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ENCODE cell lines, expression (Ernst 2011)

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Results for NKX2-5

Z-value: 0.52

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Transcription factors associated with NKX2-5

Gene Symbol Gene ID Gene Info
NKX2-5
ENSG00000183072.9 NKX2-5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NKX2-5hg19_v2_chr5_-_172662303_172662360-0.411.2e-01Click!

Activity profile of NKX2-5 motif

Sorted Z-values of NKX2-5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_-_149792295 0.96 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
 CD74
 CD74 molecule, major histocompatibility complex, class II invariant chain
chr14_-_106406090 0.95 ENST00000390593.2
 IGHV6-1
 immunoglobulin heavy variable 6-1
chr17_-_29641104 0.85 ENST00000577894.1
ENST00000330927.4
 EVI2B
 ecotropic viral integration site 2B
chr17_-_29641084 0.69 ENST00000544462.1
 EVI2B
 ecotropic viral integration site 2B
chr14_-_106963409 0.66 ENST00000390621.2
 IGHV1-45
 immunoglobulin heavy variable 1-45
chr12_+_113354341 0.63 ENST00000553152.1
 OAS1
 2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr7_+_99775366 0.60 ENST00000394018.2
ENST00000416412.1
 STAG3
 stromal antigen 3
chr7_+_99775520 0.58 ENST00000317296.5
ENST00000422690.1
ENST00000439782.1
 STAG3
 stromal antigen 3
chr13_-_41240717 0.55 ENST00000379561.5
 FOXO1
 forkhead box O1
chr5_+_75699040 0.53 ENST00000274364.6
 IQGAP2
 IQ motif containing GTPase activating protein 2
chr15_+_81589254 0.51 ENST00000394652.2
 IL16
 interleukin 16
chr2_-_175499294 0.50 ENST00000392547.2
 WIPF1
 WAS/WASL interacting protein family, member 1
chr8_-_120651020 0.46 ENST00000522826.1
ENST00000520066.1
ENST00000259486.6
ENST00000075322.6
 ENPP2
 ectonucleotide pyrophosphatase/phosphodiesterase 2
chr17_+_26646175 0.44 ENST00000583381.1
ENST00000582113.1
ENST00000582384.1
 TMEM97
 transmembrane protein 97
chr1_+_186798073 0.41 ENST00000367466.3
ENST00000442353.2
 PLA2G4A
 phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr17_+_26646121 0.39 ENST00000226230.6
 TMEM97
 transmembrane protein 97
chr7_-_37488834 0.39 ENST00000310758.4
 ELMO1
 engulfment and cell motility 1
chr3_-_15374659 0.34 ENST00000426925.1
 SH3BP5
 SH3-domain binding protein 5 (BTK-associated)
chr17_+_48624450 0.33 ENST00000006658.6
ENST00000356488.4
ENST00000393244.3
 SPATA20
 spermatogenesis associated 20
chr5_-_171615315 0.32 ENST00000176763.5
 STK10
 serine/threonine kinase 10
chr5_+_122110691 0.30 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
 SNX2
 sorting nexin 2
chr22_+_40322595 0.29 ENST00000420971.1
ENST00000544756.1
 GRAP2
 GRB2-related adaptor protein 2
chr22_+_40322623 0.29 ENST00000399090.2
 GRAP2
 GRB2-related adaptor protein 2
chr11_+_108093839 0.28 ENST00000452508.2
 ATM
 ataxia telangiectasia mutated
chr3_-_111314230 0.28 ENST00000317012.4
 ZBED2
 zinc finger, BED-type containing 2
chr9_-_34048873 0.27 ENST00000449054.1
ENST00000379239.4
ENST00000539807.1
ENST00000379238.1
ENST00000418786.2
ENST00000360802.1
ENST00000412543.1
 UBAP2
 ubiquitin associated protein 2
chr12_+_93772402 0.27 ENST00000546925.1
 NUDT4
 nudix (nucleoside diphosphate linked moiety X)-type motif 4
chr1_-_55352834 0.25 ENST00000371269.3
 DHCR24
 24-dehydrocholesterol reductase
chrX_-_154299501 0.23 ENST00000369476.3
ENST00000369484.3
 MTCP1
CMC4
 mature T-cell proliferation 1
C-x(9)-C motif containing 4
chr4_+_2470664 0.23 ENST00000314289.8
ENST00000541204.1
ENST00000502316.1
ENST00000507247.1
ENST00000509258.1
ENST00000511859.1
 RNF4
 ring finger protein 4
chr18_+_42260861 0.22 ENST00000282030.5
 SETBP1
 SET binding protein 1
chr1_+_27153173 0.22 ENST00000374142.4
 ZDHHC18
 zinc finger, DHHC-type containing 18
chr3_-_56717246 0.21 ENST00000355628.5
 FAM208A
 family with sequence similarity 208, member A
chr3_-_11685345 0.21 ENST00000430365.2
 VGLL4
 vestigial like 4 (Drosophila)
chr5_-_76788317 0.20 ENST00000296679.4
 WDR41
 WD repeat domain 41
chr15_+_42841008 0.20 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
 HAUS2
 HAUS augmin-like complex, subunit 2
chr1_-_22109682 0.19 ENST00000400301.1
ENST00000532737.1
 USP48
 ubiquitin specific peptidase 48
chr16_+_77233294 0.18 ENST00000378644.4
 SYCE1L
 synaptonemal complex central element protein 1-like
chr11_+_64879317 0.18 ENST00000526809.1
ENST00000279263.7
ENST00000524986.1
ENST00000534371.1
ENST00000540748.1
ENST00000525385.1
ENST00000345348.5
ENST00000531321.1
ENST00000529414.1
ENST00000526085.1
ENST00000530750.1
 TM7SF2
 transmembrane 7 superfamily member 2
chr20_+_57226284 0.17 ENST00000458280.1
ENST00000355957.5
ENST00000361770.5
ENST00000312283.8
ENST00000412911.1
ENST00000359617.4
ENST00000371141.4
 STX16
 syntaxin 16
chr10_+_76586348 0.17 ENST00000372724.1
ENST00000287239.4
ENST00000372714.1
 KAT6B
 K(lysine) acetyltransferase 6B
chr12_+_56360550 0.17 ENST00000266970.4
 CDK2
 cyclin-dependent kinase 2
chr9_-_117692697 0.17 ENST00000223795.2
 TNFSF8
 tumor necrosis factor (ligand) superfamily, member 8
chr16_+_33006369 0.16 ENST00000425181.3
 IGHV3OR16-10
 immunoglobulin heavy variable 3/OR16-10 (non-functional)
chr20_+_57226841 0.16 ENST00000358029.4
ENST00000361830.3
 STX16
 syntaxin 16
chr19_+_5681153 0.15 ENST00000579559.1
ENST00000577222.1
 HSD11B1L
RPL36
 hydroxysteroid (11-beta) dehydrogenase 1-like
ribosomal protein L36
chr11_+_18417813 0.15 ENST00000540430.1
ENST00000379412.5
 LDHA
 lactate dehydrogenase A
chr6_-_41715128 0.14 ENST00000356667.4
ENST00000373025.3
ENST00000425343.2
 PGC
 progastricsin (pepsinogen C)
chr17_+_53342311 0.14 ENST00000226067.5
 HLF
 hepatic leukemia factor
chr10_+_73156664 0.13 ENST00000398809.4
ENST00000398842.3
ENST00000461841.3
ENST00000299366.7
 CDH23
 cadherin-related 23
chr7_-_87342564 0.13 ENST00000265724.3
ENST00000416177.1
 ABCB1
 ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr17_-_29624343 0.13 ENST00000247271.4
 OMG
 oligodendrocyte myelin glycoprotein
chr3_+_42201653 0.12 ENST00000341421.3
ENST00000396175.1
 TRAK1
 trafficking protein, kinesin binding 1
chr12_+_93772326 0.12 ENST00000550056.1
ENST00000549992.1
ENST00000548662.1
ENST00000547014.1
 NUDT4
 nudix (nucleoside diphosphate linked moiety X)-type motif 4
chrX_-_14047996 0.12 ENST00000380523.4
ENST00000398355.3
 GEMIN8
 gem (nuclear organelle) associated protein 8
chrX_+_115567767 0.12 ENST00000371900.4
 SLC6A14
 solute carrier family 6 (amino acid transporter), member 14
chr8_+_76452097 0.12 ENST00000396423.2
 HNF4G
 hepatocyte nuclear factor 4, gamma
chr8_-_95220775 0.11 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
 CDH17
 cadherin 17, LI cadherin (liver-intestine)
chr7_-_81399355 0.11 ENST00000457544.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr19_+_5681011 0.11 ENST00000581893.1
ENST00000411793.2
ENST00000301382.4
ENST00000581773.1
ENST00000423665.2
ENST00000583928.1
ENST00000342970.2
ENST00000422535.2
ENST00000581521.1
ENST00000339423.2
 HSD11B1L
 hydroxysteroid (11-beta) dehydrogenase 1-like
chr2_+_201997492 0.11 ENST00000494258.1
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr15_-_74726283 0.11 ENST00000543145.2
 SEMA7A
 semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
chr19_+_1026566 0.11 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
 CNN2
 calponin 2
chr11_+_43702236 0.11 ENST00000531185.1
ENST00000278353.4
 HSD17B12
 hydroxysteroid (17-beta) dehydrogenase 12
chr22_-_38577782 0.10 ENST00000430886.1
ENST00000332509.3
ENST00000447598.2
ENST00000435484.1
ENST00000402064.1
ENST00000436218.1
 PLA2G6
 phospholipase A2, group VI (cytosolic, calcium-independent)
chr7_-_81399438 0.10 ENST00000222390.5
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_81399329 0.10 ENST00000453411.1
ENST00000444829.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr10_+_133753533 0.10 ENST00000422256.2
 PPP2R2D
 protein phosphatase 2, regulatory subunit B, delta
chr17_+_75447326 0.10 ENST00000591088.1
 SEPT9
 septin 9
chr12_-_371994 0.10 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
 SLC6A13
 solute carrier family 6 (neurotransmitter transporter), member 13
chr22_-_38577731 0.09 ENST00000335539.3
 PLA2G6
 phospholipase A2, group VI (cytosolic, calcium-independent)
chr11_-_19223523 0.09 ENST00000265968.3
 CSRP3
 cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr15_-_42840961 0.09 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
 LRRC57
 leucine rich repeat containing 57
chr17_+_29421987 0.09 ENST00000431387.4
 NF1
 neurofibromin 1
chr7_+_129007964 0.09 ENST00000460109.1
ENST00000474594.1
ENST00000446212.1
 AHCYL2
 adenosylhomocysteinase-like 2
chr17_-_3500392 0.09 ENST00000571088.1
ENST00000174621.6
 TRPV1
 transient receptor potential cation channel, subfamily V, member 1
chr7_-_81399411 0.09 ENST00000423064.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr10_-_101841588 0.08 ENST00000370418.3
 CPN1
 carboxypeptidase N, polypeptide 1
chr15_+_42696992 0.08 ENST00000561817.1
 CAPN3
 calpain 3, (p94)
chr4_+_81118647 0.08 ENST00000415738.2
 PRDM8
 PR domain containing 8
chr8_+_48873453 0.08 ENST00000523944.1
 MCM4
 minichromosome maintenance complex component 4
chr6_-_112115074 0.08 ENST00000368667.2
 FYN
 FYN oncogene related to SRC, FGR, YES
chr15_-_81282133 0.08 ENST00000261758.4
 MESDC2
 mesoderm development candidate 2
chr17_+_40811283 0.08 ENST00000251412.7
 TUBG2
 tubulin, gamma 2
chr1_-_11907829 0.08 ENST00000376480.3
 NPPA
 natriuretic peptide A
chr15_+_42697018 0.08 ENST00000397204.4
 CAPN3
 calpain 3, (p94)
chr2_-_220041617 0.07 ENST00000451647.1
ENST00000360507.5
 CNPPD1
 cyclin Pas1/PHO80 domain containing 1
chr18_+_61575200 0.07 ENST00000238508.3
 SERPINB10
 serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr19_-_5680499 0.07 ENST00000587589.1
 C19orf70
 chromosome 19 open reading frame 70
chr8_+_48873479 0.07 ENST00000262105.2
 MCM4
 minichromosome maintenance complex component 4
chr8_+_132916318 0.07 ENST00000254624.5
ENST00000522709.1
 EFR3A
 EFR3 homolog A (S. cerevisiae)
chr13_+_25670268 0.07 ENST00000281589.3
 PABPC3
 poly(A) binding protein, cytoplasmic 3
chr19_+_16999654 0.07 ENST00000248076.3
 F2RL3
 coagulation factor II (thrombin) receptor-like 3
chr16_+_8814563 0.07 ENST00000425191.2
ENST00000569156.1
 ABAT
 4-aminobutyrate aminotransferase
chr4_+_113970772 0.07 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
 ANK2
 ankyrin 2, neuronal
chr3_-_187388173 0.07 ENST00000287641.3
 SST
 somatostatin
chr7_+_142457315 0.07 ENST00000486171.1
ENST00000311737.7
 PRSS1
 protease, serine, 1 (trypsin 1)
chr5_+_140345820 0.07 ENST00000289269.5
 PCDHAC2
 protocadherin alpha subfamily C, 2
chr12_-_49259643 0.07 ENST00000309739.5
 RND1
 Rho family GTPase 1
chr9_+_33265011 0.06 ENST00000419016.2
 CHMP5
 charged multivesicular body protein 5
chr9_+_118950325 0.06 ENST00000534838.1
 PAPPA
 pregnancy-associated plasma protein A, pappalysin 1
chr21_+_44313375 0.06 ENST00000354250.2
ENST00000340344.4
 NDUFV3
 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
chr1_+_211433275 0.06 ENST00000367005.4
 RCOR3
 REST corepressor 3
chr15_+_42696954 0.05 ENST00000337571.4
ENST00000569136.1
 CAPN3
 calpain 3, (p94)
chr3_+_23847394 0.05 ENST00000306627.3
 UBE2E1
 ubiquitin-conjugating enzyme E2E 1
chr17_-_7493390 0.05 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
 SOX15
 SRY (sex determining region Y)-box 15
chr3_+_45984947 0.05 ENST00000304552.4
 CXCR6
 chemokine (C-X-C motif) receptor 6
chr20_-_44485835 0.05 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
 ACOT8
 acyl-CoA thioesterase 8
chr8_-_10588010 0.05 ENST00000304501.1
 SOX7
 SRY (sex determining region Y)-box 7
chr7_-_128415844 0.05 ENST00000249389.2
 OPN1SW
 opsin 1 (cone pigments), short-wave-sensitive
chr17_+_38333263 0.04 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
 RAPGEFL1
 Rap guanine nucleotide exchange factor (GEF)-like 1
chr10_+_75504105 0.04 ENST00000535742.1
ENST00000546025.1
ENST00000345254.4
ENST00000540668.1
ENST00000339365.2
ENST00000411652.2
 SEC24C
 SEC24 family member C
chr1_-_113498943 0.04 ENST00000369626.3
 SLC16A1
 solute carrier family 16 (monocarboxylate transporter), member 1
chr1_-_115259337 0.03 ENST00000369535.4
 NRAS
 neuroblastoma RAS viral (v-ras) oncogene homolog
chr17_+_58755184 0.03 ENST00000589222.1
ENST00000407086.3
ENST00000390652.5
 BCAS3
 breast carcinoma amplified sequence 3
chr12_+_14518598 0.03 ENST00000261168.4
ENST00000538511.1
ENST00000545723.1
ENST00000543189.1
ENST00000536444.1
 ATF7IP
 activating transcription factor 7 interacting protein
chr4_-_74853897 0.03 ENST00000296028.3
 PPBP
 pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr6_-_94129244 0.03 ENST00000369303.4
ENST00000369297.1
 EPHA7
 EPH receptor A7
chr22_-_50524298 0.03 ENST00000311597.5
 MLC1
 megalencephalic leukoencephalopathy with subcortical cysts 1
chr11_-_108464321 0.03 ENST00000265843.4
 EXPH5
 exophilin 5
chr11_+_120973375 0.03 ENST00000264037.2
 TECTA
 tectorin alpha
chr22_-_50523760 0.03 ENST00000395876.2
 MLC1
 megalencephalic leukoencephalopathy with subcortical cysts 1
chr2_-_96874553 0.03 ENST00000337288.5
ENST00000443962.1
 STARD7
 StAR-related lipid transfer (START) domain containing 7
chr2_+_152214098 0.03 ENST00000243347.3
 TNFAIP6
 tumor necrosis factor, alpha-induced protein 6
chr2_-_201936302 0.02 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
 FAM126B
 family with sequence similarity 126, member B
chr1_+_32671236 0.02 ENST00000537469.1
ENST00000291358.6
 IQCC
 IQ motif containing C
chr2_+_219646462 0.02 ENST00000258415.4
 CYP27A1
 cytochrome P450, family 27, subfamily A, polypeptide 1
chr9_+_33264861 0.02 ENST00000223500.8
 CHMP5
 charged multivesicular body protein 5
chr6_+_31916733 0.02 ENST00000483004.1
 CFB
 complement factor B
chr13_-_95364389 0.02 ENST00000376945.2
 SOX21
 SRY (sex determining region Y)-box 21
chr3_+_23847432 0.02 ENST00000346855.3
 UBE2E1
 ubiquitin-conjugating enzyme E2E 1
chr10_-_81320151 0.02 ENST00000372325.2
ENST00000372327.5
ENST00000417041.1
 SFTPA2
 surfactant protein A2
chr11_+_76813886 0.02 ENST00000529803.1
 OMP
 olfactory marker protein
chr11_-_108464465 0.02 ENST00000525344.1
 EXPH5
 exophilin 5
chr2_-_27545431 0.02 ENST00000233545.2
 MPV17
 MpV17 mitochondrial inner membrane protein
chr2_+_136289030 0.02 ENST00000409478.1
ENST00000264160.4
ENST00000329971.3
ENST00000438014.1
 R3HDM1
 R3H domain containing 1
chr17_+_27055798 0.02 ENST00000268766.6
 NEK8
 NIMA-related kinase 8
chr9_+_116263639 0.02 ENST00000343817.5
 RGS3
 regulator of G-protein signaling 3
chr3_+_108321623 0.02 ENST00000497905.1
ENST00000463306.1
 DZIP3
 DAZ interacting zinc finger protein 3
chr12_+_4918342 0.01 ENST00000280684.3
ENST00000433855.1
 KCNA6
 potassium voltage-gated channel, shaker-related subfamily, member 6
chr14_+_22963806 0.01 ENST00000390493.1
 TRAJ44
 T cell receptor alpha joining 44
chr5_+_74062806 0.01 ENST00000296802.5
 NSA2
 NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr7_+_129906660 0.01 ENST00000222481.4
 CPA2
 carboxypeptidase A2 (pancreatic)
chrX_-_49041242 0.01 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
 PRICKLE3
 prickle homolog 3 (Drosophila)
chr12_+_123717458 0.01 ENST00000253233.1
 C12orf65
 chromosome 12 open reading frame 65
chr16_+_69458537 0.01 ENST00000515314.1
ENST00000561792.1
ENST00000568237.1
 CYB5B
 cytochrome b5 type B (outer mitochondrial membrane)
chrX_+_86772787 0.01 ENST00000373114.4
 KLHL4
 kelch-like family member 4
chr14_+_81421355 0.01 ENST00000541158.2
 TSHR
 thyroid stimulating hormone receptor
chr1_-_149982624 0.01 ENST00000417191.1
ENST00000369135.4
 OTUD7B
 OTU domain containing 7B
chr14_+_81421861 0.01 ENST00000298171.2
 TSHR
 thyroid stimulating hormone receptor
chr2_+_48541776 0.01 ENST00000413569.1
ENST00000340553.3
 FOXN2
 forkhead box N2
chr1_-_23520755 0.01 ENST00000314113.3
 HTR1D
 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
chr17_-_15244894 0.00 ENST00000338696.2
ENST00000543896.1
ENST00000539245.1
ENST00000539316.1
ENST00000395930.1
 TEKT3
 tektin 3
chr12_-_123717643 0.00 ENST00000541437.1
ENST00000606320.1
 MPHOSPH9
 M-phase phosphoprotein 9
chrY_+_16634483 0.00 ENST00000382872.1
 NLGN4Y
 neuroligin 4, Y-linked
chr14_+_81421921 0.00 ENST00000554263.1
ENST00000554435.1
 TSHR
 thyroid stimulating hormone receptor
chr7_+_130020180 0.00 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
 CPA1
 carboxypeptidase A1 (pancreatic)
chr5_-_74062930 0.00 ENST00000509430.1
ENST00000345239.2
ENST00000427854.2
ENST00000506778.1
 GFM2
 G elongation factor, mitochondrial 2

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.5 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 0.4 GO:0052842 endopolyphosphatase activity(GO:0000298) diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) bis(5'-adenosyl)-hexaphosphatase activity(GO:0034431) bis(5'-adenosyl)-pentaphosphatase activity(GO:0034432) inositol diphosphate tetrakisphosphate diphosphatase activity(GO:0052840) inositol bisdiphosphate tetrakisphosphate diphosphatase activity(GO:0052841) inositol diphosphate pentakisphosphate diphosphatase activity(GO:0052842) inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity(GO:0052843) inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity(GO:0052844) inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity(GO:0052845) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity(GO:0052846) inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052847) inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity(GO:0052848)
0.1 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 0.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.6 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.2 GO:0050613 delta14-sterol reductase activity(GO:0050613)
0.1 0.3 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.3 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.0 0.4 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.0 1.8 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.1 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.5 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.0 0.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.2 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.0 0.1 GO:0097603 temperature-gated ion channel activity(GO:0097603)
0.0 0.1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0 0.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.1 GO:0047298 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)
0.0 0.1 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.2 GO:0031432 titin binding(GO:0031432)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 0.1 GO:0015057 thrombin receptor activity(GO:0015057)
0.0 0.0 GO:0010698 acetyltransferase activator activity(GO:0010698)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0030893 meiotic cohesin complex(GO:0030893)
0.1 1.0 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 0.2 GO:0097134 Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134)
0.1 0.3 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.6 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.8 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 0.2 GO:0070652 HAUS complex(GO:0070652)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.1 GO:0032144 4-aminobutyrate transaminase complex(GO:0032144)
0.0 0.1 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 0.6 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.2 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.7 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 1.1 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.4 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.1 0.5 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.1 0.4 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.1 0.3 GO:1904884 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.1 1.4 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 0.4 GO:1901910 diadenosine polyphosphate catabolic process(GO:0015961) diphosphoinositol polyphosphate metabolic process(GO:0071543) diadenosine pentaphosphate metabolic process(GO:1901906) diadenosine pentaphosphate catabolic process(GO:1901907) diadenosine hexaphosphate metabolic process(GO:1901908) diadenosine hexaphosphate catabolic process(GO:1901909) adenosine 5'-(hexahydrogen pentaphosphate) metabolic process(GO:1901910) adenosine 5'-(hexahydrogen pentaphosphate) catabolic process(GO:1901911)
0.1 0.2 GO:0090234 regulation of kinetochore assembly(GO:0090234)
0.1 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0 0.2 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.0 0.2 GO:0032049 cardiolipin biosynthetic process(GO:0032049)
0.0 0.3 GO:0014718 regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) positive regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014718) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.0 0.5 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.1 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.0 0.1 GO:0050960 detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.0 0.2 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0 0.1 GO:0050957 equilibrioception(GO:0050957)
0.0 1.8 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0002803 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
0.0 0.5 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 0.1 GO:0035995 detection of muscle stretch(GO:0035995)
0.0 0.1 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.3 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.3 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.1 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.0 0.4 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.1 GO:1904448 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.2 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.0 0.3 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.1 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.1 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.0 0.2 GO:0006089 lactate metabolic process(GO:0006089)
0.0 0.8 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.4 GO:0016601 Rac protein signal transduction(GO:0016601)