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ENCODE cell lines, expression (Ernst 2011)

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Results for NKX6-2

Z-value: 0.84

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Transcription factors associated with NKX6-2

Gene Symbol Gene ID Gene Info
NKX6-2
ENSG00000148826.6 NKX6-2

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_79816965 2.56 ENST00000464233.1
 ROBO1
 roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr2_-_238322800 1.56 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
 COL6A3
 collagen, type VI, alpha 3
chr5_-_111091948 1.42 ENST00000447165.2
 NREP
 neuronal regeneration related protein
chr2_-_238323007 1.34 ENST00000295550.4
 COL6A3
 collagen, type VI, alpha 3
chr14_-_25479811 1.30 ENST00000550887.1
 STXBP6
 syntaxin binding protein 6 (amisyn)
chr4_+_41258786 1.28 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
 UCHL1
 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr6_+_114178512 1.25 ENST00000368635.4
 MARCKS
 myristoylated alanine-rich protein kinase C substrate
chr8_+_97597148 1.22 ENST00000521590.1
 SDC2
 syndecan 2
chr2_-_175712270 0.83 ENST00000295497.7
ENST00000444394.1
 CHN1
 chimerin 1
chr13_-_33760216 0.76 ENST00000255486.4
 STARD13
 StAR-related lipid transfer (START) domain containing 13
chr3_-_114790179 0.74 ENST00000462705.1
 ZBTB20
 zinc finger and BTB domain containing 20
chrX_+_135230712 0.73 ENST00000535737.1
 FHL1
 four and a half LIM domains 1
chr4_+_88896819 0.72 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
 SPP1
 secreted phosphoprotein 1
chr5_+_95066823 0.71 ENST00000506817.1
ENST00000379982.3
 RHOBTB3
 Rho-related BTB domain containing 3
chr7_+_150065278 0.71 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
 REPIN1
 replication initiator 1
chr4_+_55095264 0.69 ENST00000257290.5
 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
chr1_+_210501589 0.68 ENST00000413764.2
ENST00000541565.1
 HHAT
 hedgehog acyltransferase
chr4_+_74269956 0.67 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
 ALB
 albumin
chr2_-_217560248 0.65 ENST00000233813.4
 IGFBP5
 insulin-like growth factor binding protein 5
chr11_+_7618413 0.63 ENST00000528883.1
 PPFIBP2
 PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr18_-_10701979 0.62 ENST00000538948.1
ENST00000285141.4
 PIEZO2
 piezo-type mechanosensitive ion channel component 2
chrX_+_102840408 0.62 ENST00000468024.1
ENST00000472484.1
ENST00000415568.2
ENST00000490644.1
ENST00000459722.1
ENST00000472745.1
ENST00000494801.1
ENST00000434216.2
ENST00000425011.1
 TCEAL4
 transcription elongation factor A (SII)-like 4
chr6_-_131277510 0.58 ENST00000525193.1
ENST00000527659.1
 EPB41L2
 erythrocyte membrane protein band 4.1-like 2
chr1_+_79115503 0.56 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44
 interferon-induced protein 44
chr1_-_109935819 0.55 ENST00000538502.1
 SORT1
 sortilin 1
chr4_+_100495864 0.50 ENST00000265517.5
ENST00000422897.2
 MTTP
 microsomal triglyceride transfer protein
chr16_+_14841923 0.45 ENST00000530328.1
ENST00000529166.1
 NPIPA2
 nuclear pore complex interacting protein family, member A2
chr5_+_155753745 0.44 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
 SGCD
 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
chr12_+_25205568 0.41 ENST00000548766.1
ENST00000556887.1
 LRMP
 lymphoid-restricted membrane protein
chr4_-_110723194 0.41 ENST00000394635.3
 CFI
 complement factor I
chrX_+_105937068 0.40 ENST00000324342.3
 RNF128
 ring finger protein 128, E3 ubiquitin protein ligase
chr9_+_82186872 0.40 ENST00000376544.3
ENST00000376520.4
 TLE4
 transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr10_-_63995871 0.39 ENST00000315289.2
 RTKN2
 rhotekin 2
chr4_-_23891693 0.38 ENST00000264867.2
 PPARGC1A
 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr1_-_221915418 0.38 ENST00000323825.3
ENST00000366899.3
 DUSP10
 dual specificity phosphatase 10
chr6_+_41021027 0.37 ENST00000244669.2
 APOBEC2
 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
chr16_+_14802801 0.36 ENST00000526520.1
ENST00000531598.2
 NPIPA3
 nuclear pore complex interacting protein family, member A3
chr18_+_13218769 0.36 ENST00000399848.3
ENST00000361205.4
 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
chr3_-_98241358 0.35 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
 CLDND1
 claudin domain containing 1
chr1_+_70820451 0.35 ENST00000361764.4
ENST00000359875.5
ENST00000370940.5
ENST00000531950.1
ENST00000432224.1
 HHLA3
 HERV-H LTR-associating 3
chr18_+_76829441 0.35 ENST00000458297.2
 ATP9B
 ATPase, class II, type 9B
chrX_+_68835911 0.35 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
 EDA
 ectodysplasin A
chr2_+_211342432 0.34 ENST00000430249.2
 CPS1
 carbamoyl-phosphate synthase 1, mitochondrial
chr3_+_178276488 0.33 ENST00000432997.1
ENST00000455865.1
 KCNMB2
 potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr16_+_31271274 0.32 ENST00000287497.8
ENST00000544665.3
 ITGAM
 integrin, alpha M (complement component 3 receptor 3 subunit)
chr20_+_30697298 0.31 ENST00000398022.2
 TM9SF4
 transmembrane 9 superfamily protein member 4
chr7_-_137028498 0.29 ENST00000393083.2
 PTN
 pleiotrophin
chr1_+_229440129 0.29 ENST00000366688.3
 SPHAR
 S-phase response (cyclin related)
chr7_-_137028534 0.29 ENST00000348225.2
 PTN
 pleiotrophin
chr22_+_29138013 0.25 ENST00000216027.3
ENST00000398941.2
 HSCB
 HscB mitochondrial iron-sulfur cluster co-chaperone
chr8_-_57123815 0.25 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
 PLAG1
 pleiomorphic adenoma gene 1
chr1_-_21377447 0.25 ENST00000374937.3
ENST00000264211.8
 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
chr17_+_72581057 0.25 ENST00000392620.1
 C17orf77
 chromosome 17 open reading frame 77
chr9_+_116263778 0.25 ENST00000394646.3
 RGS3
 regulator of G-protein signaling 3
chr9_-_23826298 0.24 ENST00000380117.1
 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
chr10_-_73848086 0.23 ENST00000536168.1
 SPOCK2
 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr7_-_22233442 0.23 ENST00000401957.2
 RAPGEF5
 Rap guanine nucleotide exchange factor (GEF) 5
chr1_+_174670143 0.22 ENST00000367687.1
ENST00000347255.2
 RABGAP1L
 RAB GTPase activating protein 1-like
chr2_+_207024306 0.22 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
 EEF1B2
 eukaryotic translation elongation factor 1 beta 2
chr6_+_42749759 0.21 ENST00000314073.5
 GLTSCR1L
 GLTSCR1-like
chr5_+_31193847 0.21 ENST00000514738.1
ENST00000265071.2
 CDH6
 cadherin 6, type 2, K-cadherin (fetal kidney)
chr1_-_150738261 0.21 ENST00000448301.2
ENST00000368985.3
 CTSS
 cathepsin S
chr1_+_174933899 0.20 ENST00000367688.3
 RABGAP1L
 RAB GTPase activating protein 1-like
chr3_+_52245458 0.20 ENST00000459884.1
 ALAS1
 aminolevulinate, delta-, synthase 1
chr18_+_76829385 0.20 ENST00000426216.2
ENST00000307671.7
ENST00000586672.1
ENST00000586722.1
 ATP9B
 ATPase, class II, type 9B
chrX_+_55744228 0.20 ENST00000262850.7
 RRAGB
 Ras-related GTP binding B
chr1_+_209878182 0.20 ENST00000367027.3
 HSD11B1
 hydroxysteroid (11-beta) dehydrogenase 1
chr8_-_103876965 0.19 ENST00000337198.5
 AZIN1
 antizyme inhibitor 1
chr9_-_110540419 0.19 ENST00000398726.3
 AL162389.1
 Uncharacterized protein
chr9_-_23825956 0.19 ENST00000397312.2
 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
chr18_+_61575200 0.18 ENST00000238508.3
 SERPINB10
 serpin peptidase inhibitor, clade B (ovalbumin), member 10
chr7_-_37024665 0.17 ENST00000396040.2
 ELMO1
 engulfment and cell motility 1
chr19_+_52772832 0.17 ENST00000593703.1
ENST00000601711.1
ENST00000599581.1
 ZNF766
 zinc finger protein 766
chr4_+_169418255 0.17 ENST00000505667.1
ENST00000511948.1
 PALLD
 palladin, cytoskeletal associated protein
chr1_-_110933611 0.17 ENST00000472422.2
ENST00000437429.2
 SLC16A4
 solute carrier family 16, member 4
chr20_-_18477862 0.16 ENST00000337227.4
 RBBP9
 retinoblastoma binding protein 9
chrX_+_55744166 0.16 ENST00000374941.4
ENST00000414239.1
 RRAGB
 Ras-related GTP binding B
chr1_-_110933663 0.16 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
 SLC16A4
 solute carrier family 16, member 4
chr2_-_217559517 0.16 ENST00000449583.1
 IGFBP5
 insulin-like growth factor binding protein 5
chrX_-_48901012 0.16 ENST00000315869.7
 TFE3
 transcription factor binding to IGHM enhancer 3
chr6_+_25963020 0.16 ENST00000357085.3
 TRIM38
 tripartite motif containing 38
chr5_+_161275320 0.16 ENST00000437025.2
 GABRA1
 gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr17_-_56494882 0.15 ENST00000584437.1
 RNF43
 ring finger protein 43
chr10_-_100995603 0.15 ENST00000370552.3
ENST00000370549.1
 HPSE2
 heparanase 2
chr4_+_71337834 0.14 ENST00000304887.5
 MUC7
 mucin 7, secreted
chr14_-_60097524 0.14 ENST00000342503.4
 RTN1
 reticulon 1
chr12_-_76462713 0.14 ENST00000552056.1
 NAP1L1
 nucleosome assembly protein 1-like 1
chr17_-_56494908 0.13 ENST00000577716.1
 RNF43
 ring finger protein 43
chr14_-_60097297 0.13 ENST00000395090.1
 RTN1
 reticulon 1
chr22_+_24198890 0.13 ENST00000345044.6
 SLC2A11
 solute carrier family 2 (facilitated glucose transporter), member 11
chr16_+_25228242 0.13 ENST00000219660.5
 AQP8
 aquaporin 8
chr3_-_45838011 0.13 ENST00000358525.4
ENST00000413781.1
 SLC6A20
 solute carrier family 6 (proline IMINO transporter), member 20
chr7_+_16828866 0.13 ENST00000597084.1
 AC073333.1
 Uncharacterized protein
chr22_-_39268308 0.13 ENST00000407418.3
 CBX6
 chromobox homolog 6
chr13_+_97928395 0.12 ENST00000445661.2
 MBNL2
 muscleblind-like splicing regulator 2
chr20_+_42136308 0.12 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
 L3MBTL1
 l(3)mbt-like 1 (Drosophila)
chr1_-_49242553 0.12 ENST00000371833.3
 BEND5
 BEN domain containing 5
chr17_-_7307358 0.11 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
 TMEM256
TMEM256-PLSCR3
 transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr2_-_207024134 0.11 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
 NDUFS1
 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr6_+_158733692 0.11 ENST00000367094.2
ENST00000367097.3
 TULP4
 tubby like protein 4
chr3_+_39509163 0.11 ENST00000436143.2
ENST00000441980.2
ENST00000311042.6
 MOBP
 myelin-associated oligodendrocyte basic protein
chr1_+_50459990 0.10 ENST00000448346.1
 AL645730.2
 AL645730.2
chr6_+_31582961 0.10 ENST00000376059.3
ENST00000337917.7
 AIF1
 allograft inflammatory factor 1
chr2_+_233527443 0.10 ENST00000410095.1
 EFHD1
 EF-hand domain family, member D1
chr2_-_136678123 0.10 ENST00000422708.1
 DARS
 aspartyl-tRNA synthetase
chr17_-_56494713 0.09 ENST00000407977.2
 RNF43
 ring finger protein 43
chr5_-_88119580 0.09 ENST00000539796.1
 MEF2C
 myocyte enhancer factor 2C
chr5_+_161274940 0.09 ENST00000393943.4
 GABRA1
 gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr15_+_49715293 0.09 ENST00000267843.4
ENST00000560270.1
 FGF7
 fibroblast growth factor 7
chr2_-_207023918 0.09 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
 NDUFS1
 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr21_-_27462351 0.09 ENST00000448850.1
 APP
 amyloid beta (A4) precursor protein
chr10_-_100995540 0.09 ENST00000370546.1
ENST00000404542.1
 HPSE2
 heparanase 2
chr1_+_115397424 0.09 ENST00000369522.3
ENST00000455987.1
 SYCP1
 synaptonemal complex protein 1
chr7_+_138943265 0.09 ENST00000483726.1
 UBN2
 ubinuclein 2
chr7_-_102283238 0.09 ENST00000340457.8
 UPK3BL
 uroplakin 3B-like
chr5_-_20575959 0.08 ENST00000507958.1
 CDH18
 cadherin 18, type 2
chr3_-_45837959 0.08 ENST00000353278.4
ENST00000456124.2
 SLC6A20
 solute carrier family 6 (proline IMINO transporter), member 20
chr10_+_48189612 0.08 ENST00000453919.1
 AGAP9
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 9
chr22_-_39268192 0.08 ENST00000216083.6
 CBX6
 chromobox homolog 6
chr15_-_49103184 0.08 ENST00000399334.3
ENST00000325747.5
 CEP152
 centrosomal protein 152kDa
chr14_-_98444386 0.08 ENST00000556462.1
ENST00000556138.1
 C14orf64
 chromosome 14 open reading frame 64
chr6_+_26402465 0.07 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
 BTN3A1
 butyrophilin, subfamily 3, member A1
chr18_+_32290218 0.07 ENST00000348997.5
ENST00000588949.1
ENST00000597599.1
 DTNA
 dystrobrevin, alpha
chr4_+_169418195 0.07 ENST00000261509.6
ENST00000335742.7
 PALLD
 palladin, cytoskeletal associated protein
chr2_-_207024233 0.07 ENST00000423725.1
ENST00000233190.6
 NDUFS1
 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr2_-_74570520 0.06 ENST00000394019.2
ENST00000346834.4
ENST00000359484.4
ENST00000423644.1
ENST00000377634.4
ENST00000436454.1
 SLC4A5
 solute carrier family 4 (sodium bicarbonate cotransporter), member 5
chr1_+_32379174 0.06 ENST00000391369.1
 AL136115.1
 HCG2032337; PRO1848; Uncharacterized protein
chr10_-_115904361 0.06 ENST00000428953.1
ENST00000543782.1
 C10orf118
 chromosome 10 open reading frame 118
chr5_+_67586465 0.06 ENST00000336483.5
 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_226926864 0.06 ENST00000429204.1
ENST00000366784.1
 ITPKB
 inositol-trisphosphate 3-kinase B
chr4_+_169013666 0.05 ENST00000359299.3
 ANXA10
 annexin A10
chr7_-_102184083 0.05 ENST00000379357.5
 POLR2J3
 polymerase (RNA) II (DNA directed) polypeptide J3
chr19_+_54641444 0.05 ENST00000221232.5
ENST00000358389.3
 CNOT3
 CCR4-NOT transcription complex, subunit 3
chr4_-_87374283 0.05 ENST00000361569.2
 MAPK10
 mitogen-activated protein kinase 10
chr17_-_42992856 0.05 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
 GFAP
 glial fibrillary acidic protein
chr12_+_122241928 0.04 ENST00000604567.1
ENST00000542440.1
 SETD1B
 SET domain containing 1B
chr5_+_161274685 0.04 ENST00000428797.2
 GABRA1
 gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr14_+_72399833 0.04 ENST00000553530.1
ENST00000556437.1
 RGS6
 regulator of G-protein signaling 6
chr18_-_47018769 0.03 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
 RPL17
 ribosomal protein L17
chr3_+_39509070 0.03 ENST00000354668.4
ENST00000428261.1
ENST00000420739.1
ENST00000415443.1
ENST00000447324.1
ENST00000383754.3
 MOBP
 myelin-associated oligodendrocyte basic protein
chr8_+_79428539 0.03 ENST00000352966.5
 PKIA
 protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr16_+_21610879 0.03 ENST00000396014.4
 METTL9
 methyltransferase like 9
chr10_+_26505179 0.02 ENST00000376261.3
 GAD2
 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr6_-_64029879 0.02 ENST00000370658.5
ENST00000485906.2
ENST00000370657.4
 LGSN
 lengsin, lens protein with glutamine synthetase domain
chr5_-_58295712 0.02 ENST00000317118.8
 PDE4D
 phosphodiesterase 4D, cAMP-specific
chr6_-_74231444 0.02 ENST00000331523.2
ENST00000356303.2
 EEF1A1
 eukaryotic translation elongation factor 1 alpha 1
chr16_+_31128978 0.02 ENST00000448516.2
ENST00000219797.4
 KAT8
 K(lysine) acetyltransferase 8
chr15_+_79166065 0.01 ENST00000559690.1
ENST00000559158.1
 MORF4L1
 mortality factor 4 like 1
chr2_+_218990727 0.01 ENST00000318507.2
ENST00000454148.1
 CXCR2
 chemokine (C-X-C motif) receptor 2
chr17_-_73663245 0.01 ENST00000584999.1
ENST00000317905.5
ENST00000420326.2
ENST00000340830.5
 RECQL5
 RecQ protein-like 5
chr6_-_26043885 0.01 ENST00000357905.2
 HIST1H2BB
 histone cluster 1, H2bb
chr5_+_7373230 0.01 ENST00000500616.2
 CTD-2296D1.5
 CTD-2296D1.5
chr1_+_196621002 0.01 ENST00000367429.4
ENST00000439155.2
 CFH
 complement factor H
chr2_+_68962014 0.01 ENST00000467265.1
 ARHGAP25
 Rho GTPase activating protein 25
chr19_+_12175504 0.01 ENST00000439326.3
 ZNF844
 zinc finger protein 844
chr17_+_57232690 0.00 ENST00000262293.4
 PRR11
 proline rich 11
chr12_-_53045948 0.00 ENST00000309680.3
 KRT2
 keratin 2
chr15_-_89764929 0.00 ENST00000268125.5
 RLBP1
 retinaldehyde binding protein 1

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 2.9 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.8 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 1.3 GO:0043073 germ cell nucleus(GO:0043073)
0.1 0.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.1 0.4 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.3 GO:0000145 exocyst(GO:0000145)
0.1 0.4 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 0.7 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1 0.3 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.1 GO:0097679 other organism cytoplasm(GO:0097679)
0.0 0.6 GO:0008091 spectrin(GO:0008091)
0.0 0.2 GO:0036021 endolysosome lumen(GO:0036021)
0.0 1.3 GO:1904115 axon cytoplasm(GO:1904115)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0097440 apical dendrite(GO:0097440)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.1 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.9 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 2.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 0.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.0 PID FGF PATHWAY FGF signaling pathway
0.0 1.0 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.4 1.3 GO:0007412 axon target recognition(GO:0007412)
0.3 0.8 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.2 0.7 GO:2000861 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.2 0.7 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.2 0.7 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.2 0.6 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.2 1.2 GO:0008218 bioluminescence(GO:0008218)
0.2 1.3 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 0.8 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.1 0.4 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) regulation of progesterone biosynthetic process(GO:2000182)
0.1 0.4 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.1 0.4 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1 0.3 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 0.4 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 0.4 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.1 1.3 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.3 GO:0019856 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) response to oleic acid(GO:0034201)
0.1 0.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.2 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.1 GO:0060437 lung growth(GO:0060437)
0.0 0.4 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.0 0.3 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.7 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.6 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.5 GO:0034379 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) chylomicron assembly(GO:0034378) very-low-density lipoprotein particle assembly(GO:0034379)
0.0 3.1 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.2 GO:0015824 proline transport(GO:0015824)
0.0 0.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.6 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.0 0.3 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.8 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.1 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.0 0.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.1 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
0.0 0.6 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.1 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.3 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.2 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.3 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 0.3 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.7 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.7 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.4 GO:0048738 cardiac muscle tissue development(GO:0048738)
0.0 0.1 GO:0033326 cerebrospinal fluid secretion(GO:0033326)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.6 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 1.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.2 0.7 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 0.3 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.1 0.5 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 0.6 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.8 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 1.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.2 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 0.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.2 GO:0030305 heparanase activity(GO:0030305)
0.1 0.6 GO:0042731 PH domain binding(GO:0042731)
0.1 0.4 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.7 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.1 GO:0032093 SAM domain binding(GO:0032093)
0.0 0.3 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.3 GO:0001851 complement component C3b binding(GO:0001851)
0.0 3.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.2 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.0 0.4 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.7 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) mitogen-activated protein kinase p38 binding(GO:0048273)
0.0 0.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.3 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.1 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.5 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 1.1 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 1.3 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.3 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.3 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)