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ENCODE cell lines, expression (Ernst 2011)

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Results for NKX1-1

Z-value: 0.34

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Transcription factors associated with NKX1-1

Gene Symbol Gene ID Gene Info
NKX1-1
ENSG00000235608.1 NKX1-1

Activity profile of NKX1-1 motif

Sorted Z-values of NKX1-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_8822113 1.22 ENST00000396290.1
ENST00000331129.3
 ID2
 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr1_-_221915418 0.56 ENST00000323825.3
ENST00000366899.3
 DUSP10
 dual specificity phosphatase 10
chr7_-_86849883 0.53 ENST00000433078.1
 TMEM243
 transmembrane protein 243, mitochondrial
chr7_+_26331541 0.52 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
 SNX10
 sorting nexin 10
chr3_-_105588231 0.43 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr4_+_128554081 0.39 ENST00000335251.6
ENST00000296461.5
 INTU
 inturned planar cell polarity protein
chr8_+_26371763 0.32 ENST00000521913.1
 DPYSL2
 dihydropyrimidinase-like 2
chr1_+_174843548 0.25 ENST00000478442.1
ENST00000465412.1
 RABGAP1L
 RAB GTPase activating protein 1-like
chr2_-_239197238 0.22 ENST00000254657.3
 PER2
 period circadian clock 2
chr18_-_33709268 0.20 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6
 solute carrier family 39 (zinc transporter), member 6
chr3_+_57261743 0.20 ENST00000288266.3
 APPL1
 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
chr17_-_61777459 0.19 ENST00000578993.1
ENST00000583211.1
ENST00000259006.3
 LIMD2
 LIM domain containing 2
chr2_-_239197201 0.18 ENST00000254658.3
 PER2
 period circadian clock 2
chr14_-_24711865 0.17 ENST00000399423.4
ENST00000267415.7
 TINF2
 TERF1 (TRF1)-interacting nuclear factor 2
chr3_-_105587879 0.17 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
 CBLB
 Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr14_-_24711806 0.16 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
 TINF2
 TERF1 (TRF1)-interacting nuclear factor 2
chr17_-_8113886 0.16 ENST00000577833.1
ENST00000534871.1
ENST00000583915.1
ENST00000316199.6
ENST00000581511.1
ENST00000585124.1
 AURKB
 aurora kinase B
chr12_-_6961050 0.15 ENST00000538862.2
 CDCA3
 cell division cycle associated 3
chr12_+_7014126 0.15 ENST00000415834.1
ENST00000436789.1
 LRRC23
 leucine rich repeat containing 23
chr12_+_7014064 0.13 ENST00000443597.2
 LRRC23
 leucine rich repeat containing 23
chr17_-_45266542 0.13 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
 CDC27
 cell division cycle 27
chr8_+_98656693 0.13 ENST00000519934.1
 MTDH
 metadherin
chr7_+_50348268 0.13 ENST00000438033.1
ENST00000439701.1
 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
chr12_+_7013897 0.12 ENST00000007969.8
ENST00000323702.5
 LRRC23
 leucine rich repeat containing 23
chr8_+_98656336 0.11 ENST00000336273.3
 MTDH
 metadherin
chr15_-_78526855 0.11 ENST00000541759.1
ENST00000558130.1
 ACSBG1
 acyl-CoA synthetase bubblegum family member 1
chr3_+_23851928 0.10 ENST00000467766.1
ENST00000424381.1
 UBE2E1
 ubiquitin-conjugating enzyme E2E 1
chr1_+_46972668 0.09 ENST00000371956.4
ENST00000360032.3
 DMBX1
 diencephalon/mesencephalon homeobox 1
chr17_-_44657017 0.08 ENST00000573185.1
ENST00000570550.1
ENST00000445552.2
ENST00000336125.5
ENST00000329240.4
ENST00000337845.7
 ARL17A
 ADP-ribosylation factor-like 17A
chr17_-_44439084 0.08 ENST00000575960.1
ENST00000575698.1
ENST00000571246.1
ENST00000434041.2
ENST00000570618.1
ENST00000450673.3
 ARL17B
 ADP-ribosylation factor-like 17B
chr14_-_24711470 0.08 ENST00000559969.1
 TINF2
 TERF1 (TRF1)-interacting nuclear factor 2
chr11_-_111741994 0.07 ENST00000398006.2
 ALG9
 ALG9, alpha-1,2-mannosyltransferase
chr11_-_71823715 0.07 ENST00000545944.1
ENST00000502597.2
 ANAPC15
 anaphase promoting complex subunit 15
chr11_-_62494821 0.07 ENST00000301785.5
 HNRNPUL2
 heterogeneous nuclear ribonucleoprotein U-like 2
chr11_-_71823796 0.07 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
 ANAPC15
 anaphase promoting complex subunit 15
chr1_-_51796226 0.06 ENST00000451380.1
ENST00000371747.3
ENST00000439482.1
 TTC39A
 tetratricopeptide repeat domain 39A
chr1_-_108507631 0.06 ENST00000527011.1
ENST00000370056.4
 VAV3
 vav 3 guanine nucleotide exchange factor
chr19_-_6424783 0.06 ENST00000398148.3
 KHSRP
 KH-type splicing regulatory protein
chr12_+_102513950 0.06 ENST00000378128.3
ENST00000327680.2
ENST00000541394.1
ENST00000543784.1
 PARPBP
 PARP1 binding protein
chr19_+_36249057 0.06 ENST00000301165.5
ENST00000536950.1
ENST00000537459.1
ENST00000421853.2
 C19orf55
 chromosome 19 open reading frame 55
chr4_-_103682145 0.06 ENST00000226578.4
 MANBA
 mannosidase, beta A, lysosomal
chr4_-_8873531 0.05 ENST00000400677.3
 HMX1
 H6 family homeobox 1
chr14_+_32798462 0.05 ENST00000280979.4
 AKAP6
 A kinase (PRKA) anchor protein 6
chr1_+_62439037 0.05 ENST00000545929.1
 INADL
 InaD-like (Drosophila)
chr9_+_139780942 0.05 ENST00000247668.2
ENST00000359662.3
 TRAF2
 TNF receptor-associated factor 2
chr19_+_45504688 0.05 ENST00000221452.8
ENST00000540120.1
ENST00000505236.1
 RELB
 v-rel avian reticuloendotheliosis viral oncogene homolog B
chr2_+_187371440 0.04 ENST00000445547.1
 ZC3H15
 zinc finger CCCH-type containing 15
chr17_-_8055747 0.04 ENST00000317276.4
ENST00000581703.1
 PER1
 period circadian clock 1
chr17_-_27418537 0.04 ENST00000408971.2
 TIAF1
 TGFB1-induced anti-apoptotic factor 1
chr1_-_51796987 0.04 ENST00000262676.5
 TTC39A
 tetratricopeptide repeat domain 39A
chr10_-_1095050 0.03 ENST00000381344.3
 IDI1
 isopentenyl-diphosphate delta isomerase 1
chr22_-_39151463 0.03 ENST00000405510.1
ENST00000433561.1
 SUN2
 Sad1 and UNC84 domain containing 2
chr12_-_23737534 0.03 ENST00000396007.2
 SOX5
 SRY (sex determining region Y)-box 5
chr12_+_2921788 0.03 ENST00000228799.2
ENST00000419778.2
ENST00000542548.1
 ITFG2
 integrin alpha FG-GAP repeat containing 2
chr6_-_82957433 0.03 ENST00000306270.7
 IBTK
 inhibitor of Bruton agammaglobulinemia tyrosine kinase
chr10_+_120789223 0.03 ENST00000425699.1
 NANOS1
 nanos homolog 1 (Drosophila)
chr12_-_91451758 0.03 ENST00000266719.3
 KERA
 keratocan
chr15_+_64386261 0.03 ENST00000560829.1
 SNX1
 sorting nexin 1
chrX_-_47509887 0.02 ENST00000247161.3
ENST00000592066.1
ENST00000376983.3
 ELK1
 ELK1, member of ETS oncogene family
chr3_+_186560476 0.02 ENST00000320741.2
ENST00000444204.2
 ADIPOQ
 adiponectin, C1Q and collagen domain containing
chr3_+_186560462 0.02 ENST00000412955.2
 ADIPOQ
 adiponectin, C1Q and collagen domain containing
chr13_-_36050819 0.02 ENST00000379919.4
 MAB21L1
 mab-21-like 1 (C. elegans)
chr17_-_40337470 0.02 ENST00000293330.1
 HCRT
 hypocretin (orexin) neuropeptide precursor
chr4_-_66536196 0.02 ENST00000511294.1
 EPHA5
 EPH receptor A5
chr19_-_8070474 0.01 ENST00000407627.2
ENST00000593807.1
 ELAVL1
 ELAV like RNA binding protein 1
chr12_+_28410128 0.01 ENST00000381259.1
ENST00000381256.1
 CCDC91
 coiled-coil domain containing 91
chr7_+_144052381 0.01 ENST00000498580.1
ENST00000056217.5
 ARHGEF5
 Rho guanine nucleotide exchange factor (GEF) 5
chr20_-_50722183 0.01 ENST00000371523.4
 ZFP64
 ZFP64 zinc finger protein
chr4_-_66536057 0.01 ENST00000273854.3
 EPHA5
 EPH receptor A5
chrX_-_153363125 0.01 ENST00000407218.1
ENST00000453960.2
 MECP2
 methyl CpG binding protein 2 (Rett syndrome)
chrX_+_55026763 0.01 ENST00000374987.3
 APEX2
 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
chr17_-_10372875 0.01 ENST00000255381.2
 MYH4
 myosin, heavy chain 4, skeletal muscle
chr11_+_72983246 0.01 ENST00000393590.2
 P2RY6
 pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_-_190446759 0.01 ENST00000367462.3
 BRINP3
 bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr15_-_78526942 0.00 ENST00000258873.4
 ACSBG1
 acyl-CoA synthetase bubblegum family member 1

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 0.4 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.2 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 0.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.6 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.6 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.6 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.6 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.4 GO:0051946 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1 0.4 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.1 0.2 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
0.0 0.6 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.0 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.0 GO:1903719 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.0 0.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.1 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.2 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.0 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)