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ENCODE cell lines, expression (Ernst 2011)

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Results for POU6F1

Z-value: 0.55

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Transcription factors associated with POU6F1

Gene Symbol Gene ID Gene Info
POU6F1
ENSG00000184271.11 POU6F1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
POU6F1hg19_v2_chr12_-_51611477_516116120.439.3e-02Click!

Activity profile of POU6F1 motif

Sorted Z-values of POU6F1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of POU6F1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_91546926 1.80 ENST00000550758.1
 DCN
 decorin
chr6_+_151646800 1.61 ENST00000354675.6
 AKAP12
 A kinase (PRKA) anchor protein 12
chr3_-_127541194 1.45 ENST00000453507.2
 MGLL
 monoglyceride lipase
chr2_-_217560248 0.99 ENST00000233813.4
 IGFBP5
 insulin-like growth factor binding protein 5
chr2_+_102721023 0.95 ENST00000409589.1
ENST00000409329.1
 IL1R1
 interleukin 1 receptor, type I
chr18_+_61554932 0.81 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
 SERPINB2
 serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr7_-_83824169 0.76 ENST00000265362.4
 SEMA3A
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr7_+_80267973 0.48 ENST00000394788.3
ENST00000447544.2
 CD36
 CD36 molecule (thrombospondin receptor)
chr9_-_13165457 0.36 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
 MPDZ
 multiple PDZ domain protein
chr14_-_70883708 0.36 ENST00000256366.4
 SYNJ2BP
 synaptojanin 2 binding protein
chr3_-_114343768 0.29 ENST00000393785.2
 ZBTB20
 zinc finger and BTB domain containing 20
chr9_+_128509624 0.29 ENST00000342287.5
ENST00000373487.4
 PBX3
 pre-B-cell leukemia homeobox 3
chr11_-_89224139 0.25 ENST00000413594.2
 NOX4
 NADPH oxidase 4
chr13_+_58206655 0.24 ENST00000377918.3
 PCDH17
 protocadherin 17
chr19_+_52076425 0.24 ENST00000436511.2
 ZNF175
 zinc finger protein 175
chr6_-_111804905 0.22 ENST00000358835.3
ENST00000435970.1
 REV3L
 REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr5_+_115177178 0.22 ENST00000316788.7
 AP3S1
 adaptor-related protein complex 3, sigma 1 subunit
chr19_-_58662139 0.21 ENST00000598312.1
 ZNF329
 zinc finger protein 329
chr11_-_89223883 0.20 ENST00000528341.1
 NOX4
 NADPH oxidase 4
chr20_-_58515344 0.19 ENST00000370996.3
 PPP1R3D
 protein phosphatase 1, regulatory subunit 3D
chr15_-_85259330 0.19 ENST00000560266.1
 SEC11A
 SEC11 homolog A (S. cerevisiae)
chr15_-_85259294 0.18 ENST00000558217.1
ENST00000558196.1
ENST00000558134.1
 SEC11A
 SEC11 homolog A (S. cerevisiae)
chr15_-_85259384 0.15 ENST00000455959.3
 SEC11A
 SEC11 homolog A (S. cerevisiae)
chr15_+_59279851 0.13 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
 RNF111
 ring finger protein 111
chr6_-_110501200 0.12 ENST00000392586.1
ENST00000419252.1
ENST00000392589.1
ENST00000392588.1
ENST00000359451.2
 WASF1
 WAS protein family, member 1
chr15_-_85259360 0.10 ENST00000559729.1
 SEC11A
 SEC11 homolog A (S. cerevisiae)
chr18_+_9475001 0.10 ENST00000019317.4
 RALBP1
 ralA binding protein 1
chr2_+_242289502 0.10 ENST00000451310.1
 SEPT2
 septin 2
chr20_+_34129770 0.10 ENST00000348547.2
ENST00000357394.4
ENST00000447986.1
ENST00000279052.6
ENST00000416206.1
ENST00000411577.1
ENST00000413587.1
 ERGIC3
 ERGIC and golgi 3
chr15_+_80351977 0.10 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
 ZFAND6
 zinc finger, AN1-type domain 6
chr5_+_162864575 0.09 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
 CCNG1
 cyclin G1
chr2_+_128403720 0.08 ENST00000272644.3
 GPR17
 G protein-coupled receptor 17
chr4_+_113970772 0.07 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
 ANK2
 ankyrin 2, neuronal
chrX_+_119737806 0.07 ENST00000371317.5
 MCTS1
 malignant T cell amplified sequence 1
chr15_+_80351910 0.07 ENST00000261749.6
ENST00000561060.1
 ZFAND6
 zinc finger, AN1-type domain 6
chr2_+_128403439 0.05 ENST00000544369.1
 GPR17
 G protein-coupled receptor 17
chr6_+_25754927 0.05 ENST00000377905.4
ENST00000439485.2
 SLC17A4
 solute carrier family 17, member 4
chr6_+_42123141 0.05 ENST00000418175.1
ENST00000541991.1
ENST00000053469.4
ENST00000394237.1
ENST00000372963.1
 GUCA1A
RP1-139D8.6
 guanylate cyclase activator 1A (retina)
RP1-139D8.6
chr6_+_110501621 0.05 ENST00000368930.1
ENST00000307731.1
 CDC40
 cell division cycle 40
chr22_-_32767017 0.04 ENST00000400234.1
 RFPL3S
 RFPL3 antisense
chr11_+_85339623 0.04 ENST00000358867.6
ENST00000534341.1
ENST00000393375.1
ENST00000531274.1
 TMEM126B
 transmembrane protein 126B
chr9_-_86955598 0.03 ENST00000376238.4
 SLC28A3
 solute carrier family 28 (concentrative nucleoside transporter), member 3
chr11_+_2323349 0.03 ENST00000381121.3
 TSPAN32
 tetraspanin 32
chr7_-_38407770 0.03 ENST00000390348.2
 TRGV1
 T cell receptor gamma variable 1 (non-functional)
chr1_-_21377383 0.03 ENST00000374935.3
 EIF4G3
 eukaryotic translation initiation factor 4 gamma, 3
chr3_-_108248169 0.02 ENST00000273353.3
 MYH15
 myosin, heavy chain 15
chr6_+_110501344 0.02 ENST00000368932.1
 CDC40
 cell division cycle 40
chr22_+_31518938 0.02 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
 INPP5J
 inositol polyphosphate-5-phosphatase J
chr10_-_94257512 0.02 ENST00000371581.5
 IDE
 insulin-degrading enzyme
chr16_-_87350970 0.02 ENST00000567970.1
 C16orf95
 chromosome 16 open reading frame 95
chr4_+_110749143 0.01 ENST00000317735.4
 RRH
 retinal pigment epithelium-derived rhodopsin homolog
chr11_+_2323236 0.01 ENST00000182290.4
 TSPAN32
 tetraspanin 32
chr1_+_176432298 0.01 ENST00000367661.3
ENST00000367662.3
 PAPPA2
 pappalysin 2
chr9_-_118687405 0.00 ENST00000374014.3
 LINC00474
 long intergenic non-protein coding RNA 474
chr2_-_166060571 0.00 ENST00000360093.3
 SCN3A
 sodium channel, voltage-gated, type III, alpha subunit
chr8_-_146176199 0.00 ENST00000532351.1
ENST00000276816.4
ENST00000394909.2
 ZNF16
 zinc finger protein 16
chr17_-_40337470 0.00 ENST00000293330.1
 HCRT
 hypocretin (orexin) neuropeptide precursor
chr1_-_47655686 0.00 ENST00000294338.2
 PDZK1IP1
 PDZK1 interacting protein 1

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.9 PID IL1 PATHWAY IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 1.4 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.8 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 0.6 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 1.0 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.1 0.6 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.3 0.9 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.2 1.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.2 0.8 GO:0048880 sensory system development(GO:0048880)
0.1 1.8 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 1.6 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 0.5 GO:0070543 response to linoleic acid(GO:0070543)
0.0 0.3 GO:0007386 compartment pattern specification(GO:0007386)
0.0 0.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.2 GO:2000807 regulation of synaptic vesicle clustering(GO:2000807)
0.0 0.6 GO:0006465 signal peptide processing(GO:0006465)
0.0 0.8 GO:0042730 fibrinolysis(GO:0042730)
0.0 0.1 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0002188 translation reinitiation(GO:0002188)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.2 GO:0099514 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.4 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.1 GO:0002862 negative regulation of inflammatory response to antigenic stimulus(GO:0002862)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.1 1.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 1.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 1.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.5 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.1 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.4 GO:0019826 oxygen sensor activity(GO:0019826)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 1.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.0 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389)