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ENCODE cell lines, expression (Ernst 2011)

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Results for RORC

Z-value: 0.68

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RORC

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151804222_151804228,
hg19_v2_chr1_-_151804314_151804348,
hg19_v2_chr1_-_151798546_151798590		-0.165.4e-01Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_93964158 2.71 ENST00000549206.1
 SOCS2
 suppressor of cytokine signaling 2
chr12_+_93963590 2.67 ENST00000340600.2
 SOCS2
 suppressor of cytokine signaling 2
chr10_-_121296045 1.41 ENST00000392865.1
 RGS10
 regulator of G-protein signaling 10
chr17_-_46623441 1.40 ENST00000330070.4
 HOXB2
 homeobox B2
chr3_+_185303962 0.82 ENST00000296257.5
 SENP2
 SUMO1/sentrin/SMT3 specific peptidase 2
chr3_+_185304059 0.74 ENST00000427465.2
 SENP2
 SUMO1/sentrin/SMT3 specific peptidase 2
chr9_-_110251836 0.69 ENST00000374672.4
 KLF4
 Kruppel-like factor 4 (gut)
chr18_-_23671139 0.66 ENST00000579061.1
ENST00000542420.2
 SS18
 synovial sarcoma translocation, chromosome 18
chr1_-_153522562 0.65 ENST00000368714.1
 S100A4
 S100 calcium binding protein A4
chr16_-_1821496 0.57 ENST00000564628.1
ENST00000563498.1
 NME3
 NME/NM23 nucleoside diphosphate kinase 3
chr2_+_160590469 0.56 ENST00000409591.1
 MARCH7
 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr16_-_67514982 0.51 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
 ATP6V0D1
 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr6_-_111927062 0.44 ENST00000359831.4
 TRAF3IP2
 TRAF3 interacting protein 2
chr1_+_26869597 0.43 ENST00000530003.1
 RPS6KA1
 ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr10_-_105845674 0.42 ENST00000353479.5
ENST00000369733.3
 COL17A1
 collagen, type XVII, alpha 1
chr7_+_112063192 0.40 ENST00000005558.4
 IFRD1
 interferon-related developmental regulator 1
chr11_-_19223523 0.39 ENST00000265968.3
 CSRP3
 cysteine and glycine-rich protein 3 (cardiac LIM protein)
chr4_-_120243545 0.39 ENST00000274024.3
 FABP2
 fatty acid binding protein 2, intestinal
chr1_+_114447763 0.38 ENST00000369563.3
 DCLRE1B
 DNA cross-link repair 1B
chr19_-_10450287 0.36 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
 ICAM3
 intercellular adhesion molecule 3
chr8_-_95449155 0.30 ENST00000481490.2
 FSBP
 fibrinogen silencer binding protein
chr1_-_150207017 0.27 ENST00000369119.3
 ANP32E
 acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr1_+_205197304 0.24 ENST00000358024.3
 TMCC2
 transmembrane and coiled-coil domain family 2
chr1_-_185286461 0.22 ENST00000367498.3
 IVNS1ABP
 influenza virus NS1A binding protein
chr11_+_13299186 0.20 ENST00000527998.1
ENST00000396441.3
ENST00000533520.1
ENST00000529825.1
ENST00000389707.4
ENST00000401424.1
ENST00000529388.1
ENST00000530357.1
ENST00000403290.1
ENST00000361003.4
ENST00000389708.3
ENST00000403510.3
ENST00000482049.1
 ARNTL
 aryl hydrocarbon receptor nuclear translocator-like
chr7_+_20686946 0.20 ENST00000443026.2
ENST00000406935.1
 ABCB5
 ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr14_-_23451467 0.20 ENST00000555074.1
ENST00000361265.4
 RP11-298I3.5
AJUBA
 RP11-298I3.5
ajuba LIM protein
chr12_+_7167980 0.19 ENST00000360817.5
ENST00000402681.3
 C1S
 complement component 1, s subcomponent
chr10_-_103578182 0.19 ENST00000439817.1
 MGEA5
 meningioma expressed antigen 5 (hyaluronidase)
chr1_-_145826450 0.19 ENST00000462900.2
 GPR89A
 G protein-coupled receptor 89A
chr12_-_54652060 0.19 ENST00000552562.1
 CBX5
 chromobox homolog 5
chr1_-_211752073 0.17 ENST00000367001.4
 SLC30A1
 solute carrier family 30 (zinc transporter), member 1
chr10_-_103578162 0.17 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
 MGEA5
 meningioma expressed antigen 5 (hyaluronidase)
chr2_-_148778323 0.16 ENST00000440042.1
ENST00000535373.1
ENST00000540442.1
ENST00000536575.1
 ORC4
 origin recognition complex, subunit 4
chr3_-_164914640 0.16 ENST00000241274.3
 SLITRK3
 SLIT and NTRK-like family, member 3
chr4_+_85504075 0.14 ENST00000295887.5
 CDS1
 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr1_+_171810606 0.14 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
 DNM3
 dynamin 3
chr17_-_3030875 0.14 ENST00000328890.2
 OR1G1
 olfactory receptor, family 1, subfamily G, member 1
chr7_-_128415844 0.13 ENST00000249389.2
 OPN1SW
 opsin 1 (cone pigments), short-wave-sensitive
chr3_-_65583561 0.13 ENST00000460329.2
 MAGI1
 membrane associated guanylate kinase, WW and PDZ domain containing 1
chr13_+_109248500 0.13 ENST00000356711.2
 MYO16
 myosin XVI
chr17_-_42992856 0.12 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
 GFAP
 glial fibrillary acidic protein
chrX_-_110655391 0.11 ENST00000356915.2
ENST00000356220.3
 DCX
 doublecortin
chrX_-_43832711 0.10 ENST00000378062.5
 NDP
 Norrie disease (pseudoglioma)
chr1_+_159796534 0.10 ENST00000289707.5
 SLAMF8
 SLAM family member 8
chr12_+_4671352 0.09 ENST00000542744.1
 DYRK4
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chrX_-_49089771 0.08 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
 CACNA1F
 calcium channel, voltage-dependent, L type, alpha 1F subunit
chr19_+_1269324 0.07 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
 CIRBP
 cold inducible RNA binding protein
chr19_-_49140609 0.07 ENST00000601104.1
 DBP
 D site of albumin promoter (albumin D-box) binding protein
chr1_-_149908710 0.06 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
 MTMR11
 myotubularin related protein 11
chr1_-_62190793 0.05 ENST00000371177.2
ENST00000606498.1
 TM2D1
 TM2 domain containing 1
chr17_-_48785216 0.03 ENST00000285243.6
 ANKRD40
 ankyrin repeat domain 40
chr19_+_38924316 0.02 ENST00000355481.4
ENST00000360985.3
ENST00000359596.3
 RYR1
 ryanodine receptor 1 (skeletal)
chr2_-_30144432 0.02 ENST00000389048.3
 ALK
 anaplastic lymphoma receptor tyrosine kinase
chr4_+_110749143 0.01 ENST00000317735.4
 RRH
 retinal pigment epithelium-derived rhodopsin homolog

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0021569 rhombomere 3 development(GO:0021569)
0.3 5.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.2 0.7 GO:0071409 negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409)
0.2 1.6 GO:0016926 protein desumoylation(GO:0016926)
0.1 0.4 GO:0007518 myoblast fate determination(GO:0007518)
0.1 0.4 GO:0031627 telomeric loop formation(GO:0031627)
0.1 0.4 GO:0035995 detection of muscle stretch(GO:0035995)
0.1 1.4 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.1 0.4 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.1 0.2 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.1 0.2 GO:0048749 compound eye development(GO:0048749)
0.0 0.6 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.0 0.1 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.7 GO:0097150 neuronal stem cell population maintenance(GO:0097150)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.6 GO:0002643 regulation of tolerance induction(GO:0002643)
0.0 0.4 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.0 0.1 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.4 GO:0001783 B cell apoptotic process(GO:0001783)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.4 GO:0031581 hemidesmosome assembly(GO:0031581)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.1 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 0.7 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0033391 chromatoid body(GO:0033391)
0.0 0.4 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.3 GO:0000812 Swr1 complex(GO:0000812)
0.0 1.6 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.7 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.5 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.0 0.1 REACTOME OPSINS Genes involved in Opsins
0.0 0.4 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.4 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.6 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.4 1.6 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.7 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.1 0.5 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.4 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.1 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 1.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.4 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.4 GO:0031433 telethonin binding(GO:0031433)
0.0 0.6 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.6 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.2 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.0 0.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)