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ENCODE cell lines, expression (Ernst 2011)

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Results for PLAG1

Z-value: 1.14

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Transcription factors associated with PLAG1

Gene Symbol Gene ID Gene Info
PLAG1
ENSG00000181690.3 PLAG1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PLAG1hg19_v2_chr8_-_57123815_571238670.552.8e-02Click!

Activity profile of PLAG1 motif

Sorted Z-values of PLAG1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PLAG1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_51927919 4.41 ENST00000416960.1
 MAGED4
 melanoma antigen family D, 4
chr11_-_2160180 4.35 ENST00000381406.4
 IGF2
 insulin-like growth factor 2 (somatomedin A)
chr14_-_25519317 3.17 ENST00000323944.5
 STXBP6
 syntaxin binding protein 6 (amisyn)
chr14_-_25519095 2.87 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
 STXBP6
 syntaxin binding protein 6 (amisyn)
chr2_-_21266935 2.64 ENST00000233242.1
 APOB
 apolipoprotein B
chrY_+_22737604 2.10 ENST00000361365.2
 EIF1AY
 eukaryotic translation initiation factor 1A, Y-linked
chr1_-_31845914 1.94 ENST00000373713.2
 FABP3
 fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)
chr9_+_139874683 1.86 ENST00000444903.1
 PTGDS
 prostaglandin D2 synthase 21kDa (brain)
chr20_+_35169885 1.75 ENST00000279022.2
ENST00000346786.2
 MYL9
 myosin, light chain 9, regulatory
chr12_+_57522258 1.68 ENST00000553277.1
ENST00000243077.3
 LRP1
 low density lipoprotein receptor-related protein 1
chr19_+_41725088 1.66 ENST00000301178.4
 AXL
 AXL receptor tyrosine kinase
chr4_-_155533787 1.60 ENST00000407946.1
ENST00000405164.1
ENST00000336098.3
ENST00000393846.2
ENST00000404648.3
ENST00000443553.1
 FGG
 fibrinogen gamma chain
chr16_+_31483374 1.56 ENST00000394863.3
 TGFB1I1
 transforming growth factor beta 1 induced transcript 1
chr16_+_31483451 1.49 ENST00000565360.1
ENST00000361773.3
 TGFB1I1
 transforming growth factor beta 1 induced transcript 1
chr12_-_106641728 1.47 ENST00000378026.4
 CKAP4
 cytoskeleton-associated protein 4
chr1_-_23886285 1.15 ENST00000374561.5
 ID3
 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chr16_-_65155833 1.02 ENST00000566827.1
ENST00000394156.3
ENST00000562998.1
 CDH11
 cadherin 11, type 2, OB-cadherin (osteoblast)
chr16_-_29910853 1.01 ENST00000308713.5
 SEZ6L2
 seizure related 6 homolog (mouse)-like 2
chr22_-_30642782 0.93 ENST00000249075.3
 LIF
 leukemia inhibitory factor
chr1_+_163038565 0.90 ENST00000421743.2
 RGS4
 regulator of G-protein signaling 4
chr11_+_46299199 0.88 ENST00000529193.1
ENST00000288400.3
 CREB3L1
 cAMP responsive element binding protein 3-like 1
chr4_+_55095264 0.87 ENST00000257290.5
 PDGFRA
 platelet-derived growth factor receptor, alpha polypeptide
chr2_-_85788652 0.85 ENST00000430215.3
 GGCX
 gamma-glutamyl carboxylase
chr14_-_75079026 0.84 ENST00000261978.4
 LTBP2
 latent transforming growth factor beta binding protein 2
chr2_-_86850949 0.80 ENST00000237455.4
 RNF103
 ring finger protein 103
chr12_+_56546363 0.79 ENST00000551834.1
ENST00000552568.1
 MYL6B
 myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr6_-_43021437 0.79 ENST00000265348.3
 CUL7
 cullin 7
chr16_-_30134524 0.79 ENST00000395202.1
ENST00000395199.3
ENST00000263025.4
ENST00000322266.5
ENST00000403394.1
 MAPK3
 mitogen-activated protein kinase 3
chr14_+_32546485 0.79 ENST00000345122.3
ENST00000432921.1
ENST00000433497.1
 ARHGAP5
 Rho GTPase activating protein 5
chr17_-_79805146 0.77 ENST00000415593.1
 P4HB
 prolyl 4-hydroxylase, beta polypeptide
chr3_-_73673991 0.75 ENST00000308537.4
ENST00000263666.4
 PDZRN3
 PDZ domain containing ring finger 3
chr1_-_20306909 0.75 ENST00000375111.3
ENST00000400520.3
 PLA2G2A
 phospholipase A2, group IIA (platelets, synovial fluid)
chr16_-_29910365 0.74 ENST00000346932.5
ENST00000350527.3
ENST00000537485.1
ENST00000568380.1
 SEZ6L2
 seizure related 6 homolog (mouse)-like 2
chr6_-_43021612 0.70 ENST00000535468.1
 CUL7
 cullin 7
chr14_+_79745746 0.70 ENST00000281127.7
 NRXN3
 neurexin 3
chr17_-_56065484 0.68 ENST00000581208.1
 VEZF1
 vascular endothelial zinc finger 1
chr7_+_72742162 0.68 ENST00000431982.2
 FKBP6
 FK506 binding protein 6, 36kDa
chr6_+_43044003 0.67 ENST00000230419.4
ENST00000476760.1
ENST00000471863.1
ENST00000349241.2
ENST00000352931.2
ENST00000345201.2
 PTK7
 protein tyrosine kinase 7
chr16_-_18573396 0.65 ENST00000543392.1
ENST00000381474.3
ENST00000330537.6
 NOMO2
 NODAL modulator 2
chr2_-_128399706 0.65 ENST00000426981.1
 LIMS2
 LIM and senescent cell antigen-like domains 2
chr3_+_124303539 0.65 ENST00000428018.2
 KALRN
 kalirin, RhoGEF kinase
chr10_+_111767720 0.64 ENST00000356080.4
ENST00000277900.8
 ADD3
 adducin 3 (gamma)
chr17_-_3599327 0.59 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
 P2RX5
 purinergic receptor P2X, ligand-gated ion channel, 5
chr7_-_158380371 0.58 ENST00000389418.4
ENST00000389416.4
 PTPRN2
 protein tyrosine phosphatase, receptor type, N polypeptide 2
chr7_-_158380465 0.56 ENST00000389413.3
ENST00000409483.1
 PTPRN2
 protein tyrosine phosphatase, receptor type, N polypeptide 2
chr11_-_73309228 0.54 ENST00000356467.4
ENST00000064778.4
 FAM168A
 family with sequence similarity 168, member A
chr3_-_52001448 0.54 ENST00000461554.1
ENST00000395013.3
ENST00000428823.2
ENST00000483411.1
ENST00000461544.1
ENST00000355852.2
 PCBP4
 poly(rC) binding protein 4
chr9_+_34652164 0.53 ENST00000441545.2
ENST00000553620.1
 IL11RA
 interleukin 11 receptor, alpha
chr7_-_22233442 0.53 ENST00000401957.2
 RAPGEF5
 Rap guanine nucleotide exchange factor (GEF) 5
chr8_-_23261589 0.51 ENST00000524168.1
ENST00000523833.2
ENST00000519243.1
ENST00000389131.3
 LOXL2
 lysyl oxidase-like 2
chr7_+_72742178 0.50 ENST00000442793.1
ENST00000413573.2
ENST00000252037.4
 FKBP6
 FK506 binding protein 6, 36kDa
chr16_+_29984962 0.50 ENST00000308893.4
 TAOK2
 TAO kinase 2
chr5_+_75699149 0.49 ENST00000379730.3
 IQGAP2
 IQ motif containing GTPase activating protein 2
chr14_+_79745682 0.48 ENST00000557594.1
 NRXN3
 neurexin 3
chr21_-_15755446 0.47 ENST00000544452.1
ENST00000285667.3
 HSPA13
 heat shock protein 70kDa family, member 13
chr19_+_41725140 0.46 ENST00000359092.3
 AXL
 AXL receptor tyrosine kinase
chr20_+_18269121 0.45 ENST00000377671.3
ENST00000360010.5
ENST00000396026.3
ENST00000402618.2
ENST00000401790.1
ENST00000434018.1
ENST00000538547.1
ENST00000535822.1
 ZNF133
 zinc finger protein 133
chr5_-_59189545 0.43 ENST00000340635.6
 PDE4D
 phosphodiesterase 4D, cAMP-specific
chr10_-_99447024 0.43 ENST00000370626.3
 AVPI1
 arginine vasopressin-induced 1
chr11_+_1940925 0.42 ENST00000453458.1
ENST00000381557.2
ENST00000381589.3
ENST00000381579.3
ENST00000381563.4
ENST00000344578.4
 TNNT3
 troponin T type 3 (skeletal, fast)
chr18_-_51750948 0.42 ENST00000583046.1
ENST00000398398.2
 MBD2
 methyl-CpG binding domain protein 2
chr13_+_53602894 0.40 ENST00000219022.2
 OLFM4
 olfactomedin 4
chr8_+_21912328 0.37 ENST00000432128.1
ENST00000443491.2
ENST00000517600.1
ENST00000523782.2
 DMTN
 dematin actin binding protein
chr11_-_6440283 0.37 ENST00000299402.6
ENST00000609360.1
ENST00000389906.2
ENST00000532020.2
 APBB1
 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr9_-_135819987 0.36 ENST00000298552.3
ENST00000403810.1
 TSC1
 tuberous sclerosis 1
chr1_-_24469602 0.35 ENST00000270800.1
 IL22RA1
 interleukin 22 receptor, alpha 1
chr3_-_58419537 0.35 ENST00000474765.1
ENST00000485460.1
ENST00000302746.6
ENST00000383714.4
 PDHB
 pyruvate dehydrogenase (lipoamide) beta
chr2_-_74618964 0.34 ENST00000417090.1
ENST00000409868.1
 DCTN1
 dynactin 1
chr2_-_74619152 0.34 ENST00000440727.1
ENST00000409240.1
 DCTN1
 dynactin 1
chr11_-_57282349 0.32 ENST00000528450.1
 SLC43A1
 solute carrier family 43 (amino acid system L transporter), member 1
chr16_-_18812746 0.31 ENST00000546206.2
ENST00000562819.1
ENST00000562234.2
ENST00000304414.7
ENST00000567078.2
 ARL6IP1
RP11-1035H13.3
 ADP-ribosylation factor-like 6 interacting protein 1
Uncharacterized protein
chr13_-_49107303 0.30 ENST00000344532.3
 RCBTB2
 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
chr17_-_3819751 0.28 ENST00000225538.3
 P2RX1
 purinergic receptor P2X, ligand-gated ion channel, 1
chr12_-_112819896 0.28 ENST00000377560.5
ENST00000430131.2
ENST00000550722.1
ENST00000550724.1
 HECTD4
 HECT domain containing E3 ubiquitin protein ligase 4
chr6_-_150039249 0.27 ENST00000543571.1
 LATS1
 large tumor suppressor kinase 1
chr6_-_31940065 0.24 ENST00000375349.3
ENST00000337523.5
 DXO
 decapping exoribonuclease
chr5_-_137368708 0.24 ENST00000033079.3
 FAM13B
 family with sequence similarity 13, member B
chr19_+_45973120 0.24 ENST00000592811.1
ENST00000586615.1
 FOSB
 FBJ murine osteosarcoma viral oncogene homolog B
chr14_+_79746249 0.22 ENST00000428277.2
 NRXN3
 neurexin 3
chr3_+_32726774 0.21 ENST00000538368.1
 CNOT10
 CCR4-NOT transcription complex, subunit 10
chr10_-_126849588 0.21 ENST00000411419.2
 CTBP2
 C-terminal binding protein 2
chr11_+_63997750 0.20 ENST00000321685.3
 DNAJC4
 DnaJ (Hsp40) homolog, subfamily C, member 4
chr6_+_31939608 0.19 ENST00000375331.2
ENST00000375333.2
 STK19
 serine/threonine kinase 19
chr7_+_73703728 0.18 ENST00000361545.5
ENST00000223398.6
 CLIP2
 CAP-GLY domain containing linker protein 2
chr22_+_29469100 0.17 ENST00000327813.5
ENST00000407188.1
 KREMEN1
 kringle containing transmembrane protein 1
chr12_+_107168342 0.17 ENST00000392837.4
 RIC8B
 RIC8 guanine nucleotide exchange factor B
chr1_-_68698222 0.17 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
 WLS
 wntless Wnt ligand secretion mediator
chr6_-_33285505 0.16 ENST00000431845.2
 ZBTB22
 zinc finger and BTB domain containing 22
chr17_-_4607335 0.16 ENST00000570571.1
ENST00000575101.1
ENST00000436683.2
ENST00000574876.1
 PELP1
 proline, glutamate and leucine rich protein 1
chr1_+_202431859 0.13 ENST00000391959.3
ENST00000367270.4
 PPP1R12B
 protein phosphatase 1, regulatory subunit 12B
chr2_-_178937478 0.12 ENST00000286063.6
 PDE11A
 phosphodiesterase 11A
chr16_+_56485402 0.12 ENST00000566157.1
ENST00000562150.1
ENST00000561646.1
ENST00000568397.1
 OGFOD1
 2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr17_-_1588101 0.12 ENST00000577001.1
ENST00000572621.1
ENST00000304992.6
 PRPF8
 pre-mRNA processing factor 8
chr12_-_12419703 0.11 ENST00000543091.1
ENST00000261349.4
 LRP6
 low density lipoprotein receptor-related protein 6
chr9_-_34662651 0.11 ENST00000259631.4
 CCL27
 chemokine (C-C motif) ligand 27
chr4_-_5890145 0.10 ENST00000397890.2
 CRMP1
 collapsin response mediator protein 1
chr20_+_35201857 0.10 ENST00000373874.2
 TGIF2
 TGFB-induced factor homeobox 2
chr22_+_19744226 0.10 ENST00000332710.4
ENST00000329705.7
ENST00000359500.3
 TBX1
 T-box 1
chr2_-_152955213 0.10 ENST00000427385.1
 CACNB4
 calcium channel, voltage-dependent, beta 4 subunit
chr19_-_2702681 0.10 ENST00000382159.3
 GNG7
 guanine nucleotide binding protein (G protein), gamma 7
chr16_+_31128978 0.10 ENST00000448516.2
ENST00000219797.4
 KAT8
 K(lysine) acetyltransferase 8
chr17_+_38278826 0.09 ENST00000577454.1
ENST00000578648.1
ENST00000579565.1
 MSL1
 male-specific lethal 1 homolog (Drosophila)
chr11_-_1643368 0.09 ENST00000399682.1
 KRTAP5-4
 keratin associated protein 5-4
chr16_+_30671223 0.08 ENST00000568722.1
 FBRS
 fibrosin
chr1_+_22962948 0.07 ENST00000374642.3
 C1QA
 complement component 1, q subcomponent, A chain
chr10_-_75571566 0.07 ENST00000299641.4
 NDST2
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
chr22_+_29469012 0.07 ENST00000400335.4
ENST00000400338.2
 KREMEN1
 kringle containing transmembrane protein 1
chr11_-_64511789 0.06 ENST00000419843.1
ENST00000394430.1
 RASGRP2
 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr9_-_123476719 0.05 ENST00000373930.3
 MEGF9
 multiple EGF-like-domains 9
chr11_-_2323290 0.05 ENST00000381153.3
 C11orf21
 chromosome 11 open reading frame 21
chr9_+_2621798 0.04 ENST00000382100.3
 VLDLR
 very low density lipoprotein receptor
chr6_+_31683117 0.04 ENST00000375825.3
ENST00000375824.1
 LY6G6D
 lymphocyte antigen 6 complex, locus G6D
chr1_-_110613276 0.04 ENST00000369792.4
 ALX3
 ALX homeobox 3
chr9_-_123476612 0.04 ENST00000426959.1
 MEGF9
 multiple EGF-like-domains 9
chr11_-_111170526 0.04 ENST00000355430.4
 COLCA1
 colorectal cancer associated 1
chr12_-_122018859 0.03 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
 KDM2B
 lysine (K)-specific demethylase 2B
chr8_+_29952914 0.03 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
 LEPROTL1
 leptin receptor overlapping transcript-like 1
chr19_+_38924316 0.03 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
 RYR1
 ryanodine receptor 1 (skeletal)
chr10_-_75571341 0.03 ENST00000309979.6
 NDST2
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
chr4_-_47839966 0.02 ENST00000273857.4
ENST00000505909.1
ENST00000502252.1
 CORIN
 corin, serine peptidase
chrX_+_23682379 0.02 ENST00000379349.1
 PRDX4
 peroxiredoxin 4
chr1_+_173446405 0.02 ENST00000340385.5
 PRDX6
 peroxiredoxin 6
chr12_-_108733078 0.01 ENST00000552995.1
ENST00000312143.7
ENST00000397688.2
ENST00000550402.1
 CMKLR1
 chemokine-like receptor 1
chr17_-_1420006 0.01 ENST00000320345.6
ENST00000406424.4
 INPP5K
 inositol polyphosphate-5-phosphatase K
chr1_-_115632035 0.01 ENST00000433172.1
ENST00000369514.2
ENST00000369516.2
ENST00000369515.2
 TSPAN2
 tetraspanin 2
chr5_+_161275320 0.00 ENST00000437025.2
 GABRA1
 gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr16_-_46723066 0.00 ENST00000299138.7
 VPS35
 vacuolar protein sorting 35 homolog (S. cerevisiae)

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.6 GO:0035473 lipase binding(GO:0035473)
0.6 1.9 GO:0070538 oleic acid binding(GO:0070538)
0.5 1.9 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.4 1.7 GO:0042954 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.3 3.1 GO:0048495 Roundabout binding(GO:0048495)
0.3 6.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.3 0.9 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.2 3.9 GO:0032036 myosin heavy chain binding(GO:0032036)
0.2 0.8 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 0.4 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.7 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 4.3 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 0.4 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.1 1.4 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 0.4 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.2 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.1 0.9 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1 0.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.5 GO:0070492 oligosaccharide binding(GO:0070492)
0.1 0.5 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.1 0.1 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.1 0.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.3 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 1.1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.9 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.4 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.5 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.0 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.0 1.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 1.0 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.2 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.4 GO:0048156 tau protein binding(GO:0048156)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.6 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.1 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.4 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 0.8 GO:0042169 SH2 domain binding(GO:0042169)
0.0 0.1 GO:0031543 peptidyl-proline dioxygenase activity(GO:0031543)
0.0 0.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.0 GO:0038025 glycoprotein transporter activity(GO:0034437) reelin receptor activity(GO:0038025)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 6.0 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.6 1.9 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.6 1.7 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.5 4.3 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.4 3.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.4 2.6 GO:0006642 triglyceride mobilization(GO:0006642) response to selenium ion(GO:0010269)
0.4 2.1 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.3 0.9 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.3 0.9 GO:0072277 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
0.2 0.8 GO:0000189 MAPK import into nucleus(GO:0000189)
0.1 1.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.1 0.6 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.1 0.4 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.1 1.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.0 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.1 0.9 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
0.1 0.8 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.7 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.1 1.6 GO:0090331 negative regulation of platelet aggregation(GO:0090331)
0.1 1.4 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.1 0.7 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.1 0.4 GO:0051029 rRNA transport(GO:0051029)
0.1 1.1 GO:0030903 notochord development(GO:0030903)
0.1 0.7 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.1 0.4 GO:0070560 protein secretion by platelet(GO:0070560)
0.1 0.4 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 0.1 GO:0090118 receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport(GO:0090118)
0.1 0.3 GO:0002554 serotonin production involved in inflammatory response(GO:0002351) serotonin secretion involved in inflammatory response(GO:0002442) serotonin secretion by platelet(GO:0002554)
0.1 0.3 GO:0001826 inner cell mass cell differentiation(GO:0001826)
0.1 0.8 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0 0.4 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.7 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0 0.3 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.0 0.4 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.0 0.1 GO:1902809 skeletal muscle fiber differentiation(GO:0098528) regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 1.6 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.6 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 1.8 GO:0070527 platelet aggregation(GO:0070527)
0.0 1.0 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.0 0.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.7 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 0.0 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.6 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.1 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.5 GO:0046688 response to copper ion(GO:0046688)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.0 0.8 GO:0097435 fibril organization(GO:0097435)
0.0 0.2 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 1.2 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.1 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 0.8 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.5 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 0.0 GO:0021592 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
0.0 0.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic cell cycle checkpoint(GO:0072413) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) signal transduction involved in mitotic DNA damage checkpoint(GO:1902402) signal transduction involved in mitotic DNA integrity checkpoint(GO:1902403)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.3 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 3.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 0.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 0.8 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 2.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.0 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.2 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 0.4 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 1.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.3 1.5 GO:1990393 3M complex(GO:1990393)
0.3 6.0 GO:0000145 exocyst(GO:0000145)
0.3 0.8 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 2.1 GO:0033643 host cell part(GO:0033643)
0.1 1.6 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 2.5 GO:0005859 muscle myosin complex(GO:0005859)
0.1 1.5 GO:0042599 lamellar body(GO:0042599)
0.1 0.4 GO:1990812 growth cone filopodium(GO:1990812)
0.1 0.3 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0 0.7 GO:0005869 dynactin complex(GO:0005869)
0.0 0.9 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 4.3 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.1 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.8 GO:0031143 pseudopodium(GO:0031143)
0.0 1.2 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.4 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.2 GO:0072487 MSL complex(GO:0072487)
0.0 0.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 2.0 GO:0016528 sarcoplasm(GO:0016528)
0.0 0.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 1.9 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.0 GO:0016363 nuclear matrix(GO:0016363)
0.0 0.2 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.4 GO:0005861 troponin complex(GO:0005861)
0.0 1.4 GO:0005902 microvillus(GO:0005902)
0.0 1.7 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 1.1 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 0.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.6 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.5 GO:0005891 voltage-gated calcium channel complex(GO:0005891)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 3.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 0.7 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 3.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.3 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 2.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 3.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 0.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 2.1 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.8 PID RHOA REG PATHWAY Regulation of RhoA activity