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ENCODE cell lines, expression (Ernst 2011)

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Results for POU4F2

Z-value: 0.50

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Transcription factors associated with POU4F2

Gene Symbol Gene ID Gene Info
POU4F2
ENSG00000151615.3 POU4F2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU4F2hg19_v2_chr4_+_147560042_147560046-0.332.1e-01Click!

Activity profile of POU4F2 motif

Sorted Z-values of POU4F2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU4F2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_49834299 1.70 ENST00000396822.1
 SNAI2
 snail family zinc finger 2
chr8_-_18541603 1.61 ENST00000428502.2
 PSD3
 pleckstrin and Sec7 domain containing 3
chr12_-_89746173 1.58 ENST00000308385.6
 DUSP6
 dual specificity phosphatase 6
chr8_-_49833978 1.57 ENST00000020945.1
 SNAI2
 snail family zinc finger 2
chr4_+_169418195 1.54 ENST00000261509.6
ENST00000335742.7
 PALLD
 palladin, cytoskeletal associated protein
chr3_-_79816965 1.50 ENST00000464233.1
 ROBO1
 roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr4_+_169418255 1.11 ENST00000505667.1
ENST00000511948.1
 PALLD
 palladin, cytoskeletal associated protein
chr7_-_81399329 0.90 ENST00000453411.1
ENST00000444829.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr7_-_81399438 0.59 ENST00000222390.5
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr9_+_125132803 0.47 ENST00000540753.1
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr14_-_70883708 0.47 ENST00000256366.4
 SYNJ2BP
 synaptojanin 2 binding protein
chr3_+_159557637 0.46 ENST00000445224.2
 SCHIP1
 schwannomin interacting protein 1
chr1_+_40506392 0.43 ENST00000414893.1
ENST00000414281.1
ENST00000420216.1
ENST00000372792.2
ENST00000372798.1
ENST00000340450.3
ENST00000372805.3
ENST00000435719.1
ENST00000427843.1
ENST00000417287.1
ENST00000424977.1
ENST00000446031.1
 CAP1
 CAP, adenylate cyclase-associated protein 1 (yeast)
chr7_-_81399411 0.42 ENST00000423064.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr17_-_64225508 0.41 ENST00000205948.6
 APOH
 apolipoprotein H (beta-2-glycoprotein I)
chr9_+_125133315 0.35 ENST00000223423.4
ENST00000362012.2
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr7_-_81399355 0.32 ENST00000457544.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr6_-_109777128 0.31 ENST00000358807.3
ENST00000358577.3
 MICAL1
 microtubule associated monooxygenase, calponin and LIM domain containing 1
chr5_-_134914673 0.27 ENST00000512158.1
 CXCL14
 chemokine (C-X-C motif) ligand 14
chr13_-_36050819 0.27 ENST00000379919.4
 MAB21L1
 mab-21-like 1 (C. elegans)
chr12_-_30887948 0.23 ENST00000433722.2
 CAPRIN2
 caprin family member 2
chr4_-_10686475 0.22 ENST00000226951.6
 CLNK
 cytokine-dependent hematopoietic cell linker
chr18_-_71959159 0.20 ENST00000494131.2
ENST00000397914.4
ENST00000340533.4
 CYB5A
 cytochrome b5 type A (microsomal)
chr6_+_39760129 0.18 ENST00000274867.4
 DAAM2
 dishevelled associated activator of morphogenesis 2
chr12_+_109577202 0.15 ENST00000377848.3
ENST00000377854.5
 ACACB
 acetyl-CoA carboxylase beta
chr18_+_28898052 0.15 ENST00000257192.4
 DSG1
 desmoglein 1
chr17_-_7832753 0.14 ENST00000303790.2
 KCNAB3
 potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr14_+_32030582 0.14 ENST00000550649.1
ENST00000281081.7
 NUBPL
 nucleotide binding protein-like
chr20_+_56136136 0.12 ENST00000319441.4
ENST00000543666.1
 PCK1
 phosphoenolpyruvate carboxykinase 1 (soluble)
chr12_-_118797475 0.12 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
 TAOK3
 TAO kinase 3
chr19_+_1269324 0.11 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
 CIRBP
 cold inducible RNA binding protein
chrX_-_18690210 0.11 ENST00000379984.3
 RS1
 retinoschisin 1
chr4_+_169013666 0.11 ENST00000359299.3
 ANXA10
 annexin A10
chr1_+_229440129 0.09 ENST00000366688.3
 SPHAR
 S-phase response (cyclin related)
chr5_-_140998481 0.09 ENST00000518047.1
 DIAPH1
 diaphanous-related formin 1
chr1_-_44482979 0.08 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
 SLC6A9
 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr8_+_22857048 0.08 ENST00000251822.6
 RHOBTB2
 Rho-related BTB domain containing 2
chr5_+_66300446 0.07 ENST00000261569.7
 MAST4
 microtubule associated serine/threonine kinase family member 4
chr12_-_118796910 0.06 ENST00000541186.1
ENST00000539872.1
 TAOK3
 TAO kinase 3
chr11_-_125550764 0.05 ENST00000527795.1
 ACRV1
 acrosomal vesicle protein 1
chr6_-_111136513 0.05 ENST00000368911.3
 CDK19
 cyclin-dependent kinase 19
chr11_+_118175132 0.04 ENST00000361763.4
 CD3E
 CD3e molecule, epsilon (CD3-TCR complex)
chr12_+_53848505 0.03 ENST00000552819.1
ENST00000455667.3
 PCBP2
 poly(rC) binding protein 2
chr14_+_55221541 0.03 ENST00000555192.1
 SAMD4A
 sterile alpha motif domain containing 4A
chr2_+_44502597 0.03 ENST00000260649.6
ENST00000409387.1
 SLC3A1
 solute carrier family 3 (amino acid transporter heavy chain), member 1
chr2_-_70780572 0.01 ENST00000450929.1
 TGFA
 transforming growth factor, alpha
chr12_+_56510368 0.01 ENST00000546591.1
ENST00000501597.3
 RPL41
 ribosomal protein L41
chrX_+_68835911 0.00 ENST00000525810.1
ENST00000527388.1
ENST00000374553.2
ENST00000374552.4
ENST00000338901.3
ENST00000524573.1
 EDA
 ectodysplasin A

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 1.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 1.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.1 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.6 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.5 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.3 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.5 1.5 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.4 1.6 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.3 2.2 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 2.6 GO:0003334 keratinocyte development(GO:0003334)
0.1 0.3 GO:0019417 sulfur oxidation(GO:0019417)
0.1 1.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.5 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 0.4 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.2 GO:2001295 malonyl-CoA biosynthetic process(GO:2001295)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
0.0 0.1 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.2 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 0.8 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 2.6 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 1.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 1.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 2.2 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.1 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.2 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.0 0.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 3.3 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 3.1 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly