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ENCODE cell lines, expression (Ernst 2011)

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Results for SIX1_SIX3_SIX2

Z-value: 0.89

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Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
SIX1
ENSG00000126778.7 SIX1
SIX3
ENSG00000138083.3 SIX3
SIX2
ENSG00000170577.7 SIX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX3hg19_v2_chr2_+_45168875_451689160.505.0e-02Click!
SIX1hg19_v2_chr14_-_61116168_611161800.175.3e-01Click!
SIX2hg19_v2_chr2_-_45236540_452365770.058.4e-01Click!

Activity profile of SIX1_SIX3_SIX2 motif

Sorted Z-values of SIX1_SIX3_SIX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr13_-_46679144 2.32 ENST00000181383.4
 CPB2
 carboxypeptidase B2 (plasma)
chr13_-_46679185 2.31 ENST00000439329.3
 CPB2
 carboxypeptidase B2 (plasma)
chr16_-_28550348 1.57 ENST00000324873.6
 NUPR1
 nuclear protein, transcriptional regulator, 1
chr5_+_125758865 1.54 ENST00000542322.1
ENST00000544396.1
 GRAMD3
 GRAM domain containing 3
chr16_-_28550320 1.45 ENST00000395641.2
 NUPR1
 nuclear protein, transcriptional regulator, 1
chr5_+_125758813 1.44 ENST00000285689.3
ENST00000515200.1
 GRAMD3
 GRAM domain containing 3
chr3_-_149095652 1.32 ENST00000305366.3
 TM4SF1
 transmembrane 4 L six family member 1
chr10_+_48255253 1.22 ENST00000357718.4
ENST00000344416.5
ENST00000456111.2
ENST00000374258.3
 ANXA8
AL591684.1
 annexin A8
Protein LOC100996760
chr11_-_118134997 1.12 ENST00000278937.2
 MPZL2
 myelin protein zero-like 2
chr10_-_47173994 1.09 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
 ANXA8L1
LINC00842
 annexin A8-like 1
long intergenic non-protein coding RNA 842
chr10_+_47746929 1.08 ENST00000340243.6
ENST00000374277.5
ENST00000449464.2
ENST00000538825.1
ENST00000335083.5
 ANXA8L2
AL603965.1
 annexin A8-like 2
Protein LOC100996760
chr6_-_138428613 1.07 ENST00000421351.3
 PERP
 PERP, TP53 apoptosis effector
chr1_+_15256230 1.05 ENST00000376028.4
ENST00000400798.2
 KAZN
 kazrin, periplakin interacting protein
chr12_-_52845910 1.02 ENST00000252252.3
 KRT6B
 keratin 6B
chr18_+_55816546 0.96 ENST00000435432.2
ENST00000357895.5
ENST00000586263.1
 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr3_-_111314230 0.94 ENST00000317012.4
 ZBED2
 zinc finger, BED-type containing 2
chr10_+_5005445 0.90 ENST00000380872.4
 AKR1C1
 aldo-keto reductase family 1, member C1
chr2_-_113594279 0.73 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B
 interleukin 1, beta
chr2_+_211421262 0.71 ENST00000233072.5
 CPS1
 carbamoyl-phosphate synthase 1, mitochondrial
chr6_-_136847099 0.69 ENST00000438100.2
 MAP7
 microtubule-associated protein 7
chr10_+_7745232 0.66 ENST00000358415.4
 ITIH2
 inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745303 0.65 ENST00000429820.1
ENST00000379587.4
 ITIH2
 inter-alpha-trypsin inhibitor heavy chain 2
chr12_+_81471816 0.64 ENST00000261206.3
 ACSS3
 acyl-CoA synthetase short-chain family member 3
chr14_+_95047725 0.61 ENST00000554760.1
ENST00000554866.1
ENST00000329597.7
ENST00000556775.1
 SERPINA5
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_+_4675175 0.60 ENST00000270560.3
 TM4SF5
 transmembrane 4 L six family member 5
chr11_+_70244510 0.59 ENST00000346329.3
ENST00000301843.8
ENST00000376561.3
 CTTN
 cortactin
chr16_+_56642041 0.58 ENST00000245185.5
 MT2A
 metallothionein 2A
chr8_-_48651648 0.57 ENST00000408965.3
 CEBPD
 CCAAT/enhancer binding protein (C/EBP), delta
chr10_+_5005598 0.56 ENST00000442997.1
 AKR1C1
 aldo-keto reductase family 1, member C1
chr3_+_100211412 0.53 ENST00000323523.4
ENST00000403410.1
ENST00000449609.1
 TMEM45A
 transmembrane protein 45A
chr6_+_28048753 0.50 ENST00000377325.1
 ZNF165
 zinc finger protein 165
chr20_+_4667094 0.49 ENST00000424424.1
ENST00000457586.1
 PRNP
 prion protein
chr11_-_112034831 0.48 ENST00000280357.7
 IL18
 interleukin 18 (interferon-gamma-inducing factor)
chr12_+_19358228 0.46 ENST00000424268.1
ENST00000543806.1
 PLEKHA5
 pleckstrin homology domain containing, family A member 5
chr3_-_11685345 0.45 ENST00000430365.2
 VGLL4
 vestigial like 4 (Drosophila)
chrX_+_152907913 0.44 ENST00000370167.4
 DUSP9
 dual specificity phosphatase 9
chr2_+_211342432 0.44 ENST00000430249.2
 CPS1
 carbamoyl-phosphate synthase 1, mitochondrial
chr19_-_48389651 0.44 ENST00000222002.3
 SULT2A1
 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr1_+_207277590 0.43 ENST00000367070.3
 C4BPA
 complement component 4 binding protein, alpha
chr4_+_155484155 0.40 ENST00000509493.1
 FGB
 fibrinogen beta chain
chr8_-_18666360 0.39 ENST00000286485.8
 PSD3
 pleckstrin and Sec7 domain containing 3
chr2_+_234826016 0.38 ENST00000324695.4
ENST00000433712.2
 TRPM8
 transient receptor potential cation channel, subfamily M, member 8
chr3_+_111718036 0.35 ENST00000455401.2
 TAGLN3
 transgelin 3
chr12_+_57623869 0.35 ENST00000414700.3
ENST00000557703.1
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr14_-_94759361 0.35 ENST00000393096.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr17_+_1665345 0.33 ENST00000576406.1
ENST00000571149.1
 SERPINF1
 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_+_2867325 0.33 ENST00000307635.2
ENST00000586426.1
 ZNF556
 zinc finger protein 556
chr6_+_131894284 0.33 ENST00000368087.3
ENST00000356962.2
 ARG1
 arginase 1
chr1_+_73771844 0.32 ENST00000440762.1
ENST00000444827.1
ENST00000415686.1
ENST00000411903.1
 RP4-598G3.1
 RP4-598G3.1
chr6_-_136847610 0.32 ENST00000454590.1
ENST00000432797.2
 MAP7
 microtubule-associated protein 7
chr3_+_111717600 0.32 ENST00000273368.4
 TAGLN3
 transgelin 3
chr4_-_156298028 0.29 ENST00000433024.1
ENST00000379248.2
 MAP9
 microtubule-associated protein 9
chr1_+_145293371 0.29 ENST00000342960.5
 NBPF10
 neuroblastoma breakpoint family, member 10
chr7_+_29519486 0.29 ENST00000409041.4
 CHN2
 chimerin 2
chr16_+_28763108 0.29 ENST00000357796.3
ENST00000550983.1
 NPIPB9
 nuclear pore complex interacting protein family, member B9
chr2_-_114514181 0.27 ENST00000409342.1
 SLC35F5
 solute carrier family 35, member F5
chr7_+_139025875 0.27 ENST00000297534.6
 C7orf55
 chromosome 7 open reading frame 55
chr20_+_34700333 0.27 ENST00000441639.1
 EPB41L1
 erythrocyte membrane protein band 4.1-like 1
chr4_-_156297949 0.27 ENST00000515654.1
 MAP9
 microtubule-associated protein 9
chr11_-_62521614 0.26 ENST00000527994.1
ENST00000394807.3
 ZBTB3
 zinc finger and BTB domain containing 3
chr3_+_42850959 0.25 ENST00000442925.1
ENST00000422265.1
ENST00000497921.1
ENST00000426937.1
 ACKR2
KRBOX1
 atypical chemokine receptor 2
KRAB box domain containing 1
chr3_+_111718173 0.25 ENST00000494932.1
 TAGLN3
 transgelin 3
chr4_-_156298087 0.25 ENST00000311277.4
 MAP9
 microtubule-associated protein 9
chr19_+_45445491 0.24 ENST00000592954.1
ENST00000419266.2
ENST00000589057.1
 APOC4
APOC4-APOC2
 apolipoprotein C-IV
APOC4-APOC2 readthrough (NMD candidate)
chr14_-_94759595 0.23 ENST00000261994.4
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr12_+_57624085 0.23 ENST00000553474.1
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_57624119 0.23 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr19_+_36605850 0.22 ENST00000221855.3
 TBCB
 tubulin folding cofactor B
chr1_+_93913665 0.22 ENST00000271234.7
ENST00000370256.4
ENST00000260506.8
 FNBP1L
 formin binding protein 1-like
chr11_+_61520075 0.22 ENST00000278836.5
 MYRF
 myelin regulatory factor
chr10_+_5238793 0.22 ENST00000263126.1
 AKR1C4
 aldo-keto reductase family 1, member C4
chr16_-_29517141 0.22 ENST00000550665.1
 RP11-231C14.4
 Uncharacterized protein
chr2_-_55496174 0.22 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
 MTIF2
 mitochondrial translational initiation factor 2
chr3_+_52448539 0.21 ENST00000461861.1
 PHF7
 PHD finger protein 7
chr11_-_111794446 0.21 ENST00000527950.1
 CRYAB
 crystallin, alpha B
chr16_-_15463926 0.20 ENST00000432570.2
 NPIPA5
 nuclear pore complex interacting protein family, member A5
chr1_+_13736907 0.20 ENST00000316412.5
 PRAMEF20
 PRAME family member 20
chr9_-_6645628 0.20 ENST00000321612.6
 GLDC
 glycine dehydrogenase (decarboxylating)
chr14_+_73563735 0.20 ENST00000532192.1
 RBM25
 RNA binding motif protein 25
chr1_-_109618566 0.19 ENST00000338366.5
 TAF13
 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr1_+_158149737 0.19 ENST00000368171.3
 CD1D
 CD1d molecule
chr15_-_72523454 0.18 ENST00000565154.1
ENST00000565184.1
ENST00000389093.3
ENST00000449901.2
ENST00000335181.5
ENST00000319622.6
 PKM
 pyruvate kinase, muscle
chr1_+_13359819 0.18 ENST00000376168.1
 PRAMEF5
 PRAME family member 5
chr21_+_37442239 0.18 ENST00000530908.1
ENST00000290349.6
ENST00000439427.2
ENST00000399191.3
 CBR1
 carbonyl reductase 1
chr4_+_89299994 0.18 ENST00000264346.7
 HERC6
 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
chr14_-_24911448 0.18 ENST00000555355.1
ENST00000553343.1
ENST00000556523.1
ENST00000556249.1
ENST00000538105.2
ENST00000555225.1
 SDR39U1
 short chain dehydrogenase/reductase family 39U, member 1
chr2_-_55496344 0.18 ENST00000403721.1
ENST00000263629.4
 MTIF2
 mitochondrial translational initiation factor 2
chr20_+_34824355 0.16 ENST00000397286.3
ENST00000320849.4
ENST00000373932.3
 AAR2
 AAR2 splicing factor homolog (S. cerevisiae)
chr2_+_105953972 0.16 ENST00000410049.1
 C2orf49
 chromosome 2 open reading frame 49
chr3_-_178984759 0.16 ENST00000349697.2
ENST00000497599.1
 KCNMB3
 potassium large conductance calcium-activated channel, subfamily M beta member 3
chr1_-_54665664 0.16 ENST00000542737.1
ENST00000537208.1
 CYB5RL
 cytochrome b5 reductase-like
chr2_-_219134822 0.15 ENST00000444053.1
ENST00000248450.4
 AAMP
 angio-associated, migratory cell protein
chr1_+_169337172 0.15 ENST00000367807.3
ENST00000367808.3
ENST00000329281.2
ENST00000420531.1
 BLZF1
 basic leucine zipper nuclear factor 1
chr2_+_61404624 0.15 ENST00000394457.3
 AHSA2
 AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)
chr10_+_104613980 0.15 ENST00000339834.5
 C10orf32
 chromosome 10 open reading frame 32
chr11_+_73661364 0.15 ENST00000339764.1
 DNAJB13
 DnaJ (Hsp40) homolog, subfamily B, member 13
chr16_+_451826 0.14 ENST00000219481.5
ENST00000397710.1
ENST00000424398.2
 DECR2
 2,4-dienoyl CoA reductase 2, peroxisomal
chr19_+_36606354 0.14 ENST00000589996.1
ENST00000591296.1
 TBCB
 tubulin folding cofactor B
chr6_-_35656712 0.14 ENST00000357266.4
ENST00000542713.1
 FKBP5
 FK506 binding protein 5
chr7_+_72349920 0.14 ENST00000395270.1
ENST00000446813.1
ENST00000257622.4
 POM121
 POM121 transmembrane nucleoporin
chr11_-_76155618 0.14 ENST00000530759.1
 RP11-111M22.3
 RP11-111M22.3
chr6_-_31509714 0.14 ENST00000456662.1
ENST00000431908.1
ENST00000456976.1
ENST00000428450.1
ENST00000453105.2
ENST00000418897.1
ENST00000415382.2
ENST00000449074.2
ENST00000419020.1
ENST00000428098.1
 DDX39B
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chrX_+_144908928 0.14 ENST00000408967.2
 TMEM257
 transmembrane protein 257
chr1_+_145293114 0.14 ENST00000369338.1
 NBPF10
 neuroblastoma breakpoint family, member 10
chr16_+_69458537 0.14 ENST00000515314.1
ENST00000561792.1
ENST00000568237.1
 CYB5B
 cytochrome b5 type B (outer mitochondrial membrane)
chr13_+_28712614 0.13 ENST00000380958.3
 PAN3
 PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
chr6_-_35656685 0.13 ENST00000539068.1
ENST00000540787.1
 FKBP5
 FK506 binding protein 5
chr14_-_24740709 0.13 ENST00000399409.3
ENST00000216840.6
 RABGGTA
 Rab geranylgeranyltransferase, alpha subunit
chr14_+_75761099 0.13 ENST00000561000.1
ENST00000558575.1
 RP11-293M10.5
 RP11-293M10.5
chr14_-_21924209 0.13 ENST00000557364.1
 CHD8
 chromodomain helicase DNA binding protein 8
chr16_+_29690358 0.13 ENST00000395384.4
ENST00000562473.1
 QPRT
 quinolinate phosphoribosyltransferase
chr11_-_59633951 0.13 ENST00000257264.3
 TCN1
 transcobalamin I (vitamin B12 binding protein, R binder family)
chr15_+_62853562 0.13 ENST00000561311.1
 TLN2
 talin 2
chr6_-_167797887 0.13 ENST00000476779.2
ENST00000460930.2
ENST00000397829.4
ENST00000366827.2
 TCP10
 t-complex 10
chr17_-_6915646 0.12 ENST00000574377.1
ENST00000399541.2
ENST00000399540.2
ENST00000575727.1
ENST00000573939.1
 AC027763.2
 Uncharacterized protein
chr18_+_616672 0.12 ENST00000338387.7
 CLUL1
 clusterin-like 1 (retinal)
chr19_-_11039188 0.12 ENST00000588347.1
 YIPF2
 Yip1 domain family, member 2
chr7_-_73133959 0.12 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
 STX1A
 syntaxin 1A (brain)
chr8_+_119294456 0.12 ENST00000366457.2
 AC023590.1
 Uncharacterized protein
chr11_+_117947724 0.12 ENST00000534111.1
 TMPRSS4
 transmembrane protease, serine 4
chr2_-_9563319 0.12 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
 ITGB1BP1
 integrin beta 1 binding protein 1
chr1_+_152975488 0.12 ENST00000542696.1
 SPRR3
 small proline-rich protein 3
chr3_-_9834375 0.11 ENST00000343450.2
ENST00000301964.2
 TADA3
 transcriptional adaptor 3
chr2_-_152589670 0.11 ENST00000604864.1
ENST00000603639.1
 NEB
 nebulin
chr20_+_44637526 0.11 ENST00000372330.3
 MMP9
 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr1_+_12916941 0.11 ENST00000240189.2
 PRAMEF2
 PRAME family member 2
chr3_+_70048881 0.11 ENST00000483525.1
 RP11-460N16.1
 RP11-460N16.1
chr10_-_6622258 0.11 ENST00000263125.5
 PRKCQ
 protein kinase C, theta
chr11_+_117947782 0.11 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
 TMPRSS4
 transmembrane protease, serine 4
chr3_-_178976996 0.11 ENST00000485523.1
 KCNMB3
 potassium large conductance calcium-activated channel, subfamily M beta member 3
chr8_-_134115118 0.11 ENST00000395352.3
ENST00000338087.5
 SLA
 Src-like-adaptor
chr1_-_53793725 0.11 ENST00000371454.2
 LRP8
 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr1_-_85462623 0.10 ENST00000370608.3
 MCOLN2
 mucolipin 2
chr13_-_41837620 0.10 ENST00000379477.1
ENST00000452359.1
ENST00000379480.4
ENST00000430347.2
 MTRF1
 mitochondrial translational release factor 1
chr6_-_11779014 0.10 ENST00000229583.5
 ADTRP
 androgen-dependent TFPI-regulating protein
chr1_+_120049826 0.10 ENST00000369413.3
ENST00000235547.6
ENST00000528909.1
 HSD3B1
 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
chr6_-_11779174 0.10 ENST00000379413.2
 ADTRP
 androgen-dependent TFPI-regulating protein
chr1_-_13007420 0.10 ENST00000376189.1
 PRAMEF6
 PRAME family member 6
chr19_-_15344243 0.10 ENST00000602233.1
 EPHX3
 epoxide hydrolase 3
chr11_-_76155700 0.10 ENST00000572035.1
 RP11-111M22.3
 RP11-111M22.3
chr10_-_74856608 0.10 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
 P4HA1
 prolyl 4-hydroxylase, alpha polypeptide I
chr12_-_118796910 0.10 ENST00000541186.1
ENST00000539872.1
 TAOK3
 TAO kinase 3
chr9_+_6716478 0.09 ENST00000452643.1
 RP11-390F4.3
 RP11-390F4.3
chr14_-_95942173 0.09 ENST00000334258.5
ENST00000557275.1
ENST00000553340.1
 SYNE3
 spectrin repeat containing, nuclear envelope family member 3
chr6_-_52710893 0.09 ENST00000284562.2
 GSTA5
 glutathione S-transferase alpha 5
chr22_+_32455111 0.09 ENST00000543737.1
 SLC5A1
 solute carrier family 5 (sodium/glucose cotransporter), member 1
chr12_-_96429423 0.09 ENST00000228740.2
 LTA4H
 leukotriene A4 hydrolase
chr4_-_153332886 0.08 ENST00000603841.1
 FBXW7
 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr1_+_160709076 0.08 ENST00000359331.4
ENST00000495334.1
 SLAMF7
 SLAM family member 7
chr8_-_134072593 0.08 ENST00000427060.2
 SLA
 Src-like-adaptor
chr1_+_215740709 0.08 ENST00000259154.4
 KCTD3
 potassium channel tetramerization domain containing 3
chr1_-_13115578 0.08 ENST00000414205.2
 PRAMEF6
 PRAME family member 6
chr15_+_40331456 0.08 ENST00000504245.1
ENST00000560341.1
 SRP14-AS1
 SRP14 antisense RNA1 (head to head)
chr21_-_34185944 0.08 ENST00000479548.1
 C21orf62
 chromosome 21 open reading frame 62
chr1_-_13117736 0.08 ENST00000376192.5
ENST00000376182.1
 PRAMEF6
 PRAME family member 6
chr3_+_89156674 0.08 ENST00000336596.2
 EPHA3
 EPH receptor A3
chr13_+_53226963 0.08 ENST00000343788.6
ENST00000535397.1
ENST00000310528.8
 SUGT1
 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)
chr1_-_150979333 0.08 ENST00000312210.5
 FAM63A
 family with sequence similarity 63, member A
chr7_-_71912046 0.08 ENST00000395276.2
ENST00000431984.1
 CALN1
 calneuron 1
chr7_+_12727250 0.08 ENST00000404894.1
 ARL4A
 ADP-ribosylation factor-like 4A
chr11_+_27062502 0.08 ENST00000263182.3
 BBOX1
 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr1_-_13390765 0.08 ENST00000357367.2
 PRAMEF8
 PRAME family member 8
chr19_+_57999101 0.07 ENST00000347466.6
ENST00000523138.1
ENST00000415379.2
ENST00000521754.1
ENST00000221735.7
ENST00000518999.1
ENST00000521137.1
 ZNF419
 zinc finger protein 419
chr4_-_84255935 0.07 ENST00000513463.1
 HPSE
 heparanase
chr1_+_244816237 0.07 ENST00000302550.11
 DESI2
 desumoylating isopeptidase 2
chr7_-_14880892 0.07 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
 DGKB
 diacylglycerol kinase, beta 90kDa
chr5_-_59481406 0.07 ENST00000546160.1
 PDE4D
 phosphodiesterase 4D, cAMP-specific
chr3_+_149191723 0.07 ENST00000305354.4
 TM4SF4
 transmembrane 4 L six family member 4
chr19_+_1026298 0.07 ENST00000263097.4
 CNN2
 calponin 2
chr18_-_51750948 0.07 ENST00000583046.1
ENST00000398398.2
 MBD2
 methyl-CpG binding domain protein 2
chr20_+_18488137 0.07 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
 SEC23B
 Sec23 homolog B (S. cerevisiae)
chr5_+_70220768 0.07 ENST00000351205.4
ENST00000503079.2
ENST00000380707.4
ENST00000514951.1
ENST00000506163.1
 SMN1
 survival of motor neuron 1, telomeric
chr2_+_161993465 0.07 ENST00000457476.1
 TANK
 TRAF family member-associated NFKB activator
chr6_+_31802364 0.07 ENST00000375640.3
ENST00000375641.2
 C6orf48
 chromosome 6 open reading frame 48
chr8_+_18248755 0.07 ENST00000286479.3
 NAT2
 N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr2_-_127963343 0.07 ENST00000335247.7
 CYP27C1
 cytochrome P450, family 27, subfamily C, polypeptide 1
chr16_+_16481306 0.06 ENST00000422673.2
 NPIPA7
 nuclear pore complex interacting protein family, member A7
chr2_+_228189867 0.06 ENST00000423098.1
ENST00000304593.9
 MFF
 mitochondrial fission factor
chr19_+_57999079 0.06 ENST00000426954.2
ENST00000354197.4
ENST00000523882.1
ENST00000520540.1
ENST00000519310.1
ENST00000442920.2
ENST00000523312.1
ENST00000424930.2
 ZNF419
 zinc finger protein 419
chr1_+_186265399 0.06 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
 PRG4
 proteoglycan 4
chr1_-_43637915 0.06 ENST00000236051.2
 EBNA1BP2
 EBNA1 binding protein 2
chr4_+_70894130 0.06 ENST00000526767.1
ENST00000530128.1
ENST00000381057.3
 HTN3
 histatin 3
chr8_+_18248786 0.06 ENST00000520116.1
 NAT2
 N-acetyltransferase 2 (arylamine N-acetyltransferase)
chr7_+_16685756 0.06 ENST00000415365.1
ENST00000258761.3
ENST00000433922.2
ENST00000452975.2
ENST00000405202.1
 BZW2
 basic leucine zipper and W2 domains 2
chr19_+_37464063 0.06 ENST00000586353.1
ENST00000433993.1
ENST00000592567.1
 ZNF568
 zinc finger protein 568
chr4_-_83719884 0.06 ENST00000282709.4
ENST00000273908.4
 SCD5
 stearoyl-CoA desaturase 5
chr2_-_158732340 0.06 ENST00000539637.1
ENST00000413751.1
ENST00000434821.1
ENST00000424669.1
 ACVR1
 activin A receptor, type I
chr5_-_81574160 0.06 ENST00000510210.1
ENST00000512493.1
ENST00000507980.1
ENST00000511844.1
ENST00000510019.1
 RPS23
 ribosomal protein S23
chr1_-_12958101 0.05 ENST00000235347.4
 PRAMEF10
 PRAME family member 10
chr12_-_10962767 0.05 ENST00000240691.2
 TAS2R9
 taste receptor, type 2, member 9
chr1_+_12976450 0.05 ENST00000361079.2
 PRAMEF7
 PRAME family member 7
chr20_-_44600810 0.05 ENST00000322927.2
ENST00000426788.1
 ZNF335
 zinc finger protein 335
chr22_+_41074754 0.05 ENST00000249016.4
 MCHR1
 melanin-concentrating hormone receptor 1
chr17_+_37356586 0.05 ENST00000579260.1
ENST00000582193.1
 RPL19
 ribosomal protein L19
chr19_-_48547294 0.05 ENST00000293255.2
 CABP5
 calcium binding protein 5
chr3_+_35722487 0.05 ENST00000441454.1
 ARPP21
 cAMP-regulated phosphoprotein, 21kDa
chrX_-_65259900 0.05 ENST00000412866.2
 VSIG4
 V-set and immunoglobulin domain containing 4
chr17_-_56769382 0.05 ENST00000240361.8
ENST00000349033.5
ENST00000389934.3
 TEX14
 testis expressed 14
chrX_+_1733876 0.05 ENST00000381241.3
 ASMT
 acetylserotonin O-methyltransferase
chr15_-_90892669 0.05 ENST00000412799.2
 GABARAPL3
 GABA(A) receptors associated protein like 3, pseudogene

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.6 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.4 1.2 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
0.2 0.7 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.2 1.7 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.2 1.0 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 1.1 GO:0034201 response to oleic acid(GO:0034201)
0.2 0.5 GO:1902938 regulation of intracellular calcium activated chloride channel activity(GO:1902938)
0.2 2.7 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 0.6 GO:0061107 seminal vesicle development(GO:0061107)
0.1 0.5 GO:0042231 interleukin-13 biosynthetic process(GO:0042231)
0.1 0.8 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.1 0.6 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 1.1 GO:0002934 desmosome organization(GO:0002934)
0.1 0.8 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 0.3 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.1 0.6 GO:0008218 bioluminescence(GO:0008218)
0.1 0.4 GO:0050955 thermoception(GO:0050955)
0.1 0.3 GO:1902023 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.1 0.6 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.1 0.1 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
0.1 0.6 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.4 GO:0032790 ribosome disassembly(GO:0032790)
0.0 0.4 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.0 0.2 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.4 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.2 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.1 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.2 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.1 GO:2000570 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.0 0.1 GO:0097156 fasciculation of motor neuron axon(GO:0097156)
0.0 0.9 GO:0007398 ectoderm development(GO:0007398)
0.0 0.1 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.0 GO:0032466 negative regulation of cytokinesis(GO:0032466)
0.0 0.2 GO:0016045 detection of bacterium(GO:0016045)
0.0 0.2 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 1.3 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.1 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.0 0.4 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.1 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.1 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.0 0.1 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.0 0.2 GO:0042373 vitamin K metabolic process(GO:0042373)
0.0 0.4 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 0.1 GO:2000639 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.0 0.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.2 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.1 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.1 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 0.1 GO:0052422 modulation by symbiont of host molecular function(GO:0052055) modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) negative regulation by host of symbiont molecular function(GO:0052405) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.1 GO:1900063 regulation of peroxisome organization(GO:1900063)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.0 0.1 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.0 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0097180 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.1 0.8 GO:0070552 BRISC complex(GO:0070552)
0.1 0.8 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 0.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 0.2 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 2.1 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0031251 PAN complex(GO:0031251)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.5 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.3 GO:0043203 axon hillock(GO:0043203)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 1.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.2 GO:0012505 endomembrane system(GO:0012505)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.2 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.1 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.0 0.1 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.0 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.0 0.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.4 1.1 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.2 4.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.0 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.8 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.1 0.5 GO:1903135 cupric ion binding(GO:1903135)
0.1 0.6 GO:0032190 acrosin binding(GO:0032190)
0.1 0.4 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.1 0.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 1.2 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.2 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.6 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0 0.6 GO:0016405 CoA-ligase activity(GO:0016405)
0.0 0.7 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) steroid delta-isomerase activity(GO:0004769)
0.0 0.6 GO:0005522 profilin binding(GO:0005522)
0.0 0.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.0 0.1 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.4 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.0 0.1 GO:0038025 reelin receptor activity(GO:0038025)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.3 GO:0043008 ATP-dependent protein binding(GO:0043008)
0.0 0.1 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 2.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.1 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.2 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0 0.1 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.0 0.1 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.1 GO:0005502 11-cis retinal binding(GO:0005502)
0.0 0.2 GO:0016594 glycine binding(GO:0016594)
0.0 0.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.1 GO:0016361 activin receptor activity, type I(GO:0016361)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 0.0 GO:0032217 riboflavin transporter activity(GO:0032217)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 1.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 0.4 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.0 0.2 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.7 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.1 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis