ISMARA results: SHOX

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ENCODE cell lines, expression (Ernst 2011)

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Results for SHOX

Z-value: 0.80

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Transcription factors associated with SHOX

Gene Symbol	Gene ID	Gene Info
SHOX Ensembl NCBI GeneCards UniProt	ENSG00000185960.8	SHOX
SHOX Ensembl NCBI GeneCards UniProt	ENSGR0000185960.8	SHOX

Activity profile of SHOX motif

Sorted Z-values of SHOX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr3_-_151034734	2.52	ENST00000260843.4	GPR87	G protein-coupled receptor 87
chr12_-_28123206	2.13	ENST00000542963.1 ENST00000535992.1	PTHLH	parathyroid hormone-like hormone
chr19_-_51522955	2.03	ENST00000358789.3	KLK10	kallikrein-related peptidase 10
chr12_-_52967600	1.94	ENST00000549343.1 ENST00000305620.2	KRT74	keratin 74
chr5_-_1882858	1.88	ENST00000511126.1 ENST00000231357.2	IRX4	iroquois homeobox 4
chr12_-_28122980	1.84	ENST00000395868.3 ENST00000534890.1	PTHLH	parathyroid hormone-like hormone
chr15_+_101420028	1.61	ENST00000557963.1 ENST00000346623.6	ALDH1A3	aldehyde dehydrogenase 1 family, member A3
chr12_-_89746173	1.12	ENST00000308385.6	DUSP6	dual specificity phosphatase 6
chr17_+_47448102	1.05	ENST00000576461.1	RP11-81K2.1	Uncharacterized protein
chr7_+_115862858	1.01	ENST00000393481.2	TES	testis derived transcript (3 LIM domains)
chr13_-_46716969	0.94	ENST00000435666.2	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chrX_+_105937068	0.92	ENST00000324342.3	RNF128	ring finger protein 128, E3 ubiquitin protein ligase
chr2_+_68961934	0.84	ENST00000409202.3	ARHGAP25	Rho GTPase activating protein 25
chr12_+_4385230	0.83	ENST00000536537.1	CCND2	cyclin D2
chr2_+_68961905	0.81	ENST00000295381.3	ARHGAP25	Rho GTPase activating protein 25
chr12_-_28125638	0.81	ENST00000545234.1	PTHLH	parathyroid hormone-like hormone
chr19_-_51523412	0.76	ENST00000391805.1 ENST00000599077.1	KLK10	kallikrein-related peptidase 10
chr17_-_39191107	0.74	ENST00000344363.5	KRTAP1-3	keratin associated protein 1-3
chr3_+_141106643	0.74	ENST00000514251.1	ZBTB38	zinc finger and BTB domain containing 38
chr19_-_51523275	0.73	ENST00000309958.3	KLK10	kallikrein-related peptidase 10
chr16_+_12059050	0.73	ENST00000396495.3	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr4_-_41884620	0.71	ENST00000504870.1	LINC00682	long intergenic non-protein coding RNA 682
chr3_-_79816965	0.71	ENST00000464233.1	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr6_-_32908792	0.70	ENST00000418107.2	HLA-DMB	major histocompatibility complex, class II, DM beta
chr17_-_64225508	0.70	ENST00000205948.6	APOH	apolipoprotein H (beta-2-glycoprotein I)
chr17_+_72427477	0.66	ENST00000342648.5 ENST00000481232.1	GPRC5C	G protein-coupled receptor, family C, group 5, member C
chr4_-_116034979	0.66	ENST00000264363.2	NDST4	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr12_-_10282742	0.65	ENST00000298523.5 ENST00000396484.2 ENST00000310002.4	CLEC7A	C-type lectin domain family 7, member A
chr1_-_92952433	0.65	ENST00000294702.5	GFI1	growth factor independent 1 transcription repressor
chr7_-_22234381	0.65	ENST00000458533.1	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr11_-_129062093	0.64	ENST00000310343.9	ARHGAP32	Rho GTPase activating protein 32
chr8_+_101170563	0.64	ENST00000520508.1 ENST00000388798.2	SPAG1	sperm associated antigen 1
chrX_+_43515467	0.64	ENST00000338702.3 ENST00000542639.1	MAOA	monoamine oxidase A
chr6_-_41039567	0.62	ENST00000468811.1	OARD1	O-acyl-ADP-ribose deacylase 1
chr7_-_25268104	0.62	ENST00000222674.2	NPVF	neuropeptide VF precursor
chr16_+_12059091	0.61	ENST00000562385.1	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr15_-_55562479	0.60	ENST00000564609.1	RAB27A	RAB27A, member RAS oncogene family
chr2_-_216946500	0.58	ENST00000265322.7	PECR	peroxisomal trans-2-enoyl-CoA reductase
chrX_-_110655306	0.58	ENST00000371993.2	DCX	doublecortin
chr5_-_24645078	0.57	ENST00000264463.4	CDH10	cadherin 10, type 2 (T2-cadherin)
chr7_+_138145076	0.56	ENST00000343526.4	TRIM24	tripartite motif containing 24
chr12_+_28410128	0.54	ENST00000381259.1 ENST00000381256.1	CCDC91	coiled-coil domain containing 91
chr6_-_111927062	0.54	ENST00000359831.4	TRAF3IP2	TRAF3 interacting protein 2
chr16_-_29910853	0.53	ENST00000308713.5	SEZ6L2	seizure related 6 homolog (mouse)-like 2
chr17_-_27418537	0.53	ENST00000408971.2	TIAF1	TGFB1-induced anti-apoptotic factor 1
chr12_+_19358228	0.53	ENST00000424268.1 ENST00000543806.1	PLEKHA5	pleckstrin homology domain containing, family A member 5
chr15_+_75080883	0.53	ENST00000567571.1	CSK	c-src tyrosine kinase
chr2_+_143635067	0.53	ENST00000264170.4	KYNU	kynureninase
chr3_+_111718173	0.52	ENST00000494932.1	TAGLN3	transgelin 3
chr2_-_61697862	0.52	ENST00000398571.2	USP34	ubiquitin specific peptidase 34
chr7_+_116660246	0.52	ENST00000434836.1 ENST00000393443.1 ENST00000465133.1 ENST00000477742.1 ENST00000393447.4 ENST00000393444.3	ST7	suppression of tumorigenicity 7
chr9_+_2159850	0.52	ENST00000416751.1	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr6_-_39693111	0.52	ENST00000373215.3 ENST00000538893.1 ENST00000287152.7 ENST00000373216.3	KIF6	kinesin family member 6
chr13_-_95131923	0.50	ENST00000377028.5 ENST00000446125.1	DCT	dopachrome tautomerase
chr8_-_42234745	0.49	ENST00000220812.2	DKK4	dickkopf WNT signaling pathway inhibitor 4
chr14_-_38064198	0.48	ENST00000250448.2	FOXA1	forkhead box A1
chr4_-_105416039	0.47	ENST00000394767.2	CXXC4	CXXC finger protein 4
chr3_-_52090461	0.47	ENST00000296483.6 ENST00000495880.1	DUSP7	dual specificity phosphatase 7
chr3_+_111718036	0.46	ENST00000455401.2	TAGLN3	transgelin 3
chr6_-_87804815	0.46	ENST00000369582.2	CGA	glycoprotein hormones, alpha polypeptide
chr3_-_157824292	0.46	ENST00000483851.2	SHOX2	short stature homeobox 2
chr15_+_93443419	0.45	ENST00000557381.1 ENST00000420239.2	CHD2	chromodomain helicase DNA binding protein 2
chr15_-_55563072	0.45	ENST00000567380.1 ENST00000565972.1 ENST00000569493.1	RAB27A	RAB27A, member RAS oncogene family
chr13_+_78109884	0.44	ENST00000377246.3 ENST00000349847.3	SCEL	sciellin
chr13_+_78109804	0.44	ENST00000535157.1	SCEL	sciellin
chr18_+_57567180	0.44	ENST00000316660.6 ENST00000269518.9	PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1
chr1_+_214161272	0.44	ENST00000498508.2 ENST00000366958.4	PROX1	prospero homeobox 1
chr9_-_123812542	0.43	ENST00000223642.1	C5	complement component 5
chr1_+_214161854	0.42	ENST00000435016.1	PROX1	prospero homeobox 1
chr12_-_52828147	0.42	ENST00000252245.5	KRT75	keratin 75
chr3_+_111717600	0.41	ENST00000273368.4	TAGLN3	transgelin 3
chr12_-_10282836	0.40	ENST00000304084.8 ENST00000353231.5 ENST00000525605.1	CLEC7A	C-type lectin domain family 7, member A
chr12_-_31479045	0.40	ENST00000539409.1 ENST00000395766.1	FAM60A	family with sequence similarity 60, member A
chr20_+_30697298	0.39	ENST00000398022.2	TM9SF4	transmembrane 9 superfamily protein member 4
chr13_-_41593425	0.39	ENST00000239882.3	ELF1	E74-like factor 1 (ets domain transcription factor)
chr8_+_105235572	0.39	ENST00000523362.1	RIMS2	regulating synaptic membrane exocytosis 2
chr3_+_121774202	0.39	ENST00000469710.1 ENST00000493101.1 ENST00000330540.2 ENST00000264468.5	CD86	CD86 molecule
chr1_+_153747746	0.39	ENST00000368661.3	SLC27A3	solute carrier family 27 (fatty acid transporter), member 3
chrX_-_71458802	0.37	ENST00000373657.1 ENST00000334463.3	ERCC6L	excision repair cross-complementing rodent repair deficiency, complementation group 6-like
chr7_-_87342564	0.36	ENST00000265724.3 ENST00000416177.1	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr7_-_22233442	0.36	ENST00000401957.2	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr18_-_33709268	0.36	ENST00000269187.5 ENST00000590986.1 ENST00000440549.2	SLC39A6	solute carrier family 39 (zinc transporter), member 6
chr6_+_31895254	0.36	ENST00000299367.5 ENST00000442278.2	C2	complement component 2
chr11_-_117747327	0.35	ENST00000584230.1 ENST00000527429.1 ENST00000584394.1 ENST00000532984.1	FXYD6 FXYD6-FXYD2	FXYD domain containing ion transport regulator 6 FXYD6-FXYD2 readthrough
chr4_-_143227088	0.33	ENST00000511838.1	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa
chr2_-_166930131	0.32	ENST00000303395.4 ENST00000409050.1 ENST00000423058.2 ENST00000375405.3	SCN1A	sodium channel, voltage-gated, type I, alpha subunit
chr12_-_14133053	0.32	ENST00000609686.1	GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr1_+_50569575	0.32	ENST00000371827.1	ELAVL4	ELAV like neuron-specific RNA binding protein 4
chr20_-_21494654	0.32	ENST00000377142.4	NKX2-2	NK2 homeobox 2
chr14_+_72052983	0.31	ENST00000358550.2	SIPA1L1	signal-induced proliferation-associated 1 like 1
chr3_+_111717511	0.31	ENST00000478951.1 ENST00000393917.2	TAGLN3	transgelin 3
chrX_+_68835911	0.31	ENST00000525810.1 ENST00000527388.1 ENST00000374553.2 ENST00000374552.4 ENST00000338901.3 ENST00000524573.1	EDA	ectodysplasin A
chr1_+_167298281	0.31	ENST00000367862.5	POU2F1	POU class 2 homeobox 1
chr4_-_57547870	0.31	ENST00000381260.3 ENST00000420433.1 ENST00000554144.1 ENST00000557328.1	HOPX	HOP homeobox
chr1_+_180601139	0.31	ENST00000367590.4 ENST00000367589.3	XPR1	xenotropic and polytropic retrovirus receptor 1
chr15_-_37393406	0.30	ENST00000338564.5 ENST00000558313.1 ENST00000340545.5	MEIS2	Meis homeobox 2
chr13_-_28545276	0.30	ENST00000381020.7	CDX2	caudal type homeobox 2
chr12_-_53994805	0.30	ENST00000328463.7	ATF7	activating transcription factor 7
chr8_-_102803163	0.29	ENST00000523645.1 ENST00000520346.1 ENST00000220931.6 ENST00000522448.1 ENST00000522951.1 ENST00000522252.1 ENST00000519098.1	NCALD	neurocalcin delta
chr5_+_66300446	0.29	ENST00000261569.7	MAST4	microtubule associated serine/threonine kinase family member 4
chr14_+_21156915	0.29	ENST00000397990.4 ENST00000555597.1	ANG RNASE4	angiogenin, ribonuclease, RNase A family, 5 ribonuclease, RNase A family, 4
chr9_-_69229650	0.29	ENST00000416428.1	CBWD6	COBW domain containing 6
chr1_+_74701062	0.28	ENST00000326637.3	TNNI3K	TNNI3 interacting kinase
chr4_-_57547454	0.28	ENST00000556376.2	HOPX	HOP homeobox
chr18_-_3219847	0.27	ENST00000261606.7	MYOM1	myomesin 1
chr12_+_41831485	0.27	ENST00000539469.2 ENST00000298919.7	PDZRN4	PDZ domain containing ring finger 4
chr19_+_48949030	0.27	ENST00000253237.5	GRWD1	glutamate-rich WD repeat containing 1
chr2_-_74619152	0.26	ENST00000440727.1 ENST00000409240.1	DCTN1	dynactin 1
chr15_+_58702742	0.26	ENST00000356113.6 ENST00000414170.3	LIPC	lipase, hepatic
chr18_+_59000815	0.26	ENST00000262717.4	CDH20	cadherin 20, type 2
chr6_-_32157947	0.26	ENST00000375050.4	PBX2	pre-B-cell leukemia homeobox 2
chr15_-_55562582	0.26	ENST00000396307.2	RAB27A	RAB27A, member RAS oncogene family
chr4_+_69313145	0.25	ENST00000305363.4	TMPRSS11E	transmembrane protease, serine 11E
chr2_-_50201327	0.25	ENST00000412315.1	NRXN1	neurexin 1
chr3_-_57233966	0.25	ENST00000473921.1 ENST00000295934.3	HESX1	HESX homeobox 1
chr6_+_153552455	0.25	ENST00000392385.2	AL590867.1	Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr2_-_74618964	0.25	ENST00000417090.1 ENST00000409868.1	DCTN1	dynactin 1
chr5_+_59783540	0.24	ENST00000515734.2	PART1	prostate androgen-regulated transcript 1 (non-protein coding)
chr3_+_130569429	0.24	ENST00000505330.1 ENST00000504381.1 ENST00000507488.2 ENST00000393221.4	ATP2C1	ATPase, Ca++ transporting, type 2C, member 1
chr1_+_68150744	0.24	ENST00000370986.4 ENST00000370985.3	GADD45A	growth arrest and DNA-damage-inducible, alpha
chr2_+_234826016	0.24	ENST00000324695.4 ENST00000433712.2	TRPM8	transient receptor potential cation channel, subfamily M, member 8
chr1_-_45956800	0.24	ENST00000538496.1	TESK2	testis-specific kinase 2
chr2_+_162272605	0.24	ENST00000389554.3	TBR1	T-box, brain, 1
chr20_+_42136308	0.24	ENST00000434666.1 ENST00000427442.2 ENST00000439769.1 ENST00000418998.1	L3MBTL1	l(3)mbt-like 1 (Drosophila)
chr6_-_136788001	0.24	ENST00000544465.1	MAP7	microtubule-associated protein 7
chr7_-_44580861	0.24	ENST00000546276.1 ENST00000289547.4 ENST00000381160.3 ENST00000423141.1	NPC1L1	NPC1-like 1
chr12_-_86650077	0.23	ENST00000552808.2 ENST00000547225.1	MGAT4C	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr14_-_64194745	0.23	ENST00000247225.6	SGPP1	sphingosine-1-phosphate phosphatase 1
chr12_-_86650045	0.22	ENST00000604798.1	MGAT4C	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_-_136678123	0.22	ENST00000422708.1	DARS	aspartyl-tRNA synthetase
chr7_-_14026063	0.22	ENST00000443608.1 ENST00000438956.1	ETV1	ets variant 1
chrX_+_107288197	0.22	ENST00000415430.3	VSIG1	V-set and immunoglobulin domain containing 1
chr7_-_23510086	0.22	ENST00000258729.3	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3
chr6_-_22297730	0.22	ENST00000306482.1	PRL	prolactin
chr5_+_179159813	0.21	ENST00000292599.3	MAML1	mastermind-like 1 (Drosophila)
chr8_-_20040601	0.21	ENST00000265808.7 ENST00000522513.1	SLC18A1	solute carrier family 18 (vesicular monoamine transporter), member 1
chr1_-_150738261	0.21	ENST00000448301.2 ENST00000368985.3	CTSS	cathepsin S
chr8_+_107738240	0.21	ENST00000449762.2 ENST00000297447.6	OXR1	oxidation resistance 1
chr8_-_20040638	0.21	ENST00000519026.1 ENST00000276373.5 ENST00000440926.1 ENST00000437980.1	SLC18A1	solute carrier family 18 (vesicular monoamine transporter), member 1
chr14_-_51027838	0.21	ENST00000555216.1	MAP4K5	mitogen-activated protein kinase kinase kinase kinase 5
chr10_+_119301928	0.21	ENST00000553456.3	EMX2	empty spiracles homeobox 2
chr4_+_114214125	0.20	ENST00000509550.1	ANK2	ankyrin 2, neuronal
chrX_-_20236970	0.20	ENST00000379548.4	RPS6KA3	ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr1_-_45956822	0.20	ENST00000372086.3 ENST00000341771.6	TESK2	testis-specific kinase 2
chr3_-_113897545	0.20	ENST00000467632.1	DRD3	dopamine receptor D3
chr11_-_69633792	0.20	ENST00000334134.2	FGF3	fibroblast growth factor 3
chr18_+_32173276	0.19	ENST00000591816.1 ENST00000588125.1 ENST00000598334.1 ENST00000588684.1 ENST00000554864.3 ENST00000399121.5 ENST00000595022.1 ENST00000269190.7 ENST00000399097.3	DTNA	dystrobrevin, alpha
chr10_+_102222798	0.19	ENST00000343737.5	WNT8B	wingless-type MMTV integration site family, member 8B
chr1_+_153746683	0.19	ENST00000271857.2	SLC27A3	solute carrier family 27 (fatty acid transporter), member 3
chr17_-_48785216	0.19	ENST00000285243.6	ANKRD40	ankyrin repeat domain 40
chr4_+_88571429	0.19	ENST00000339673.6 ENST00000282479.7	DMP1	dentin matrix acidic phosphoprotein 1
chr16_-_4852915	0.18	ENST00000322048.7	ROGDI	rogdi homolog (Drosophila)
chr5_+_59783941	0.18	ENST00000506884.1 ENST00000504876.2	PART1	prostate androgen-regulated transcript 1 (non-protein coding)
chr7_+_129015484	0.18	ENST00000490911.1	AHCYL2	adenosylhomocysteinase-like 2
chrX_+_107288239	0.18	ENST00000217957.5	VSIG1	V-set and immunoglobulin domain containing 1
chr17_+_39411636	0.18	ENST00000394008.1	KRTAP9-9	keratin associated protein 9-9
chr2_+_45168875	0.18	ENST00000260653.3	SIX3	SIX homeobox 3
chr4_-_170897045	0.18	ENST00000508313.1	RP11-205M3.3	RP11-205M3.3
chr14_-_36988882	0.17	ENST00000498187.2	NKX2-1	NK2 homeobox 1
chr20_+_56964253	0.17	ENST00000395802.3	VAPB	VAMP (vesicle-associated membrane protein)-associated protein B and C
chr1_+_62439037	0.17	ENST00000545929.1	INADL	InaD-like (Drosophila)
chr12_-_102591604	0.17	ENST00000329406.4	PMCH	pro-melanin-concentrating hormone
chr1_+_198608146	0.17	ENST00000367376.2 ENST00000352140.3 ENST00000594404.1 ENST00000598951.1 ENST00000530727.1 ENST00000442510.2 ENST00000367367.4 ENST00000348564.6 ENST00000367364.1 ENST00000413409.2	PTPRC	protein tyrosine phosphatase, receptor type, C
chr6_+_135502501	0.17	ENST00000527615.1 ENST00000420123.2 ENST00000525369.1 ENST00000528774.1 ENST00000534121.1 ENST00000534044.1 ENST00000533624.1	MYB	v-myb avian myeloblastosis viral oncogene homolog
chr21_-_42219065	0.17	ENST00000400454.1	DSCAM	Down syndrome cell adhesion molecule
chr18_-_31803435	0.17	ENST00000589544.1 ENST00000269185.4 ENST00000261592.5	NOL4	nucleolar protein 4
chr7_+_100136811	0.17	ENST00000300176.4 ENST00000262935.4	AGFG2	ArfGAP with FG repeats 2
chr9_+_470288	0.17	ENST00000382303.1	KANK1	KN motif and ankyrin repeat domains 1
chr2_-_176046391	0.17	ENST00000392541.3 ENST00000409194.1	ATP5G3	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr14_-_98444386	0.16	ENST00000556462.1 ENST00000556138.1	C14orf64	chromosome 14 open reading frame 64
chr1_+_209878182	0.16	ENST00000367027.3	HSD11B1	hydroxysteroid (11-beta) dehydrogenase 1
chr3_-_33686743	0.16	ENST00000333778.6 ENST00000539981.1	CLASP2	cytoplasmic linker associated protein 2
chr16_+_89334512	0.16	ENST00000602042.1	AC137932.1	AC137932.1
chr17_-_9929581	0.16	ENST00000437099.2 ENST00000396115.2	GAS7	growth arrest-specific 7
chr2_+_68962014	0.16	ENST00000467265.1	ARHGAP25	Rho GTPase activating protein 25
chr8_-_17533838	0.16	ENST00000400046.1	MTUS1	microtubule associated tumor suppressor 1
chr4_+_88754113	0.16	ENST00000560249.1 ENST00000540395.1 ENST00000511670.1 ENST00000361056.3	MEPE	matrix extracellular phosphoglycoprotein
chr19_-_53758094	0.16	ENST00000601828.1 ENST00000598513.1 ENST00000599012.1 ENST00000333952.4 ENST00000598806.1	ZNF677	zinc finger protein 677
chr6_+_31583761	0.15	ENST00000376049.4	AIF1	allograft inflammatory factor 1
chr4_+_78432907	0.15	ENST00000286758.4	CXCL13	chemokine (C-X-C motif) ligand 13
chr10_-_50970322	0.15	ENST00000374103.4	OGDHL	oxoglutarate dehydrogenase-like
chr14_+_32798547	0.15	ENST00000557354.1 ENST00000557102.1 ENST00000557272.1	AKAP6	A kinase (PRKA) anchor protein 6
chr6_-_111927449	0.15	ENST00000368761.5 ENST00000392556.4 ENST00000340026.6	TRAF3IP2	TRAF3 interacting protein 2
chr20_+_3776371	0.15	ENST00000245960.5	CDC25B	cell division cycle 25B
chr16_+_103816	0.15	ENST00000383018.3 ENST00000417493.1	SNRNP25	small nuclear ribonucleoprotein 25kDa (U11/U12)
chr19_-_46088068	0.15	ENST00000263275.4 ENST00000323060.3	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr4_-_39979576	0.15	ENST00000303538.8 ENST00000503396.1	PDS5A	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr2_+_171034646	0.15	ENST00000409044.3 ENST00000408978.4	MYO3B	myosin IIIB
chr7_+_154002189	0.14	ENST00000332007.3	DPP6	dipeptidyl-peptidase 6
chr9_-_5304432	0.14	ENST00000416837.1 ENST00000308420.3	RLN2	relaxin 2
chr5_+_69321074	0.14	ENST00000380751.5 ENST00000380750.3 ENST00000503931.1 ENST00000506542.1	SERF1B	small EDRK-rich factor 1B (centromeric)
chr8_+_94752349	0.14	ENST00000391680.1	RBM12B-AS1	RBM12B antisense RNA 1
chr2_-_30144432	0.14	ENST00000389048.3	ALK	anaplastic lymphoma receptor tyrosine kinase
chr17_-_40337470	0.14	ENST00000293330.1	HCRT	hypocretin (orexin) neuropeptide precursor
chr20_-_50722183	0.14	ENST00000371523.4	ZFP64	ZFP64 zinc finger protein
chr11_+_75526212	0.14	ENST00000356136.3	UVRAG	UV radiation resistance associated
chr11_-_128894053	0.14	ENST00000392657.3	ARHGAP32	Rho GTPase activating protein 32
chr3_-_113897899	0.14	ENST00000383673.2 ENST00000295881.7	DRD3	dopamine receptor D3
chr12_-_91398796	0.14	ENST00000261172.3 ENST00000551767.1	EPYC	epiphycan
chr4_-_66536196	0.14	ENST00000511294.1	EPHA5	EPH receptor A5

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	0.6	GO:0005726	perichromatin fibrils(GO:0005726)
0.1	1.8	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1	0.4	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.1	3.3	GO:0045095	keratin filament(GO:0045095)
0.1	1.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.3	GO:0032311	angiogenin-PRI complex(GO:0032311)
0.0	0.4	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.4	GO:0070083	clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083)
0.0	0.2	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.3	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.3	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0	0.7	GO:0031089	platelet dense granule lumen(GO:0031089)
0.0	0.5	GO:0001673	male germ cell nucleus(GO:0001673)
0.0	0.5	GO:0005869	dynactin complex(GO:0005869)
0.0	0.7	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.2	GO:0036021	endolysosome lumen(GO:0036021)
0.0	0.2	GO:0014802	terminal cisterna(GO:0014802)
0.0	0.1	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
0.0	0.1	GO:0070826	paraferritin complex(GO:0070826)
0.0	0.5	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0097442	CA3 pyramidal cell dendrite(GO:0097442)
0.0	0.3	GO:0030130	clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0	0.9	GO:0001533	cornified envelope(GO:0001533)
0.0	0.4	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.2	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0036449	microtubule minus-end(GO:0036449)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.2	GO:0043194	voltage-gated sodium channel complex(GO:0001518) axon initial segment(GO:0043194)
0.0	0.5	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.1	GO:0016013	syntrophin complex(GO:0016013)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	0.8	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1	1.3	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.5	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	4.1	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	0.5	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	0.4	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.7	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.7	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.4	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.0	0.5	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.3	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.7	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.7	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.5	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.3	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.4	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.3	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1	Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0	0.3	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.6	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.3	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	0.7	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	0.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.3	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.8	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.2	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	1.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.1	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	1.2	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	0.4	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.6	GO:0060166	olfactory pit development(GO:0060166)
0.3	0.9	GO:0046619	optic placode formation involved in camera-type eye formation(GO:0046619)
0.3	1.1	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.2	0.7	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.2	0.7	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.2	1.3	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.2	0.6	GO:0070105	positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
0.2	0.5	GO:0097052	tryptophan catabolic process to acetyl-CoA(GO:0019442) L-kynurenine metabolic process(GO:0097052)
0.2	4.9	GO:0032331	negative regulation of chondrocyte differentiation(GO:0032331)
0.2	0.3	GO:0021778	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2	0.2	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.1	0.4	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.1	0.4	GO:0032641	negative regulation of tolerance induction(GO:0002644) lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1	2.5	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1	0.5	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1	0.3	GO:0050883	musculoskeletal movement, spinal reflex action(GO:0050883)
0.1	0.6	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1	0.2	GO:0003162	atrioventricular node development(GO:0003162)
0.1	0.5	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.1	0.9	GO:1904352	positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.1	0.2	GO:2000854	positive regulation of corticosterone secretion(GO:2000854)
0.1	0.4	GO:1901529	positive regulation of anion channel activity(GO:1901529)
0.1	0.2	GO:0014016	neuroblast differentiation(GO:0014016)
0.1	0.5	GO:0051799	negative regulation of hair follicle development(GO:0051799)
0.1	0.5	GO:0007352	zygotic specification of dorsal/ventral axis(GO:0007352)
0.1	0.1	GO:0035992	tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1	0.2	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.1	0.3	GO:0014807	regulation of somitogenesis(GO:0014807)
0.1	0.5	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.1	0.4	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842)
0.1	0.3	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1	0.2	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1	0.1	GO:0048867	stem cell fate determination(GO:0048867)
0.1	0.7	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.1	0.5	GO:0090063	positive regulation of microtubule nucleation(GO:0090063)
0.1	0.6	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.1	0.3	GO:0061152	trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1	0.2	GO:0006668	sphinganine-1-phosphate metabolic process(GO:0006668)
0.1	0.3	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.1	0.6	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.1	0.9	GO:0051639	actin filament network formation(GO:0051639)
0.1	0.2	GO:1904897	regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.1	0.2	GO:2000393	negative regulation of lamellipodium morphogenesis(GO:2000393)
0.1	0.7	GO:0030210	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1	0.2	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.1	0.3	GO:0032468	Golgi calcium ion homeostasis(GO:0032468)
0.0	0.2	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.5	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.0	0.1	GO:0030309	poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0	0.4	GO:0010917	negative regulation of mitochondrial membrane potential(GO:0010917)
0.0	0.4	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0	0.2	GO:0030916	otic vesicle formation(GO:0030916)
0.0	0.5	GO:2000172	regulation of branching morphogenesis of a nerve(GO:2000172)
0.0	1.1	GO:0042832	defense response to protozoan(GO:0042832)
0.0	1.9	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.0	0.2	GO:0021764	amygdala development(GO:0021764)
0.0	0.8	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.4	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.1	GO:0036269	swimming behavior(GO:0036269)
0.0	0.2	GO:0021759	globus pallidus development(GO:0021759)
0.0	0.7	GO:0002230	positive regulation of defense response to virus by host(GO:0002230)
0.0	0.2	GO:0048539	immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539)
0.0	0.6	GO:0070286	axonemal dynein complex assembly(GO:0070286)
0.0	0.4	GO:0070072	proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.2	GO:0014738	regulation of muscle hyperplasia(GO:0014738)
0.0	0.4	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.1	GO:1901994	meiotic cell cycle phase transition(GO:0044771) establishment of meiotic spindle localization(GO:0051295) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0	0.5	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.1	GO:0045229	cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.0	0.3	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.2	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0	0.1	GO:0002384	hepatic immune response(GO:0002384)
0.0	0.4	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.1	GO:0071600	otic vesicle morphogenesis(GO:0071600)
0.0	0.2	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.2	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.2	GO:0048263	determination of dorsal identity(GO:0048263)
0.0	0.1	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.1	GO:0044878	mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0	0.5	GO:0007249	I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0	0.1	GO:0070574	cadmium ion transport(GO:0015691) lead ion transport(GO:0015692) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.0	0.2	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.4	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.1	GO:0007568	aging(GO:0007568)
0.0	0.4	GO:0001829	trophectodermal cell differentiation(GO:0001829)
0.0	0.3	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.2	GO:0014877	response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0	0.2	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.5	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.2	GO:0098856	intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.0	0.4	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.3	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0	0.2	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.1	GO:1902310	positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0	0.1	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948) regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072366)
0.0	0.4	GO:0030336	negative regulation of cell migration(GO:0030336)
0.0	1.2	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.0	0.2	GO:0070170	regulation of tooth mineralization(GO:0070170)
0.0	0.6	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.3	GO:0086069	bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.3	GO:0018105	peptidyl-serine phosphorylation(GO:0018105)
0.0	0.4	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.2	GO:1902083	cellular response to hydroperoxide(GO:0071447) negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.1	GO:0007154	cell communication(GO:0007154)
0.0	1.5	GO:0031424	keratinization(GO:0031424)
0.0	0.1	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0	0.2	GO:0072643	interferon-gamma secretion(GO:0072643)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0021815	modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration(GO:0021815)
0.0	0.0	GO:0061743	motor learning(GO:0061743)
0.0	0.1	GO:0035063	nuclear speck organization(GO:0035063)
0.0	0.1	GO:0006898	receptor-mediated endocytosis(GO:0006898)
0.0	0.2	GO:0032793	positive regulation of CREB transcription factor activity(GO:0032793)
0.0	0.1	GO:0048842	positive regulation of axon extension involved in axon guidance(GO:0048842)
0.0	0.2	GO:0071711	basement membrane organization(GO:0071711)
0.0	0.1	GO:0010172	embryonic body morphogenesis(GO:0010172)
0.0	0.3	GO:0006337	nucleosome disassembly(GO:0006337)
0.0	0.2	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.5	GO:0016486	peptide hormone processing(GO:0016486)
0.0	0.3	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	7.4	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.2	2.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.1	6.6	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.1	1.0	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.1	1.9	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	1.4	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.1	1.8	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1	1.4	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.1	1.3	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	4.5	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.1	0.7	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.1	1.3	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	0.5	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	0.4	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	2.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.5	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	1.1	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.8	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.7	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.7	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	3.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	2.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	0.7	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	1.4	REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0	1.5	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.0	1.1	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.7	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	0.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.6	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	1.9	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.8	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.0	1.5	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.5	REACTOME INTEGRATION OF PROVIRUS	Genes involved in Integration of provirus
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.4	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.0	0.6	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	1.1	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.9	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.3	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.7	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.0	1.1	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	0.7	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.2	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.5	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.7	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
0.0	1.4	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	0.3	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.1	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	1.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.7	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	1.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.3	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	0.3	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.6	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.2	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.2	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.0	0.7	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	1.2	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.6	REACTOME MEIOSIS	Genes involved in Meiosis
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	1.4	REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL	Genes involved in Cell surface interactions at the vascular wall
0.0	0.5	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
0.0	0.3	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.3	REACTOME TRNA AMINOACYLATION	Genes involved in tRNA Aminoacylation
0.0	0.4	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.2	REACTOME G PROTEIN ACTIVATION	Genes involved in G-protein activation
0.0	0.2	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.5	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.2	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.5	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.3	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	4.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	1.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	1.4	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.0	1.0	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	1.2	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	0.3	PID REELIN PATHWAY	Reelin signaling pathway
0.0	1.0	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.0	0.7	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	0.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	1.1	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.6	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	1.0	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	10.2	GO:0097577	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.7	2.9	GO:0043126	regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.6	7.5	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.6	1.8	GO:0093001	glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
0.5	1.6	GO:0051311	meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.5	2.6	GO:0002399	MHC class II protein complex assembly(GO:0002399)
0.5	2.5	GO:0048539	bone marrow development(GO:0048539)
0.4	1.8	GO:0031860	telomeric 3' overhang formation(GO:0031860)
0.4	1.2	GO:0072709	cellular response to sorbitol(GO:0072709)
0.4	1.4	GO:0042357	thiamine diphosphate metabolic process(GO:0042357)
0.3	1.0	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.3	1.0	GO:0002184	cytoplasmic translational termination(GO:0002184)
0.3	0.9	GO:0071284	cellular response to lead ion(GO:0071284)
0.3	0.8	GO:0031548	regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
0.3	0.8	GO:1902523	positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.3	2.1	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.3	1.0	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.2	0.7	GO:0051697	protein delipidation(GO:0051697)
0.2	1.2	GO:0052199	negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.2	0.9	GO:2000253	positive regulation of feeding behavior(GO:2000253)
0.2	2.0	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2	1.5	GO:0098532	histone H3-K27 trimethylation(GO:0098532)
0.2	2.0	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.2	0.7	GO:0071461	cellular response to redox state(GO:0071461)
0.2	0.5	GO:0002727	natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.2	0.7	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.2	0.8	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2	0.5	GO:0009183	purine deoxyribonucleoside diphosphate biosynthetic process(GO:0009183) dGDP metabolic process(GO:0046066)
0.1	0.4	GO:0006478	peptidyl-tyrosine sulfation(GO:0006478)
0.1	1.0	GO:0032594	protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
0.1	0.7	GO:0015722	canalicular bile acid transport(GO:0015722)
0.1	0.6	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.1	1.6	GO:0002315	marginal zone B cell differentiation(GO:0002315)
0.1	0.4	GO:0006427	histidyl-tRNA aminoacylation(GO:0006427)
0.1	0.8	GO:1903960	regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960)
0.1	0.4	GO:0090149	mitochondrial membrane fission(GO:0090149)
0.1	1.0	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1	0.4	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
0.1	0.6	GO:0006574	valine catabolic process(GO:0006574)
0.1	1.3	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)
0.1	0.6	GO:0061767	negative regulation of lung blood pressure(GO:0061767)
0.1	0.4	GO:0051097	negative regulation of helicase activity(GO:0051097)
0.1	0.8	GO:0016098	monoterpenoid metabolic process(GO:0016098)
0.1	0.5	GO:1900533	medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
0.1	1.2	GO:0042262	DNA protection(GO:0042262)
0.1	0.7	GO:0035407	histone H3-T11 phosphorylation(GO:0035407)
0.1	0.5	GO:0000103	sulfate assimilation(GO:0000103)
0.1	1.7	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.1	0.5	GO:0072166	posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.1	0.1	GO:1903056	regulation of melanosome organization(GO:1903056)
0.1	0.3	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
0.1	0.8	GO:0046485	ether lipid metabolic process(GO:0046485)
0.1	0.5	GO:2001106	regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001106)
0.1	0.3	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.1	0.3	GO:0014016	neuroblast differentiation(GO:0014016)
0.1	15.5	GO:0006958	complement activation, classical pathway(GO:0006958)
0.1	0.6	GO:0051661	maintenance of centrosome location(GO:0051661)
0.1	0.3	GO:0051102	DNA ligation involved in DNA recombination(GO:0051102)
0.1	0.6	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1	2.4	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.1	0.7	GO:0044245	polysaccharide digestion(GO:0044245)
0.1	3.6	GO:0050869	negative regulation of B cell activation(GO:0050869)
0.1	0.3	GO:1901253	negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
0.1	0.3	GO:1990168	protein K33-linked deubiquitination(GO:1990168)
0.1	1.2	GO:0070986	left/right axis specification(GO:0070986)
0.1	0.4	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
0.1	0.4	GO:0035502	metanephric part of ureteric bud development(GO:0035502)
0.1	0.9	GO:0006268	DNA unwinding involved in DNA replication(GO:0006268)
0.1	0.4	GO:1904844	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1	0.6	GO:0071896	protein localization to adherens junction(GO:0071896)
0.1	0.4	GO:0060406	positive regulation of penile erection(GO:0060406)
0.1	0.4	GO:0006127	glycerophosphate shuttle(GO:0006127)
0.1	1.2	GO:0045793	positive regulation of cell size(GO:0045793)
0.1	1.1	GO:0045919	positive regulation of cytolysis(GO:0045919)
0.1	0.5	GO:0061737	leukotriene signaling pathway(GO:0061737)
0.1	0.6	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.1	0.3	GO:1904502	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1	0.3	GO:0060084	synaptic transmission involved in micturition(GO:0060084)
0.1	0.5	GO:1990253	cellular response to leucine starvation(GO:1990253)
0.1	0.2	GO:0035377	transepithelial water transport(GO:0035377) positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.1	0.9	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1	0.2	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.4	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.1	1.1	GO:0015671	oxygen transport(GO:0015671)
0.1	0.2	GO:1903487	regulation of lactation(GO:1903487)
0.1	0.1	GO:1905064	negative regulation of vascular smooth muscle cell differentiation(GO:1905064)
0.1	0.2	GO:0098905	regulation of bundle of His cell action potential(GO:0098905)
0.1	0.5	GO:0031118	rRNA pseudouridine synthesis(GO:0031118)
0.1	0.2	GO:0010430	fatty acid omega-oxidation(GO:0010430)
0.1	5.0	GO:0030574	collagen catabolic process(GO:0030574)
0.1	0.2	GO:0030910	olfactory placode formation(GO:0030910) myotome development(GO:0061055) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1	2.9	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1	1.5	GO:0003334	keratinocyte development(GO:0003334)
0.1	0.2	GO:1903676	regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1	1.1	GO:1903504	regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1	0.7	GO:0048743	positive regulation of skeletal muscle fiber development(GO:0048743)
0.1	0.4	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.1	0.3	GO:0030581	intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1	0.4	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.1	0.6	GO:0045040	protein import into mitochondrial outer membrane(GO:0045040)
0.1	0.3	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.1	0.2	GO:0007386	compartment pattern specification(GO:0007386)
0.1	1.7	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1	0.4	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.1	1.0	GO:0006312	mitotic recombination(GO:0006312)
0.1	0.4	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1	0.3	GO:0072143	mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
0.1	0.1	GO:0070301	response to hydrogen peroxide(GO:0042542) cellular response to hydrogen peroxide(GO:0070301)
0.1	2.7	GO:0070206	protein trimerization(GO:0070206)
0.1	0.6	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.1	0.3	GO:1901096	regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.1	0.3	GO:0090166	Golgi disassembly(GO:0090166)
0.1	0.1	GO:0001810	regulation of type I hypersensitivity(GO:0001810) positive regulation of type I hypersensitivity(GO:0001812) type I hypersensitivity(GO:0016068)
0.1	1.1	GO:0001829	trophectodermal cell differentiation(GO:0001829)
0.1	2.2	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.1	2.8	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.1	0.3	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.3	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
0.0	0.4	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.2	GO:0061355	Wnt protein secretion(GO:0061355) regulation of Wnt protein secretion(GO:0061356) negative regulation of Wnt protein secretion(GO:0061358)
0.0	0.2	GO:0071874	response to norepinephrine(GO:0071873) cellular response to norepinephrine stimulus(GO:0071874)
0.0	0.3	GO:0006226	dUMP biosynthetic process(GO:0006226) dTMP biosynthetic process(GO:0006231) dTMP metabolic process(GO:0046073)
0.0	0.4	GO:0002318	myeloid progenitor cell differentiation(GO:0002318)
0.0	1.2	GO:0006825	copper ion transport(GO:0006825)
0.0	0.9	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.3	GO:0006348	chromatin silencing at telomere(GO:0006348)
0.0	0.2	GO:0018230	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0	0.4	GO:0035721	intraciliary retrograde transport(GO:0035721)
0.0	0.3	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
0.0	0.2	GO:0051490	negative regulation of filopodium assembly(GO:0051490)
0.0	0.4	GO:0051095	regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096)
0.0	0.6	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.0	1.2	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:1903179	detoxification of mercury ion(GO:0050787) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
0.0	0.1	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0	0.2	GO:0097498	endothelial tube lumen extension(GO:0097498)
0.0	1.1	GO:0090022	regulation of neutrophil chemotaxis(GO:0090022)
0.0	0.2	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.2	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636)
0.0	1.1	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.3	GO:0042492	gamma-delta T cell differentiation(GO:0042492)
0.0	0.3	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.7	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.4	GO:0006782	protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0	0.1	GO:0031642	negative regulation of myelination(GO:0031642)
0.0	0.2	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.0	0.1	GO:0015888	thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.0	0.1	GO:0060434	bronchus morphogenesis(GO:0060434)
0.0	0.2	GO:0097338	response to clozapine(GO:0097338)
0.0	0.2	GO:1904798	positive regulation of core promoter binding(GO:1904798)
0.0	0.7	GO:0045730	respiratory burst(GO:0045730)
0.0	0.3	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.8	GO:0042359	vitamin D metabolic process(GO:0042359)
0.0	1.5	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.9	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.3	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:0031446	regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.0	0.2	GO:0032377	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0	0.4	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.1	GO:0071301	cellular response to vitamin B1(GO:0071301) response to formaldehyde(GO:1904404)
0.0	0.1	GO:0015783	GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.0	0.8	GO:0050961	detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.0	0.6	GO:0001682	tRNA 5'-leader removal(GO:0001682)
0.0	0.4	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0	0.2	GO:0033197	response to vitamin E(GO:0033197)
0.0	0.1	GO:0002881	negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
0.0	0.4	GO:0060087	relaxation of vascular smooth muscle(GO:0060087)
0.0	0.3	GO:0030091	protein repair(GO:0030091)
0.0	0.2	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:1904749	regulation of protein localization to nucleolus(GO:1904749)
0.0	0.8	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736)
0.0	0.4	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.4	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592)
0.0	0.2	GO:0044351	macropinocytosis(GO:0044351)
0.0	0.2	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.2	GO:0010836	negative regulation of protein ADP-ribosylation(GO:0010836) telomere assembly(GO:0032202)
0.0	0.1	GO:0035897	proteolysis in other organism(GO:0035897)
0.0	0.2	GO:0006848	pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0	0.2	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.4	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)
0.0	0.3	GO:0045838	positive regulation of membrane potential(GO:0045838)
0.0	0.1	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0	0.7	GO:0034198	cellular response to amino acid starvation(GO:0034198)
0.0	0.2	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.7	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.1	GO:0033326	cerebrospinal fluid secretion(GO:0033326)
0.0	0.2	GO:0098881	exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0	0.9	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.0	1.0	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.5	GO:0001502	cartilage condensation(GO:0001502)
0.0	0.2	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.1	GO:0044376	RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0	0.1	GO:1902714	negative regulation of interferon-gamma secretion(GO:1902714)
0.0	0.3	GO:0016446	somatic hypermutation of immunoglobulin genes(GO:0016446)
0.0	0.3	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.6	GO:0030048	actin filament-based movement(GO:0030048)
0.0	1.1	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0	0.4	GO:0000338	protein deneddylation(GO:0000338)
0.0	0.6	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.1	GO:2000143	negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0089700	protein kinase D signaling(GO:0089700)
0.0	0.3	GO:1900017	positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0	0.1	GO:2000773	negative regulation of cellular senescence(GO:2000773)
0.0	0.3	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.4	GO:0007021	tubulin complex assembly(GO:0007021)
0.0	0.7	GO:0044247	polysaccharide catabolic process(GO:0000272) glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.0	0.0	GO:0000965	mitochondrial RNA 3'-end processing(GO:0000965)
0.0	0.2	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.0	0.3	GO:0045116	protein neddylation(GO:0045116)
0.0	0.2	GO:0044829	positive regulation by host of viral genome replication(GO:0044829)
0.0	0.4	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0	0.2	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.5	GO:0070886	positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.0	0.3	GO:0006265	DNA topological change(GO:0006265)
0.0	0.8	GO:0006911	phagocytosis, engulfment(GO:0006911)
0.0	1.2	GO:0042267	natural killer cell mediated cytotoxicity(GO:0042267)
0.0	0.4	GO:0061077	chaperone-mediated protein folding(GO:0061077)
0.0	1.5	GO:0033275	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0	0.3	GO:0050930	induction of positive chemotaxis(GO:0050930)
0.0	0.1	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.1	GO:0042699	follicle-stimulating hormone signaling pathway(GO:0042699)
0.0	0.2	GO:0070129	regulation of mitochondrial translation(GO:0070129)
0.0	0.1	GO:0075525	viral translational termination-reinitiation(GO:0075525)
0.0	0.3	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.5	GO:1904659	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0	0.3	GO:0006221	pyrimidine nucleotide biosynthetic process(GO:0006221)
0.0	0.2	GO:0014029	neural crest formation(GO:0014029)
0.0	0.0	GO:0090234	regulation of kinetochore assembly(GO:0090234)
0.0	0.4	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.0	0.1	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0	0.7	GO:1901998	toxin transport(GO:1901998)
0.0	0.1	GO:0021784	postganglionic parasympathetic fiber development(GO:0021784)
0.0	0.1	GO:0050852	T cell receptor signaling pathway(GO:0050852)
0.0	0.0	GO:0070305	response to cGMP(GO:0070305)
0.0	0.1	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051)
0.0	0.3	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0	0.1	GO:0050851	antigen receptor-mediated signaling pathway(GO:0050851)
0.0	0.2	GO:0035493	SNARE complex assembly(GO:0035493)
0.0	0.6	GO:0003254	regulation of membrane depolarization(GO:0003254)
0.0	0.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.1	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.2	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.0	0.2	GO:0043457	regulation of cellular respiration(GO:0043457)
0.0	0.2	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.0	0.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.0	GO:0090400	stress-induced premature senescence(GO:0090400)
0.0	0.5	GO:0046039	GTP metabolic process(GO:0046039)
0.0	0.2	GO:0033189	response to vitamin A(GO:0033189)
0.0	0.1	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	0.8	GO:1902403	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic cell cycle checkpoint(GO:0072413) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400) signal transduction involved in mitotic DNA damage checkpoint(GO:1902402) signal transduction involved in mitotic DNA integrity checkpoint(GO:1902403)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.0	0.3	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0	0.1	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.3	GO:0097435	fibril organization(GO:0097435)
0.0	0.0	GO:0021997	response to chlorate(GO:0010157) neural plate axis specification(GO:0021997)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.0	GO:2001023	regulation of response to drug(GO:2001023)
0.0	0.5	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0	0.1	GO:0045956	positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.0	0.5	GO:0050829	defense response to Gram-negative bacterium(GO:0050829)
0.0	0.2	GO:0050850	positive regulation of calcium-mediated signaling(GO:0050850)
0.0	0.2	GO:0007507	heart development(GO:0007507)
0.0	0.2	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.0	GO:0002580	regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002580) negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.0	0.2	GO:0046606	negative regulation of centrosome cycle(GO:0046606)
0.0	0.0	GO:0045792	negative regulation of cell size(GO:0045792)
0.0	0.4	GO:0007340	acrosome reaction(GO:0007340)
0.0	0.2	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.0	0.1	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
0.0	0.1	GO:0032468	Golgi calcium ion homeostasis(GO:0032468)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.3	GO:0045599	negative regulation of fat cell differentiation(GO:0045599)
0.0	0.3	GO:0035690	cellular response to drug(GO:0035690)
0.0	0.1	GO:0034334	adherens junction maintenance(GO:0034334)
0.0	0.4	GO:0031102	neuron projection regeneration(GO:0031102)
0.0	0.1	GO:0042421	norepinephrine biosynthetic process(GO:0042421)
0.0	0.2	GO:0036315	cellular response to sterol(GO:0036315)
0.0	0.4	GO:0006509	membrane protein ectodomain proteolysis(GO:0006509)
0.0	0.6	GO:0045454	cell redox homeostasis(GO:0045454)
0.0	0.1	GO:0007197	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.0	1.1	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
0.0	0.7	GO:0071349	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0	0.4	GO:0033119	negative regulation of RNA splicing(GO:0033119)
0.0	0.2	GO:0007094	mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0	0.2	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.1	GO:1902415	regulation of mRNA binding(GO:1902415) positive regulation of mRNA binding(GO:1902416) regulation of RNA binding(GO:1905214) positive regulation of RNA binding(GO:1905216)
0.0	0.1	GO:0042340	keratan sulfate catabolic process(GO:0042340)
0.0	0.1	GO:0031571	mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.0	0.1	GO:0035855	secretory granule organization(GO:0033363) megakaryocyte development(GO:0035855)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.9	GO:1990254	keratin filament binding(GO:1990254)
0.2	0.6	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.2	4.7	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.2	1.6	GO:0070324	thyroid hormone binding(GO:0070324)
0.1	0.4	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.1	0.7	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.1	0.5	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1	2.5	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.7	GO:0008046	axon guidance receptor activity(GO:0008046)
0.1	0.7	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1	0.9	GO:0050692	DBD domain binding(GO:0050692)
0.1	1.6	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1	0.5	GO:0004167	dopachrome isomerase activity(GO:0004167)
0.1	0.6	GO:0008131	primary amine oxidase activity(GO:0008131)
0.1	0.2	GO:0032093	SAM domain binding(GO:0032093)
0.1	1.0	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1	0.3	GO:0000822	inositol hexakisphosphate binding(GO:0000822)
0.1	0.4	GO:0090554	phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1	0.2	GO:0005148	prolactin receptor binding(GO:0005148)
0.1	0.3	GO:0052828	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.1	0.2	GO:0033149	FFAT motif binding(GO:0033149)
0.1	0.5	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	1.5	GO:0031489	myosin V binding(GO:0031489)
0.1	0.3	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.1	0.2	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1	0.7	GO:0030280	structural constituent of epidermis(GO:0030280)
0.1	0.6	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.3	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.2	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.3	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.2	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.6	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.1	GO:0005174	CD40 receptor binding(GO:0005174)
0.0	0.4	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.2	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.0	0.3	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.7	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.2	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.3	GO:0031013	troponin I binding(GO:0031013)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.7	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.1	GO:0015639	cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.0	0.5	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	1.1	GO:0042287	MHC protein binding(GO:0042287)
0.0	0.1	GO:0004704	NF-kappaB-inducing kinase activity(GO:0004704)
0.0	0.1	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.4	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.1	GO:0019981	interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0	0.4	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.3	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.3	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	4.3	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	0.2	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.5	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.3	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.2	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.3	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.0	0.3	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.2	GO:0001161	intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0	0.2	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.1	GO:0004647	phosphoserine phosphatase activity(GO:0004647)
0.0	0.3	GO:0043014	alpha-tubulin binding(GO:0043014)
0.0	0.1	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.3	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	2.4	GO:0051015	actin filament binding(GO:0051015)
0.0	0.1	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	10.2	GO:0044326	dendritic spine neck(GO:0044326)
0.9	12.4	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.5	1.6	GO:0005715	late recombination nodule(GO:0005715)
0.4	1.8	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.3	1.0	GO:0018444	translation release factor complex(GO:0018444)
0.3	0.3	GO:0005641	nuclear envelope lumen(GO:0005641)
0.3	2.1	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.3	1.2	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.3	1.8	GO:0030870	Mre11 complex(GO:0030870)
0.2	1.0	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.1	1.0	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.1	7.4	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	1.0	GO:0030061	mitochondrial crista(GO:0030061)
0.1	2.4	GO:0001726	ruffle(GO:0001726)
0.1	2.6	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	0.4	GO:0036194	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1	0.3	GO:0032437	cuticular plate(GO:0032437)
0.1	0.5	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.1	3.2	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	0.6	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.1	1.7	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	0.6	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.1	1.0	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.1	0.3	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.1	0.4	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.1	0.7	GO:0032010	phagolysosome(GO:0032010)
0.1	0.2	GO:0043224	nuclear SCF ubiquitin ligase complex(GO:0043224)
0.1	0.6	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.1	0.5	GO:0072588	box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.1	0.3	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	1.1	GO:0005833	hemoglobin complex(GO:0005833)
0.1	0.5	GO:0036021	endolysosome lumen(GO:0036021)
0.1	0.3	GO:0036502	Derlin-1-VIMP complex(GO:0036502)
0.1	0.5	GO:0036449	microtubule minus-end(GO:0036449)
0.1	0.2	GO:0002178	palmitoyltransferase complex(GO:0002178)
0.1	0.4	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.1	0.4	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	0.4	GO:0034448	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1	0.4	GO:0005927	muscle tendon junction(GO:0005927)
0.1	0.3	GO:0031205	endoplasmic reticulum Sec complex(GO:0031205)
0.1	1.4	GO:0005666	DNA-directed RNA polymerase III complex(GO:0005666)
0.1	1.7	GO:0005680	anaphase-promoting complex(GO:0005680)
0.1	1.0	GO:0005665	DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1	1.6	GO:0030990	intraciliary transport particle(GO:0030990)
0.1	0.7	GO:0042555	MCM complex(GO:0042555)
0.1	0.9	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.1	3.3	GO:0015030	Cajal body(GO:0015030)
0.1	0.6	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.1	0.4	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
0.1	0.6	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.3	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958) DNA ligase IV complex(GO:0032807)
0.0	0.4	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.2	GO:0031510	SUMO activating enzyme complex(GO:0031510)
0.0	0.2	GO:0034688	integrin alphaM-beta2 complex(GO:0034688)
0.0	2.3	GO:0001772	immunological synapse(GO:0001772)
0.0	0.3	GO:0061617	MICOS complex(GO:0061617)
0.0	0.4	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.3	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.2	GO:1990796	photoreceptor cell terminal bouton(GO:1990796)
0.0	1.1	GO:0032420	stereocilium(GO:0032420)
0.0	1.3	GO:0005859	muscle myosin complex(GO:0005859)
0.0	0.4	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	1.2	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.0	0.6	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0097449	astrocyte projection(GO:0097449) growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.0	0.2	GO:0071203	WASH complex(GO:0071203)
0.0	0.2	GO:0010370	perinucleolar chromocenter(GO:0010370)
0.0	0.1	GO:0000798	nuclear cohesin complex(GO:0000798)
0.0	0.7	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.0	0.2	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0033150	perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.0	1.7	GO:0000786	nucleosome(GO:0000786)
0.0	0.4	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	1.5	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.2	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.5	GO:0034709	methylosome(GO:0034709)
0.0	0.1	GO:0071439	clathrin complex(GO:0071439)
0.0	0.7	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	1.9	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	0.9	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.4	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.3	GO:0030175	filopodium(GO:0030175) actin-based cell projection(GO:0098858)
0.0	0.1	GO:0016235	aggresome(GO:0016235)
0.0	0.9	GO:0072562	blood microparticle(GO:0072562)
0.0	0.3	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.3	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.4	GO:0097512	cardiac myofibril(GO:0097512)
0.0	0.3	GO:0031595	nuclear proteasome complex(GO:0031595)
0.0	0.1	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.0	0.3	GO:0042589	zymogen granule membrane(GO:0042589)
0.0	0.3	GO:0033010	paranodal junction(GO:0033010)
0.0	0.4	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.2	GO:0014802	terminal cisterna(GO:0014802)
0.0	0.2	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.3	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.4	GO:0005605	basal lamina(GO:0005605)
0.0	0.9	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0	0.1	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.0	GO:0005873	plus-end kinesin complex(GO:0005873)
0.0	0.4	GO:0031011	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0	0.1	GO:0097224	sperm connecting piece(GO:0097224)
0.0	0.5	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.9	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.1	GO:0071012	catalytic step 1 spliceosome(GO:0071012)
0.0	0.5	GO:0005921	gap junction(GO:0005921)
0.0	0.2	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.2	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.3	GO:0071011	precatalytic spliceosome(GO:0071011)
0.0	0.1	GO:1990246	uniplex complex(GO:1990246)
0.0	0.0	GO:0097679	other organism cytoplasm(GO:0097679)
0.0	0.4	GO:0030660	Golgi-associated vesicle membrane(GO:0030660)
0.0	0.1	GO:0033063	DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	6.8	GO:0005667	transcription factor complex(GO:0005667)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.2	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.4	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.0	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.0	0.0	GO:0001940	male pronucleus(GO:0001940)
0.0	0.9	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.1	GO:0005889	hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0	0.3	GO:0097228	sperm principal piece(GO:0097228)
0.0	0.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0	0.1	GO:0042584	chromaffin granule membrane(GO:0042584)
0.0	0.3	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.2	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.3	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.9	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	2.0	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0	0.2	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	1.2	GO:0005856	cytoskeleton(GO:0005856)
0.0	0.2	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.1	GO:0036038	MKS complex(GO:0036038)
0.0	0.1	GO:0005688	U6 snRNP(GO:0005688)
0.0	0.4	GO:0008180	COP9 signalosome(GO:0008180)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.7	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.4	1.3	GO:0015616	DNA translocase activity(GO:0015616)
0.3	2.0	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.3	1.0	GO:0047273	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.3	0.3	GO:0003990	acetylcholinesterase activity(GO:0003990)
0.3	1.8	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.3	1.5	GO:0030613	oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
0.3	0.9	GO:0032767	copper-dependent protein binding(GO:0032767)
0.3	0.8	GO:0005169	neurotrophin TRKB receptor binding(GO:0005169)
0.3	10.2	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3	1.3	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.2	1.0	GO:0004666	prostaglandin-endoperoxide synthase activity(GO:0004666)
0.2	0.9	GO:0030760	nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.2	0.7	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
0.2	1.6	GO:0032137	guanine/thymine mispair binding(GO:0032137)
0.2	1.2	GO:0005499	vitamin D binding(GO:0005499)
0.2	2.2	GO:1990459	transferrin receptor binding(GO:1990459)
0.2	1.4	GO:0016778	diphosphotransferase activity(GO:0016778)
0.2	0.7	GO:0008466	glycogenin glucosyltransferase activity(GO:0008466)
0.2	0.7	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.2	0.8	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.2	0.5	GO:0003863	alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.2	1.0	GO:0008079	translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.2	1.3	GO:0001849	complement component C1q binding(GO:0001849)
0.2	0.8	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.2	0.5	GO:0004781	adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.1	0.6	GO:0043398	HLH domain binding(GO:0043398)
0.1	0.4	GO:0008476	protein-tyrosine sulfotransferase activity(GO:0008476)
0.1	0.6	GO:0015265	glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.1	0.4	GO:0003870	5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1	7.4	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	0.4	GO:0004821	histidine-tRNA ligase activity(GO:0004821)
0.1	0.6	GO:0031962	mineralocorticoid receptor binding(GO:0031962)
0.1	1.1	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	0.4	GO:0045155	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
0.1	0.4	GO:0008798	beta-aspartyl-peptidase activity(GO:0008798)
0.1	2.3	GO:0050786	RAGE receptor binding(GO:0050786)
0.1	0.7	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
0.1	8.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	0.5	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.1	3.1	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	0.7	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	0.4	GO:0008431	vitamin E binding(GO:0008431)
0.1	0.4	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	0.4	GO:0052591	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.1	0.3	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.1	0.3	GO:0002113	interleukin-33 binding(GO:0002113)
0.1	1.2	GO:0089720	caspase binding(GO:0089720)
0.1	1.0	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.1	2.5	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.1	0.3	GO:1904455	ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1	0.5	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
0.1	0.4	GO:0004883	glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1	0.3	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.1	1.1	GO:0005344	oxygen transporter activity(GO:0005344)
0.1	0.3	GO:0004132	dCMP deaminase activity(GO:0004132)
0.1	0.4	GO:0004692	cGMP-dependent protein kinase activity(GO:0004692)
0.1	0.5	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.1	0.3	GO:0022850	serotonin-gated cation channel activity(GO:0022850)
0.1	0.2	GO:0005260	channel-conductance-controlling ATPase activity(GO:0005260)
0.1	1.7	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.1	0.7	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1	1.6	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.1	1.2	GO:0070513	death domain binding(GO:0070513)
0.1	4.2	GO:0070888	E-box binding(GO:0070888)
0.1	0.6	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.1	0.7	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.1	0.6	GO:0015266	protein channel activity(GO:0015266)
0.1	1.1	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1	0.2	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.1	2.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.1	0.3	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.1	8.9	GO:0003823	antigen binding(GO:0003823)
0.1	0.6	GO:0033038	bitter taste receptor activity(GO:0033038)
0.1	0.2	GO:0005477	pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1	0.3	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.1	0.3	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1	0.4	GO:0004064	arylesterase activity(GO:0004064)
0.0	2.6	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899)
0.0	0.3	GO:0050733	RS domain binding(GO:0050733)
0.0	0.2	GO:0035276	aldehyde oxidase activity(GO:0004031) ethanol binding(GO:0035276)
0.0	1.4	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	2.7	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	1.1	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.3	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.9	GO:0005522	profilin binding(GO:0005522)
0.0	0.3	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.2	GO:0004979	beta-endorphin receptor activity(GO:0004979) morphine receptor activity(GO:0038047)
0.0	0.2	GO:0031493	nucleosomal histone binding(GO:0031493)
0.0	0.1	GO:0030627	pre-mRNA 5'-splice site binding(GO:0030627)
0.0	0.6	GO:0016289	CoA hydrolase activity(GO:0016289)
0.0	0.2	GO:0017022	myosin binding(GO:0017022)
0.0	0.1	GO:0017130	poly(C) RNA binding(GO:0017130)
0.0	0.1	GO:0030107	HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.0	0.3	GO:0044388	small protein activating enzyme binding(GO:0044388)
0.0	1.0	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.3	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
0.0	0.2	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0	0.1	GO:0047275	glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.0	0.3	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.5	GO:0001968	fibronectin binding(GO:0001968)
0.0	1.6	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.6	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.7	GO:0008391	arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0	0.1	GO:0001861	complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.0	0.1	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.2	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.2	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.1	GO:0033858	N-acetylgalactosamine kinase activity(GO:0033858)
0.0	0.2	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.0	0.3	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	1.6	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.6	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0015234	thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.0	0.4	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0033857	diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0	0.5	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.2	GO:0001851	complement component C3b binding(GO:0001851)
0.0	0.8	GO:0043548	phosphatidylinositol 3-kinase binding(GO:0043548)
0.0	0.1	GO:0005457	GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.0	0.3	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.6	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.3	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.5	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0	0.1	GO:0019960	C-X3-C chemokine receptor activity(GO:0016495) C-X3-C chemokine binding(GO:0019960)
0.0	0.2	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.4	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.1	GO:0032564	adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.0	1.1	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.3	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.3	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.0	0.2	GO:0030507	spectrin binding(GO:0030507)
0.0	0.6	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.2	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.2	GO:0000285	1-phosphatidylinositol-3-phosphate 5-kinase activity(GO:0000285)
0.0	0.5	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	0.6	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.2	GO:0030621	U4 snRNA binding(GO:0030621)
0.0	0.1	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	0.6	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	1.1	GO:0004984	olfactory receptor activity(GO:0004984)
0.0	0.2	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.4	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	1.0	GO:0061650	ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0	0.7	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	0.3	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.4	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
0.0	0.2	GO:0035381	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0	0.1	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.3	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.5	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.2	GO:0016421	CoA carboxylase activity(GO:0016421)
0.0	0.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.1	GO:0070568	guanylyltransferase activity(GO:0070568)
0.0	0.1	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.1	GO:0004139	deoxyribose-phosphate aldolase activity(GO:0004139)
0.0	0.1	GO:0043142	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	0.2	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	0.1	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.4	GO:0042166	acetylcholine binding(GO:0042166)
0.0	0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.2	GO:1901567	icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567)
0.0	0.3	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.4	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.2	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.4	GO:0030515	snoRNA binding(GO:0030515)
0.0	0.1	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.3	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0	0.4	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.0	0.2	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
0.0	0.2	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.0	GO:0050528	acyloxyacyl hydrolase activity(GO:0050528)
0.0	0.4	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	1.2	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.4	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.3	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.1	GO:0030197	extracellular matrix constituent, lubricant activity(GO:0030197)
0.0	0.7	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.2	GO:0032183	SUMO binding(GO:0032183)
0.0	0.1	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.0	0.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.4	GO:0008308	voltage-gated anion channel activity(GO:0008308)
0.0	0.1	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	2.0	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0	1.2	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.0	0.1	GO:0045029	UDP-activated nucleotide receptor activity(GO:0045029)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0035240	dopamine binding(GO:0035240)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.2	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0	0.1	GO:0008821	crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0	0.1	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0	0.5	GO:0003713	transcription coactivator activity(GO:0003713)
0.0	0.6	GO:0004693	cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0	0.1	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.0	0.4	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.1	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.2	GO:0010485	H4 histone acetyltransferase activity(GO:0010485)
0.0	0.2	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0	0.1	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.2	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.0	0.0	GO:0004549	tRNA-specific ribonuclease activity(GO:0004549)
0.0	0.2	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	5.2	NABA COLLAGENS	Genes encoding collagen proteins
0.1	2.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	0.8	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.1	2.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1	2.8	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.1	0.8	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	2.7	PID BARD1 PATHWAY	BARD1 signaling events
0.1	0.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.6	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	1.2	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	2.2	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	1.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.0	2.9	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	1.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.0	1.7	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.6	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	0.6	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.6	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	1.1	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.1	ST GAQ PATHWAY	G alpha q Pathway
0.0	1.9	PID E2F PATHWAY	E2F transcription factor network
0.0	1.5	PID NOTCH PATHWAY	Notch signaling pathway
0.0	0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.8	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	0.6	PID SHP2 PATHWAY	SHP2 signaling
0.0	2.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0	0.3	PID IFNG PATHWAY	IFN-gamma pathway
0.0	0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.5	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	1.6	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.4	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.0	0.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	0.2	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.7	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.0	1.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	0.4	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.3	PID INSULIN PATHWAY	Insulin Pathway
0.0	0.3	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway

Results for SHOX

Z-value: 0.80

Motif logo

Transcription factors associated with SHOX

Activity profile of SHOX motif

Sorted Z-values of SHOX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category: