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ENCODE cell lines, expression (Ernst 2011)

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Results for NKX6-3

Z-value: 0.51

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
ENSG00000165066.11 NKX6-3

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_64225508 1.14 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr18_+_32558208 0.97 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr11_+_22689648 0.85 ENST00000278187.3
GAS2
growth arrest-specific 2
chr7_+_138145076 0.84 ENST00000343526.4
TRIM24
tripartite motif containing 24
chrX_-_130423200 0.59 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chr20_-_33735070 0.57 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr4_+_80584903 0.53 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr1_-_151431647 0.46 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr1_-_151431909 0.42 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chrX_+_43515467 0.36 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr20_+_30697298 0.35 ENST00000398022.2
TM9SF4
transmembrane 9 superfamily protein member 4
chr3_-_141747950 0.32 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_-_25268104 0.32 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr19_+_50016610 0.21 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr15_+_93443419 0.19 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr16_-_67517716 0.18 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr2_+_234826016 0.18 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chrX_-_110655306 0.17 ENST00000371993.2
DCX
doublecortin
chr5_-_58295712 0.15 ENST00000317118.8
PDE4D
phosphodiesterase 4D, cAMP-specific
chr17_-_10372875 0.14 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chrX_+_107288197 0.12 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_13517565 0.11 ENST00000282091.1
ENST00000529816.1
PTH
parathyroid hormone
chr14_-_51027838 0.10 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr12_-_52761262 0.09 ENST00000257901.3
KRT85
keratin 85
chr8_-_90769422 0.08 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr4_-_123542224 0.07 ENST00000264497.3
IL21
interleukin 21
chr19_+_4402659 0.07 ENST00000301280.5
ENST00000585854.1
CHAF1A
chromatin assembly factor 1, subunit A (p150)
chrX_+_107288239 0.07 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr3_+_138340049 0.05 ENST00000464668.1
FAIM
Fas apoptotic inhibitory molecule
chr8_+_77593448 0.05 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr10_+_18549645 0.04 ENST00000396576.2
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chrX_+_47696275 0.03 ENST00000376954.1
ENST00000338637.7
ZNF81
zinc finger protein 81
chr3_+_136649311 0.00 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.1 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.0 GO:0035371 microtubule plus-end(GO:0035371)
0.0 0.1 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.6 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.8 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.4 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.8 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.6 GO:0034711 inhibin binding(GO:0034711)
0.1 0.2 GO:0019770 IgG receptor activity(GO:0019770)
0.1 0.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.4 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.1 GO:0005134 interleukin-2 receptor binding(GO:0005134)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0036512 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1 0.8 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 1.1 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.1 0.9 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.2 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.1 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 0.3 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.3 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0 0.2 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 0.4 GO:0042420 dopamine catabolic process(GO:0042420)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)