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ENCODE cell lines, expression (Ernst 2011)

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Results for SMAD3

Z-value: 1.33

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Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
SMAD3
ENSG00000166949.11 SMAD3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD3hg19_v2_chr15_+_67358163_67358192-0.485.7e-02Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_-_27114577 4.28 ENST00000356950.1
ENST00000396891.4
 HIST1H2BK
 histone cluster 1, H2bk
chr6_+_26273144 3.23 ENST00000377733.2
 HIST1H2BI
 histone cluster 1, H2bi
chr11_-_107729887 2.78 ENST00000525815.1
 SLC35F2
 solute carrier family 35, member F2
chr6_-_26216872 2.36 ENST00000244601.3
 HIST1H2BG
 histone cluster 1, H2bg
chr6_-_26285737 2.08 ENST00000377727.1
ENST00000289352.1
 HIST1H4H
 histone cluster 1, H4h
chr12_-_9913489 2.06 ENST00000228434.3
ENST00000536709.1
 CD69
 CD69 molecule
chr6_+_27806319 2.00 ENST00000606613.1
ENST00000396980.3
 HIST1H2BN
 histone cluster 1, H2bn
chr20_-_43280361 1.97 ENST00000372874.4
 ADA
 adenosine deaminase
chr1_-_9129735 1.95 ENST00000377424.4
 SLC2A5
 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr15_-_83316711 1.94 ENST00000568128.1
 CPEB1
 cytoplasmic polyadenylation element binding protein 1
chr19_-_11688447 1.89 ENST00000590420.1
 ACP5
 acid phosphatase 5, tartrate resistant
chr20_-_43280325 1.89 ENST00000537820.1
 ADA
 adenosine deaminase
chr6_+_26240561 1.87 ENST00000377745.2
 HIST1H4F
 histone cluster 1, H4f
chr1_-_9129598 1.81 ENST00000535586.1
 SLC2A5
 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr1_-_9129631 1.77 ENST00000377414.3
 SLC2A5
 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr19_-_11688500 1.75 ENST00000433365.2
 ACP5
 acid phosphatase 5, tartrate resistant
chr1_-_9129895 1.75 ENST00000473209.1
 SLC2A5
 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr6_-_27100529 1.68 ENST00000607124.1
ENST00000339812.2
ENST00000541790.1
 HIST1H2BJ
 histone cluster 1, H2bj
chr15_-_83316254 1.62 ENST00000567678.1
ENST00000450751.2
 CPEB1
 cytoplasmic polyadenylation element binding protein 1
chr6_+_26217159 1.49 ENST00000303910.2
 HIST1H2AE
 histone cluster 1, H2ae
chr6_-_26189304 1.43 ENST00000340756.2
 HIST1H4D
 histone cluster 1, H4d
chr6_+_26124373 1.43 ENST00000377791.2
ENST00000602637.1
 HIST1H2AC
 histone cluster 1, H2ac
chr6_+_27100811 1.39 ENST00000359193.2
 HIST1H2AG
 histone cluster 1, H2ag
chr10_+_94451574 1.33 ENST00000492654.2
 HHEX
 hematopoietically expressed homeobox
chr11_-_34937858 1.30 ENST00000278359.5
 APIP
 APAF1 interacting protein
chr19_+_51728316 1.29 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
 CD33
 CD33 molecule
chr7_+_50348268 1.27 ENST00000438033.1
ENST00000439701.1
 IKZF1
 IKAROS family zinc finger 1 (Ikaros)
chr6_-_27775694 1.25 ENST00000377401.2
 HIST1H2BL
 histone cluster 1, H2bl
chr5_-_41870621 1.21 ENST00000196371.5
 OXCT1
 3-oxoacid CoA transferase 1
chr15_+_81591757 1.21 ENST00000558332.1
 IL16
 interleukin 16
chr16_-_31076332 1.18 ENST00000539836.3
ENST00000535577.1
ENST00000442862.2
 ZNF668
 zinc finger protein 668
chr17_+_30813576 1.12 ENST00000313401.3
 CDK5R1
 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr6_+_27114861 1.12 ENST00000377459.1
 HIST1H2AH
 histone cluster 1, H2ah
chr6_+_27775899 1.11 ENST00000358739.3
 HIST1H2AI
 histone cluster 1, H2ai
chr16_+_30483962 1.10 ENST00000356798.6
 ITGAL
 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr6_-_26124138 1.07 ENST00000314332.5
ENST00000396984.1
 HIST1H2BC
 histone cluster 1, H2bc
chr6_-_26027480 1.06 ENST00000377364.3
 HIST1H4B
 histone cluster 1, H4b
chr6_-_27860956 1.05 ENST00000359611.2
 HIST1H2AM
 histone cluster 1, H2am
chr3_+_12838161 1.02 ENST00000456430.2
 CAND2
 cullin-associated and neddylation-dissociated 2 (putative)
chr3_+_190105909 0.99 ENST00000456423.1
 CLDN16
 claudin 16
chr18_+_9102592 0.95 ENST00000318388.6
 NDUFV2
 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr15_+_63796779 0.93 ENST00000561442.1
ENST00000560070.1
ENST00000540797.1
ENST00000380324.3
ENST00000268049.7
ENST00000536001.1
ENST00000539772.1
 USP3
 ubiquitin specific peptidase 3
chr4_-_39033963 0.92 ENST00000381938.3
 TMEM156
 transmembrane protein 156
chr9_+_37486005 0.91 ENST00000377792.3
 POLR1E
 polymerase (RNA) I polypeptide E, 53kDa
chr3_+_14219858 0.91 ENST00000306024.3
 LSM3
 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr16_-_31076273 0.89 ENST00000426488.2
 ZNF668
 zinc finger protein 668
chr9_+_37485932 0.89 ENST00000377798.4
ENST00000442009.2
 POLR1E
 polymerase (RNA) I polypeptide E, 53kDa
chr11_-_34938039 0.88 ENST00000395787.3
 APIP
 APAF1 interacting protein
chr15_-_83316087 0.88 ENST00000568757.1
 CPEB1
 cytoplasmic polyadenylation element binding protein 1
chr1_+_149804218 0.86 ENST00000610125.1
 HIST2H4A
 histone cluster 2, H4a
chr1_-_156399184 0.84 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
 C1orf61
 chromosome 1 open reading frame 61
chr6_-_99842041 0.83 ENST00000254759.3
ENST00000369242.1
 COQ3
 coenzyme Q3 methyltransferase
chr12_-_110906027 0.83 ENST00000537466.2
ENST00000550974.1
ENST00000228827.3
 GPN3
 GPN-loop GTPase 3
chr6_+_27791862 0.82 ENST00000355057.1
 HIST1H4J
 histone cluster 1, H4j
chr12_+_67663056 0.77 ENST00000545606.1
 CAND1
 cullin-associated and neddylation-dissociated 1
chr5_-_79950775 0.76 ENST00000439211.2
 DHFR
 dihydrofolate reductase
chr9_+_136399929 0.75 ENST00000393060.1
 ADAMTSL2
 ADAMTS-like 2
chrX_-_110513703 0.71 ENST00000324068.1
 CAPN6
 calpain 6
chr4_-_26492076 0.71 ENST00000295589.3
 CCKAR
 cholecystokinin A receptor
chr8_+_10530155 0.71 ENST00000521818.1
 C8orf74
 chromosome 8 open reading frame 74
chr21_+_33031935 0.71 ENST00000270142.6
ENST00000389995.4
 SOD1
 superoxide dismutase 1, soluble
chr6_-_27782548 0.70 ENST00000333151.3
 HIST1H2AJ
 histone cluster 1, H2aj
chr18_+_13611763 0.66 ENST00000585931.1
 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
chr18_+_43753974 0.64 ENST00000282059.6
ENST00000321319.6
 C18orf25
 chromosome 18 open reading frame 25
chr1_-_11918988 0.62 ENST00000376468.3
 NPPB
 natriuretic peptide B
chr4_-_38666430 0.62 ENST00000436901.1
 AC021860.1
 Uncharacterized protein
chr7_+_139528952 0.62 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
 TBXAS1
 thromboxane A synthase 1 (platelet)
chr2_-_128784846 0.61 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
 SAP130
 Sin3A-associated protein, 130kDa
chr6_+_292051 0.60 ENST00000344450.5
 DUSP22
 dual specificity phosphatase 22
chr12_+_110906169 0.59 ENST00000377673.5
 FAM216A
 family with sequence similarity 216, member A
chr19_-_55691472 0.57 ENST00000537500.1
 SYT5
 synaptotagmin V
chr14_-_24551137 0.55 ENST00000396995.1
 NRL
 neural retina leucine zipper
chr1_-_89357179 0.50 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
 GTF2B
 general transcription factor IIB
chr5_+_79950463 0.50 ENST00000265081.6
 MSH3
 mutS homolog 3
chr7_-_22862406 0.49 ENST00000372879.4
 TOMM7
 translocase of outer mitochondrial membrane 7 homolog (yeast)
chr6_+_41888926 0.49 ENST00000230340.4
 BYSL
 bystin-like
chrX_-_46618490 0.48 ENST00000328306.4
 SLC9A7
 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
chr1_+_193091080 0.48 ENST00000367435.3
 CDC73
 cell division cycle 73
chr20_-_60795296 0.48 ENST00000340177.5
 HRH3
 histamine receptor H3
chr8_-_80942061 0.47 ENST00000519386.1
 MRPS28
 mitochondrial ribosomal protein S28
chr19_-_46148820 0.46 ENST00000587152.1
 EML2
 echinoderm microtubule associated protein like 2
chr20_+_55926274 0.45 ENST00000371242.2
ENST00000527947.1
 RAE1
 ribonucleic acid export 1
chr15_-_43785303 0.45 ENST00000382039.3
ENST00000450115.2
ENST00000382044.4
 TP53BP1
 tumor protein p53 binding protein 1
chr9_-_34691201 0.45 ENST00000378800.3
ENST00000311925.2
 CCL19
 chemokine (C-C motif) ligand 19
chr11_-_72145426 0.45 ENST00000535990.1
ENST00000437826.2
ENST00000340729.5
 CLPB
 ClpB caseinolytic peptidase B homolog (E. coli)
chr7_+_139529040 0.43 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
 TBXAS1
 thromboxane A synthase 1 (platelet)
chr2_-_49381572 0.42 ENST00000454032.1
ENST00000304421.4
 FSHR
 follicle stimulating hormone receptor
chr7_-_22862448 0.41 ENST00000358435.4
 TOMM7
 translocase of outer mitochondrial membrane 7 homolog (yeast)
chr20_-_60795316 0.40 ENST00000317393.6
 HRH3
 histamine receptor H3
chr12_+_26111823 0.39 ENST00000381352.3
ENST00000535907.1
ENST00000405154.2
 RASSF8
 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr6_+_26204825 0.39 ENST00000360441.4
 HIST1H4E
 histone cluster 1, H4e
chr1_-_160832642 0.38 ENST00000368034.4
 CD244
 CD244 molecule, natural killer cell receptor 2B4
chr11_-_46142615 0.37 ENST00000529734.1
ENST00000323180.6
 PHF21A
 PHD finger protein 21A
chr20_+_55926583 0.36 ENST00000395840.2
 RAE1
 ribonucleic acid export 1
chr1_-_159684371 0.36 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
 CRP
 C-reactive protein, pentraxin-related
chr14_+_91580708 0.35 ENST00000518868.1
 C14orf159
 chromosome 14 open reading frame 159
chr9_+_114287433 0.35 ENST00000358151.4
ENST00000355824.3
ENST00000374374.3
ENST00000309235.5
 ZNF483
 zinc finger protein 483
chr14_+_91581011 0.35 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
 C14orf159
 chromosome 14 open reading frame 159
chr16_-_15180257 0.34 ENST00000540462.1
 RRN3
 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr14_-_24551195 0.33 ENST00000560550.1
 NRL
 neural retina leucine zipper
chr2_+_75061108 0.33 ENST00000290573.2
 HK2
 hexokinase 2
chr11_+_46383121 0.32 ENST00000454345.1
 DGKZ
 diacylglycerol kinase, zeta
chr8_-_80942139 0.31 ENST00000521434.1
ENST00000519120.1
ENST00000520946.1
 MRPS28
 mitochondrial ribosomal protein S28
chr2_-_49381646 0.31 ENST00000346173.3
ENST00000406846.2
 FSHR
 follicle stimulating hormone receptor
chr14_+_91580357 0.31 ENST00000298858.4
ENST00000521081.1
ENST00000520328.1
ENST00000256324.10
ENST00000524232.1
ENST00000522170.1
ENST00000519950.1
ENST00000523879.1
ENST00000521077.2
ENST00000518665.2
 C14orf159
 chromosome 14 open reading frame 159
chr19_-_55691614 0.30 ENST00000592470.1
ENST00000354308.3
 SYT5
 synaptotagmin V
chr6_-_27841289 0.30 ENST00000355981.2
 HIST1H4L
 histone cluster 1, H4l
chr6_-_11807277 0.30 ENST00000379415.2
 ADTRP
 androgen-dependent TFPI-regulating protein
chr1_+_25757376 0.30 ENST00000399766.3
ENST00000399763.3
ENST00000374343.4
 TMEM57
 transmembrane protein 57
chr22_+_41956767 0.29 ENST00000306149.7
 CSDC2
 cold shock domain containing C2, RNA binding
chr12_-_323689 0.28 ENST00000428720.1
 SLC6A12
 solute carrier family 6 (neurotransmitter transporter), member 12
chr11_+_33563821 0.28 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
 KIAA1549L
 KIAA1549-like
chr14_+_91580732 0.28 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
 C14orf159
 chromosome 14 open reading frame 159
chr5_-_132362226 0.28 ENST00000509437.1
ENST00000355372.2
ENST00000513541.1
ENST00000509008.1
ENST00000513848.1
ENST00000504170.1
ENST00000324170.3
 ZCCHC10
 zinc finger, CCHC domain containing 10
chr12_+_65563329 0.27 ENST00000308330.2
 LEMD3
 LEM domain containing 3
chr18_+_29598335 0.27 ENST00000217740.3
 RNF125
 ring finger protein 125, E3 ubiquitin protein ligase
chr11_+_60869867 0.26 ENST00000347785.3
 CD5
 CD5 molecule
chr5_-_127674883 0.26 ENST00000507835.1
 FBN2
 fibrillin 2
chr14_+_91580777 0.25 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
 C14orf159
 chromosome 14 open reading frame 159
chr5_+_167913450 0.24 ENST00000231572.3
ENST00000538719.1
 RARS
 arginyl-tRNA synthetase
chr6_-_41888843 0.23 ENST00000434077.1
ENST00000409312.1
 MED20
 mediator complex subunit 20
chr16_+_30484021 0.22 ENST00000358164.5
 ITGAL
 integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr19_+_41594377 0.22 ENST00000330436.3
 CYP2A13
 cytochrome P450, family 2, subfamily A, polypeptide 13
chr6_+_146920116 0.21 ENST00000367493.3
 ADGB
 androglobin
chr7_-_14942944 0.20 ENST00000403951.2
 DGKB
 diacylglycerol kinase, beta 90kDa
chr8_+_38585704 0.20 ENST00000519416.1
ENST00000520615.1
 TACC1
 transforming, acidic coiled-coil containing protein 1
chr12_+_50135588 0.17 ENST00000423828.1
ENST00000550445.1
 TMBIM6
 transmembrane BAX inhibitor motif containing 6
chr1_+_59762642 0.17 ENST00000371218.4
ENST00000303721.7
 FGGY
 FGGY carbohydrate kinase domain containing
chr7_+_39125365 0.17 ENST00000559001.1
ENST00000464276.2
 POU6F2
 POU class 6 homeobox 2
chr6_-_27806117 0.17 ENST00000330180.2
 HIST1H2AK
 histone cluster 1, H2ak
chr6_+_27861190 0.17 ENST00000303806.4
 HIST1H2BO
 histone cluster 1, H2bo
chr19_-_36304201 0.16 ENST00000301175.3
 PRODH2
 proline dehydrogenase (oxidase) 2
chr1_-_226129083 0.15 ENST00000420304.2
 LEFTY2
 left-right determination factor 2
chr6_+_146920097 0.15 ENST00000397944.3
ENST00000522242.1
 ADGB
 androglobin
chr4_+_55524085 0.14 ENST00000412167.2
ENST00000288135.5
 KIT
 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr2_+_220110177 0.14 ENST00000409638.3
ENST00000396738.2
ENST00000409516.3
 STK16
 serine/threonine kinase 16
chr1_-_160040038 0.13 ENST00000368089.3
 KCNJ10
 potassium inwardly-rectifying channel, subfamily J, member 10
chr10_+_118350522 0.13 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr2_+_204732487 0.12 ENST00000302823.3
 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
chr10_+_118350468 0.12 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr11_+_62538775 0.11 ENST00000294168.3
ENST00000526261.1
 TAF6L
 TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
chr1_-_226129189 0.10 ENST00000366820.5
 LEFTY2
 left-right determination factor 2
chr11_+_124824000 0.08 ENST00000529051.1
ENST00000344762.5
 CCDC15
 coiled-coil domain containing 15
chr1_+_52682052 0.07 ENST00000371591.1
 ZFYVE9
 zinc finger, FYVE domain containing 9
chr11_+_72983246 0.07 ENST00000393590.2
 P2RY6
 pyrimidinergic receptor P2Y, G-protein coupled, 6
chr16_+_25228242 0.07 ENST00000219660.5
 AQP8
 aquaporin 8
chr11_+_34938119 0.06 ENST00000227868.4
ENST00000430469.2
ENST00000533262.1
 PDHX
 pyruvate dehydrogenase complex, component X
chr14_+_96858454 0.05 ENST00000555570.1
 AK7
 adenylate kinase 7
chr3_+_51741072 0.05 ENST00000395052.3
 GRM2
 glutamate receptor, metabotropic 2
chr18_+_77623668 0.04 ENST00000316249.3
 KCNG2
 potassium voltage-gated channel, subfamily G, member 2
chr2_+_204732666 0.04 ENST00000295854.6
ENST00000472206.1
 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
chr18_+_13612613 0.03 ENST00000586765.1
 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
chr15_-_22473353 0.03 ENST00000557788.2
 IGHV4OR15-8
 immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr20_+_24449821 0.02 ENST00000376862.3
 SYNDIG1
 synapse differentiation inducing 1
chrX_-_2847366 0.01 ENST00000381154.1
 ARSD
 arylsulfatase D
chr1_-_44482979 0.01 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
 SLC6A9
 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr2_+_16080659 0.01 ENST00000281043.3
 MYCN
 v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
chr6_+_27782788 0.00 ENST00000359465.4
 HIST1H2BM
 histone cluster 1, H2bm
chr12_+_14927270 0.00 ENST00000544848.1
 H2AFJ
 H2A histone family, member J

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID AURORA A PATHWAY Aurora A signaling
0.0 1.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 4.0 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 0.7 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 28.2 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.3 7.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 3.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 2.2 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.1 4.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 0.9 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.7 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 1.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 1.1 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.3 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 0.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.9 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 1.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.3 14.8 GO:0000786 nucleosome(GO:0000786)
0.2 4.4 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 1.3 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
0.2 0.9 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.2 0.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.2 0.9 GO:1990769 proximal neuron projection(GO:1990769)
0.2 0.5 GO:0032302 MutSbeta complex(GO:0032302)
0.1 4.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 0.9 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.1 1.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.1 1.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.1 0.9 GO:0070938 contractile ring(GO:0070938)
0.1 8.6 GO:0035579 specific granule membrane(GO:0035579)
0.1 0.8 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.8 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.6 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.5 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.3 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0 0.3 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.7 GO:0005876 spindle microtubule(GO:0005876)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0046102 hypoxanthine salvage(GO:0043103) inosine metabolic process(GO:0046102)
1.0 7.3 GO:0098704 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.7 3.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.6 4.4 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.5 1.8 GO:0001188 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.4 1.3 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.4 1.1 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.4 7.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.3 2.2 GO:0070269 pyroptosis(GO:0070269)
0.3 0.8 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.2 1.2 GO:0046952 ketone body catabolic process(GO:0046952)
0.2 0.7 GO:0038188 cholecystokinin signaling pathway(GO:0038188)
0.2 0.9 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.2 0.8 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.2 0.7 GO:0001545 primary ovarian follicle growth(GO:0001545)
0.2 1.8 GO:0010265 SCF complex assembly(GO:0010265)
0.2 0.5 GO:0097026 dendritic cell dendrite assembly(GO:0097026) regulation of dendritic cell dendrite assembly(GO:2000547)
0.1 0.7 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1 0.4 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1 0.9 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.1 0.3 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.1 1.3 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.1 0.7 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.1 0.5 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.1 0.9 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.1 0.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 1.0 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 0.8 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 0.3 GO:0034398 telomere tethering at nuclear periphery(GO:0034398) meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.8 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.1 1.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 0.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 0.2 GO:0048867 stem cell fate determination(GO:0048867)
0.1 0.5 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.5 GO:0043570 maintenance of DNA repeat elements(GO:0043570)
0.1 1.2 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.0 4.4 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.1 GO:0048170 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162) positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0 0.3 GO:1904925 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.5 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.5 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.0 0.9 GO:0033962 cytoplasmic mRNA processing body assembly(GO:0033962)
0.0 1.7 GO:0006536 glutamate metabolic process(GO:0006536)
0.0 0.2 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.6 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.9 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.2 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.0 0.5 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.3 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 3.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.1 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.0 0.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.4 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.5 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.1 GO:0035690 cellular response to drug(GO:0035690)
0.0 0.9 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 0.2 GO:0019321 pentose metabolic process(GO:0019321) neuron cellular homeostasis(GO:0070050)
0.0 0.7 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.8 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.3 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.5 3.9 GO:0004000 adenosine deaminase activity(GO:0004000)
0.4 1.1 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.3 1.0 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.3 1.5 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.3 1.2 GO:0008410 CoA-transferase activity(GO:0008410)
0.3 3.6 GO:0008199 ferric iron binding(GO:0008199)
0.3 4.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 0.7 GO:0004951 cholecystokinin receptor activity(GO:0004951)
0.2 1.3 GO:0030369 ICAM-3 receptor activity(GO:0030369)
0.2 0.7 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.2 0.5 GO:0000404 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1 0.7 GO:0050436 microfibril binding(GO:0050436)
0.1 0.8 GO:0051870 methotrexate binding(GO:0051870)
0.1 0.3 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.1 0.5 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.1 1.8 GO:0001054 RNA polymerase I activity(GO:0001054)
0.1 0.9 GO:0004969 histamine receptor activity(GO:0004969)
0.1 1.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 0.9 GO:0015266 protein channel activity(GO:0015266)
0.1 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.1 0.7 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.1 0.5 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 0.4 GO:0033265 choline binding(GO:0033265)
0.1 1.0 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 2.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 1.2 GO:0042609 CD4 receptor binding(GO:0042609)
0.0 0.9 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.5 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 1.7 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.3 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.0 0.3 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.8 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 2.2 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.3 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.5 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 13.9 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 2.1 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0070330 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392) aromatase activity(GO:0070330)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.4 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 3.1 GO:0030246 carbohydrate binding(GO:0030246)