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ENCODE cell lines, expression (Ernst 2011)

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Results for PKNOX2

Z-value: 0.68

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Transcription factors associated with PKNOX2

Gene Symbol Gene ID Gene Info
PKNOX2
ENSG00000165495.11 PKNOX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PKNOX2hg19_v2_chr11_+_125034586_1250346040.341.9e-01Click!

Activity profile of PKNOX2 motif

Sorted Z-values of PKNOX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PKNOX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_33010175 2.02 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
 GREM1
 gremlin 1, DAN family BMP antagonist
chr4_+_169418195 2.01 ENST00000261509.6
ENST00000335742.7
 PALLD
 palladin, cytoskeletal associated protein
chr5_+_125758813 1.88 ENST00000285689.3
ENST00000515200.1
 GRAMD3
 GRAM domain containing 3
chr3_-_127541679 1.88 ENST00000265052.5
 MGLL
 monoglyceride lipase
chr5_+_125758865 1.85 ENST00000542322.1
ENST00000544396.1
 GRAMD3
 GRAM domain containing 3
chr4_-_157892498 1.72 ENST00000502773.1
 PDGFC
 platelet derived growth factor C
chr3_-_127541194 1.60 ENST00000453507.2
 MGLL
 monoglyceride lipase
chr4_+_169418255 1.49 ENST00000505667.1
ENST00000511948.1
 PALLD
 palladin, cytoskeletal associated protein
chr5_-_81046841 1.48 ENST00000509013.2
ENST00000505980.1
ENST00000509053.1
 SSBP2
 single-stranded DNA binding protein 2
chr5_-_81046922 1.36 ENST00000514493.1
ENST00000320672.4
 SSBP2
 single-stranded DNA binding protein 2
chr5_-_81046904 1.21 ENST00000515395.1
 SSBP2
 single-stranded DNA binding protein 2
chr1_+_181057638 0.93 ENST00000367577.4
 IER5
 immediate early response 5
chr18_+_54318616 0.93 ENST00000254442.3
 WDR7
 WD repeat domain 7
chr18_+_54318566 0.91 ENST00000589935.1
ENST00000357574.3
 WDR7
 WD repeat domain 7
chr7_-_137028534 0.88 ENST00000348225.2
 PTN
 pleiotrophin
chr7_-_137028498 0.85 ENST00000393083.2
 PTN
 pleiotrophin
chr2_+_219081817 0.75 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
 ARPC2
 actin related protein 2/3 complex, subunit 2, 34kDa
chr2_-_211179883 0.75 ENST00000352451.3
 MYL1
 myosin, light chain 1, alkali; skeletal, fast
chr2_-_179672142 0.72 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
 TTN
 titin
chr17_-_26220366 0.62 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
 LYRM9
RP1-66C13.4
 LYR motif containing 9
Uncharacterized protein
chr10_-_101945771 0.57 ENST00000370408.2
ENST00000407654.3
 ERLIN1
 ER lipid raft associated 1
chr6_-_101329191 0.57 ENST00000324723.6
ENST00000369162.2
ENST00000522650.1
 ASCC3
 activating signal cointegrator 1 complex subunit 3
chr16_+_50776021 0.54 ENST00000566679.2
ENST00000564634.1
ENST00000398568.2
 CYLD
 cylindromatosis (turban tumor syndrome)
chr11_+_12132117 0.53 ENST00000256194.4
 MICAL2
 microtubule associated monooxygenase, calponin and LIM domain containing 2
chr9_-_79307096 0.51 ENST00000376717.2
ENST00000223609.6
ENST00000443509.2
 PRUNE2
 prune homolog 2 (Drosophila)
chr11_+_6411636 0.50 ENST00000299397.3
ENST00000356761.2
ENST00000342245.4
 SMPD1
 sphingomyelin phosphodiesterase 1, acid lysosomal
chr5_+_118407053 0.50 ENST00000311085.8
ENST00000539542.1
 DMXL1
 Dmx-like 1
chrX_-_153775426 0.39 ENST00000393562.2
 G6PD
 glucose-6-phosphate dehydrogenase
chr19_+_41281416 0.39 ENST00000597140.1
 MIA
 melanoma inhibitory activity
chr6_+_29910301 0.38 ENST00000376809.5
ENST00000376802.2
 HLA-A
 major histocompatibility complex, class I, A
chr11_+_842928 0.38 ENST00000397408.1
 TSPAN4
 tetraspanin 4
chr7_-_42276612 0.38 ENST00000395925.3
ENST00000437480.1
 GLI3
 GLI family zinc finger 3
chr12_+_62654155 0.37 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
 USP15
 ubiquitin specific peptidase 15
chr11_-_842509 0.37 ENST00000322028.4
 POLR2L
 polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
chr5_-_52405564 0.30 ENST00000510818.2
ENST00000396954.3
ENST00000508922.1
ENST00000361377.4
ENST00000582677.1
ENST00000584946.1
ENST00000450852.3
 MOCS2
 molybdenum cofactor synthesis 2
chr11_+_842808 0.30 ENST00000397397.2
ENST00000397411.2
ENST00000397396.1
 TSPAN4
 tetraspanin 4
chr19_+_41281060 0.29 ENST00000594436.1
ENST00000597784.1
 MIA
 melanoma inhibitory activity
chr2_-_202316260 0.29 ENST00000332624.3
 TRAK2
 trafficking protein, kinesin binding 2
chr18_-_54318353 0.29 ENST00000590954.1
ENST00000540155.1
 TXNL1
 thioredoxin-like 1
chr14_+_61995722 0.26 ENST00000556347.1
 RP11-47I22.4
 RP11-47I22.4
chr19_+_41281282 0.24 ENST00000263369.3
 MIA
 melanoma inhibitory activity
chr2_+_191208196 0.24 ENST00000392329.2
ENST00000322522.4
ENST00000430311.1
ENST00000541441.1
 INPP1
 inositol polyphosphate-1-phosphatase
chr9_-_132805430 0.24 ENST00000446176.2
ENST00000355681.3
ENST00000420781.1
 FNBP1
 formin binding protein 1
chr8_+_31496809 0.23 ENST00000518104.1
ENST00000519301.1
 NRG1
 neuregulin 1
chr6_-_116575226 0.23 ENST00000420283.1
 TSPYL4
 TSPY-like 4
chr11_+_6411670 0.22 ENST00000530395.1
ENST00000527275.1
 SMPD1
 sphingomyelin phosphodiesterase 1, acid lysosomal
chr12_+_62654119 0.21 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
 USP15
 ubiquitin specific peptidase 15
chr11_-_64013288 0.20 ENST00000542235.1
 PPP1R14B
 protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_-_77225135 0.20 ENST00000458128.1
 PGAM4
 phosphoglycerate mutase family member 4
chr21_-_32931290 0.20 ENST00000286827.3
 TIAM1
 T-cell lymphoma invasion and metastasis 1
chr10_+_49514698 0.19 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
 MAPK8
 mitogen-activated protein kinase 8
chr10_+_70661014 0.19 ENST00000373585.3
 DDX50
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr8_+_133787586 0.18 ENST00000395379.1
ENST00000395386.2
ENST00000337920.4
 PHF20L1
 PHD finger protein 20-like 1
chr18_-_54305658 0.17 ENST00000586262.1
ENST00000217515.6
 TXNL1
 thioredoxin-like 1
chr4_-_149365827 0.17 ENST00000344721.4
 NR3C2
 nuclear receptor subfamily 3, group C, member 2
chr3_-_52001448 0.16 ENST00000461554.1
ENST00000395013.3
ENST00000428823.2
ENST00000483411.1
ENST00000461544.1
ENST00000355852.2
 PCBP4
 poly(rC) binding protein 4
chr1_+_109756523 0.16 ENST00000234677.2
ENST00000369923.4
 SARS
 seryl-tRNA synthetase
chr17_+_68071389 0.16 ENST00000283936.1
ENST00000392671.1
 KCNJ16
 potassium inwardly-rectifying channel, subfamily J, member 16
chr17_+_68071458 0.15 ENST00000589377.1
 KCNJ16
 potassium inwardly-rectifying channel, subfamily J, member 16
chr5_-_94620239 0.15 ENST00000515393.1
 MCTP1
 multiple C2 domains, transmembrane 1
chr8_+_57124245 0.15 ENST00000521831.1
ENST00000355315.3
ENST00000303759.3
ENST00000517636.1
ENST00000517933.1
ENST00000518801.1
ENST00000523975.1
ENST00000396723.5
ENST00000523061.1
ENST00000521524.1
 CHCHD7
 coiled-coil-helix-coiled-coil-helix domain containing 7
chr11_-_59383617 0.14 ENST00000263847.1
 OSBP
 oxysterol binding protein
chr16_-_1275257 0.14 ENST00000234798.4
 TPSG1
 tryptase gamma 1
chr3_-_33481835 0.14 ENST00000283629.3
 UBP1
 upstream binding protein 1 (LBP-1a)
chr17_-_29151794 0.13 ENST00000324238.6
 CRLF3
 cytokine receptor-like factor 3
chr12_+_103981044 0.13 ENST00000388887.2
 STAB2
 stabilin 2
chr1_-_201081579 0.12 ENST00000367338.3
ENST00000362061.3
 CACNA1S
 calcium channel, voltage-dependent, L type, alpha 1S subunit
chr11_+_74660278 0.11 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
 SPCS2
 signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr6_+_42123141 0.11 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
 GUCA1A
RP1-139D8.6
 guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr6_-_84418860 0.10 ENST00000521743.1
 SNAP91
 synaptosomal-associated protein, 91kDa
chr1_-_35658736 0.09 ENST00000357214.5
 SFPQ
 splicing factor proline/glutamine-rich
chr6_-_84418841 0.09 ENST00000369694.2
ENST00000195649.6
 SNAP91
 synaptosomal-associated protein, 91kDa
chr6_+_31674639 0.09 ENST00000556581.1
ENST00000375832.4
ENST00000503322.1
 LY6G6F
MEGT1
 lymphocyte antigen 6 complex, locus G6F
HCG43720, isoform CRA_a; Lymphocyte antigen 6 complex locus protein G6f; Megakaryocyte-enhanced gene transcript 1 protein; Uncharacterized protein
chr8_-_20161466 0.09 ENST00000381569.1
 LZTS1
 leucine zipper, putative tumor suppressor 1
chr6_+_150070831 0.08 ENST00000367380.5
 PCMT1
 protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr1_-_179198702 0.08 ENST00000502732.1
 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
chrX_+_16804544 0.08 ENST00000380122.5
ENST00000398155.4
 TXLNG
 taxilin gamma
chr22_+_30279144 0.07 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
 MTMR3
 myotubularin related protein 3
chr4_+_140222609 0.07 ENST00000296543.5
ENST00000398947.1
 NAA15
 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr9_+_87285539 0.06 ENST00000359847.3
 NTRK2
 neurotrophic tyrosine kinase, receptor, type 2
chr12_+_49621658 0.06 ENST00000541364.1
 TUBA1C
 tubulin, alpha 1c
chr6_+_37225540 0.05 ENST00000373491.3
 TBC1D22B
 TBC1 domain family, member 22B
chr22_+_50946645 0.05 ENST00000420993.2
ENST00000395698.3
ENST00000395701.3
ENST00000523045.1
ENST00000299821.11
 NCAPH2
 non-SMC condensin II complex, subunit H2
chr12_-_121734489 0.05 ENST00000412367.2
ENST00000402834.4
ENST00000404169.3
 CAMKK2
 calcium/calmodulin-dependent protein kinase kinase 2, beta
chr17_-_4046257 0.05 ENST00000381638.2
 ZZEF1
 zinc finger, ZZ-type with EF-hand domain 1
chr9_+_137772652 0.04 ENST00000350339.2
ENST00000291744.6
 FCN2
 ficolin (collagen/fibrinogen domain containing lectin) 2
chr5_-_132073111 0.04 ENST00000403231.1
 KIF3A
 kinesin family member 3A
chr11_+_129245796 0.04 ENST00000281437.4
 BARX2
 BARX homeobox 2
chr17_+_39868577 0.04 ENST00000329402.3
 GAST
 gastrin
chr20_+_43514320 0.04 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
 YWHAB
 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr6_+_150070857 0.03 ENST00000544496.1
 PCMT1
 protein-L-isoaspartate (D-aspartate) O-methyltransferase
chr4_-_100871506 0.03 ENST00000296417.5
 H2AFZ
 H2A histone family, member Z
chr1_+_170904612 0.03 ENST00000367759.4
ENST00000367758.3
 MROH9
 maestro heat-like repeat family member 9
chr16_+_57481382 0.03 ENST00000564655.1
ENST00000567072.1
ENST00000567933.1
ENST00000563166.1
 COQ9
 coenzyme Q9
chr20_-_3065362 0.02 ENST00000380293.3
 AVP
 arginine vasopressin
chr8_-_99837856 0.02 ENST00000518165.1
ENST00000419617.2
 STK3
 serine/threonine kinase 3
chr11_-_132813566 0.01 ENST00000331898.7
 OPCML
 opioid binding protein/cell adhesion molecule-like
chr22_-_31885514 0.00 ENST00000397525.1
 EIF4ENIF1
 eukaryotic translation initiation factor 4E nuclear import factor 1

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 0.5 GO:0043291 RAVE complex(GO:0043291)
0.1 0.3 GO:0019008 molybdopterin synthase complex(GO:0019008)
0.1 3.5 GO:0002102 podosome(GO:0002102)
0.0 1.5 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.7 GO:0042599 lamellar body(GO:0042599)
0.0 0.9 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.0 GO:0097542 ciliary tip(GO:0097542)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 2.0 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.1 GO:0042382 paraspeckles(GO:0042382)
0.0 3.7 GO:0019898 extrinsic component of membrane(GO:0019898)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 PID TRAIL PATHWAY TRAIL signaling pathway
0.0 1.0 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.7 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.4 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.0 0.5 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.7 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.8 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:1900158 negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.6 1.7 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.5 3.5 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 0.7 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.2 0.5 GO:1990108 protein linear deubiquitination(GO:1990108)
0.2 0.5 GO:0019417 sulfur oxidation(GO:0019417)
0.2 3.5 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.6 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.4 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 0.6 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.7 GO:0023021 termination of signal transduction(GO:0023021)
0.1 0.3 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.1 2.0 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 0.5 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.1 0.2 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 0.2 GO:0006434 seryl-tRNA aminoacylation(GO:0006434) selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056)
0.1 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 0.5 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0 0.4 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.3 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.0 0.2 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.6 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 0.1 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.0 0.1 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0 0.1 GO:0061762 CAMKK-AMPK signaling cascade(GO:0061762)
0.0 0.1 GO:0071313 cellular response to caffeine(GO:0071313)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.3 2.0 GO:0016015 morphogen activity(GO:0016015)
0.3 3.5 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.2 4.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.4 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.1 0.3 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.1 0.6 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.7 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.7 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.1 0.6 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.1 0.5 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.1 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 0.5 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 0.2 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.1 0.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.1 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0 0.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 3.9 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.4 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.0 0.5 GO:0071949 FAD binding(GO:0071949)
0.0 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.1 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 0.1 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.6 GO:0015485 cholesterol binding(GO:0015485)