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ENCODE cell lines, expression (Ernst 2011)

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Results for PAX1_PAX9

Z-value: 0.49

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Transcription factors associated with PAX1_PAX9

Gene Symbol Gene ID Gene Info
PAX1
ENSG00000125813.9 PAX1
PAX9
ENSG00000198807.8 PAX9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX9hg19_v2_chr14_+_37126765_37126799,
hg19_v2_chr14_+_37131058_37131139		-0.476.3e-02Click!
PAX1hg19_v2_chr20_+_21686290_21686311-0.391.4e-01Click!

Activity profile of PAX1_PAX9 motif

Sorted Z-values of PAX1_PAX9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX1_PAX9

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_23261589 1.33 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
 LOXL2
 lysyl oxidase-like 2
chr4_+_123747834 0.85 ENST00000264498.3
 FGF2
 fibroblast growth factor 2 (basic)
chr2_-_175712270 0.79 ENST00000295497.7
ENST00000444394.1
 CHN1
 chimerin 1
chr8_-_101965559 0.78 ENST00000353245.3
 YWHAZ
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr4_+_75230853 0.77 ENST00000244869.2
 EREG
 epiregulin
chr4_+_123747979 0.66 ENST00000608478.1
 FGF2
 fibroblast growth factor 2 (basic)
chr18_+_39766626 0.66 ENST00000593234.1
ENST00000585627.1
ENST00000591199.1
ENST00000586990.1
ENST00000593051.1
ENST00000593316.1
ENST00000591381.1
ENST00000585639.1
ENST00000589068.1
 LINC00907
 long intergenic non-protein coding RNA 907
chrX_-_153707545 0.63 ENST00000357360.4
 LAGE3
 L antigen family, member 3
chr9_+_33750515 0.58 ENST00000361005.5
 PRSS3
 protease, serine, 3
chr9_+_33750667 0.56 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
 PRSS3
 protease, serine, 3
chrX_-_153707246 0.55 ENST00000407062.1
 LAGE3
 L antigen family, member 3
chr8_-_101965146 0.49 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
 YWHAZ
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr9_+_33795533 0.43 ENST00000379405.3
 PRSS3
 protease, serine, 3
chr7_-_19157248 0.40 ENST00000242261.5
 TWIST1
 twist family bHLH transcription factor 1
chr17_+_15848231 0.39 ENST00000304222.2
 ADORA2B
 adenosine A2b receptor
chr9_-_104249400 0.29 ENST00000374848.3
 TMEM246
 transmembrane protein 246
chr8_+_84824920 0.28 ENST00000523678.1
 RP11-120I21.2
 RP11-120I21.2
chr6_+_34857019 0.26 ENST00000360359.3
ENST00000535627.1
 ANKS1A
 ankyrin repeat and sterile alpha motif domain containing 1A
chr15_+_63569731 0.21 ENST00000261879.5
 APH1B
 APH1B gamma secretase subunit
chr11_+_6947720 0.19 ENST00000414517.2
 ZNF215
 zinc finger protein 215
chr15_+_63569785 0.17 ENST00000380343.4
ENST00000560353.1
 APH1B
 APH1B gamma secretase subunit
chrX_-_148669116 0.17 ENST00000243314.5
 MAGEA9B
 melanoma antigen family A, 9B
chr1_-_213031418 0.17 ENST00000356684.3
ENST00000426161.1
ENST00000424044.1
 FLVCR1-AS1
 FLVCR1 antisense RNA 1 (head to head)
chr13_+_21141270 0.16 ENST00000319980.6
ENST00000537103.1
ENST00000389373.3
 IFT88
 intraflagellar transport 88 homolog (Chlamydomonas)
chr6_+_74104471 0.16 ENST00000370336.4
 DDX43
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
chr17_-_39968406 0.15 ENST00000393928.1
 LEPREL4
 leprecan-like 4
chr14_+_24540046 0.13 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
 CPNE6
 copine VI (neuronal)
chr6_-_132945414 0.12 ENST00000367931.1
ENST00000537809.1
 TAAR2
 trace amine associated receptor 2
chr9_-_21142144 0.12 ENST00000380229.2
 IFNW1
 interferon, omega 1
chr13_+_21141208 0.12 ENST00000351808.5
 IFT88
 intraflagellar transport 88 homolog (Chlamydomonas)
chrX_+_148622513 0.11 ENST00000393985.3
ENST00000423421.1
ENST00000423540.2
ENST00000434353.2
ENST00000514208.1
 CXorf40A
 chromosome X open reading frame 40A
chr1_+_26758790 0.11 ENST00000427245.2
ENST00000525682.2
ENST00000236342.7
ENST00000526219.1
ENST00000374185.3
ENST00000360009.2
 DHDDS
 dehydrodolichyl diphosphate synthase
chr7_+_142457315 0.11 ENST00000486171.1
ENST00000311737.7
 PRSS1
 protease, serine, 1 (trypsin 1)
chr11_+_6947647 0.10 ENST00000278319.5
 ZNF215
 zinc finger protein 215
chr19_-_40791302 0.10 ENST00000392038.2
ENST00000578123.1
 AKT2
 v-akt murine thymoma viral oncogene homolog 2
chr3_+_15247686 0.08 ENST00000253693.2
 CAPN7
 calpain 7
chr19_-_40791211 0.07 ENST00000579047.1
 AKT2
 v-akt murine thymoma viral oncogene homolog 2
chr3_+_127771212 0.06 ENST00000243253.3
ENST00000481210.1
 SEC61A1
 Sec61 alpha 1 subunit (S. cerevisiae)
chr12_-_101801505 0.06 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
 ARL1
 ADP-ribosylation factor-like 1
chr12_+_57828521 0.05 ENST00000309668.2
 INHBC
 inhibin, beta C
chr10_-_99393242 0.04 ENST00000370635.3
ENST00000478953.1
ENST00000335628.3
 MORN4
 MORN repeat containing 4
chr17_-_39968855 0.04 ENST00000355468.3
ENST00000590496.1
 LEPREL4
 leprecan-like 4
chr2_+_119699864 0.04 ENST00000541757.1
ENST00000412481.1
 MARCO
 macrophage receptor with collagenous structure
chr10_-_43904608 0.04 ENST00000337970.3
 HNRNPF
 heterogeneous nuclear ribonucleoprotein F
chr22_+_39745930 0.03 ENST00000318801.4
ENST00000216155.7
ENST00000406293.3
ENST00000328933.5
 SYNGR1
 synaptogyrin 1
chr19_-_5838768 0.03 ENST00000527106.1
ENST00000531199.1
ENST00000529165.1
 FUT6
 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr14_+_39703112 0.03 ENST00000555143.1
ENST00000280082.3
 MIA2
 melanoma inhibitory activity 2
chr6_-_137366163 0.03 ENST00000367748.1
 IL20RA
 interleukin 20 receptor, alpha
chr10_-_99393208 0.01 ENST00000307450.6
 MORN4
 MORN repeat containing 4
chr4_+_619347 0.01 ENST00000255622.6
 PDE6B
 phosphodiesterase 6B, cGMP-specific, rod, beta

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.3 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 0.4 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.8 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.4 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 0.4 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.0 1.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.1 GO:0001594 trace-amine receptor activity(GO:0001594)
0.0 1.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.2 1.5 GO:1904849 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.4 GO:2000276 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276)
0.1 0.4 GO:0002545 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
0.1 1.3 GO:0090168 Golgi reassembly(GO:0090168)
0.1 0.3 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.1 1.7 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 1.3 GO:0032332 positive regulation of chondrocyte differentiation(GO:0032332)
0.0 0.2 GO:0010748 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.8 GO:0008045 motor neuron axon guidance(GO:0008045)
0.0 0.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.1 GO:0046465 dolichyl diphosphate biosynthetic process(GO:0006489) dolichyl diphosphate metabolic process(GO:0046465)
0.0 0.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 1.2 GO:0008033 tRNA processing(GO:0008033)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 2.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.0 0.4 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 1.6 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.3 GO:0005604 basement membrane(GO:0005604)