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ENCODE cell lines, expression (Ernst 2011)

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Results for SIX4

Z-value: 0.67

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.8 SIX4

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr14_-_106406090 2.26 ENST00000390593.2
 IGHV6-1
 immunoglobulin heavy variable 6-1
chr15_-_20193370 0.97 ENST00000558565.2
 IGHV3OR15-7
 immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr14_-_106692191 0.97 ENST00000390607.2
 IGHV3-21
 immunoglobulin heavy variable 3-21
chr1_-_173176452 0.58 ENST00000281834.3
 TNFSF4
 tumor necrosis factor (ligand) superfamily, member 4
chr2_+_85811525 0.58 ENST00000306384.4
 VAMP5
 vesicle-associated membrane protein 5
chrX_+_108780347 0.56 ENST00000372103.1
 NXT2
 nuclear transport factor 2-like export factor 2
chr11_+_117049854 0.54 ENST00000278951.7
 SIDT2
 SID1 transmembrane family, member 2
chr11_-_64511575 0.52 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
 RASGRP2
 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr3_-_52488048 0.52 ENST00000232975.3
 TNNC1
 troponin C type 1 (slow)
chr11_+_117049445 0.51 ENST00000324225.4
ENST00000532960.1
 SIDT2
 SID1 transmembrane family, member 2
chr12_-_102874102 0.50 ENST00000392905.2
 IGF1
 insulin-like growth factor 1 (somatomedin C)
chr8_+_56014949 0.48 ENST00000327381.6
 XKR4
 XK, Kell blood group complex subunit-related family, member 4
chr1_-_114414316 0.47 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
 PTPN22
 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr1_-_247335269 0.43 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
 ZNF124
 zinc finger protein 124
chr10_+_89622870 0.43 ENST00000371953.3
 PTEN
 phosphatase and tensin homolog
chr19_+_30414551 0.42 ENST00000360605.4
ENST00000570564.1
ENST00000574233.1
ENST00000585655.1
 URI1
 URI1, prefoldin-like chaperone
chr11_+_125462690 0.38 ENST00000392708.4
ENST00000529196.1
ENST00000531491.1
 STT3A
 STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr6_-_31704282 0.38 ENST00000375784.3
ENST00000375779.2
 CLIC1
 chloride intracellular channel 1
chr19_+_50887585 0.37 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
 POLD1
 polymerase (DNA directed), delta 1, catalytic subunit
chr11_+_34073269 0.36 ENST00000389645.3
 CAPRIN1
 cell cycle associated protein 1
chr11_+_117049910 0.34 ENST00000431081.2
ENST00000524842.1
 SIDT2
 SID1 transmembrane family, member 2
chr11_+_34073195 0.31 ENST00000341394.4
 CAPRIN1
 cell cycle associated protein 1
chr22_-_39268308 0.31 ENST00000407418.3
 CBX6
 chromobox homolog 6
chr1_+_35734562 0.31 ENST00000314607.6
ENST00000373297.2
 ZMYM4
 zinc finger, MYM-type 4
chr7_+_69064300 0.27 ENST00000342771.4
 AUTS2
 autism susceptibility candidate 2
chr11_-_2906979 0.27 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
 CDKN1C
 cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr9_+_132427883 0.26 ENST00000372469.4
 PRRX2
 paired related homeobox 2
chr1_+_26737292 0.25 ENST00000254231.4
 LIN28A
 lin-28 homolog A (C. elegans)
chr1_-_38061522 0.25 ENST00000373062.3
 GNL2
 guanine nucleotide binding protein-like 2 (nucleolar)
chr17_+_7465216 0.23 ENST00000321337.7
 SENP3
 SUMO1/sentrin/SMT3 specific peptidase 3
chr20_-_52687059 0.23 ENST00000371435.2
ENST00000395961.3
 BCAS1
 breast carcinoma amplified sequence 1
chr13_+_33160553 0.23 ENST00000315596.10
 PDS5B
 PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr6_-_41040195 0.22 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
 OARD1
 O-acyl-ADP-ribose deacylase 1
chrX_-_119763835 0.22 ENST00000371313.2
ENST00000304661.5
 C1GALT1C1
 C1GALT1-specific chaperone 1
chr8_-_95907423 0.20 ENST00000396133.3
ENST00000308108.4
 CCNE2
 cyclin E2
chr3_+_32147997 0.19 ENST00000282541.5
 GPD1L
 glycerol-3-phosphate dehydrogenase 1-like
chr6_-_41040268 0.19 ENST00000373154.2
ENST00000244558.9
ENST00000464633.1
ENST00000424266.2
ENST00000479950.1
ENST00000482515.1
 OARD1
 O-acyl-ADP-ribose deacylase 1
chr1_+_116915855 0.18 ENST00000295598.5
 ATP1A1
 ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr11_-_46615498 0.17 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
 AMBRA1
 autophagy/beclin-1 regulator 1
chr1_+_26737253 0.17 ENST00000326279.6
 LIN28A
 lin-28 homolog A (C. elegans)
chr22_-_39268192 0.17 ENST00000216083.6
 CBX6
 chromobox homolog 6
chr1_+_226250379 0.15 ENST00000366815.3
ENST00000366814.3
 H3F3A
 H3 histone, family 3A
chr11_-_113644491 0.15 ENST00000200135.3
 ZW10
 zw10 kinetochore protein
chr15_+_59279851 0.13 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
 RNF111
 ring finger protein 111
chr11_+_46958248 0.13 ENST00000536126.1
ENST00000278460.7
ENST00000378618.2
ENST00000395460.2
ENST00000378615.3
ENST00000543718.1
 C11orf49
 chromosome 11 open reading frame 49
chrX_-_110655391 0.12 ENST00000356915.2
ENST00000356220.3
 DCX
 doublecortin
chr4_-_13546632 0.12 ENST00000382438.5
 NKX3-2
 NK3 homeobox 2
chr1_+_161123536 0.12 ENST00000368003.5
 UFC1
 ubiquitin-fold modifier conjugating enzyme 1
chr14_-_107083690 0.12 ENST00000455737.1
ENST00000390629.2
 IGHV4-59
 immunoglobulin heavy variable 4-59
chr20_+_57875457 0.11 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
 EDN3
 endothelin 3
chr1_-_78148324 0.10 ENST00000370801.3
ENST00000433749.1
 ZZZ3
 zinc finger, ZZ-type containing 3
chr16_-_15180257 0.10 ENST00000540462.1
 RRN3
 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr7_-_99063769 0.10 ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000430982.1
ENST00000555673.1
ENST00000413834.1
 ATP5J2
PTCD1
ATP5J2-PTCD1
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
pentatricopeptide repeat domain 1
ATP5J2-PTCD1 readthrough
chr14_-_92413353 0.09 ENST00000556154.1
 FBLN5
 fibulin 5
chr3_-_87325612 0.09 ENST00000561167.1
ENST00000560656.1
ENST00000344265.3
 POU1F1
 POU class 1 homeobox 1
chrX_+_54466829 0.09 ENST00000375151.4
 TSR2
 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr7_+_97361388 0.08 ENST00000350485.4
ENST00000346867.4
 TAC1
 tachykinin, precursor 1
chr1_-_42800614 0.08 ENST00000372572.1
 FOXJ3
 forkhead box J3
chr12_+_133758115 0.08 ENST00000541009.2
ENST00000592241.1
 ZNF268
 zinc finger protein 268
chr20_+_57875658 0.08 ENST00000371025.3
 EDN3
 endothelin 3
chr11_+_33279850 0.07 ENST00000531504.1
ENST00000456517.1
 HIPK3
 homeodomain interacting protein kinase 3
chr1_-_42801540 0.07 ENST00000372573.1
 FOXJ3
 forkhead box J3
chr6_+_41040678 0.07 ENST00000341376.6
ENST00000353205.5
 NFYA
 nuclear transcription factor Y, alpha
chr19_-_47128294 0.07 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
 PTGIR
 prostaglandin I2 (prostacyclin) receptor (IP)
chr10_+_26505594 0.06 ENST00000259271.3
 GAD2
 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr9_+_138437985 0.06 ENST00000340780.3
ENST00000342114.4
ENST00000371776.1
ENST00000539850.1
 OBP2A
 odorant binding protein 2A
chr2_-_113999260 0.06 ENST00000468980.2
 PAX8
 paired box 8
chr12_-_10282742 0.06 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A
 C-type lectin domain family 7, member A
chr1_+_117297007 0.06 ENST00000369478.3
ENST00000369477.1
 CD2
 CD2 molecule
chr11_-_35547572 0.05 ENST00000378880.2
 PAMR1
 peptidase domain containing associated with muscle regeneration 1
chr1_-_42800860 0.05 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
 FOXJ3
 forkhead box J3
chr3_-_183966717 0.05 ENST00000446569.1
ENST00000418734.2
ENST00000397676.3
 ALG3
 ALG3, alpha-1,3- mannosyltransferase
chr5_+_149569520 0.05 ENST00000230671.2
ENST00000524041.1
 SLC6A7
 solute carrier family 6 (neurotransmitter transporter), member 7
chr9_-_136084628 0.04 ENST00000372034.3
ENST00000372032.2
 OBP2B
 odorant binding protein 2B
chr7_+_97361218 0.04 ENST00000319273.5
 TAC1
 tachykinin, precursor 1
chr1_+_116184566 0.04 ENST00000355485.2
ENST00000369510.4
 VANGL1
 VANGL planar cell polarity protein 1
chr1_+_38022572 0.04 ENST00000541606.1
 DNALI1
 dynein, axonemal, light intermediate chain 1
chr7_-_26578407 0.03 ENST00000242109.3
 KIAA0087
 KIAA0087
chr1_+_17559776 0.03 ENST00000537499.1
ENST00000413717.2
ENST00000536552.1
 PADI1
 peptidyl arginine deiminase, type I
chr19_+_55235969 0.03 ENST00000402254.2
ENST00000538269.1
ENST00000541392.1
ENST00000291860.1
ENST00000396284.2
 KIR3DL1
KIR3DL3
KIR2DL4
 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
chr1_+_156611704 0.02 ENST00000329117.5
 BCAN
 brevican
chr5_+_85913721 0.02 ENST00000247655.3
ENST00000509578.1
ENST00000515763.1
 COX7C
 cytochrome c oxidase subunit VIIc
chr1_+_160097462 0.02 ENST00000447527.1
 ATP1A2
 ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr10_-_75255724 0.01 ENST00000342558.3
ENST00000360663.5
ENST00000394829.2
ENST00000394828.2
ENST00000394822.2
 PPP3CB
 protein phosphatase 3, catalytic subunit, beta isozyme
chr19_+_13135386 0.01 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
 NFIX
 nuclear factor I/X (CCAAT-binding transcription factor)
chr5_-_1295104 0.00 ENST00000334602.6
ENST00000508104.2
ENST00000310581.5
ENST00000296820.5
 TERT
 telomerase reverse transcriptase
chr19_+_55249969 0.00 ENST00000342376.3
ENST00000434419.2
 KIR2DL3
 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.0 0.5 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:2000525 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.2 0.5 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1 0.5 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.1 1.4 GO:0033227 dsRNA transport(GO:0033227)
0.1 0.4 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1 0.5 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.1 0.4 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.3 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.1 0.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 3.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.2 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072) negative regulation of protein kinase C signaling(GO:0090038)
0.0 0.2 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.1 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.0 0.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.1 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.0 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.2 GO:0090032 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.0 0.2 GO:0071840 cellular component organization or biogenesis(GO:0071840)
0.0 0.1 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.0 0.7 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.1 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.1 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.0 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.0 0.6 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 0.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 3.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.5 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.2 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.4 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 1.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.4 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 3.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.5 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.4 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.0 0.4 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0 0.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.2 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0019237 centromeric DNA binding(GO:0019237)
0.0 0.2 GO:0048531 beta-1,3-galactosyltransferase activity(GO:0048531)
0.0 0.2 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.6 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.4 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation