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ENCODE cell lines, expression (Ernst 2011)

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Results for PITX2

Z-value: 0.32

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.11 PITX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111563076_111563172,
hg19_v2_chr4_-_111544254_111544270,
hg19_v2_chr4_-_111558135_111558198		0.811.3e-04Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_36429763 0.55 ENST00000379893.1
 DCLK1
 doublecortin-like kinase 1
chr12_-_90049828 0.53 ENST00000261173.2
ENST00000348959.3
 ATP2B1
 ATPase, Ca++ transporting, plasma membrane 1
chr12_-_90049878 0.51 ENST00000359142.3
 ATP2B1
 ATPase, Ca++ transporting, plasma membrane 1
chr1_-_31230650 0.42 ENST00000294507.3
 LAPTM5
 lysosomal protein transmembrane 5
chr19_+_2476116 0.28 ENST00000215631.4
ENST00000587345.1
 GADD45B
 growth arrest and DNA-damage-inducible, beta
chrX_-_6146876 0.24 ENST00000381095.3
 NLGN4X
 neuroligin 4, X-linked
chr13_+_73632897 0.24 ENST00000377687.4
 KLF5
 Kruppel-like factor 5 (intestinal)
chr3_+_158787041 0.19 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
 IQCJ-SCHIP1
 IQCJ-SCHIP1 readthrough
chr4_+_126237554 0.15 ENST00000394329.3
 FAT4
 FAT atypical cadherin 4
chr2_+_201994569 0.15 ENST00000457277.1
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr16_-_5116025 0.12 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
 C16orf89
 chromosome 16 open reading frame 89
chr14_+_75988851 0.11 ENST00000555504.1
 BATF
 basic leucine zipper transcription factor, ATF-like
chrX_-_54384425 0.10 ENST00000375169.3
ENST00000354646.2
 WNK3
 WNK lysine deficient protein kinase 3
chr2_+_120770645 0.09 ENST00000443902.2
 EPB41L5
 erythrocyte membrane protein band 4.1 like 5
chrX_-_48931648 0.09 ENST00000376386.3
ENST00000376390.4
 PRAF2
 PRA1 domain family, member 2
chr2_+_120770581 0.09 ENST00000263713.5
 EPB41L5
 erythrocyte membrane protein band 4.1 like 5
chr5_+_64920543 0.09 ENST00000399438.3
ENST00000510585.2
 TRAPPC13
CTC-534A2.2
 trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr6_-_111804905 0.08 ENST00000358835.3
ENST00000435970.1
 REV3L
 REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr14_+_75988768 0.07 ENST00000286639.6
 BATF
 basic leucine zipper transcription factor, ATF-like
chr7_+_73868220 0.06 ENST00000455841.2
 GTF2IRD1
 GTF2I repeat domain containing 1
chr5_-_64920115 0.06 ENST00000381018.3
ENST00000274327.7
 TRIM23
 tripartite motif containing 23
chr22_-_39096661 0.06 ENST00000216039.5
 JOSD1
 Josephin domain containing 1
chr7_+_73868439 0.06 ENST00000424337.2
 GTF2IRD1
 GTF2I repeat domain containing 1
chr16_+_28722684 0.05 ENST00000331666.6
ENST00000395587.1
ENST00000569690.1
ENST00000564243.1
 EIF3C
 eukaryotic translation initiation factor 3, subunit C
chr4_+_70916119 0.05 ENST00000246896.3
ENST00000511674.1
 HTN1
 histatin 1
chr22_-_30234218 0.04 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
 ASCC2
 activating signal cointegrator 1 complex subunit 2
chr18_-_47017956 0.03 ENST00000584895.1
ENST00000332968.6
ENST00000580210.1
ENST00000579408.1
 RPL17-C18orf32
RPL17
 RPL17-C18orf32 readthrough
ribosomal protein L17
chr4_-_76912070 0.02 ENST00000395711.4
ENST00000356260.5
 SDAD1
 SDA1 domain containing 1
chr1_+_92417716 0.02 ENST00000402388.1
 BRDT
 bromodomain, testis-specific
chr21_-_19775973 0.02 ENST00000284885.3
 TMPRSS15
 transmembrane protease, serine 15
chr2_+_3622893 0.02 ENST00000407445.3
ENST00000403564.1
 RPS7
 ribosomal protein S7
chr21_-_34915147 0.01 ENST00000381831.3
ENST00000381839.3
 GART
 phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr9_+_8858102 0.01 ENST00000447950.1
ENST00000430766.1
 RP11-75C9.1
 RP11-75C9.1
chr12_-_323689 0.01 ENST00000428720.1
 SLC6A12
 solute carrier family 6 (neurotransmitter transporter), member 12
chr17_+_79495397 0.01 ENST00000417245.2
ENST00000334850.7
 FSCN2
 fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr3_-_50388522 0.00 ENST00000232501.3
 NPRL2
 nitrogen permease regulator-like 2 (S. cerevisiae)
chr16_-_68014732 0.00 ENST00000268793.4
 DPEP3
 dipeptidase 3

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 GO:0032591 dendritic spine membrane(GO:0032591)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:1990034 calcium ion export from cell(GO:1990034)
0.1 0.2 GO:0003383 apical constriction(GO:0003383) mesoderm migration involved in gastrulation(GO:0007509)
0.1 0.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.2 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0 0.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.1 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0042043 neurexin family protein binding(GO:0042043)