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ENCODE cell lines, expression (Ernst 2011)

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Results for PRDM14

Z-value: 0.40

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Transcription factors associated with PRDM14

Gene Symbol Gene ID Gene Info
PRDM14
ENSG00000147596.3 PRDM14

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PRDM14hg19_v2_chr8_-_70983506_70983562-0.116.7e-01Click!

Activity profile of PRDM14 motif

Sorted Z-values of PRDM14 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PRDM14

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr22_+_23241661 0.96 ENST00000390322.2
 IGLJ2
 immunoglobulin lambda joining 2
chr18_+_57567180 0.86 ENST00000316660.6
ENST00000269518.9
 PMAIP1
 phorbol-12-myristate-13-acetate-induced protein 1
chr19_-_49314169 0.85 ENST00000597011.1
ENST00000601681.1
 BCAT2
 branched chain amino-acid transaminase 2, mitochondrial
chr4_-_103266626 0.83 ENST00000356736.4
 SLC39A8
 solute carrier family 39 (zinc transporter), member 8
chr19_-_49314269 0.80 ENST00000545387.2
ENST00000316273.6
ENST00000402551.1
ENST00000598162.1
ENST00000599246.1
 BCAT2
 branched chain amino-acid transaminase 2, mitochondrial
chrX_+_15525426 0.59 ENST00000342014.6
 BMX
 BMX non-receptor tyrosine kinase
chr11_-_62474803 0.59 ENST00000533982.1
ENST00000360796.5
 BSCL2
 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr3_+_16926441 0.51 ENST00000418129.2
ENST00000396755.2
 PLCL2
 phospholipase C-like 2
chr1_+_36621529 0.42 ENST00000316156.4
 MAP7D1
 MAP7 domain containing 1
chr2_-_145278475 0.38 ENST00000558170.2
 ZEB2
 zinc finger E-box binding homeobox 2
chr9_+_132597722 0.36 ENST00000372429.3
ENST00000315480.4
ENST00000358355.1
 USP20
 ubiquitin specific peptidase 20
chr3_+_37035289 0.32 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
 MLH1
 mutL homolog 1
chr12_+_121647868 0.30 ENST00000359949.7
ENST00000541532.1
ENST00000543171.1
ENST00000538701.1
 P2RX4
 purinergic receptor P2X, ligand-gated ion channel, 4
chr19_+_39109735 0.30 ENST00000593149.1
ENST00000248342.4
ENST00000538434.1
ENST00000588934.1
ENST00000545173.2
ENST00000589307.1
ENST00000586513.1
ENST00000591409.1
ENST00000592558.1
 EIF3K
 eukaryotic translation initiation factor 3, subunit K
chr1_-_27216729 0.30 ENST00000431781.2
ENST00000374135.4
 GPN2
 GPN-loop GTPase 2
chr3_+_37035263 0.30 ENST00000458205.2
ENST00000539477.1
 MLH1
 mutL homolog 1
chr12_+_121647962 0.29 ENST00000542067.1
 P2RX4
 purinergic receptor P2X, ligand-gated ion channel, 4
chr19_+_49838653 0.29 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
 CD37
 CD37 molecule
chr11_+_85956182 0.26 ENST00000327320.4
ENST00000351625.6
ENST00000534595.1
 EED
 embryonic ectoderm development
chrX_+_41193407 0.25 ENST00000457138.2
ENST00000441189.2
 DDX3X
 DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr12_-_49351228 0.25 ENST00000541959.1
ENST00000447318.2
 ARF3
 ADP-ribosylation factor 3
chr14_-_21492251 0.23 ENST00000554398.1
 NDRG2
 NDRG family member 2
chr12_-_49351148 0.22 ENST00000398092.4
ENST00000539611.1
 RP11-302B13.5
ARF3
 ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr14_-_21492113 0.21 ENST00000554094.1
 NDRG2
 NDRG family member 2
chr2_-_192711968 0.20 ENST00000304141.4
 SDPR
 serum deprivation response
chr8_-_102216925 0.20 ENST00000517844.1
 ZNF706
 zinc finger protein 706
chr12_-_49351303 0.18 ENST00000256682.4
 ARF3
 ADP-ribosylation factor 3
chr19_+_3572758 0.17 ENST00000416526.1
 HMG20B
 high mobility group 20B
chr1_+_65730385 0.15 ENST00000263441.7
ENST00000395325.3
 DNAJC6
 DnaJ (Hsp40) homolog, subfamily C, member 6
chr7_-_124405681 0.15 ENST00000303921.2
 GPR37
 G protein-coupled receptor 37 (endothelin receptor type B-like)
chr2_+_113033164 0.14 ENST00000409871.1
ENST00000343936.4
 ZC3H6
 zinc finger CCCH-type containing 6
chr7_-_140714430 0.13 ENST00000393008.3
 MRPS33
 mitochondrial ribosomal protein S33
chr4_+_81187753 0.12 ENST00000312465.7
ENST00000456523.3
 FGF5
 fibroblast growth factor 5
chr5_+_32711419 0.12 ENST00000265074.8
 NPR3
 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr7_-_140714739 0.11 ENST00000467334.1
ENST00000324787.5
 MRPS33
 mitochondrial ribosomal protein S33
chr6_-_46048116 0.11 ENST00000185206.6
 CLIC5
 chloride intracellular channel 5
chr2_-_69098566 0.10 ENST00000295379.1
 BMP10
 bone morphogenetic protein 10
chr3_+_10289707 0.10 ENST00000287652.4
 TATDN2
 TatD DNase domain containing 2
chr19_-_6279932 0.10 ENST00000252674.7
 MLLT1
 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr7_+_39989611 0.09 ENST00000181839.4
 CDK13
 cyclin-dependent kinase 13
chr1_+_50571949 0.09 ENST00000357083.4
 ELAVL4
 ELAV like neuron-specific RNA binding protein 4
chr8_+_110346546 0.09 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
 ENY2
 enhancer of yellow 2 homolog (Drosophila)
chr17_-_46691990 0.08 ENST00000576562.1
 HOXB8
 homeobox B8
chr7_-_139763521 0.07 ENST00000263549.3
 PARP12
 poly (ADP-ribose) polymerase family, member 12
chr11_+_62475130 0.07 ENST00000294117.5
 GNG3
 guanine nucleotide binding protein (G protein), gamma 3
chr2_-_228244013 0.06 ENST00000304568.3
 TM4SF20
 transmembrane 4 L six family member 20
chr6_-_109777128 0.06 ENST00000358807.3
ENST00000358577.3
 MICAL1
 microtubule associated monooxygenase, calponin and LIM domain containing 1
chr5_+_32710736 0.06 ENST00000415685.2
 NPR3
 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr17_-_46692287 0.06 ENST00000239144.4
 HOXB8
 homeobox B8
chr1_-_116383322 0.03 ENST00000429731.1
 NHLH2
 nescient helix loop helix 2
chr1_-_42384343 0.03 ENST00000372584.1
 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
chr1_+_153963227 0.03 ENST00000368567.4
ENST00000392558.4
 RPS27
 ribosomal protein S27
chr15_+_45694523 0.02 ENST00000305560.6
 SPATA5L1
 spermatogenesis associated 5-like 1
chr11_-_65624415 0.02 ENST00000524553.1
ENST00000527344.1
 CFL1
 cofilin 1 (non-muscle)
chr20_-_48770174 0.01 ENST00000341698.2
 TMEM189-UBE2V1
 TMEM189-UBE2V1 readthrough
chr12_+_3600356 0.01 ENST00000382622.3
 PRMT8
 protein arginine methyltransferase 8
chr12_+_56325812 0.01 ENST00000394147.1
ENST00000551156.1
ENST00000553783.1
ENST00000557080.1
ENST00000432422.3
ENST00000556001.1
 DGKA
 diacylglycerol kinase, alpha 80kDa
chr2_-_37193606 0.00 ENST00000379213.2
ENST00000263918.4
 STRN
 striatin, calmodulin binding protein

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0005715 late recombination nodule(GO:0005715)
0.0 0.1 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.0 0.6 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.3 GO:0001739 sex chromatin(GO:0001739)
0.0 0.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0052655 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.6 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.6 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.0 0.3 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.5 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.2 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 0.1 GO:0031433 telethonin binding(GO:0031433)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0006550 isoleucine catabolic process(GO:0006550)
0.2 0.6 GO:0043060 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.2 0.5 GO:0001923 B-1 B cell differentiation(GO:0001923)
0.1 0.3 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.9 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.1 0.8 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 0.6 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 0.6 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.0 0.4 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.0 0.6 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.1 GO:0019417 sulfur oxidation(GO:0019417)
0.0 0.2 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
0.0 0.2 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.0 0.1 GO:0045915 positive regulation of catecholamine metabolic process(GO:0045915) positive regulation of dopamine metabolic process(GO:0045964)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.2 GO:0002158 osteoclast proliferation(GO:0002158)
0.0 0.1 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 0.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.6 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane