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ENCODE cell lines, expression (Ernst 2011)

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Results for NKX1-2_RAX

Z-value: 0.53

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Transcription factors associated with NKX1-2_RAX

Gene Symbol Gene ID Gene Info
NKX1-2
ENSG00000229544.6 NKX1-2
RAX
ENSG00000134438.9 RAX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RAXhg19_v2_chr18_-_56940611_569406600.439.5e-02Click!

Activity profile of NKX1-2_RAX motif

Sorted Z-values of NKX1-2_RAX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX1-2_RAX

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_-_62521614 1.87 ENST00000527994.1
ENST00000394807.3
 ZBTB3
 zinc finger and BTB domain containing 3
chr7_-_87856280 1.56 ENST00000490437.1
ENST00000431660.1
 SRI
 sorcin
chr7_-_87856303 1.55 ENST00000394641.3
 SRI
 sorcin
chr4_-_25865159 1.44 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
 SEL1L3
 sel-1 suppressor of lin-12-like 3 (C. elegans)
chr3_-_151034734 1.41 ENST00000260843.4
 GPR87
 G protein-coupled receptor 87
chr5_+_66300446 0.75 ENST00000261569.7
 MAST4
 microtubule associated serine/threonine kinase family member 4
chr6_+_34204642 0.58 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
 HMGA1
 high mobility group AT-hook 1
chr12_-_10022735 0.53 ENST00000228438.2
 CLEC2B
 C-type lectin domain family 2, member B
chr10_-_105845674 0.45 ENST00000353479.5
ENST00000369733.3
 COL17A1
 collagen, type XVII, alpha 1
chr12_+_32832203 0.40 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
 DNM1L
 dynamin 1-like
chr11_+_5710919 0.38 ENST00000379965.3
ENST00000425490.1
 TRIM22
 tripartite motif containing 22
chr11_-_102651343 0.37 ENST00000279441.4
ENST00000539681.1
 MMP10
 matrix metallopeptidase 10 (stromelysin 2)
chr2_+_90077680 0.34 ENST00000390270.2
 IGKV3D-20
 immunoglobulin kappa variable 3D-20
chr17_-_41466555 0.29 ENST00000586231.1
 LINC00910
 long intergenic non-protein coding RNA 910
chr1_+_155278539 0.28 ENST00000447866.1
 FDPS
 farnesyl diphosphate synthase
chr3_+_183853052 0.26 ENST00000273783.3
ENST00000432569.1
ENST00000444495.1
 EIF2B5
 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa
chr6_-_111927062 0.26 ENST00000359831.4
 TRAF3IP2
 TRAF3 interacting protein 2
chr1_+_155278625 0.25 ENST00000368356.4
ENST00000356657.6
 FDPS
 farnesyl diphosphate synthase
chr12_-_112279694 0.24 ENST00000443596.1
ENST00000442119.1
 MAPKAPK5-AS1
 MAPKAPK5 antisense RNA 1
chrX_+_43515467 0.24 ENST00000338702.3
ENST00000542639.1
 MAOA
 monoamine oxidase A
chr10_+_124914285 0.23 ENST00000407911.2
 BUB3
 BUB3 mitotic checkpoint protein
chr20_-_50722183 0.23 ENST00000371523.4
 ZFP64
 ZFP64 zinc finger protein
chr2_+_217524323 0.22 ENST00000456764.1
 IGFBP2
 insulin-like growth factor binding protein 2, 36kDa
chrX_-_77225135 0.21 ENST00000458128.1
 PGAM4
 phosphoglycerate mutase family member 4
chr11_-_59383617 0.20 ENST00000263847.1
 OSBP
 oxysterol binding protein
chr15_+_64680003 0.20 ENST00000261884.3
 TRIP4
 thyroid hormone receptor interactor 4
chr6_+_26402517 0.19 ENST00000414912.2
 BTN3A1
 butyrophilin, subfamily 3, member A1
chr1_-_190446759 0.16 ENST00000367462.3
 BRINP3
 bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr8_-_102803163 0.16 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
 NCALD
 neurocalcin delta
chr19_+_48949030 0.16 ENST00000253237.5
 GRWD1
 glutamate-rich WD repeat containing 1
chr12_-_12837423 0.16 ENST00000540510.1
 GPR19
 G protein-coupled receptor 19
chr1_-_67266939 0.15 ENST00000304526.2
 INSL5
 insulin-like 5
chr17_-_45266542 0.15 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
 CDC27
 cell division cycle 27
chr3_+_23851928 0.15 ENST00000467766.1
ENST00000424381.1
 UBE2E1
 ubiquitin-conjugating enzyme E2E 1
chrX_+_30261847 0.15 ENST00000378981.3
ENST00000397550.1
 MAGEB1
 melanoma antigen family B, 1
chr14_+_103851712 0.15 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
 MARK3
 MAP/microtubule affinity-regulating kinase 3
chrX_+_44703249 0.14 ENST00000339042.4
 DUSP21
 dual specificity phosphatase 21
chrX_+_77154935 0.13 ENST00000481445.1
 COX7B
 cytochrome c oxidase subunit VIIb
chr6_-_94129244 0.13 ENST00000369303.4
ENST00000369297.1
 EPHA7
 EPH receptor A7
chr11_+_73498898 0.13 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
 MRPL48
 mitochondrial ribosomal protein L48
chr11_-_3859089 0.13 ENST00000396979.1
 RHOG
 ras homolog family member G
chr19_-_6424783 0.13 ENST00000398148.3
 KHSRP
 KH-type splicing regulatory protein
chr8_-_42623747 0.12 ENST00000534622.1
 CHRNA6
 cholinergic receptor, nicotinic, alpha 6 (neuronal)
chr1_+_153747746 0.11 ENST00000368661.3
 SLC27A3
 solute carrier family 27 (fatty acid transporter), member 3
chrX_+_135730373 0.11 ENST00000370628.2
 CD40LG
 CD40 ligand
chr1_+_186265399 0.11 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
 PRG4
 proteoglycan 4
chr6_-_111927449 0.11 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
 TRAF3IP2
 TRAF3 interacting protein 2
chr1_+_62439037 0.10 ENST00000545929.1
 INADL
 InaD-like (Drosophila)
chr10_+_124913930 0.08 ENST00000368858.5
 BUB3
 BUB3 mitotic checkpoint protein
chrX_+_135618258 0.08 ENST00000440515.1
ENST00000456412.1
 VGLL1
 vestigial like 1 (Drosophila)
chr5_-_20575959 0.08 ENST00000507958.1
 CDH18
 cadherin 18, type 2
chr8_+_105235572 0.08 ENST00000523362.1
 RIMS2
 regulating synaptic membrane exocytosis 2
chr1_+_100818156 0.08 ENST00000336454.3
 CDC14A
 cell division cycle 14A
chr9_+_125133315 0.07 ENST00000223423.4
ENST00000362012.2
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr1_+_153746683 0.07 ENST00000271857.2
 SLC27A3
 solute carrier family 27 (fatty acid transporter), member 3
chrX_-_6453159 0.07 ENST00000381089.3
ENST00000398729.1
 VCX3A
 variable charge, X-linked 3A
chr17_-_40337470 0.07 ENST00000293330.1
 HCRT
 hypocretin (orexin) neuropeptide precursor
chr19_-_14785622 0.07 ENST00000443157.2
 EMR3
 egf-like module containing, mucin-like, hormone receptor-like 3
chr9_-_21202204 0.07 ENST00000239347.3
 IFNA7
 interferon, alpha 7
chr7_+_50348268 0.07 ENST00000438033.1
ENST00000439701.1
 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
chr19_-_14785698 0.07 ENST00000344373.4
ENST00000595472.1
 EMR3
 egf-like module containing, mucin-like, hormone receptor-like 3
chr1_-_152386732 0.06 ENST00000271835.3
 CRNN
 cornulin
chr8_-_30670384 0.06 ENST00000221138.4
ENST00000518243.1
 PPP2CB
 protein phosphatase 2, catalytic subunit, beta isozyme
chr2_+_27008865 0.06 ENST00000335756.4
ENST00000233505.8
 CENPA
 centromere protein A
chr1_-_211307404 0.06 ENST00000367007.4
 KCNH1
 potassium voltage-gated channel, subfamily H (eag-related), member 1
chr19_+_11071546 0.06 ENST00000358026.2
 SMARCA4
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr2_-_169887827 0.06 ENST00000263817.6
 ABCB11
 ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr2_+_166095898 0.06 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
 SCN2A
 sodium channel, voltage-gated, type II, alpha subunit
chr22_+_22730353 0.06 ENST00000390296.2
 IGLV5-45
 immunoglobulin lambda variable 5-45
chr19_-_14785674 0.06 ENST00000253673.5
 EMR3
 egf-like module containing, mucin-like, hormone receptor-like 3
chr1_-_28969517 0.05 ENST00000263974.4
ENST00000373824.4
 TAF12
 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr9_-_21239978 0.05 ENST00000380222.2
 IFNA14
 interferon, alpha 14
chr4_-_66536196 0.05 ENST00000511294.1
 EPHA5
 EPH receptor A5
chr3_+_129247479 0.05 ENST00000296271.3
 RHO
 rhodopsin
chr3_+_186560462 0.05 ENST00000412955.2
 ADIPOQ
 adiponectin, C1Q and collagen domain containing
chr3_+_186560476 0.05 ENST00000320741.2
ENST00000444204.2
 ADIPOQ
 adiponectin, C1Q and collagen domain containing
chr2_-_89597542 0.05 ENST00000465170.1
 IGKV1-37
 immunoglobulin kappa variable 1-37 (non-functional)
chr9_-_21368075 0.04 ENST00000449498.1
 IFNA13
 interferon, alpha 13
chr6_+_30687978 0.04 ENST00000327892.8
ENST00000435534.1
 TUBB
 tubulin, beta class I
chrX_-_18690210 0.04 ENST00000379984.3
 RS1
 retinoschisin 1
chr4_+_80584903 0.04 ENST00000506460.1
 RP11-452C8.1
 RP11-452C8.1
chr17_-_10372875 0.04 ENST00000255381.2
 MYH4
 myosin, heavy chain 4, skeletal muscle
chr10_-_114206649 0.04 ENST00000369404.3
ENST00000369405.3
 ZDHHC6
 zinc finger, DHHC-type containing 6
chr14_+_32798547 0.04 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
 AKAP6
 A kinase (PRKA) anchor protein 6
chr1_+_28261492 0.03 ENST00000373894.3
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chr4_-_74486347 0.03 ENST00000342081.3
 RASSF6
 Ras association (RalGDS/AF-6) domain family member 6
chr6_+_154360357 0.03 ENST00000330432.7
ENST00000360422.4
 OPRM1
 opioid receptor, mu 1
chr1_+_100818009 0.03 ENST00000370125.2
ENST00000361544.6
ENST00000370124.3
 CDC14A
 cell division cycle 14A
chr4_+_110736659 0.03 ENST00000394631.3
ENST00000226796.6
 GAR1
 GAR1 ribonucleoprotein
chr12_-_25348007 0.03 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
 CASC1
 cancer susceptibility candidate 1
chr15_+_93443419 0.03 ENST00000557381.1
ENST00000420239.2
 CHD2
 chromodomain helicase DNA binding protein 2
chr4_-_66536057 0.02 ENST00000273854.3
 EPHA5
 EPH receptor A5
chr16_-_20702578 0.02 ENST00000307493.4
ENST00000219151.4
 ACSM1
 acyl-CoA synthetase medium-chain family member 1
chr10_+_124913793 0.02 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
 BUB3
 BUB3 mitotic checkpoint protein
chr11_+_33061543 0.02 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
 TCP11L1
 t-complex 11, testis-specific-like 1
chr12_-_10959892 0.02 ENST00000240615.2
 TAS2R8
 taste receptor, type 2, member 8
chr10_+_18549645 0.02 ENST00000396576.2
 CACNB2
 calcium channel, voltage-dependent, beta 2 subunit
chr2_+_113763031 0.02 ENST00000259211.6
 IL36A
 interleukin 36, alpha
chr9_+_34646651 0.02 ENST00000378842.3
 GALT
 galactose-1-phosphate uridylyltransferase
chrX_-_8139308 0.02 ENST00000317103.4
 VCX2
 variable charge, X-linked 2
chr7_-_86849883 0.01 ENST00000433078.1
 TMEM243
 transmembrane protein 243, mitochondrial
chr1_-_151804314 0.01 ENST00000318247.6
 RORC
 RAR-related orphan receptor C
chr18_+_22040620 0.01 ENST00000426880.2
 HRH4
 histamine receptor H4
chr9_+_34646624 0.01 ENST00000450095.2
ENST00000556278.1
 GALT
GALT
 galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr20_-_1447467 0.00 ENST00000353088.2
ENST00000350991.4
 NSFL1C
 NSFL1 (p97) cofactor (p47)
chrX_-_13835147 0.00 ENST00000493677.1
ENST00000355135.2
 GPM6B
 glycoprotein M6B
chr1_+_192605252 0.00 ENST00000391995.2
ENST00000543215.1
 RGS13
 regulator of G-protein signaling 13
chr18_+_22040593 0.00 ENST00000256906.4
 HRH4
 histamine receptor H4
chr2_+_74682150 0.00 ENST00000233331.7
ENST00000431187.1
ENST00000409917.1
ENST00000409493.2
 INO80B
 INO80 complex subunit B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.1 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.1 0.6 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.1 0.4 GO:0036466 synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
0.1 0.5 GO:0033384 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.1 1.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.3 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.0 0.1 GO:0097018 renal albumin absorption(GO:0097018) regulation of renal albumin absorption(GO:2000532) regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000583) negative regulation of platelet-derived growth factor receptor-alpha signaling pathway(GO:2000584)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.4 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.2 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.1 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.0 0.1 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0051256 mitotic spindle midzone assembly(GO:0051256)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.1 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0 0.6 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.2 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 3.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 1.4 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 0.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.2 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.4 GO:0051400 BH domain binding(GO:0051400)
0.0 0.2 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0 0.0 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.1 GO:0044326 dendritic spine neck(GO:0044326)
0.1 0.3 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
0.1 0.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.3 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.1 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0 0.1 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0060091 kinocilium(GO:0060091)
0.0 0.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)