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ENCODE cell lines, expression (Ernst 2011)

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Results for REST

Z-value: 0.61

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 REST

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_577741140.194.7e-01Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_-_153141302 1.24 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
 L1CAM
 L1 cell adhesion molecule
chr9_-_123812542 1.20 ENST00000223642.1
 C5
 complement component 5
chr12_+_71833550 1.08 ENST00000266674.5
 LGR5
 leucine-rich repeat containing G protein-coupled receptor 5
chr3_+_193853927 0.84 ENST00000232424.3
 HES1
 hes family bHLH transcription factor 1
chr3_-_8686479 0.84 ENST00000544814.1
ENST00000427408.1
 SSUH2
 ssu-2 homolog (C. elegans)
chr13_-_111214015 0.82 ENST00000267328.3
 RAB20
 RAB20, member RAS oncogene family
chr14_-_94759595 0.65 ENST00000261994.4
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759361 0.65 ENST00000393096.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 0.65 ENST00000554723.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr3_-_48700310 0.60 ENST00000164024.4
ENST00000544264.1
 CELSR3
 cadherin, EGF LAG seven-pass G-type receptor 3
chr11_-_66115032 0.49 ENST00000311181.4
 B3GNT1
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr6_+_25652432 0.47 ENST00000377961.2
 SCGN
 secretagogin, EF-hand calcium binding protein
chrX_-_47479246 0.39 ENST00000295987.7
ENST00000340666.4
 SYN1
 synapsin I
chr12_+_71833756 0.37 ENST00000536515.1
ENST00000540815.2
 LGR5
 leucine-rich repeat containing G protein-coupled receptor 5
chr20_+_62327996 0.37 ENST00000369996.1
 TNFRSF6B
 tumor necrosis factor receptor superfamily, member 6b, decoy
chr10_-_50970382 0.36 ENST00000419399.1
ENST00000432695.1
 OGDHL
 oxoglutarate dehydrogenase-like
chr10_-_50970322 0.36 ENST00000374103.4
 OGDHL
 oxoglutarate dehydrogenase-like
chr20_+_36012051 0.36 ENST00000373567.2
 SRC
 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr12_+_175930 0.32 ENST00000538872.1
ENST00000326261.4
 IQSEC3
 IQ motif and Sec7 domain 3
chr4_+_158141899 0.30 ENST00000264426.9
ENST00000506284.1
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr7_+_145813453 0.29 ENST00000361727.3
 CNTNAP2
 contactin associated protein-like 2
chr2_+_46524537 0.28 ENST00000263734.3
 EPAS1
 endothelial PAS domain protein 1
chr15_+_75287861 0.27 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
 SCAMP5
 secretory carrier membrane protein 5
chr2_-_51259292 0.27 ENST00000401669.2
 NRXN1
 neurexin 1
chr5_+_175298573 0.27 ENST00000512824.1
 CPLX2
 complexin 2
chr2_-_51259229 0.25 ENST00000405472.3
 NRXN1
 neurexin 1
chr12_-_12837423 0.25 ENST00000540510.1
 GPR19
 G protein-coupled receptor 19
chr15_-_83378611 0.24 ENST00000542200.1
 AP3B2
 adaptor-related protein complex 3, beta 2 subunit
chr2_-_47798044 0.23 ENST00000327876.4
 KCNK12
 potassium channel, subfamily K, member 12
chr2_-_30143525 0.22 ENST00000431873.1
 ALK
 anaplastic lymphoma receptor tyrosine kinase
chr6_+_25652501 0.22 ENST00000334979.6
 SCGN
 secretagogin, EF-hand calcium binding protein
chr4_+_158141806 0.18 ENST00000393815.2
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr6_+_110299501 0.18 ENST00000414000.2
 GPR6
 G protein-coupled receptor 6
chr4_+_158141843 0.17 ENST00000509417.1
ENST00000296526.7
 GRIA2
 glutamate receptor, ionotropic, AMPA 2
chr11_+_64808675 0.17 ENST00000529996.1
 SAC3D1
 SAC3 domain containing 1
chr11_+_22359562 0.17 ENST00000263160.3
 SLC17A6
 solute carrier family 17 (vesicular glutamate transporter), member 6
chr12_+_113229543 0.16 ENST00000447659.2
 RPH3A
 rabphilin 3A homolog (mouse)
chr5_+_175298674 0.16 ENST00000514150.1
 CPLX2
 complexin 2
chr17_-_3301704 0.16 ENST00000322608.2
 OR1E1
 olfactory receptor, family 1, subfamily E, member 1
chr5_+_175298487 0.15 ENST00000393745.3
 CPLX2
 complexin 2
chr10_+_26505179 0.15 ENST00000376261.3
 GAD2
 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chrX_+_153237740 0.15 ENST00000369982.4
 TMEM187
 transmembrane protein 187
chrX_-_153237258 0.14 ENST00000310441.7
 HCFC1
 host cell factor C1 (VP16-accessory protein)
chr2_+_226265364 0.14 ENST00000272907.6
 NYAP2
 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr3_-_113897545 0.13 ENST00000467632.1
 DRD3
 dopamine receptor D3
chr7_-_100808394 0.12 ENST00000445482.2
 VGF
 VGF nerve growth factor inducible
chr12_+_113229737 0.12 ENST00000551052.1
ENST00000415485.3
 RPH3A
 rabphilin 3A homolog (mouse)
chr12_+_113229452 0.11 ENST00000389385.4
 RPH3A
 rabphilin 3A homolog (mouse)
chr3_-_113897899 0.10 ENST00000383673.2
ENST00000295881.7
 DRD3
 dopamine receptor D3
chr1_-_175712665 0.10 ENST00000263525.2
 TNR
 tenascin R
chr10_-_102790852 0.09 ENST00000470414.1
ENST00000370215.3
 PDZD7
 PDZ domain containing 7
chr12_+_52695617 0.09 ENST00000293525.5
 KRT86
 keratin 86
chr17_+_42385927 0.09 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
 RUNDC3A
 RUN domain containing 3A
chr4_+_96012614 0.09 ENST00000264568.4
 BMPR1B
 bone morphogenetic protein receptor, type IB
chr9_+_140033862 0.09 ENST00000350902.5
ENST00000371550.4
ENST00000371546.4
ENST00000371555.4
ENST00000371553.3
ENST00000371559.4
ENST00000371560.3
 GRIN1
 glutamate receptor, ionotropic, N-methyl D-aspartate 1
chr6_+_153071925 0.08 ENST00000367244.3
ENST00000367243.3
 VIP
 vasoactive intestinal peptide
chr12_-_57443886 0.08 ENST00000300119.3
 MYO1A
 myosin IA
chr10_+_102790980 0.07 ENST00000393459.1
ENST00000224807.5
 SFXN3
 sideroflexin 3
chr16_+_335680 0.07 ENST00000435833.1
 PDIA2
 protein disulfide isomerase family A, member 2
chr15_-_83378526 0.07 ENST00000535348.1
ENST00000535359.1
 AP3B2
 adaptor-related protein complex 3, beta 2 subunit
chr2_-_51259528 0.07 ENST00000404971.1
 NRXN1
 neurexin 1
chr20_-_62284766 0.06 ENST00000370053.1
 STMN3
 stathmin-like 3
chr1_-_151689259 0.06 ENST00000420342.1
ENST00000290583.4
 CELF3
 CUGBP, Elav-like family member 3
chr2_-_27531313 0.06 ENST00000296099.2
 UCN
 urocortin
chr1_+_154540246 0.06 ENST00000368476.3
 CHRNB2
 cholinergic receptor, nicotinic, beta 2 (neuronal)
chr20_+_44657845 0.05 ENST00000243964.3
 SLC12A5
 solute carrier family 12 (potassium/chloride transporter), member 5
chr1_+_212606219 0.05 ENST00000366988.3
 NENF
 neudesin neurotrophic factor
chr11_+_637246 0.05 ENST00000176183.5
 DRD4
 dopamine receptor D4
chr20_+_5892037 0.04 ENST00000378961.4
 CHGB
 chromogranin B (secretogranin 1)
chr16_+_3019246 0.04 ENST00000318782.8
ENST00000293978.8
 PAQR4
 progestin and adipoQ receptor family member IV
chr17_-_3337135 0.04 ENST00000248384.1
 OR1E2
 olfactory receptor, family 1, subfamily E, member 2
chr15_-_83378638 0.04 ENST00000261722.3
 AP3B2
 adaptor-related protein complex 3, beta 2 subunit
chr7_-_100808843 0.04 ENST00000249330.2
 VGF
 VGF nerve growth factor inducible
chrX_-_49056635 0.04 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
 SYP
 synaptophysin
chr2_-_51259641 0.04 ENST00000406316.2
ENST00000405581.1
 NRXN1
 neurexin 1
chr7_+_150748288 0.03 ENST00000490540.1
 ASIC3
 acid-sensing (proton-gated) ion channel 3
chr1_-_40105617 0.03 ENST00000372852.3
 HEYL
 hes-related family bHLH transcription factor with YRPW motif-like
chr19_-_45927622 0.03 ENST00000300853.3
ENST00000589165.1
 ERCC1
 excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr10_+_26505594 0.02 ENST00000259271.3
 GAD2
 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr4_-_175750364 0.02 ENST00000340217.5
ENST00000274093.3
 GLRA3
 glycine receptor, alpha 3
chr20_-_60795316 0.01 ENST00000317393.6
 HRH3
 histamine receptor H3
chr9_-_139096955 0.01 ENST00000371748.5
 LHX3
 LIM homeobox 3
chr12_-_99288536 0.01 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
 ANKS1B
 ankyrin repeat and sterile alpha motif domain containing 1B
chr15_-_22473353 0.01 ENST00000557788.2
 IGHV4OR15-8
 immunoglobulin heavy variable 4/OR15-8 (non-functional)

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 1.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.4 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.4 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.0 0.5 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST STAT3 PATHWAY STAT3 Pathway
0.0 1.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.7 PID NCADHERIN PATHWAY N-cadherin signaling events

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.3 0.8 GO:0021558 midbrain-hindbrain boundary morphogenesis(GO:0021555) trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164)
0.3 2.0 GO:0008218 bioluminescence(GO:0008218)
0.2 0.8 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 0.6 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.1 1.5 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 0.3 GO:0071109 superior temporal gyrus development(GO:0071109)
0.1 0.4 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.1 0.2 GO:0050883 musculoskeletal movement, spinal reflex action(GO:0050883)
0.1 0.6 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1 0.1 GO:0035483 gastric motility(GO:0035482) gastric emptying(GO:0035483)
0.1 0.2 GO:0036269 swimming behavior(GO:0036269)
0.0 0.4 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 0.3 GO:0043129 surfactant homeostasis(GO:0043129)
0.0 0.1 GO:0043449 olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449)
0.0 0.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 0.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.4 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.1 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.0 0.7 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.1 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.0 GO:0050968 detection of chemical stimulus involved in sensory perception of pain(GO:0050968)
0.0 0.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) synaptic transmission involved in micturition(GO:0060084)
0.0 0.9 GO:0045773 positive regulation of axon extension(GO:0045773)
0.0 0.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.1 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.0 0.2 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1 0.7 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.3 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.6 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.4 GO:0008430 selenium binding(GO:0008430)
0.0 0.2 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 0.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.8 GO:0008009 chemokine activity(GO:0008009)
0.0 1.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0 0.2 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.0 0.1 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0 0.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.4 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.1 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.2 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.7 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.1 0.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.6 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.4 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.1 GO:0072534 perineuronal net(GO:0072534)
0.0 0.4 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.1 GO:0002139 stereocilia coupling link(GO:0002139)
0.0 0.3 GO:0033010 paranodal junction(GO:0033010)
0.0 1.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)