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ENCODE cell lines, expression (Ernst 2011)

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Results for NKX2-1

Z-value: 0.75

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Transcription factors associated with NKX2-1

Gene Symbol Gene ID Gene Info
NKX2-1
ENSG00000136352.13 NKX2-1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-1hg19_v2_chr14_-_36989336_36989354-0.204.5e-01Click!

Activity profile of NKX2-1 motif

Sorted Z-values of NKX2-1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_60223225 3.14 ENST00000524807.1
ENST00000345732.4
 MS4A1
 membrane-spanning 4-domains, subfamily A, member 1
chr11_+_60223312 3.14 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
 MS4A1
 membrane-spanning 4-domains, subfamily A, member 1
chr10_-_98031310 2.05 ENST00000427367.2
ENST00000413476.2
 BLNK
 B-cell linker
chr10_-_98031265 1.98 ENST00000224337.5
ENST00000371176.2
 BLNK
 B-cell linker
chr12_-_21810765 1.90 ENST00000450584.1
ENST00000350669.1
 LDHB
 lactate dehydrogenase B
chr12_-_21810726 1.90 ENST00000396076.1
 LDHB
 lactate dehydrogenase B
chr3_-_16524357 1.53 ENST00000432519.1
 RFTN1
 raftlin, lipid raft linker 1
chr12_+_25205666 1.46 ENST00000547044.1
 LRMP
 lymphoid-restricted membrane protein
chr12_+_25205568 1.44 ENST00000548766.1
ENST00000556887.1
 LRMP
 lymphoid-restricted membrane protein
chr6_-_137113604 1.30 ENST00000359015.4
 MAP3K5
 mitogen-activated protein kinase kinase kinase 5
chr12_+_25205446 1.22 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
 LRMP
 lymphoid-restricted membrane protein
chr15_+_89182178 1.17 ENST00000559876.1
 ISG20
 interferon stimulated exonuclease gene 20kDa
chr1_-_25291475 1.14 ENST00000338888.3
ENST00000399916.1
 RUNX3
 runt-related transcription factor 3
chr15_+_89182156 1.07 ENST00000379224.5
 ISG20
 interferon stimulated exonuclease gene 20kDa
chr15_+_89181974 1.03 ENST00000306072.5
 ISG20
 interferon stimulated exonuclease gene 20kDa
chr11_+_35160709 0.87 ENST00000415148.2
ENST00000433354.2
ENST00000449691.2
ENST00000437706.2
ENST00000360158.4
ENST00000428726.2
ENST00000526669.2
ENST00000433892.2
ENST00000278386.6
ENST00000434472.2
ENST00000352818.4
ENST00000442151.2
 CD44
 CD44 molecule (Indian blood group)
chr1_-_38397384 0.80 ENST00000373027.1
 INPP5B
 inositol polyphosphate-5-phosphatase, 75kDa
chr5_-_171615315 0.80 ENST00000176763.5
 STK10
 serine/threonine kinase 10
chr6_-_26056695 0.79 ENST00000343677.2
 HIST1H1C
 histone cluster 1, H1c
chr13_-_41240717 0.75 ENST00000379561.5
 FOXO1
 forkhead box O1
chr12_-_719573 0.74 ENST00000397265.3
 NINJ2
 ninjurin 2
chrX_+_131157322 0.70 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
 MST4
 Serine/threonine-protein kinase MST4
chrX_+_131157290 0.69 ENST00000394334.2
 MST4
 Serine/threonine-protein kinase MST4
chr8_-_80680078 0.66 ENST00000337919.5
ENST00000354724.3
 HEY1
 hes-related family bHLH transcription factor with YRPW motif 1
chr19_-_36231437 0.56 ENST00000591748.1
 IGFLR1
 IGF-like family receptor 1
chr19_+_1065922 0.55 ENST00000539243.2
 HMHA1
 histocompatibility (minor) HA-1
chr1_-_236445251 0.51 ENST00000354619.5
ENST00000327333.8
 ERO1LB
 ERO1-like beta (S. cerevisiae)
chrX_-_32173579 0.51 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
 DMD
 dystrophin
chr3_+_4535025 0.51 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
 ITPR1
 inositol 1,4,5-trisphosphate receptor, type 1
chr12_+_93772402 0.51 ENST00000546925.1
 NUDT4
 nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr8_-_28747424 0.48 ENST00000523436.1
ENST00000397363.4
ENST00000521777.1
ENST00000520184.1
ENST00000521022.1
 INTS9
 integrator complex subunit 9
chr15_-_44116873 0.48 ENST00000267812.3
 MFAP1
 microfibrillar-associated protein 1
chr19_-_46234119 0.48 ENST00000317683.3
 FBXO46
 F-box protein 46
chr17_-_76778339 0.45 ENST00000591455.1
ENST00000446868.3
ENST00000361101.4
ENST00000589296.1
 CYTH1
 cytohesin 1
chr16_-_67190152 0.43 ENST00000486556.1
 TRADD
 TNFRSF1A-associated via death domain
chr15_-_43559055 0.41 ENST00000220420.5
ENST00000349114.4
 TGM5
 transglutaminase 5
chr8_-_16859690 0.38 ENST00000180166.5
 FGF20
 fibroblast growth factor 20
chr12_+_121837905 0.37 ENST00000392465.3
ENST00000554606.1
ENST00000392464.2
ENST00000555076.1
 RNF34
 ring finger protein 34, E3 ubiquitin protein ligase
chr1_-_17380630 0.35 ENST00000375499.3
 SDHB
 succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
chr12_+_93772326 0.35 ENST00000550056.1
ENST00000549992.1
ENST00000548662.1
ENST00000547014.1
 NUDT4
 nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr3_+_23847432 0.34 ENST00000346855.3
 UBE2E1
 ubiquitin-conjugating enzyme E2E 1
chr9_+_33290491 0.34 ENST00000379540.3
ENST00000379521.4
ENST00000318524.6
 NFX1
 nuclear transcription factor, X-box binding 1
chr9_-_128246769 0.32 ENST00000444226.1
 MAPKAP1
 mitogen-activated protein kinase associated protein 1
chr15_-_44955842 0.31 ENST00000427534.2
ENST00000559193.1
ENST00000261866.7
ENST00000535302.2
ENST00000558319.1
 SPG11
 spastic paraplegia 11 (autosomal recessive)
chr22_+_24891210 0.30 ENST00000382760.2
 UPB1
 ureidopropionase, beta
chrX_+_136648297 0.29 ENST00000287538.5
 ZIC3
 Zic family member 3
chr11_+_105948216 0.29 ENST00000278618.4
 AASDHPPT
 aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
chr19_+_36235964 0.29 ENST00000587708.2
 PSENEN
 presenilin enhancer gamma secretase subunit
chr16_+_640055 0.27 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
 RAB40C
 RAB40C, member RAS oncogene family
chr19_+_48958766 0.27 ENST00000342291.2
 KCNJ14
 potassium inwardly-rectifying channel, subfamily J, member 14
chr21_+_45432174 0.26 ENST00000380221.3
ENST00000291574.4
 TRAPPC10
 trafficking protein particle complex 10
chr18_+_33877654 0.26 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
 FHOD3
 formin homology 2 domain containing 3
chr7_-_27224795 0.24 ENST00000006015.3
 HOXA11
 homeobox A11
chr18_+_42260861 0.24 ENST00000282030.5
 SETBP1
 SET binding protein 1
chr1_+_15736359 0.23 ENST00000375980.4
 EFHD2
 EF-hand domain family, member D2
chr20_-_56285595 0.22 ENST00000395816.3
ENST00000347215.4
 PMEPA1
 prostate transmembrane protein, androgen induced 1
chr8_+_70404996 0.21 ENST00000402687.4
ENST00000419716.3
 SULF1
 sulfatase 1
chr16_+_1359138 0.21 ENST00000325437.5
 UBE2I
 ubiquitin-conjugating enzyme E2I
chr6_+_31554779 0.20 ENST00000376090.2
 LST1
 leukocyte specific transcript 1
chr3_+_4535155 0.19 ENST00000544951.1
 ITPR1
 inositol 1,4,5-trisphosphate receptor, type 1
chrX_-_110655306 0.19 ENST00000371993.2
 DCX
 doublecortin
chr7_-_27224842 0.18 ENST00000517402.1
 HOXA11
 homeobox A11
chr1_+_206643787 0.17 ENST00000367120.3
 IKBKE
 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr5_+_134094461 0.16 ENST00000452510.2
ENST00000354283.4
 DDX46
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr16_-_67493110 0.15 ENST00000602876.1
 ATP6V0D1
 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr6_-_71012773 0.14 ENST00000370496.3
ENST00000357250.6
 COL9A1
 collagen, type IX, alpha 1
chr1_+_206643806 0.14 ENST00000537984.1
 IKBKE
 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr12_-_102591604 0.13 ENST00000329406.4
 PMCH
 pro-melanin-concentrating hormone
chr14_+_74353320 0.13 ENST00000540593.1
ENST00000555730.1
 ZNF410
 zinc finger protein 410
chr16_+_58533951 0.13 ENST00000566192.1
ENST00000565088.1
ENST00000568640.1
ENST00000563978.1
ENST00000569923.1
ENST00000356752.4
ENST00000563799.1
ENST00000562999.1
ENST00000570248.1
ENST00000562731.1
ENST00000568424.1
 NDRG4
 NDRG family member 4
chr17_-_40169429 0.13 ENST00000316603.7
ENST00000588641.1
 DNAJC7
 DnaJ (Hsp40) homolog, subfamily C, member 7
chr19_+_24009879 0.12 ENST00000354585.4
 RPSAP58
 ribosomal protein SA pseudogene 58
chr8_+_94752349 0.12 ENST00000391680.1
 RBM12B-AS1
 RBM12B antisense RNA 1
chr7_+_127881325 0.12 ENST00000308868.4
 LEP
 leptin
chr6_-_27841289 0.12 ENST00000355981.2
 HIST1H4L
 histone cluster 1, H4l
chr19_+_48972265 0.12 ENST00000452733.2
 CYTH2
 cytohesin 2
chr10_-_81320151 0.11 ENST00000372325.2
ENST00000372327.5
ENST00000417041.1
 SFTPA2
 surfactant protein A2
chr1_+_24019099 0.11 ENST00000443624.1
ENST00000458455.1
 RPL11
 ribosomal protein L11
chr3_-_52029830 0.11 ENST00000492277.1
ENST00000475248.1
ENST00000479017.1
ENST00000495383.1
ENST00000466397.1
ENST00000481629.1
 RPL29
 ribosomal protein L29
chr6_-_55740352 0.11 ENST00000370830.3
 BMP5
 bone morphogenetic protein 5
chr15_+_40453204 0.11 ENST00000287598.6
ENST00000412359.3
 BUB1B
 BUB1 mitotic checkpoint serine/threonine kinase B
chr21_+_45773515 0.10 ENST00000397932.2
ENST00000300481.9
 TRPM2
 transient receptor potential cation channel, subfamily M, member 2
chr19_+_48972459 0.10 ENST00000427476.1
 CYTH2
 cytohesin 2
chr3_-_52029958 0.09 ENST00000294189.6
 RPL29
 ribosomal protein L29
chr17_-_46035187 0.09 ENST00000300557.2
 PRR15L
 proline rich 15-like
chr19_-_10679644 0.09 ENST00000393599.2
 CDKN2D
 cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chrX_+_153170189 0.09 ENST00000358927.2
 AVPR2
 arginine vasopressin receptor 2
chrX_+_86772707 0.08 ENST00000373119.4
 KLHL4
 kelch-like family member 4
chr11_+_66512089 0.08 ENST00000524551.1
ENST00000525908.1
ENST00000360962.4
ENST00000346672.4
ENST00000527634.1
ENST00000540737.1
 C11orf80
 chromosome 11 open reading frame 80
chrX_-_70474499 0.08 ENST00000353904.2
 ZMYM3
 zinc finger, MYM-type 3
chr11_+_66512303 0.08 ENST00000532565.2
 C11orf80
 chromosome 11 open reading frame 80
chr12_+_60058458 0.07 ENST00000548610.1
 SLC16A7
 solute carrier family 16 (monocarboxylate transporter), member 7
chr11_-_62313090 0.07 ENST00000528508.1
ENST00000533365.1
 AHNAK
 AHNAK nucleoprotein
chr17_-_10452929 0.06 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
 MYH2
 myosin, heavy chain 2, skeletal muscle, adult
chr6_-_55739542 0.06 ENST00000446683.2
 BMP5
 bone morphogenetic protein 5
chr2_+_220379052 0.06 ENST00000347842.3
ENST00000358078.4
 ASIC4
 acid-sensing (proton-gated) ion channel family member 4
chr1_-_92952433 0.06 ENST00000294702.5
 GFI1
 growth factor independent 1 transcription repressor
chr12_+_50478977 0.05 ENST00000381513.4
 SMARCD1
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr1_-_228604328 0.05 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
 TRIM17
 tripartite motif containing 17
chr17_-_79623597 0.04 ENST00000574024.1
ENST00000331056.5
 PDE6G
 phosphodiesterase 6G, cGMP-specific, rod, gamma
chr14_+_67708137 0.04 ENST00000556345.1
ENST00000555925.1
ENST00000557783.1
 MPP5
 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr3_-_114790179 0.04 ENST00000462705.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr5_+_140345820 0.04 ENST00000289269.5
 PCDHAC2
 protocadherin alpha subfamily C, 2
chr19_+_38924316 0.04 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
 RYR1
 ryanodine receptor 1 (skeletal)
chr9_-_97356075 0.04 ENST00000375337.3
 FBP2
 fructose-1,6-bisphosphatase 2
chr14_+_81421861 0.03 ENST00000298171.2
 TSHR
 thyroid stimulating hormone receptor
chr14_+_81421921 0.03 ENST00000554263.1
ENST00000554435.1
 TSHR
 thyroid stimulating hormone receptor
chrX_-_83442915 0.03 ENST00000262752.2
ENST00000543399.1
 RPS6KA6
 ribosomal protein S6 kinase, 90kDa, polypeptide 6
chrX_+_153170455 0.03 ENST00000430697.1
ENST00000337474.5
ENST00000370049.1
 AVPR2
 arginine vasopressin receptor 2
chr6_-_160679905 0.03 ENST00000366953.3
 SLC22A2
 solute carrier family 22 (organic cation transporter), member 2
chr18_-_24283586 0.03 ENST00000579458.1
 U3
 Small nucleolar RNA U3
chr8_+_22019168 0.02 ENST00000318561.3
ENST00000521315.1
ENST00000437090.2
ENST00000520605.1
ENST00000522109.1
ENST00000524255.1
ENST00000523296.1
ENST00000518615.1
 SFTPC
 surfactant protein C
chr14_-_58893832 0.02 ENST00000556007.2
 TIMM9
 translocase of inner mitochondrial membrane 9 homolog (yeast)
chr14_-_106068065 0.02 ENST00000390541.2
 IGHE
 immunoglobulin heavy constant epsilon
chr2_+_99797542 0.02 ENST00000338148.3
ENST00000512183.2
 MRPL30
C2orf15
 mitochondrial ribosomal protein L30
chromosome 2 open reading frame 15
chr16_+_640201 0.02 ENST00000563109.1
 RAB40C
 RAB40C, member RAS oncogene family
chr2_-_85895295 0.01 ENST00000428225.1
ENST00000519937.2
 SFTPB
 surfactant protein B
chr12_-_67197760 0.01 ENST00000539540.1
ENST00000540433.1
ENST00000541947.1
ENST00000538373.1
 GRIP1
 glutamate receptor interacting protein 1
chr11_+_22688150 0.01 ENST00000454584.2
 GAS2
 growth arrest-specific 2
chrX_-_134478012 0.00 ENST00000370766.3
 ZNF75D
 zinc finger protein 75D
chr8_-_144679296 0.00 ENST00000317198.6
 EEF1D
 eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chrX_+_78003204 0.00 ENST00000435339.3
ENST00000514744.1
 LPAR4
 lysophosphatidic acid receptor 4
chr19_+_55014085 0.00 ENST00000351841.2
 LAIR2
 leukocyte-associated immunoglobulin-like receptor 2
chr17_+_76210267 0.00 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
 BIRC5
 baculoviral IAP repeat containing 5

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0008859 exoribonuclease II activity(GO:0008859)
0.5 3.8 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.2 4.0 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2 6.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.2 0.7 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.2 0.9 GO:0052842 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.2 0.7 GO:0035939 microsatellite binding(GO:0035939)
0.1 0.4 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
0.1 0.3 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.1 0.8 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.3 GO:0042296 ISG15 transferase activity(GO:0042296)
0.1 0.2 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1 0.2 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 1.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0070513 death domain binding(GO:0070513)
0.0 0.8 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.5 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.1 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.4 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.0 0.3 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 1.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.0 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.1 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.3 3.8 GO:0006089 lactate metabolic process(GO:0006089)
0.2 1.5 GO:0032594 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
0.2 1.1 GO:0070417 cellular response to cold(GO:0070417)
0.2 0.9 GO:1901908 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.2 0.7 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.1 0.7 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.8 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.1 0.3 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.1 1.3 GO:0010663 positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.1 0.3 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 0.4 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.1 0.2 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.1 6.3 GO:0042100 B cell proliferation(GO:0042100)
0.1 0.3 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 0.2 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.0 0.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.3 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0 0.5 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.3 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.1 GO:2000366 negative regulation of glucagon secretion(GO:0070093) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.0 3.9 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.4 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.0 0.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 4.4 GO:0006903 vesicle targeting(GO:0006903)
0.0 0.2 GO:0001764 neuron migration(GO:0001764)
0.0 0.8 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.3 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.1 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 0.4 GO:0006105 succinate metabolic process(GO:0006105)
0.0 0.1 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
0.0 0.7 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 0.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.5 GO:0016180 snRNA processing(GO:0016180)
0.0 0.1 GO:0035811 negative regulation of urine volume(GO:0035811)
0.0 0.8 GO:2000401 regulation of lymphocyte migration(GO:2000401)
0.0 0.3 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.1 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103) positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.3 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.1 GO:0071415 cellular response to purine-containing compound(GO:0071415)
0.0 0.1 GO:2001135 regulation of endocytic recycling(GO:2001135)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 2.4 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.4 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.2 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 0.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1 0.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.4 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.1 0.7 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.5 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.5 GO:0032039 integrator complex(GO:0032039)
0.1 4.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 3.4 GO:0015030 Cajal body(GO:0015030)
0.0 0.3 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.8 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0005594 collagen type IX trimer(GO:0005594)
0.0 0.3 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.4 GO:0031264 death-inducing signaling complex(GO:0031264)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 5.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 5.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 0.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 0.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.8 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.1 4.0 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 0.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 3.3 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.3 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 1.1 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 0.3 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.0 0.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.3 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.0 0.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.4 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components