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ENCODE cell lines, expression (Ernst 2011)

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Results for PBX2

Z-value: 0.61

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.7 PBX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg19_v2_chr6_-_32157947_32157992-0.639.2e-03Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_6420930 1.49 ENST00000325203.5
 ANGPT2
 angiopoietin 2
chr2_-_190044480 1.48 ENST00000374866.3
 COL5A2
 collagen, type V, alpha 2
chr12_-_28124903 1.32 ENST00000395872.1
ENST00000354417.3
ENST00000201015.4
 PTHLH
 parathyroid hormone-like hormone
chr2_+_234601512 0.88 ENST00000305139.6
 UGT1A6
 UDP glucuronosyltransferase 1 family, polypeptide A6
chr1_+_101702417 0.87 ENST00000305352.6
 S1PR1
 sphingosine-1-phosphate receptor 1
chr2_+_234602305 0.72 ENST00000406651.1
 UGT1A6
 UDP glucuronosyltransferase 1 family, polypeptide A6
chr7_+_134528635 0.69 ENST00000445569.2
 CALD1
 caldesmon 1
chrX_+_119737806 0.65 ENST00000371317.5
 MCTS1
 malignant T cell amplified sequence 1
chr12_-_28125638 0.53 ENST00000545234.1
 PTHLH
 parathyroid hormone-like hormone
chr2_+_20646824 0.48 ENST00000272233.4
 RHOB
 ras homolog family member B
chr13_-_107220455 0.44 ENST00000400198.3
 ARGLU1
 arginine and glutamate rich 1
chr2_+_33661382 0.36 ENST00000402538.3
 RASGRP3
 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_+_129158926 0.36 ENST00000347300.2
ENST00000296266.3
 IFT122
 intraflagellar transport 122 homolog (Chlamydomonas)
chr3_+_129159039 0.34 ENST00000507564.1
ENST00000431818.2
ENST00000504021.1
ENST00000349441.2
ENST00000348417.2
ENST00000440957.2
 IFT122
 intraflagellar transport 122 homolog (Chlamydomonas)
chr14_-_55658323 0.32 ENST00000554067.1
ENST00000247191.2
 DLGAP5
 discs, large (Drosophila) homolog-associated protein 5
chr3_-_129158676 0.31 ENST00000393278.2
 MBD4
 methyl-CpG binding domain protein 4
chr2_+_113033164 0.31 ENST00000409871.1
ENST00000343936.4
 ZC3H6
 zinc finger CCCH-type containing 6
chr15_+_67418047 0.28 ENST00000540846.2
 SMAD3
 SMAD family member 3
chrX_+_46696372 0.27 ENST00000218340.3
 RP2
 retinitis pigmentosa 2 (X-linked recessive)
chr2_+_12857043 0.24 ENST00000381465.2
 TRIB2
 tribbles pseudokinase 2
chrX_+_56590002 0.24 ENST00000338222.5
 UBQLN2
 ubiquilin 2
chr3_-_129158850 0.23 ENST00000503197.1
ENST00000249910.1
ENST00000429544.2
ENST00000507208.1
 MBD4
 methyl-CpG binding domain protein 4
chr14_-_55658252 0.21 ENST00000395425.2
 DLGAP5
 discs, large (Drosophila) homolog-associated protein 5
chr12_+_53835383 0.21 ENST00000429243.2
 PRR13
 proline rich 13
chr10_+_124320156 0.21 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
 DMBT1
 deleted in malignant brain tumors 1
chr11_+_69455855 0.20 ENST00000227507.2
ENST00000536559.1
 CCND1
 cyclin D1
chr10_+_124320195 0.20 ENST00000359586.6
 DMBT1
 deleted in malignant brain tumors 1
chr11_-_111794446 0.19 ENST00000527950.1
 CRYAB
 crystallin, alpha B
chr17_-_29624343 0.18 ENST00000247271.4
 OMG
 oligodendrocyte myelin glycoprotein
chr10_+_47894572 0.15 ENST00000355876.5
 FAM21B
 family with sequence similarity 21, member B
chr2_+_12857015 0.15 ENST00000155926.4
 TRIB2
 tribbles pseudokinase 2
chr9_-_128246769 0.15 ENST00000444226.1
 MAPKAP1
 mitogen-activated protein kinase associated protein 1
chr12_+_53835539 0.14 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
 PRR13
 proline rich 13
chr17_+_8191815 0.13 ENST00000226105.6
ENST00000407006.4
ENST00000580434.1
ENST00000439238.3
 RANGRF
 RAN guanine nucleotide release factor
chr17_-_29151794 0.07 ENST00000324238.6
 CRLF3
 cytokine receptor-like factor 3
chr8_+_110098850 0.07 ENST00000518632.1
 TRHR
 thyrotropin-releasing hormone receptor
chr1_-_39339777 0.05 ENST00000397572.2
 MYCBP
 MYC binding protein
chr6_+_26045603 0.02 ENST00000540144.1
 HIST1H3C
 histone cluster 1, H3c
chr11_+_68228186 0.02 ENST00000393799.2
ENST00000393800.2
ENST00000528635.1
ENST00000533127.1
ENST00000529907.1
ENST00000529344.1
ENST00000534534.1
ENST00000524845.1
ENST00000265637.4
ENST00000524904.1
ENST00000393801.3
ENST00000265636.5
ENST00000529710.1
 PPP6R3
 protein phosphatase 6, regulatory subunit 3
chr22_+_42017987 0.02 ENST00000405506.1
 XRCC6
 X-ray repair complementing defective repair in Chinese hamster cells 6
chr16_+_1128781 0.02 ENST00000293897.4
ENST00000562758.1
 SSTR5
 somatostatin receptor 5
chr10_-_45474237 0.02 ENST00000448778.1
ENST00000298295.3
 C10orf10
 chromosome 10 open reading frame 10
chr12_+_53835508 0.01 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
 PRR13
PCBP2
 proline rich 13
poly(rC) binding protein 2
chr3_-_52864680 0.01 ENST00000406595.1
ENST00000485816.1
ENST00000434759.3
ENST00000346281.5
ENST00000266041.4
 ITIH4
 inter-alpha-trypsin inhibitor heavy chain family, member 4
chr14_-_23624511 0.01 ENST00000529705.2
 SLC7A8
 solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr16_+_1832902 0.00 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
 NUBP2
 nucleotide binding protein 2
chr4_+_37962018 0.00 ENST00000504686.1
 PTTG2
 pituitary tumor-transforming 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.4 1.5 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.3 0.9 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.2 0.6 GO:0002188 translation reinitiation(GO:0002188)
0.2 0.7 GO:0035720 signal transduction downstream of smoothened(GO:0007227) intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1 1.6 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1 0.5 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.4 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 2.1 GO:0002076 osteoblast development(GO:0002076)
0.1 0.2 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.0 0.5 GO:0045008 depyrimidination(GO:0045008)
0.0 0.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.2 GO:0070141 response to UV-A(GO:0070141)
0.0 0.5 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.7 GO:0030991 intraciliary transport particle A(GO:0030991)
0.1 0.3 GO:1990075 periciliary membrane compartment(GO:1990075)
0.0 0.7 GO:0030478 actin cap(GO:0030478)
0.0 0.3 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0042589 zymogen granule membrane(GO:0042589)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 1.5 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 1.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.5 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.5 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.5 PID AURORA A PATHWAY Aurora A signaling

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.1 0.9 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036) sphingolipid binding(GO:0046625)
0.1 1.9 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.3 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.0 1.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.4 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 1.5 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.4 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 1.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)