ENCODE cell lines, expression (Ernst 2011)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
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Gene Symbol	Gene ID	Gene Info
PRDM1 Links Ensembl NCBI GeneCards UniProt	ENSG00000057657.10	PRDM1

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PRDM1	hg19_v2_chr6_+_106534192_106534224, hg19_v2_chr6_+_106546808_106546833	0.01	9.8e-01	Click!

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Promoter	Score	Transcript	Gene	Gene Info
chr6_-_112575912	4.27	ENST00000522006.1 ENST00000230538.7 ENST00000519932.1	LAMA4	laminin, alpha 4
chr6_-_112575687	3.31	ENST00000521398.1 ENST00000424408.2 ENST00000243219.3	LAMA4	laminin, alpha 4
chr6_-_112575838	2.78	ENST00000455073.1	LAMA4	laminin, alpha 4
chr15_-_37393406	2.44	ENST00000338564.5 ENST00000558313.1 ENST00000340545.5	MEIS2	Meis homeobox 2
chr11_+_46402583	2.36	ENST00000359803.3	MDK	midkine (neurite growth-promoting factor 2)
chr5_+_92919043	2.30	ENST00000327111.3	NR2F1	nuclear receptor subfamily 2, group F, member 1
chr6_-_112575758	2.15	ENST00000431543.2 ENST00000453937.2 ENST00000368638.4 ENST00000389463.4	LAMA4	laminin, alpha 4
chr11_+_46402744	2.00	ENST00000533952.1	MDK	midkine (neurite growth-promoting factor 2)
chr9_+_137533615	1.93	ENST00000371817.3	COL5A1	collagen, type V, alpha 1
chr8_+_97506033	1.92	ENST00000518385.1	SDC2	syndecan 2
chr11_+_46402297	1.85	ENST00000405308.2	MDK	midkine (neurite growth-promoting factor 2)
chr11_+_46402482	1.80	ENST00000441869.1	MDK	midkine (neurite growth-promoting factor 2)
chr3_+_8543393	1.72	ENST00000157600.3 ENST00000415597.1 ENST00000535732.1	LMCD1	LIM and cysteine-rich domains 1
chr10_-_44880491	1.70	ENST00000374426.2 ENST00000395795.4 ENST00000395794.2 ENST00000374429.2 ENST00000395793.3 ENST00000343575.6	CXCL12	chemokine (C-X-C motif) ligand 12
chr1_+_212782012	1.67	ENST00000341491.4 ENST00000366985.1	ATF3	activating transcription factor 3
chr3_+_8543561	1.51	ENST00000397386.3	LMCD1	LIM and cysteine-rich domains 1
chr4_-_100242549	1.22	ENST00000305046.8 ENST00000394887.3	ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide
chr22_-_36556821	1.08	ENST00000531095.1 ENST00000397293.2 ENST00000349314.2	APOL3	apolipoprotein L, 3
chrX_-_118827333	1.07	ENST00000360156.7 ENST00000354228.4 ENST00000489216.1 ENST00000354416.3 ENST00000394610.1 ENST00000343984.5	SEPT6	septin 6
chr16_-_67970990	1.07	ENST00000358514.4	PSMB10	proteasome (prosome, macropain) subunit, beta type, 10
chr3_-_114343039	1.04	ENST00000481632.1	ZBTB20	zinc finger and BTB domain containing 20
chr13_+_102104980	1.03	ENST00000545560.2	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)
chr5_-_94417339	1.03	ENST00000429576.2 ENST00000508509.1 ENST00000510732.1	MCTP1	multiple C2 domains, transmembrane 1
chr6_-_167275991	1.00	ENST00000510118.1	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr18_-_53070913	0.99	ENST00000568186.1 ENST00000564228.1	TCF4	transcription factor 4
chr5_-_96143796	0.94	ENST00000296754.3	ERAP1	endoplasmic reticulum aminopeptidase 1
chr7_+_134832808	0.93	ENST00000275767.3	TMEM140	transmembrane protein 140
chr6_-_29527702	0.92	ENST00000377050.4	UBD	ubiquitin D
chr3_-_49851313	0.91	ENST00000333486.3	UBA7	ubiquitin-like modifier activating enzyme 7
chr15_-_37392086	0.88	ENST00000561208.1	MEIS2	Meis homeobox 2
chr5_-_93447333	0.88	ENST00000395965.3 ENST00000505869.1 ENST00000509163.1	FAM172A	family with sequence similarity 172, member A
chr12_+_51318513	0.87	ENST00000332160.4	METTL7A	methyltransferase like 7A
chr3_-_46000064	0.86	ENST00000433878.1	FYCO1	FYVE and coiled-coil domain containing 1
chr6_-_167276033	0.82	ENST00000503859.1 ENST00000506565.1	RPS6KA2	ribosomal protein S6 kinase, 90kDa, polypeptide 2
chrX_-_119694538	0.82	ENST00000371322.5	CUL4B	cullin 4B
chr4_+_142558078	0.81	ENST00000529613.1	IL15	interleukin 15
chr8_-_29120580	0.81	ENST00000524189.1	KIF13B	kinesin family member 13B
chr4_+_142557771	0.80	ENST00000514653.1	IL15	interleukin 15
chr2_-_145275228	0.79	ENST00000427902.1 ENST00000409487.3 ENST00000470879.1 ENST00000435831.1	ZEB2	zinc finger E-box binding homeobox 2
chr17_-_26694979	0.78	ENST00000438614.1	VTN	vitronectin
chr1_+_207262881	0.77	ENST00000451804.2	C4BPB	complement component 4 binding protein, beta
chr17_-_26695013	0.77	ENST00000555059.2	CTB-96E2.2	Homeobox protein SEBOX
chr7_-_86849025	0.76	ENST00000257637.3	TMEM243	transmembrane protein 243, mitochondrial
chr14_+_24605389	0.76	ENST00000382708.3 ENST00000561435.1	PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr4_+_142557717	0.75	ENST00000320650.4 ENST00000296545.7	IL15	interleukin 15
chr3_+_69915385	0.75	ENST00000314589.5	MITF	microphthalmia-associated transcription factor
chr3_+_8543533	0.72	ENST00000454244.1	LMCD1	LIM and cysteine-rich domains 1
chr21_-_40033618	0.65	ENST00000417133.2 ENST00000398910.1 ENST00000442448.1	ERG	v-ets avian erythroblastosis virus E26 oncogene homolog
chr14_+_24605361	0.64	ENST00000206451.6 ENST00000559123.1	PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
chr17_+_41158742	0.63	ENST00000415816.2 ENST00000438323.2	IFI35	interferon-induced protein 35
chr11_+_128634589	0.62	ENST00000281428.8	FLI1	Fli-1 proto-oncogene, ETS transcription factor
chr7_-_122526499	0.60	ENST00000412584.2	CADPS2	Ca++-dependent secretion activator 2
chr20_+_30946106	0.54	ENST00000375687.4 ENST00000542461.1	ASXL1	additional sex combs like 1 (Drosophila)
chr3_+_159706537	0.54	ENST00000305579.2 ENST00000480787.1 ENST00000466512.1	IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
chr11_+_128563948	0.53	ENST00000534087.2	FLI1	Fli-1 proto-oncogene, ETS transcription factor
chr9_-_117568365	0.49	ENST00000374045.4	TNFSF15	tumor necrosis factor (ligand) superfamily, member 15
chr12_-_106641728	0.49	ENST00000378026.4	CKAP4	cytoskeleton-associated protein 4
chr6_-_32811771	0.47	ENST00000395339.3 ENST00000374882.3	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8
chr6_+_32811885	0.47	ENST00000458296.1 ENST00000413039.1 ENST00000429600.1 ENST00000412095.1 ENST00000415067.1 ENST00000395330.1	TAPSAR1 PSMB9	TAP1 and PSMB8 antisense RNA 1 proteasome (prosome, macropain) subunit, beta type, 9
chr2_+_231191875	0.44	ENST00000444636.1 ENST00000415673.2 ENST00000243810.6 ENST00000396563.4	SP140L	SP140 nuclear body protein-like
chr12_-_71003568	0.43	ENST00000547715.1 ENST00000451516.2 ENST00000538708.1 ENST00000550857.1 ENST00000261266.5	PTPRB	protein tyrosine phosphatase, receptor type, B
chr1_-_153919128	0.40	ENST00000361217.4	DENND4B	DENN/MADD domain containing 4B
chr12_+_94542459	0.38	ENST00000258526.4	PLXNC1	plexin C1
chr6_-_137113604	0.38	ENST00000359015.4	MAP3K5	mitogen-activated protein kinase kinase kinase 5
chr1_+_28099683	0.37	ENST00000373943.4	STX12	syntaxin 12
chr4_-_100140331	0.36	ENST00000407820.2 ENST00000394897.1 ENST00000508558.1 ENST00000394899.2	ADH6	alcohol dehydrogenase 6 (class V)
chrX_-_154563889	0.36	ENST00000369449.2 ENST00000321926.4	CLIC2	chloride intracellular channel 2
chr12_-_54653313	0.36	ENST00000550411.1 ENST00000439541.2	CBX5	chromobox homolog 5
chr11_+_128563652	0.35	ENST00000527786.2	FLI1	Fli-1 proto-oncogene, ETS transcription factor
chr2_-_64246206	0.34	ENST00000409558.4 ENST00000272322.4	VPS54	vacuolar protein sorting 54 homolog (S. cerevisiae)
chr20_+_388791	0.34	ENST00000441733.1 ENST00000353660.3	RBCK1	RanBP-type and C3HC4-type zinc finger containing 1
chr5_-_96143602	0.34	ENST00000443439.2 ENST00000503921.1 ENST00000508227.1 ENST00000507154.1	ERAP1	endoplasmic reticulum aminopeptidase 1
chr6_+_32821924	0.33	ENST00000374859.2 ENST00000453265.2	PSMB9	proteasome (prosome, macropain) subunit, beta type, 9
chr4_+_146403912	0.31	ENST00000507367.1 ENST00000394092.2 ENST00000515385.1	SMAD1	SMAD family member 1
chr11_+_64323428	0.30	ENST00000377581.3	SLC22A11	solute carrier family 22 (organic anion/urate transporter), member 11
chr19_-_6670128	0.29	ENST00000245912.3	TNFSF14	tumor necrosis factor (ligand) superfamily, member 14
chr6_+_31540056	0.29	ENST00000418386.2	LTA	lymphotoxin alpha
chr17_-_79818354	0.28	ENST00000576541.1 ENST00000576380.1 ENST00000571617.1 ENST00000576052.1 ENST00000576390.1 ENST00000573778.2 ENST00000439918.2 ENST00000574914.1 ENST00000331483.4	P4HB	prolyl 4-hydroxylase, beta polypeptide
chr2_-_175260368	0.27	ENST00000342016.3 ENST00000362053.5	CIR1	corepressor interacting with RBPJ, 1
chr1_+_110453203	0.27	ENST00000357302.4 ENST00000344188.5 ENST00000329608.6	CSF1	colony stimulating factor 1 (macrophage)
chr14_-_24615805	0.27	ENST00000560410.1	PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr17_+_46908350	0.26	ENST00000258947.3 ENST00000509507.1 ENST00000448105.2 ENST00000570513.1 ENST00000509415.1 ENST00000513119.1 ENST00000416445.2 ENST00000508679.1 ENST00000505071.1	CALCOCO2	calcium binding and coiled-coil domain 2
chr12_+_94656297	0.25	ENST00000545312.1	PLXNC1	plexin C1
chr12_+_6561190	0.25	ENST00000544021.1 ENST00000266556.7	TAPBPL	TAP binding protein-like
chr22_+_41697520	0.25	ENST00000352645.4	ZC3H7B	zinc finger CCCH-type containing 7B
chr8_-_56986768	0.23	ENST00000523936.1	RPS20	ribosomal protein S20
chr11_+_64323098	0.21	ENST00000301891.4	SLC22A11	solute carrier family 22 (organic anion/urate transporter), member 11
chr2_+_231280908	0.21	ENST00000427101.2 ENST00000432979.1	SP100	SP100 nuclear antigen
chr19_-_43032532	0.21	ENST00000403461.1 ENST00000352591.5 ENST00000358394.3 ENST00000403444.3 ENST00000308072.4 ENST00000599389.1 ENST00000351134.3 ENST00000161559.6	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
chr3_-_168864427	0.21	ENST00000468789.1	MECOM	MDS1 and EVI1 complex locus
chr10_-_82049424	0.19	ENST00000372213.3	MAT1A	methionine adenosyltransferase I, alpha
chr14_-_24615523	0.19	ENST00000559056.1	PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chrX_+_10124977	0.19	ENST00000380833.4	CLCN4	chloride channel, voltage-sensitive 4
chr1_-_244006528	0.19	ENST00000336199.5 ENST00000263826.5	AKT3	v-akt murine thymoma viral oncogene homolog 3
chr2_+_145780767	0.19	ENST00000599358.1 ENST00000596278.1 ENST00000596747.1 ENST00000608652.1 ENST00000609705.1 ENST00000608432.1 ENST00000596970.1 ENST00000602041.1 ENST00000601578.1 ENST00000596034.1 ENST00000414195.2 ENST00000594837.1	TEX41	testis expressed 41 (non-protein coding)
chr19_+_17186577	0.18	ENST00000595618.1 ENST00000594824.1	MYO9B	myosin IXB
chr16_+_30675654	0.18	ENST00000287468.5 ENST00000395073.2	FBRS	fibrosin
chr3_-_4793274	0.17	ENST00000414938.1	EGOT	eosinophil granule ontogeny transcript (non-protein coding)
chr1_-_111746966	0.16	ENST00000369752.5	DENND2D	DENN/MADD domain containing 2D
chr6_+_57182400	0.16	ENST00000607273.1	PRIM2	primase, DNA, polypeptide 2 (58kDa)
chr10_-_112678692	0.15	ENST00000605742.1	BBIP1	BBSome interacting protein 1
chr21_-_35899113	0.15	ENST00000492600.1 ENST00000481448.1 ENST00000381132.2	RCAN1	regulator of calcineurin 1
chr22_-_36635684	0.15	ENST00000358502.5	APOL2	apolipoprotein L, 2
chr19_+_49977818	0.15	ENST00000594009.1 ENST00000595510.1	FLT3LG	fms-related tyrosine kinase 3 ligand
chr22_-_31688431	0.14	ENST00000402249.3 ENST00000443175.1 ENST00000215912.5 ENST00000441972.1	PIK3IP1	phosphoinositide-3-kinase interacting protein 1
chr11_+_64323156	0.14	ENST00000377585.3	SLC22A11	solute carrier family 22 (organic anion/urate transporter), member 11
chr3_-_149375783	0.13	ENST00000467467.1 ENST00000460517.1 ENST00000360632.3	WWTR1	WW domain containing transcription regulator 1
chr13_+_31309645	0.12	ENST00000380490.3	ALOX5AP	arachidonate 5-lipoxygenase-activating protein
chr17_+_3379284	0.12	ENST00000263080.2	ASPA	aspartoacylase
chr6_-_28220002	0.11	ENST00000377294.2	ZKSCAN4	zinc finger with KRAB and SCAN domains 4
chr4_-_74088800	0.11	ENST00000509867.2	ANKRD17	ankyrin repeat domain 17
chr1_-_205326022	0.10	ENST00000367155.3	KLHDC8A	kelch domain containing 8A
chr16_-_3930724	0.09	ENST00000262367.5	CREBBP	CREB binding protein
chr2_-_209010874	0.09	ENST00000260988.4	CRYGB	crystallin, gamma B
chr11_-_72432950	0.09	ENST00000426523.1 ENST00000429686.1	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr12_+_25205446	0.08	ENST00000557489.1 ENST00000354454.3 ENST00000536173.1	LRMP	lymphoid-restricted membrane protein
chr11_+_28129795	0.08	ENST00000406787.3 ENST00000342303.5 ENST00000403099.1 ENST00000407364.3	METTL15	methyltransferase like 15
chr2_+_145780739	0.07	ENST00000597173.1 ENST00000602108.1 ENST00000420472.1	TEX41	testis expressed 41 (non-protein coding)
chr15_+_75491213	0.07	ENST00000360639.2	C15orf39	chromosome 15 open reading frame 39
chr1_-_8483723	0.07	ENST00000476556.1	RERE	arginine-glutamic acid dipeptide (RE) repeats
chr6_+_26156551	0.06	ENST00000304218.3	HIST1H1E	histone cluster 1, H1e
chr14_-_21490417	0.06	ENST00000556366.1	NDRG2	NDRG family member 2
chr14_-_23479331	0.05	ENST00000397377.1 ENST00000397379.3 ENST00000406429.2 ENST00000341470.4 ENST00000555998.1 ENST00000397376.2 ENST00000553675.1 ENST00000553931.1 ENST00000555575.1 ENST00000553958.1 ENST00000555098.1 ENST00000556419.1 ENST00000553606.1 ENST00000299088.6 ENST00000554179.1 ENST00000397382.4	C14orf93	chromosome 14 open reading frame 93
chr19_+_13106383	0.05	ENST00000397661.2	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_121655552	0.05	ENST00000275159.6	TBC1D32	TBC1 domain family, member 32
chr6_+_167525277	0.04	ENST00000400926.2	CCR6	chemokine (C-C motif) receptor 6
chr22_+_39417118	0.04	ENST00000216099.8	APOBEC3D	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
chr10_+_18429671	0.04	ENST00000282343.8	CACNB2	calcium channel, voltage-dependent, beta 2 subunit
chr1_-_205325850	0.02	ENST00000537168.1	KLHDC8A	kelch domain containing 8A
chr2_+_231280954	0.02	ENST00000409824.1 ENST00000409341.1 ENST00000409112.1 ENST00000340126.4 ENST00000341950.4	SP100	SP100 nuclear antigen
chr11_-_47736896	0.02	ENST00000525123.1 ENST00000528244.1 ENST00000532595.1 ENST00000529154.1 ENST00000530969.1	AGBL2	ATP/GTP binding protein-like 2
chr8_+_134203273	0.02	ENST00000250160.6	WISP1	WNT1 inducible signaling pathway protein 1
chr6_+_146348810	0.01	ENST00000492807.2	GRM1	glutamate receptor, metabotropic 1
chr1_+_17906970	0.01	ENST00000375415.1	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like
chr6_+_146348782	0.01	ENST00000361719.2 ENST00000392299.2	GRM1	glutamate receptor, metabotropic 1
chr14_-_21490590	0.00	ENST00000557633.1	NDRG2	NDRG family member 2
chr16_-_88851618	0.00	ENST00000301015.9	PIEZO1	piezo-type mechanosensitive ion channel component 1

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	8.0	GO:0030421	defecation(GO:0030421)
0.8	2.4	GO:0045062	extrathymic T cell selection(GO:0045062)
0.6	1.7	GO:0061394	regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.5	1.9	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.3	1.4	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.3	1.9	GO:0008218	bioluminescence(GO:0008218)
0.2	0.8	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
0.2	1.1	GO:1901096	regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.2	0.9	GO:0070842	aggresome assembly(GO:0070842)
0.2	0.5	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359) monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.2	1.6	GO:0006069	ethanol oxidation(GO:0006069)
0.2	3.9	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1	0.7	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.1	0.2	GO:1902044	regulation of Fas signaling pathway(GO:1902044)
0.1	0.9	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.1	0.8	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383)
0.1	0.6	GO:1990504	dense core granule exocytosis(GO:1990504)
0.1	0.3	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.1	0.8	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.1	0.8	GO:0030450	regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.1	12.3	GO:0045995	regulation of embryonic development(GO:0045995)
0.1	0.2	GO:0002589	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590)
0.1	0.7	GO:0002420	natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858)
0.1	0.7	GO:0015747	urate transport(GO:0015747)
0.1	1.5	GO:0035855	megakaryocyte development(GO:0035855)
0.1	0.4	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.1	0.3	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1	0.2	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.1	0.8	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.1	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
0.0	0.2	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	3.3	GO:0008542	visual learning(GO:0008542)
0.0	4.2	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
0.0	0.3	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0006533	aspartate catabolic process(GO:0006533)
0.0	0.3	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.3	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	1.2	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.0	0.4	GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315)
0.0	0.5	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	0.1	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
0.0	0.1	GO:0030037	actin filament reorganization involved in cell cycle(GO:0030037)
0.0	0.4	GO:0045663	positive regulation of myoblast differentiation(GO:0045663)
0.0	0.2	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
0.0	0.2	GO:0035385	Roundabout signaling pathway(GO:0035385)
0.0	0.7	GO:0030318	melanocyte differentiation(GO:0030318)
0.0	0.1	GO:0021691	cerebellar Purkinje cell layer maturation(GO:0021691)
0.0	0.6	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	0.8	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	2.3	GO:0010977	negative regulation of neuron projection development(GO:0010977)
0.0	0.1	GO:2001300	lipoxin metabolic process(GO:2001300)
0.0	0.1	GO:0035414	negative regulation of catenin import into nucleus(GO:0035414)
0.0	0.0	GO:0060474	positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0	0.2	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.0	GO:0060831	smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.7	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	0.9	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.2	9.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.1	1.9	NABA COLLAGENS	Genes encoding collagen proteins
0.0	1.9	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	1.8	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	0.8	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.3	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.8	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.2	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.4	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	1.2	PID AP1 PATHWAY	AP-1 transcription factor network

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0005715	late recombination nodule(GO:0005715)
0.0	0.1	GO:0002945	cyclin K-CDK13 complex(GO:0002945)
0.0	0.6	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.3	GO:0001739	sex chromatin(GO:0001739)
0.0	0.6	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.6	GO:0052655	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1	0.6	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.1	0.6	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.8	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.2	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.0	0.3	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.5	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.2	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.1	GO:0031433	telethonin binding(GO:0031433)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.6	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	1.9	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.1	4.2	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1	1.7	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	1.8	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.0	2.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.7	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.8	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	1.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.0	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.8	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.8	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	1.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.2	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.3	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.6	GO:0006550	isoleucine catabolic process(GO:0006550)
0.2	0.6	GO:0043060	meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.2	0.5	GO:0001923	B-1 B cell differentiation(GO:0001923)
0.1	0.3	GO:1990022	RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1	0.4	GO:1902748	positive regulation of lens fiber cell differentiation(GO:1902748)
0.1	0.9	GO:0010917	negative regulation of mitochondrial membrane potential(GO:0010917)
0.1	0.8	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.1	0.6	GO:0001865	NK T cell differentiation(GO:0001865)
0.0	0.6	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.2	GO:0042256	mature ribosome assembly(GO:0042256)
0.0	0.3	GO:0061087	positive regulation of histone H3-K27 methylation(GO:0061087)
0.0	0.4	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0	0.1	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.0	0.6	GO:0034389	lipid particle organization(GO:0034389)
0.0	0.1	GO:0019417	sulfur oxidation(GO:0019417)
0.0	0.2	GO:1902455	negative regulation of stem cell population maintenance(GO:1902455)
0.0	0.2	GO:0016191	synaptic vesicle uncoating(GO:0016191)
0.0	0.1	GO:0045915	positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0	0.4	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.2	GO:0002158	osteoclast proliferation(GO:0002158)
0.0	0.1	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.1	0.8	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.9	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.6	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.3	GO:0005151	interleukin-1, Type II receptor binding(GO:0005151)
0.3	2.3	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.3	1.9	GO:0061133	endopeptidase activator activity(GO:0061133)
0.3	1.6	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.2	1.9	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.2	0.9	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.1	12.5	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.1	1.7	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.1	2.3	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	1.0	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1	0.5	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.1	0.7	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1	0.6	GO:0017154	semaphorin receptor activity(GO:0017154)
0.1	0.8	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1	0.3	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0	0.9	GO:0070628	proteasome binding(GO:0070628)
0.0	8.0	GO:0008201	heparin binding(GO:0008201)
0.0	0.1	GO:0004464	leukotriene-C4 synthase activity(GO:0004464)
0.0	0.5	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	9.6	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	0.8	GO:0071889	14-3-3 protein binding(GO:0071889)
0.0	0.1	GO:0016434	rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	1.8	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0	0.9	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.0	0.2	GO:0048495	Roundabout binding(GO:0048495)
0.0	1.1	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.3	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	1.0	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.8	GO:0070412	R-SMAD binding(GO:0070412)
0.0	1.9	GO:0030165	PDZ domain binding(GO:0030165)
0.0	0.7	GO:0070888	E-box binding(GO:0070888)
0.0	0.4	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.4	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0008035	high-density lipoprotein particle binding(GO:0008035)
0.0	0.2	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.3	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.1	GO:0032564	adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0	0.6	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	1.1	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.9	GO:0005588	collagen type V trimer(GO:0005588)
0.6	1.7	GO:1990622	CHOP-ATF3 complex(GO:1990622)
0.3	1.9	GO:0008537	proteasome activator complex(GO:0008537)
0.3	12.5	GO:0005605	basal lamina(GO:0005605)
0.3	2.3	GO:1990111	spermatoproteasome complex(GO:1990111)
0.2	0.8	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1	0.8	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1	0.4	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.1	0.3	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1	0.3	GO:0000938	GARP complex(GO:0000938)
0.1	0.7	GO:0097227	sperm annulus(GO:0097227)
0.0	0.9	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.5	GO:0031906	late endosome lumen(GO:0031906)
0.0	0.2	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.5	GO:0042599	lamellar body(GO:0042599)
0.0	0.2	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.4	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.4	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.2	GO:0034464	BBSome(GO:0034464)
0.0	1.9	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.3	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.8	GO:0005871	kinesin complex(GO:0005871)
0.0	0.9	GO:1904724	lipid particle(GO:0005811) tertiary granule lumen(GO:1904724)