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ENCODE cell lines, expression (Ernst 2011)

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Results for OSR1_OSR2

Z-value: 0.99

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Transcription factors associated with OSR1_OSR2

Gene Symbol Gene ID Gene Info
OSR1
ENSG00000143867.5 OSR1
OSR2
ENSG00000164920.5 OSR2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
OSR2hg19_v2_chr8_+_99956662_99956686-0.332.2e-01Click!

Activity profile of OSR1_OSR2 motif

Sorted Z-values of OSR1_OSR2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of OSR1_OSR2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_15114492 3.69 ENST00000541546.1
 ARHGDIB
 Rho GDP dissociation inhibitor (GDI) beta
chr12_-_15114603 3.33 ENST00000228945.4
 ARHGDIB
 Rho GDP dissociation inhibitor (GDI) beta
chr12_-_10251603 2.24 ENST00000457018.2
 CLEC1A
 C-type lectin domain family 1, member A
chr12_-_10251576 2.21 ENST00000315330.4
 CLEC1A
 C-type lectin domain family 1, member A
chr3_+_193853927 1.92 ENST00000232424.3
 HES1
 hes family bHLH transcription factor 1
chr10_+_97515409 1.90 ENST00000371207.3
ENST00000543964.1
 ENTPD1
 ectonucleoside triphosphate diphosphohydrolase 1
chr12_-_10251539 1.89 ENST00000420265.2
 CLEC1A
 C-type lectin domain family 1, member A
chr22_+_37309662 1.17 ENST00000403662.3
ENST00000262825.5
 CSF2RB
 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr4_+_39460659 1.08 ENST00000513731.1
 LIAS
 lipoic acid synthetase
chr4_+_39460689 1.01 ENST00000381846.1
 LIAS
 lipoic acid synthetase
chr2_-_88125471 0.89 ENST00000398146.3
 RGPD2
 RANBP2-like and GRIP domain containing 2
chr3_-_50360192 0.75 ENST00000442581.1
ENST00000447092.1
ENST00000357750.4
 HYAL2
 hyaluronoglucosaminidase 2
chr13_-_72441315 0.65 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
 DACH1
 dachshund homolog 1 (Drosophila)
chr15_-_80263506 0.64 ENST00000335661.6
 BCL2A1
 BCL2-related protein A1
chr1_-_59043166 0.62 ENST00000371225.2
 TACSTD2
 tumor-associated calcium signal transducer 2
chr3_-_58613323 0.57 ENST00000474531.1
ENST00000465970.1
 FAM107A
 family with sequence similarity 107, member A
chr1_-_25291475 0.54 ENST00000338888.3
ENST00000399916.1
 RUNX3
 runt-related transcription factor 3
chr7_-_144533074 0.50 ENST00000360057.3
ENST00000378099.3
 TPK1
 thiamin pyrophosphokinase 1
chr15_+_75491213 0.49 ENST00000360639.2
 C15orf39
 chromosome 15 open reading frame 39
chr12_+_27396901 0.45 ENST00000541191.1
ENST00000389032.3
 STK38L
 serine/threonine kinase 38 like
chr2_-_183387064 0.45 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr2_+_178257372 0.45 ENST00000264167.4
ENST00000409888.1
 AGPS
 alkylglycerone phosphate synthase
chr16_+_23690138 0.44 ENST00000300093.4
 PLK1
 polo-like kinase 1
chr3_+_45927994 0.41 ENST00000357632.2
ENST00000395963.2
 CCR9
 chemokine (C-C motif) receptor 9
chr4_+_146403912 0.41 ENST00000507367.1
ENST00000394092.2
ENST00000515385.1
 SMAD1
 SMAD family member 1
chr5_+_68463043 0.40 ENST00000508407.1
ENST00000505500.1
 CCNB1
 cyclin B1
chr2_-_183387283 0.40 ENST00000435564.1
 PDE1A
 phosphodiesterase 1A, calmodulin-dependent
chr4_+_128554081 0.39 ENST00000335251.6
ENST00000296461.5
 INTU
 inturned planar cell polarity protein
chr2_-_74007193 0.39 ENST00000377706.4
ENST00000443070.1
ENST00000272444.3
 DUSP11
 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
chr4_-_70080449 0.39 ENST00000446444.1
 UGT2B11
 UDP glucuronosyltransferase 2 family, polypeptide B11
chr5_+_68462837 0.36 ENST00000256442.5
 CCNB1
 cyclin B1
chr19_+_36203830 0.34 ENST00000262630.3
 ZBTB32
 zinc finger and BTB domain containing 32
chr1_+_159175201 0.33 ENST00000368121.2
 DARC
 Duffy blood group, atypical chemokine receptor
chr5_+_68462944 0.32 ENST00000506572.1
 CCNB1
 cyclin B1
chr22_-_42336209 0.32 ENST00000472374.2
 CENPM
 centromere protein M
chr11_+_64808675 0.32 ENST00000529996.1
 SAC3D1
 SAC3 domain containing 1
chr1_-_231560790 0.32 ENST00000366641.3
 EGLN1
 egl-9 family hypoxia-inducible factor 1
chr1_+_233749739 0.31 ENST00000366621.3
 KCNK1
 potassium channel, subfamily K, member 1
chr21_+_42733870 0.30 ENST00000330714.3
ENST00000436410.1
ENST00000435611.1
 MX2
 myxovirus (influenza virus) resistance 2 (mouse)
chr2_-_201828356 0.28 ENST00000234296.2
 ORC2
 origin recognition complex, subunit 2
chr17_-_46690839 0.27 ENST00000498634.2
 HOXB8
 homeobox B8
chr19_+_55591743 0.27 ENST00000588359.1
ENST00000245618.5
 EPS8L1
 EPS8-like 1
chr1_+_161736072 0.26 ENST00000367942.3
 ATF6
 activating transcription factor 6
chr21_+_43919710 0.26 ENST00000398341.3
 SLC37A1
 solute carrier family 37 (glucose-6-phosphate transporter), member 1
chr13_-_52703187 0.26 ENST00000355568.4
 NEK5
 NIMA-related kinase 5
chr7_-_95225768 0.26 ENST00000005178.5
 PDK4
 pyruvate dehydrogenase kinase, isozyme 4
chr4_-_186697044 0.24 ENST00000437304.2
 SORBS2
 sorbin and SH3 domain containing 2
chr17_-_72869086 0.24 ENST00000581530.1
ENST00000420580.2
ENST00000455107.2
ENST00000413947.2
ENST00000581219.1
ENST00000582944.1
 FDXR
 ferredoxin reductase
chr1_-_179112189 0.24 ENST00000512653.1
ENST00000344730.3
 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
chr15_-_43559055 0.23 ENST00000220420.5
ENST00000349114.4
 TGM5
 transglutaminase 5
chr5_+_169010638 0.23 ENST00000265295.4
ENST00000506574.1
ENST00000515224.1
ENST00000508247.1
ENST00000513941.1
 SPDL1
 spindle apparatus coiled-coil protein 1
chr8_-_125486755 0.22 ENST00000499418.2
ENST00000530778.1
 RNF139-AS1
 RNF139 antisense RNA 1 (head to head)
chr12_-_24102576 0.22 ENST00000537393.1
ENST00000309359.1
ENST00000381381.2
ENST00000451604.2
 SOX5
 SRY (sex determining region Y)-box 5
chr17_-_72869140 0.21 ENST00000583917.1
ENST00000293195.5
ENST00000442102.2
 FDXR
 ferredoxin reductase
chr1_-_179112173 0.21 ENST00000408940.3
ENST00000504405.1
 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
chr17_-_79895097 0.21 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
 PYCR1
 pyrroline-5-carboxylate reductase 1
chr14_+_65453432 0.20 ENST00000246166.2
 FNTB
 farnesyltransferase, CAAX box, beta
chr2_+_217277466 0.20 ENST00000358207.5
ENST00000434435.1
 SMARCAL1
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
chr17_-_79895154 0.19 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
 PYCR1
 pyrroline-5-carboxylate reductase 1
chr20_+_31407692 0.18 ENST00000375571.5
 MAPRE1
 microtubule-associated protein, RP/EB family, member 1
chrX_+_11776278 0.18 ENST00000312196.4
ENST00000337339.2
 MSL3
 male-specific lethal 3 homolog (Drosophila)
chr17_-_79894651 0.17 ENST00000584848.1
ENST00000577756.1
ENST00000329875.8
 PYCR1
 pyrroline-5-carboxylate reductase 1
chr2_-_148779106 0.17 ENST00000416719.1
ENST00000264169.2
 ORC4
 origin recognition complex, subunit 4
chr7_-_43769051 0.17 ENST00000395880.3
 COA1
 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
chr2_+_79412357 0.17 ENST00000466387.1
 CTNNA2
 catenin (cadherin-associated protein), alpha 2
chr7_-_43769066 0.17 ENST00000223336.6
ENST00000310564.6
ENST00000431651.1
ENST00000415798.1
 COA1
 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
chr14_+_56127989 0.16 ENST00000555573.1
 KTN1
 kinectin 1 (kinesin receptor)
chr22_-_23974506 0.16 ENST00000317749.5
 C22orf43
 chromosome 22 open reading frame 43
chr6_+_152011628 0.15 ENST00000404742.1
ENST00000440973.1
 ESR1
 estrogen receptor 1
chr1_+_201798269 0.15 ENST00000361565.4
 IPO9
 importin 9
chr4_+_151503077 0.15 ENST00000317605.4
 MAB21L2
 mab-21-like 2 (C. elegans)
chr11_+_65407331 0.15 ENST00000527525.1
 SIPA1
 signal-induced proliferation-associated 1
chr19_+_19303008 0.14 ENST00000353145.1
ENST00000421262.3
ENST00000303088.4
ENST00000456252.3
ENST00000593273.1
 RFXANK
 regulatory factor X-associated ankyrin-containing protein
chr15_-_66649010 0.14 ENST00000367709.4
ENST00000261881.4
 TIPIN
 TIMELESS interacting protein
chr9_+_37650945 0.14 ENST00000377765.3
 FRMPD1
 FERM and PDZ domain containing 1
chr7_-_123197733 0.14 ENST00000470123.1
ENST00000471770.1
 NDUFA5
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
chr12_-_123201337 0.14 ENST00000528880.2
 HCAR3
 hydroxycarboxylic acid receptor 3
chr1_-_156722015 0.13 ENST00000368209.5
 HDGF
 hepatoma-derived growth factor
chr3_+_149192475 0.13 ENST00000465758.1
 TM4SF4
 transmembrane 4 L six family member 4
chr9_+_36572851 0.13 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
 MELK
 maternal embryonic leucine zipper kinase
chr17_-_33864772 0.13 ENST00000361112.4
 SLFN12L
 schlafen family member 12-like
chr10_-_43904608 0.12 ENST00000337970.3
 HNRNPF
 heterogeneous nuclear ribonucleoprotein F
chr13_+_53226963 0.12 ENST00000343788.6
ENST00000535397.1
ENST00000310528.8
 SUGT1
 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chr21_+_40752170 0.12 ENST00000333781.5
ENST00000541890.1
 WRB
 tryptophan rich basic protein
chr15_+_66161871 0.12 ENST00000569896.1
 RAB11A
 RAB11A, member RAS oncogene family
chr17_+_40714092 0.12 ENST00000420359.1
ENST00000449624.1
ENST00000585811.1
ENST00000585909.1
ENST00000586771.1
ENST00000421097.2
ENST00000591779.1
ENST00000587858.1
ENST00000587214.1
ENST00000587157.1
ENST00000590958.1
ENST00000393818.2
 COASY
 CoA synthase
chr22_+_32870661 0.11 ENST00000266087.7
 FBXO7
 F-box protein 7
chr3_+_179322481 0.11 ENST00000259037.3
 NDUFB5
 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
chr2_-_37458749 0.10 ENST00000234170.5
 CEBPZ
 CCAAT/enhancer binding protein (C/EBP), zeta
chr2_+_70056762 0.10 ENST00000282570.3
 GMCL1
 germ cell-less, spermatogenesis associated 1
chr4_-_186696425 0.10 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
 SORBS2
 sorbin and SH3 domain containing 2
chr22_-_26986045 0.10 ENST00000442495.1
ENST00000440953.1
ENST00000450022.1
ENST00000338754.4
 TPST2
 tyrosylprotein sulfotransferase 2
chr15_-_51397473 0.09 ENST00000327536.5
 TNFAIP8L3
 tumor necrosis factor, alpha-induced protein 8-like 3
chr10_-_48390973 0.09 ENST00000224600.4
 RBP3
 retinol binding protein 3, interstitial
chr12_-_101604185 0.09 ENST00000536262.2
 SLC5A8
 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr12_-_50419177 0.09 ENST00000454520.2
ENST00000546595.1
ENST00000548824.1
ENST00000549777.1
ENST00000546723.1
ENST00000427314.2
ENST00000552157.1
ENST00000552310.1
ENST00000548644.1
ENST00000312377.5
ENST00000546786.1
ENST00000550149.1
ENST00000546764.1
ENST00000552004.1
ENST00000548320.1
ENST00000547905.1
ENST00000550651.1
ENST00000551145.1
ENST00000434422.1
ENST00000552921.1
 RACGAP1
 Rac GTPase activating protein 1
chr15_+_66161802 0.08 ENST00000566233.1
ENST00000565075.1
ENST00000435304.2
 RAB11A
 RAB11A, member RAS oncogene family
chr9_+_33025209 0.08 ENST00000330899.4
ENST00000544625.1
 DNAJA1
 DnaJ (Hsp40) homolog, subfamily A, member 1
chr1_-_32860020 0.08 ENST00000527163.1
ENST00000341071.7
ENST00000530485.1
ENST00000446293.2
ENST00000413080.1
ENST00000449308.1
ENST00000526031.1
ENST00000419121.2
ENST00000455895.2
 BSDC1
 BSD domain containing 1
chr22_-_45559642 0.08 ENST00000426282.2
 CTA-217C2.1
 CTA-217C2.1
chrX_-_15333736 0.08 ENST00000380470.3
 ASB11
 ankyrin repeat and SOCS box containing 11
chr12_-_58165870 0.08 ENST00000257848.7
 METTL1
 methyltransferase like 1
chr21_-_34915147 0.07 ENST00000381831.3
ENST00000381839.3
 GART
 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr20_-_1472029 0.07 ENST00000359801.3
 SIRPB2
 signal-regulatory protein beta 2
chr2_+_37458776 0.07 ENST00000002125.4
ENST00000336237.6
ENST00000431821.1
 NDUFAF7
 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
chr6_+_122720681 0.07 ENST00000368455.4
ENST00000452194.1
 HSF2
 heat shock transcription factor 2
chr6_+_32938665 0.07 ENST00000374831.4
ENST00000395289.2
 BRD2
 bromodomain containing 2
chr15_-_42076229 0.07 ENST00000597767.1
 AC073657.1
 Uncharacterized protein
chr4_+_69681710 0.07 ENST00000265403.7
ENST00000458688.2
 UGT2B10
 UDP glucuronosyltransferase 2 family, polypeptide B10
chr6_+_10585979 0.07 ENST00000265012.4
 GCNT2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr12_-_123187890 0.06 ENST00000328880.5
 HCAR2
 hydroxycarboxylic acid receptor 2
chr19_-_13068012 0.06 ENST00000316939.1
 GADD45GIP1
 growth arrest and DNA-damage-inducible, gamma interacting protein 1
chr22_+_42017280 0.06 ENST00000402580.3
ENST00000428575.2
ENST00000359308.4
 XRCC6
 X-ray repair complementing defective repair in Chinese hamster cells 6
chr15_+_74422585 0.06 ENST00000561740.1
ENST00000435464.1
ENST00000453268.2
 ISLR2
 immunoglobulin superfamily containing leucine-rich repeat 2
chr14_+_93651296 0.06 ENST00000283534.4
ENST00000557574.1
 TMEM251
RP11-371E8.4
 transmembrane protein 251
Uncharacterized protein
chr13_+_97874574 0.06 ENST00000343600.4
ENST00000345429.6
ENST00000376673.3
 MBNL2
 muscleblind-like splicing regulator 2
chr22_+_42017459 0.05 ENST00000405878.1
 XRCC6
 X-ray repair complementing defective repair in Chinese hamster cells 6
chr19_+_39989535 0.05 ENST00000356433.5
 DLL3
 delta-like 3 (Drosophila)
chr22_+_41763274 0.05 ENST00000406644.3
 TEF
 thyrotrophic embryonic factor
chr5_-_140053152 0.04 ENST00000542735.1
 DND1
 DND microRNA-mediated repression inhibitor 1
chr7_+_123565286 0.04 ENST00000402183.2
ENST00000413927.1
ENST00000460182.1
ENST00000340011.5
 SPAM1
 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
chr2_-_241500447 0.04 ENST00000536462.1
ENST00000405002.1
ENST00000441168.1
ENST00000403283.1
 ANKMY1
 ankyrin repeat and MYND domain containing 1
chr18_-_40695604 0.04 ENST00000590910.1
ENST00000326695.5
ENST00000589109.1
ENST00000282028.4
 RIT2
 Ras-like without CAAX 2
chr16_+_89696692 0.04 ENST00000261615.4
 DPEP1
 dipeptidase 1 (renal)
chr8_-_80942061 0.04 ENST00000519386.1
 MRPS28
 mitochondrial ribosomal protein S28
chr1_+_47264711 0.04 ENST00000371923.4
ENST00000271153.4
ENST00000371919.4
 CYP4B1
 cytochrome P450, family 4, subfamily B, polypeptide 1
chr5_-_147211226 0.04 ENST00000296695.5
 SPINK1
 serine peptidase inhibitor, Kazal type 1
chr9_-_21217310 0.03 ENST00000380216.1
 IFNA16
 interferon, alpha 16
chr14_-_107083690 0.03 ENST00000455737.1
ENST00000390629.2
 IGHV4-59
 immunoglobulin heavy variable 4-59
chr16_-_31439735 0.03 ENST00000287490.4
 COX6A2
 cytochrome c oxidase subunit VIa polypeptide 2
chr1_+_42922173 0.03 ENST00000455780.1
ENST00000372560.3
ENST00000372561.3
ENST00000372556.3
 PPCS
 phosphopantothenoylcysteine synthetase
chr11_-_5173599 0.03 ENST00000328942.1
 OR52A1
 olfactory receptor, family 52, subfamily A, member 1
chr5_-_132166579 0.03 ENST00000378679.3
 SHROOM1
 shroom family member 1
chr12_-_95467356 0.02 ENST00000393101.3
ENST00000333003.5
 NR2C1
 nuclear receptor subfamily 2, group C, member 1
chr19_+_7459998 0.02 ENST00000319670.9
ENST00000599752.1
 ARHGEF18
 Rho/Rac guanine nucleotide exchange factor (GEF) 18
chr2_+_44589036 0.02 ENST00000402247.1
ENST00000407131.1
ENST00000403853.3
ENST00000378494.3
 CAMKMT
 calmodulin-lysine N-methyltransferase
chr8_-_99306611 0.02 ENST00000341166.3
 NIPAL2
 NIPA-like domain containing 2
chrY_-_6742068 0.02 ENST00000215479.5
 AMELY
 amelogenin, Y-linked
chr12_+_109273806 0.02 ENST00000228476.3
ENST00000547768.1
 DAO
 D-amino-acid oxidase
chr19_-_52034971 0.02 ENST00000346477.3
 SIGLEC6
 sialic acid binding Ig-like lectin 6
chr10_-_43904235 0.01 ENST00000356053.3
 HNRNPF
 heterogeneous nuclear ribonucleoprotein F
chr2_-_74735707 0.01 ENST00000233630.6
 PCGF1
 polycomb group ring finger 1
chr16_+_71560023 0.01 ENST00000572450.1
 CHST4
 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr8_+_125486939 0.01 ENST00000303545.3
 RNF139
 ring finger protein 139
chr12_-_86650045 0.01 ENST00000604798.1
 MGAT4C
 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr14_-_88459182 0.01 ENST00000544807.2
 GALC
 galactosylceramidase
chr12_-_86650077 0.00 ENST00000552808.2
ENST00000547225.1
 MGAT4C
 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr14_-_93651186 0.00 ENST00000556883.1
ENST00000298894.4
 MOAP1
 modulator of apoptosis 1
chr19_+_51645556 0.00 ENST00000601682.1
ENST00000317643.6
ENST00000305628.7
ENST00000600577.1
 SIGLEC7
 sialic acid binding Ig-like lectin 7
chrX_-_49089771 0.00 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
 CACNA1F
 calcium channel, voltage-dependent, L type, alpha 1F subunit
chr1_-_120439112 0.00 ENST00000369400.1
 ADAM30
 ADAM metallopeptidase domain 30

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 6.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.5 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 7.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7 2.1 GO:0070283 lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283)
0.4 1.2 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.2 0.7 GO:0033906 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.2 1.1 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 0.5 GO:0016730 ferredoxin-NADP+ reductase activity(GO:0004324) NADPH-adrenodoxin reductase activity(GO:0015039) oxidoreductase activity, acting on iron-sulfur proteins as donors(GO:0016730) oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor(GO:0016731)
0.1 0.6 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 1.8 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
0.1 0.4 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.1 0.3 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 0.4 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.1 0.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.5 GO:0016778 diphosphotransferase activity(GO:0016778)
0.1 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.0 0.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.1 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.5 GO:0051400 BH domain binding(GO:0051400)
0.0 0.4 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.0 0.4 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.3 GO:0042608 T cell receptor binding(GO:0042608)
0.0 0.2 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.2 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.0 0.1 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 2.0 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0 0.4 GO:0071949 FAD binding(GO:0071949)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 3.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.3 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 7.0 GO:0071461 cellular response to redox state(GO:0071461)
0.7 2.1 GO:0009107 lipoate biosynthetic process(GO:0009107)
0.6 1.9 GO:0021558 midbrain-hindbrain boundary morphogenesis(GO:0021555) trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164)
0.4 1.2 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.4 1.1 GO:0046680 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
0.2 0.7 GO:0019087 transformation of host cell by virus(GO:0019087)
0.1 0.4 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 0.5 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.1 1.8 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
0.1 0.6 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.1 0.4 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.1 0.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 0.6 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.1 0.2 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.1 0.4 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
0.1 0.3 GO:0030805 regulation of cyclic nucleotide catabolic process(GO:0030805) regulation of cAMP catabolic process(GO:0030820) regulation of purine nucleotide catabolic process(GO:0033121) regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1 0.3 GO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0 0.2 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.0 0.3 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.3 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.4 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.0 0.2 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.2 GO:0018343 protein farnesylation(GO:0018343)
0.0 0.1 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.0 0.9 GO:0000042 protein targeting to Golgi(GO:0000042)
0.0 0.1 GO:0042631 cellular response to water deprivation(GO:0042631)
0.0 0.1 GO:0048478 replication fork protection(GO:0048478)
0.0 0.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.3 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.3 GO:0003373 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.0 0.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.4 GO:0031053 primary miRNA processing(GO:0031053)
0.0 0.5 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0 0.2 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 0.1 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
0.0 0.2 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0052055 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.1 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0 0.5 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0 0.1 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
0.0 0.1 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.1 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.0 0.2 GO:0060745 prostate epithelial cord elongation(GO:0060523) mammary gland branching involved in pregnancy(GO:0060745) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.3 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.0 GO:0016999 antibiotic metabolic process(GO:0016999) cellular amide catabolic process(GO:0043605)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.0 0.1 GO:1903862 positive regulation of oxidative phosphorylation(GO:1903862)
0.0 0.0 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.4 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.0 0.3 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.3 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.1 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 1.9 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 7.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 0.4 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0 0.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
0.1 0.3 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.1 0.3 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.2 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.0 0.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.2 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.0 0.2 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.1 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.1 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.1 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.0 0.2 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.0 GO:0097447 dendritic tree(GO:0097447)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)