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ENCODE cell lines, expression (Ernst 2011)

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Results for PPARD

Z-value: 0.62

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Transcription factors associated with PPARD

Gene Symbol Gene ID Gene Info
PPARD
ENSG00000112033.9 PPARD

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PPARDhg19_v2_chr6_+_35310312_35310359-0.312.4e-01Click!

Activity profile of PPARD motif

Sorted Z-values of PPARD motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PPARD

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_+_43985084 1.39 ENST00000434505.1
ENST00000411750.1
 CKMT1A
 creatine kinase, mitochondrial 1A
chr15_+_43885252 1.29 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
 CKMT1B
 creatine kinase, mitochondrial 1B
chr6_+_33172407 0.67 ENST00000374662.3
 HSD17B8
 hydroxysteroid (17-beta) dehydrogenase 8
chr4_+_174089904 0.64 ENST00000265000.4
 GALNT7
 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr1_+_156123318 0.61 ENST00000368285.3
 SEMA4A
 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr19_+_10197463 0.54 ENST00000590378.1
ENST00000397881.3
 C19orf66
 chromosome 19 open reading frame 66
chr15_-_82555000 0.54 ENST00000557844.1
ENST00000359445.3
ENST00000268206.7
 EFTUD1
 elongation factor Tu GTP binding domain containing 1
chr19_-_10687983 0.52 ENST00000587069.1
 AP1M2
 adaptor-related protein complex 1, mu 2 subunit
chr19_-_10687907 0.52 ENST00000589348.1
 AP1M2
 adaptor-related protein complex 1, mu 2 subunit
chr19_+_10196981 0.49 ENST00000591813.1
 C19orf66
 chromosome 19 open reading frame 66
chr5_-_16509101 0.49 ENST00000399793.2
 FAM134B
 family with sequence similarity 134, member B
chr15_+_78441663 0.46 ENST00000299518.2
ENST00000558554.1
ENST00000557826.1
ENST00000561279.1
ENST00000559186.1
ENST00000560770.1
ENST00000559881.1
ENST00000559205.1
ENST00000441490.2
 IDH3A
 isocitrate dehydrogenase 3 (NAD+) alpha
chrX_-_148571884 0.46 ENST00000537071.1
 IDS
 iduronate 2-sulfatase
chr1_-_197036364 0.39 ENST00000367412.1
 F13B
 coagulation factor XIII, B polypeptide
chr3_-_48936272 0.38 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
 SLC25A20
 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr17_-_39728303 0.36 ENST00000588431.1
ENST00000246662.4
 KRT9
 keratin 9
chr8_-_80942467 0.34 ENST00000518271.1
ENST00000276585.4
ENST00000521605.1
 MRPS28
 mitochondrial ribosomal protein S28
chr9_+_126773880 0.34 ENST00000373615.4
 LHX2
 LIM homeobox 2
chr8_-_80942061 0.33 ENST00000519386.1
 MRPS28
 mitochondrial ribosomal protein S28
chr19_-_10687948 0.33 ENST00000592285.1
 AP1M2
 adaptor-related protein complex 1, mu 2 subunit
chr12_-_95467267 0.32 ENST00000330677.7
 NR2C1
 nuclear receptor subfamily 2, group C, member 1
chr8_-_80942139 0.30 ENST00000521434.1
ENST00000519120.1
ENST00000520946.1
 MRPS28
 mitochondrial ribosomal protein S28
chr16_+_2255710 0.29 ENST00000397124.1
ENST00000565250.1
 MLST8
 MTOR associated protein, LST8 homolog (S. cerevisiae)
chr22_-_51017084 0.27 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
 CPT1B
 carnitine palmitoyltransferase 1B (muscle)
chr22_-_51016846 0.27 ENST00000312108.7
ENST00000395650.2
 CPT1B
 carnitine palmitoyltransferase 1B (muscle)
chr11_-_119599794 0.27 ENST00000264025.3
 PVRL1
 poliovirus receptor-related 1 (herpesvirus entry mediator C)
chr11_-_116968987 0.27 ENST00000434315.2
ENST00000292055.4
ENST00000375288.1
ENST00000542607.1
ENST00000445177.1
ENST00000375300.1
ENST00000446921.2
 SIK3
 SIK family kinase 3
chr16_+_2255841 0.27 ENST00000301725.7
 MLST8
 MTOR associated protein, LST8 homolog (S. cerevisiae)
chr6_-_33547975 0.26 ENST00000442998.2
ENST00000360661.5
 BAK1
 BCL2-antagonist/killer 1
chr22_-_29784519 0.26 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
 AP1B1
 adaptor-related protein complex 1, beta 1 subunit
chr4_-_7069760 0.25 ENST00000264954.4
 GRPEL1
 GrpE-like 1, mitochondrial (E. coli)
chr6_-_33548006 0.24 ENST00000374467.3
 BAK1
 BCL2-antagonist/killer 1
chr22_+_30163340 0.24 ENST00000330029.6
ENST00000401406.3
 UQCR10
 ubiquinol-cytochrome c reductase, complex III subunit X
chr17_+_48610074 0.24 ENST00000503690.1
ENST00000514874.1
ENST00000537145.1
ENST00000541226.1
 EPN3
 epsin 3
chr11_+_64073699 0.23 ENST00000405666.1
ENST00000468670.1
 ESRRA
 estrogen-related receptor alpha
chr2_+_219433281 0.22 ENST00000273064.6
ENST00000509807.2
ENST00000542068.1
 RQCD1
 RCD1 required for cell differentiation1 homolog (S. pombe)
chr19_-_3062465 0.22 ENST00000327141.4
 AES
 amino-terminal enhancer of split
chr19_+_17420340 0.21 ENST00000359866.4
 DDA1
 DET1 and DDB1 associated 1
chr1_-_29508321 0.21 ENST00000546138.1
 SRSF4
 serine/arginine-rich splicing factor 4
chr16_+_81272287 0.21 ENST00000425577.2
ENST00000564552.1
 BCMO1
 beta-carotene 15,15'-monooxygenase 1
chr16_-_4401258 0.19 ENST00000577031.1
 PAM16
 presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr11_-_45939565 0.19 ENST00000525192.1
ENST00000378750.5
 PEX16
 peroxisomal biogenesis factor 16
chr11_-_45939374 0.18 ENST00000533151.1
ENST00000241041.3
 PEX16
 peroxisomal biogenesis factor 16
chrX_-_108868390 0.18 ENST00000372101.2
 KCNE1L
 KCNE1-like
chr15_+_75494214 0.17 ENST00000394987.4
 C15orf39
 chromosome 15 open reading frame 39
chr1_-_161102421 0.16 ENST00000490843.2
ENST00000368006.3
ENST00000392188.1
ENST00000545495.1
 DEDD
 death effector domain containing
chr19_+_39616410 0.16 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
 PAK4
 p21 protein (Cdc42/Rac)-activated kinase 4
chr1_-_161102367 0.15 ENST00000464113.1
 DEDD
 death effector domain containing
chr1_-_11107280 0.14 ENST00000400897.3
ENST00000400898.3
 MASP2
 mannan-binding lectin serine peptidase 2
chr20_-_44485835 0.14 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
 ACOT8
 acyl-CoA thioesterase 8
chr20_+_46130601 0.14 ENST00000341724.6
 NCOA3
 nuclear receptor coactivator 3
chr11_+_17281900 0.14 ENST00000530527.1
 NUCB2
 nucleobindin 2
chr12_+_60058458 0.13 ENST00000548610.1
 SLC16A7
 solute carrier family 16 (monocarboxylate transporter), member 7
chr1_+_165864800 0.13 ENST00000469256.2
 UCK2
 uridine-cytidine kinase 2
chr10_-_103815874 0.12 ENST00000370033.4
ENST00000311122.5
 C10orf76
 chromosome 10 open reading frame 76
chr12_+_121163538 0.12 ENST00000242592.4
 ACADS
 acyl-CoA dehydrogenase, C-2 to C-3 short chain
chr3_+_48507210 0.12 ENST00000433541.1
ENST00000422277.2
ENST00000436480.2
ENST00000444177.1
 TREX1
 three prime repair exonuclease 1
chr10_+_94050913 0.12 ENST00000358935.2
 MARCH5
 membrane-associated ring finger (C3HC4) 5
chr2_+_206547215 0.11 ENST00000360409.3
ENST00000540178.1
ENST00000540841.1
ENST00000355117.4
ENST00000450507.1
ENST00000417189.1
 NRP2
 neuropilin 2
chr6_+_30594619 0.11 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
 ATAT1
 alpha tubulin acetyltransferase 1
chr17_+_7483761 0.11 ENST00000584180.1
 CD68
 CD68 molecule
chr12_+_96252706 0.11 ENST00000266735.5
ENST00000553192.1
ENST00000552085.1
 SNRPF
 small nuclear ribonucleoprotein polypeptide F
chr3_-_187009798 0.10 ENST00000337774.5
 MASP1
 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
chr21_-_27107198 0.10 ENST00000400094.1
 ATP5J
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr4_+_140586922 0.10 ENST00000265498.1
ENST00000506797.1
 MGST2
 microsomal glutathione S-transferase 2
chr3_+_186383741 0.10 ENST00000232003.4
 HRG
 histidine-rich glycoprotein
chrX_+_2746818 0.10 ENST00000398806.3
 GYG2
 glycogenin 2
chr20_+_42187682 0.09 ENST00000373092.3
ENST00000373077.1
 SGK2
 serum/glucocorticoid regulated kinase 2
chr1_+_159175201 0.09 ENST00000368121.2
 DARC
 Duffy blood group, atypical chemokine receptor
chr16_-_4401284 0.09 ENST00000318059.3
 PAM16
 presequence translocase-associated motor 16 homolog (S. cerevisiae)
chr1_+_165864821 0.08 ENST00000470820.1
 UCK2
 uridine-cytidine kinase 2
chr20_+_42187608 0.08 ENST00000373100.1
 SGK2
 serum/glucocorticoid regulated kinase 2
chr21_-_27107283 0.08 ENST00000284971.3
ENST00000400099.1
 ATP5J
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr1_+_55107449 0.07 ENST00000421030.2
ENST00000545244.1
ENST00000339553.5
ENST00000409996.1
ENST00000454855.2
 MROH7
 maestro heat-like repeat family member 7
chr12_-_21757774 0.07 ENST00000261195.2
 GYS2
 glycogen synthase 2 (liver)
chr6_+_43265992 0.07 ENST00000449231.1
ENST00000372589.3
ENST00000372585.5
 SLC22A7
 solute carrier family 22 (organic anion transporter), member 7
chr21_-_27107344 0.07 ENST00000457143.2
 ATP5J
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr21_+_27107672 0.06 ENST00000400075.3
 GABPA
 GA binding protein transcription factor, alpha subunit 60kDa
chr2_+_178257372 0.06 ENST00000264167.4
ENST00000409888.1
 AGPS
 alkylglycerone phosphate synthase
chr12_-_56727487 0.06 ENST00000548043.1
ENST00000425394.2
 PAN2
 PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr1_-_160832642 0.05 ENST00000368034.4
 CD244
 CD244 molecule, natural killer cell receptor 2B4
chr21_-_27107881 0.05 ENST00000400090.3
ENST00000400087.3
ENST00000400093.3
 ATP5J
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr12_-_53320245 0.05 ENST00000552150.1
 KRT8
 keratin 8
chr1_-_120311517 0.04 ENST00000369406.3
ENST00000544913.2
 HMGCS2
 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
chr6_+_88299833 0.04 ENST00000392844.3
ENST00000257789.4
ENST00000546266.1
ENST00000417380.2
 ORC3
 origin recognition complex, subunit 3
chr4_+_159593271 0.04 ENST00000512251.1
ENST00000511912.1
 ETFDH
 electron-transferring-flavoprotein dehydrogenase
chr16_-_74808710 0.03 ENST00000219368.3
ENST00000544337.1
 FA2H
 fatty acid 2-hydroxylase
chrX_+_38211777 0.03 ENST00000039007.4
 OTC
 ornithine carbamoyltransferase
chr1_+_9005917 0.03 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
 CA6
 carbonic anhydrase VI
chr1_-_11863171 0.03 ENST00000376592.1
 MTHFR
 methylenetetrahydrofolate reductase (NAD(P)H)
chr11_-_61658853 0.02 ENST00000525588.1
ENST00000540820.1
 FADS3
 fatty acid desaturase 3
chr19_+_49867181 0.02 ENST00000597546.1
 DKKL1
 dickkopf-like 1
chr1_+_62417957 0.01 ENST00000307297.7
ENST00000543708.1
 INADL
 InaD-like (Drosophila)
chr6_+_43266063 0.00 ENST00000372574.3
 SLC22A7
 solute carrier family 22 (organic anion transporter), member 7
chr3_-_125094093 0.00 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
 ZNF148
 zinc finger protein 148
chr6_+_72922505 0.00 ENST00000401910.3
 RIMS1
 regulating synaptic membrane exocytosis 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.1 1.4 GO:0006600 creatine metabolic process(GO:0006600)
0.1 0.4 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.1 0.2 GO:0009224 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.0 0.9 GO:0006853 carnitine shuttle(GO:0006853)
0.0 0.6 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.3 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.6 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.2 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0 0.3 GO:0021978 telencephalon regionalization(GO:0021978)
0.0 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.7 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 0.2 GO:2000210 positive regulation of anoikis(GO:2000210)
0.0 0.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0 0.1 GO:0035624 receptor transactivation(GO:0035624)
0.0 0.1 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.1 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0 0.4 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.5 GO:0038202 TORC1 signaling(GO:0038202)
0.0 0.5 GO:0030207 chondroitin sulfate catabolic process(GO:0030207)
0.0 0.0 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.0 1.0 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 0.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.1 GO:0090141 positive regulation of mitochondrial fission(GO:0090141)
0.0 0.1 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0 0.0 GO:0070781 arginine biosynthetic process via ornithine(GO:0042450) response to biotin(GO:0070781)
0.0 0.1 GO:0016559 peroxisome fission(GO:0016559)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0004111 creatine kinase activity(GO:0004111)
0.1 0.7 GO:0070404 NADH binding(GO:0070404)
0.1 0.4 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.1 0.5 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.1 0.5 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.0 0.6 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.6 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0001855 complement component C4b binding(GO:0001855)
0.0 0.2 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.5 GO:0051400 BH domain binding(GO:0051400)
0.0 0.1 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0 0.5 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.2 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.0 0.1 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.0 0.2 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.1 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.9 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.5 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.5 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 0.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 1.0 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.2 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.4 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0005683 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0 0.0 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.0 0.0 GO:0031251 PAN complex(GO:0031251)
0.0 0.1 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.1 GO:0002116 semaphorin receptor complex(GO:0002116)