0.7	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1	0.2	GO:0060166	olfactory pit development(GO:0060166)
0.1	11.9	GO:0033209	tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0	1.4	GO:0050901	leukocyte tethering or rolling(GO:0050901)
0.0	1.3	GO:0051560	mitochondrial calcium ion homeostasis(GO:0051560)
0.0	1.3	GO:0060334	regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.0	0.7	GO:0016322	neuron remodeling(GO:0016322)
0.0	0.8	GO:0099500	synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.0	1.4	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.0	0.3	GO:0031022	nuclear migration along microfilament(GO:0031022)
0.0	0.4	GO:0007260	tyrosine phosphorylation of STAT protein(GO:0007260)
0.0	0.2	GO:0035709	memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.0	0.4	GO:0042428	serotonin metabolic process(GO:0042428)
0.0	0.2	GO:0044861	protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
0.0	3.3	GO:0035690	cellular response to drug(GO:0035690)
0.0	0.3	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.4	GO:0006477	protein sulfation(GO:0006477)
0.0	0.2	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	2.6	GO:0071391	cellular response to estrogen stimulus(GO:0071391)
0.0	0.1	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.0	2.7	GO:0007528	neuromuscular junction development(GO:0007528)
0.0	0.7	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.0	0.1	GO:0035900	response to isolation stress(GO:0035900)
0.0	0.4	GO:0097151	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0	0.7	GO:0050855	regulation of B cell receptor signaling pathway(GO:0050855)
0.0	0.4	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.6	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	2.1	GO:0000186	activation of MAPKK activity(GO:0000186)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.2	GO:0060080	inhibitory postsynaptic potential(GO:0060080)
0.0	0.1	GO:0002774	Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.0	0.6	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.5	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.0	GO:0048619	embryonic hindgut morphogenesis(GO:0048619)
0.0	2.8	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0030070	insulin processing(GO:0030070)
0.0	1.2	GO:0090003	regulation of establishment of protein localization to plasma membrane(GO:0090003)
0.0	1.0	GO:0086010	membrane depolarization during action potential(GO:0086010)
0.0	0.5	GO:0032754	positive regulation of interleukin-5 production(GO:0032754)
0.0	0.2	GO:0048840	otolith development(GO:0048840)
0.0	0.7	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0009386	translational attenuation(GO:0009386)
0.0	0.1	GO:1903697	negative regulation of microvillus assembly(GO:1903697)
0.0	0.1	GO:0048701	embryonic cranial skeleton morphogenesis(GO:0048701) cranial skeletal system development(GO:1904888)
0.0	0.3	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0	0.3	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.1	GO:0001714	endodermal cell fate specification(GO:0001714)
0.0	0.1	GO:0016260	selenocysteine biosynthetic process(GO:0016260)
0.0	0.7	GO:1904837	beta-catenin-TCF complex assembly(GO:1904837)
0.0	0.0	GO:0060167	regulation of axon diameter(GO:0031133) regulation of adenosine receptor signaling pathway(GO:0060167) positive regulation of adenosine receptor signaling pathway(GO:0060168)
0.0	0.3	GO:0006590	thyroid hormone generation(GO:0006590)
0.0	0.5	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0	0.1	GO:0009820	alkaloid metabolic process(GO:0009820)
0.0	0.1	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0	0.3	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.0	1.0	GO:0007218	neuropeptide signaling pathway(GO:0007218)
0.0	0.0	GO:0045113	regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)