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ENCODE cell lines, expression (Ernst 2011)

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Results for RFX5

Z-value: 1.48

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.13 RFX5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319710_1513198330.845.3e-05Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_32557610 9.73 ENST00000360004.5
 HLA-DRB1
 major histocompatibility complex, class II, DR beta 1
chr6_-_32498046 8.99 ENST00000374975.3
 HLA-DRB5
 major histocompatibility complex, class II, DR beta 5
chr5_-_149792295 8.28 ENST00000518797.1
ENST00000524315.1
ENST00000009530.7
ENST00000377795.3
 CD74
 CD74 molecule, major histocompatibility complex, class II invariant chain
chr6_+_33043703 8.21 ENST00000418931.2
ENST00000535465.1
 HLA-DPB1
 major histocompatibility complex, class II, DP beta 1
chr6_-_32920794 7.44 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
 HLA-DMA
XXbac-BPG181M17.5
 major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr6_-_32908792 6.43 ENST00000418107.2
 HLA-DMB
 major histocompatibility complex, class II, DM beta
chr6_-_32634425 5.75 ENST00000399082.3
ENST00000399079.3
ENST00000374943.4
ENST00000434651.2
 HLA-DQB1
 major histocompatibility complex, class II, DQ beta 1
chr6_+_32821924 4.77 ENST00000374859.2
ENST00000453265.2
 PSMB9
 proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32784687 4.50 ENST00000447394.1
ENST00000438763.2
 HLA-DOB
 major histocompatibility complex, class II, DO beta
chr6_+_32812568 4.06 ENST00000414474.1
 PSMB9
 proteasome (prosome, macropain) subunit, beta type, 9
chr6_-_32812420 3.79 ENST00000374881.2
 PSMB8
 proteasome (prosome, macropain) subunit, beta type, 8
chr6_-_32731299 3.21 ENST00000435145.2
ENST00000437316.2
 HLA-DQB2
 major histocompatibility complex, class II, DQ beta 2
chr13_-_47012325 3.07 ENST00000409879.2
 KIAA0226L
 KIAA0226-like
chr6_-_32821599 2.88 ENST00000354258.4
 TAP1
 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_242088850 2.68 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
 PASK
 PAS domain containing serine/threonine kinase
chr6_-_32908765 2.60 ENST00000416244.2
 HLA-DMB
 major histocompatibility complex, class II, DM beta
chr1_+_181003067 1.61 ENST00000434571.2
ENST00000367579.3
ENST00000282990.6
ENST00000367580.5
 MR1
 major histocompatibility complex, class I-related
chr6_-_32731243 1.50 ENST00000427449.1
ENST00000411527.1
 HLA-DQB2
 major histocompatibility complex, class II, DQ beta 2
chr6_+_26383404 1.37 ENST00000416795.2
ENST00000494184.1
 BTN2A2
 butyrophilin, subfamily 2, member A2
chr6_+_26383318 1.29 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
 BTN2A2
 butyrophilin, subfamily 2, member A2
chr1_+_249132462 1.27 ENST00000306562.3
 ZNF672
 zinc finger protein 672
chr6_-_133079022 0.96 ENST00000525289.1
ENST00000326499.6
 VNN2
 vanin 2
chr19_+_36103631 0.90 ENST00000203166.5
ENST00000379045.2
 HAUS5
 HAUS augmin-like complex, subunit 5
chr16_+_67381263 0.84 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
 LRRC36
 leucine rich repeat containing 36
chr6_+_26440700 0.83 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
 BTN3A3
 butyrophilin, subfamily 3, member A3
chr8_-_98290087 0.83 ENST00000322128.3
 TSPYL5
 TSPY-like 5
chr16_+_67381289 0.79 ENST00000435835.3
 LRRC36
 leucine rich repeat containing 36
chr16_-_74808710 0.78 ENST00000219368.3
ENST00000544337.1
 FA2H
 fatty acid 2-hydroxylase
chr2_+_242089046 0.65 ENST00000407025.1
ENST00000272983.8
 PPP1R7
 protein phosphatase 1, regulatory subunit 7
chr2_+_242088963 0.56 ENST00000438799.1
ENST00000402734.1
ENST00000423280.1
 PPP1R7
 protein phosphatase 1, regulatory subunit 7
chr8_+_101170257 0.44 ENST00000251809.3
 SPAG1
 sperm associated antigen 1
chr6_+_26365443 0.40 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
 BTN3A2
 butyrophilin, subfamily 3, member A2
chr4_-_83719884 0.36 ENST00000282709.4
ENST00000273908.4
 SCD5
 stearoyl-CoA desaturase 5
chr20_+_42875935 0.34 ENST00000438466.1
ENST00000372952.3
ENST00000537864.1
ENST00000445952.1
 GDAP1L1
 ganglioside induced differentiation associated protein 1-like 1
chr20_+_42875887 0.30 ENST00000342560.5
 GDAP1L1
 ganglioside induced differentiation associated protein 1-like 1
chr6_-_24666819 0.26 ENST00000341060.3
 TDP2
 tyrosyl-DNA phosphodiesterase 2
chr2_+_173600565 0.26 ENST00000397081.3
 RAPGEF4
 Rap guanine nucleotide exchange factor (GEF) 4
chr2_+_173600514 0.26 ENST00000264111.6
 RAPGEF4
 Rap guanine nucleotide exchange factor (GEF) 4
chr6_-_24667180 0.10 ENST00000545995.1
 TDP2
 tyrosyl-DNA phosphodiesterase 2
chr8_-_99306611 0.09 ENST00000341166.3
 NIPAL2
 NIPA-like domain containing 2
chr3_+_196466710 0.09 ENST00000327134.3
 PAK2
 p21 protein (Cdc42/Rac)-activated kinase 2
chr8_-_99306564 0.05 ENST00000430223.2
 NIPAL2
 NIPA-like domain containing 2
chr6_-_30181133 0.05 ENST00000454678.2
ENST00000434785.1
 TRIM26
 tripartite motif containing 26
chr1_+_36549676 0.04 ENST00000207457.3
 TEKT2
 tektin 2 (testicular)
chr6_-_30181156 0.01 ENST00000418026.1
ENST00000416596.1
ENST00000453195.1
 TRIM26
 tripartite motif containing 26

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 66.6 GO:0042613 MHC class II protein complex(GO:0042613)
1.6 12.6 GO:1990111 spermatoproteasome complex(GO:1990111)
0.5 2.9 GO:0042825 TAP complex(GO:0042825)
0.1 0.9 GO:0070652 HAUS complex(GO:0070652)
0.1 0.7 GO:0042611 MHC protein complex(GO:0042611)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.7 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 2.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 26.9 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2 29.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.2 11.4 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 2.0 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.3 GO:0042289 MHC class II protein binding(GO:0042289)
1.2 15.0 GO:0032395 MHC class II receptor activity(GO:0032395)
1.0 29.8 GO:0042605 peptide antigen binding(GO:0042605)
0.6 16.5 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.4 12.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 1.6 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 0.4 GO:0036317 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
0.1 0.4 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.2 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 26.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
1.7 8.3 GO:0002906 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
1.5 4.5 GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.7 2.9 GO:0046967 cytosol to ER transport(GO:0046967)
0.4 2.7 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.2 27.7 GO:0031295 T cell costimulation(GO:0031295)
0.2 2.7 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.1 11.4 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 0.8 GO:0048733 sebaceous gland development(GO:0048733)
0.1 1.0 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 1.6 GO:0032620 interleukin-17 production(GO:0032620)
0.0 0.5 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 0.4 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 1.2 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.0 0.1 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.8 GO:0071480 cellular response to gamma radiation(GO:0071480)