ISMARA results: SOX1

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ENCODE cell lines, expression (Ernst 2011)

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Results for SOX1

Z-value: 0.67

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Transcription factors associated with SOX1

Gene Symbol	Gene ID	Gene Info
SOX1 Ensembl NCBI GeneCards UniProt	ENSG00000182968.3	SOX1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SOX1	hg19_v2_chr13_+_112721913_112721913	0.35	1.9e-01	Click!

Activity profile of SOX1 motif

Sorted Z-values of SOX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr16_+_12058961	4.20	ENST00000053243.1	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr16_+_12059050	4.07	ENST00000396495.3	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr16_+_12059091	2.60	ENST00000562385.1	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr3_-_189840223	1.93	ENST00000427335.2	LEPREL1	leprecan-like 1
chr3_-_16524357	1.41	ENST00000432519.1	RFTN1	raftlin, lipid raft linker 1
chr11_+_125496619	0.98	ENST00000532669.1 ENST00000278916.3	CHEK1	checkpoint kinase 1
chr3_-_58200398	0.97	ENST00000318316.3 ENST00000460422.1 ENST00000483681.1	DNASE1L3	deoxyribonuclease I-like 3
chr11_-_57177586	0.89	ENST00000529411.1	RP11-872D17.8	Uncharacterized protein
chr14_+_21249200	0.82	ENST00000304677.2	RNASE6	ribonuclease, RNase A family, k6
chr11_+_125496124	0.70	ENST00000533778.2 ENST00000534070.1	CHEK1	checkpoint kinase 1
chr2_+_102615416	0.66	ENST00000393414.2	IL1R2	interleukin 1 receptor, type II
chr11_+_125496400	0.65	ENST00000524737.1	CHEK1	checkpoint kinase 1
chr2_-_163175133	0.62	ENST00000421365.2 ENST00000263642.2	IFIH1	interferon induced with helicase C domain 1
chr1_+_152957707	0.61	ENST00000368762.1	SPRR1A	small proline-rich protein 1A
chr18_-_51751132	0.60	ENST00000256429.3	MBD2	methyl-CpG binding domain protein 2
chr20_-_14318248	0.57	ENST00000378053.3 ENST00000341420.4	FLRT3	fibronectin leucine rich transmembrane protein 3
chr3_+_178276488	0.56	ENST00000432997.1 ENST00000455865.1	KCNMB2	potassium large conductance calcium-activated channel, subfamily M, beta member 2
chr12_-_110434096	0.55	ENST00000320063.9 ENST00000457474.2 ENST00000547815.1 ENST00000361006.5	GIT2	G protein-coupled receptor kinase interacting ArfGAP 2
chr12_+_100594557	0.45	ENST00000546902.1 ENST00000552376.1 ENST00000551617.1	ACTR6	ARP6 actin-related protein 6 homolog (yeast)
chr16_-_11876408	0.43	ENST00000396516.2	ZC3H7A	zinc finger CCCH-type containing 7A
chr17_+_75181292	0.36	ENST00000431431.2	SEC14L1	SEC14-like 1 (S. cerevisiae)
chrX_+_129040122	0.33	ENST00000394422.3 ENST00000371051.5	UTP14A	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr1_+_65613340	0.32	ENST00000546702.1	AK4	adenylate kinase 4
chr14_+_74417192	0.31	ENST00000554320.1	COQ6	coenzyme Q6 monooxygenase
chr10_-_73976025	0.29	ENST00000342444.4 ENST00000533958.1 ENST00000527593.1 ENST00000394915.3 ENST00000530461.1 ENST00000317168.6 ENST00000524829.1	ASCC1	activating signal cointegrator 1 complex subunit 1
chr19_-_10491234	0.29	ENST00000524462.1 ENST00000531836.1 ENST00000525621.1	TYK2	tyrosine kinase 2
chr1_+_65613217	0.29	ENST00000545314.1	AK4	adenylate kinase 4
chr1_-_212004090	0.28	ENST00000366997.4	LPGAT1	lysophosphatidylglycerol acyltransferase 1
chrX_+_129040094	0.27	ENST00000425117.2	UTP14A	UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr17_-_29624343	0.26	ENST00000247271.4	OMG	oligodendrocyte myelin glycoprotein
chr1_-_200379129	0.26	ENST00000367353.1	ZNF281	zinc finger protein 281
chr7_-_36634181	0.26	ENST00000538464.1	AOAH	acyloxyacyl hydrolase (neutrophil)
chrX_-_62974941	0.25	ENST00000374872.1 ENST00000253401.6 ENST00000374870.4	ARHGEF9	Cdc42 guanine nucleotide exchange factor (GEF) 9
chr1_+_174769006	0.25	ENST00000489615.1	RABGAP1L	RAB GTPase activating protein 1-like
chr4_+_154622652	0.24	ENST00000260010.6	TLR2	toll-like receptor 2
chr19_+_49588677	0.21	ENST00000598984.1 ENST00000598441.1	SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)
chr1_-_43638168	0.21	ENST00000431635.2	EBNA1BP2	EBNA1 binding protein 2
chr3_-_44519131	0.20	ENST00000425708.2 ENST00000396077.2	ZNF445	zinc finger protein 445
chr3_-_58613323	0.20	ENST00000474531.1 ENST00000465970.1	FAM107A	family with sequence similarity 107, member A
chr13_-_22178284	0.19	ENST00000468222.2 ENST00000382374.4	MICU2	mitochondrial calcium uptake 2
chr3_-_126327398	0.18	ENST00000383572.2	TXNRD3NB	thioredoxin reductase 3 neighbor
chr2_+_11864458	0.17	ENST00000396098.1 ENST00000396099.1 ENST00000425416.2	LPIN1	lipin 1
chr3_-_185655795	0.17	ENST00000342294.4 ENST00000382191.4 ENST00000453386.2	TRA2B	transformer 2 beta homolog (Drosophila)
chr11_-_104827425	0.16	ENST00000393150.3	CASP4	caspase 4, apoptosis-related cysteine peptidase
chr7_+_142457315	0.16	ENST00000486171.1 ENST00000311737.7	PRSS1	protease, serine, 1 (trypsin 1)
chr14_-_89878369	0.15	ENST00000553840.1 ENST00000556916.1	FOXN3	forkhead box N3
chr9_-_95244781	0.15	ENST00000375544.3 ENST00000375543.1 ENST00000395538.3 ENST00000450139.2	ASPN	asporin
chr19_+_49588690	0.15	ENST00000221448.5	SNRNP70	small nuclear ribonucleoprotein 70kDa (U1)
chr6_-_46048116	0.14	ENST00000185206.6	CLIC5	chloride intracellular channel 5
chr5_-_150460914	0.14	ENST00000389378.2	TNIP1	TNFAIP3 interacting protein 1
chr22_-_30662828	0.13	ENST00000403463.1 ENST00000215781.2	OSM	oncostatin M
chr1_+_19578033	0.13	ENST00000330263.4	MRTO4	mRNA turnover 4 homolog (S. cerevisiae)
chr6_+_26183958	0.12	ENST00000356530.3	HIST1H2BE	histone cluster 1, H2be
chr9_-_2844058	0.12	ENST00000397885.2	KIAA0020	KIAA0020
chr1_-_200379180	0.12	ENST00000294740.3	ZNF281	zinc finger protein 281
chr10_-_43892668	0.12	ENST00000544000.1	HNRNPF	heterogeneous nuclear ribonucleoprotein F
chr7_-_105029812	0.11	ENST00000482897.1	SRPK2	SRSF protein kinase 2
chr12_-_7848364	0.11	ENST00000329913.3	GDF3	growth differentiation factor 3
chr8_+_110551925	0.11	ENST00000395785.2	EBAG9	estrogen receptor binding site associated, antigen, 9
chr6_+_27833034	0.10	ENST00000357320.2	HIST1H2AL	histone cluster 1, H2al
chr8_-_110620284	0.10	ENST00000529690.1	SYBU	syntabulin (syntaxin-interacting)
chr1_-_200379104	0.10	ENST00000367352.3	ZNF281	zinc finger protein 281
chr18_+_21719018	0.10	ENST00000585037.1 ENST00000415309.2 ENST00000399481.2 ENST00000577705.1 ENST00000327201.6	CABYR	calcium binding tyrosine-(Y)-phosphorylation regulated
chr11_-_47399942	0.09	ENST00000227163.4	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene
chr3_+_132316081	0.07	ENST00000249887.2	ACKR4	atypical chemokine receptor 4
chr17_+_34391625	0.07	ENST00000004921.3	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
chr11_-_76381029	0.06	ENST00000407242.2 ENST00000421973.1	LRRC32	leucine rich repeat containing 32
chr11_-_18062872	0.06	ENST00000250018.2	TPH1	tryptophan hydroxylase 1
chr18_+_6834472	0.05	ENST00000581099.1 ENST00000419673.2 ENST00000531294.1	ARHGAP28	Rho GTPase activating protein 28
chr10_-_96829246	0.05	ENST00000371270.3 ENST00000535898.1 ENST00000539050.1	CYP2C8	cytochrome P450, family 2, subfamily C, polypeptide 8
chr4_-_74486347	0.04	ENST00000342081.3	RASSF6	Ras association (RalGDS/AF-6) domain family member 6
chr10_+_15085895	0.04	ENST00000378228.3	OLAH	oleoyl-ACP hydrolase
chr22_-_17302589	0.04	ENST00000331428.5	XKR3	XK, Kell blood group complex subunit-related family, member 3
chr12_+_75874460	0.03	ENST00000266659.3	GLIPR1	GLI pathogenesis-related 1
chr20_+_54823788	0.02	ENST00000243911.2	MC3R	melanocortin 3 receptor
chr5_+_140743859	0.02	ENST00000518069.1	PCDHGA5	protocadherin gamma subfamily A, 5
chr11_+_55029628	0.02	ENST00000417545.2	TRIM48	tripartite motif containing 48
chr6_+_149539767	0.02	ENST00000606202.1 ENST00000536230.1 ENST00000445901.1	TAB2 RP1-111D6.3	TGF-beta activated kinase 1/MAP3K7 binding protein 2 RP1-111D6.3
chr11_-_76381781	0.02	ENST00000260061.5 ENST00000404995.1	LRRC32	leucine rich repeat containing 32
chr17_-_39646116	0.02	ENST00000328119.6	KRT36	keratin 36
chr10_+_47894572	0.02	ENST00000355876.5	FAM21B	family with sequence similarity 21, member B
chr14_-_20801427	0.01	ENST00000557665.1 ENST00000358932.4 ENST00000353689.4	CCNB1IP1	cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr8_+_145133493	0.01	ENST00000316052.5 ENST00000525936.1	EXOSC4	exosome component 4
chr11_-_113577052	0.01	ENST00000540540.1 ENST00000545579.1 ENST00000538955.1 ENST00000299882.5	TMPRSS5	transmembrane protease, serine 5
chr13_+_49280951	0.01	ENST00000282018.3	CYSLTR2	cysteinyl leukotriene receptor 2
chr11_-_47400078	0.01	ENST00000378538.3	SPI1	spleen focus forming virus (SFFV) proviral integration oncogene
chr4_+_156680153	0.00	ENST00000502959.1 ENST00000505764.1 ENST00000507146.1 ENST00000264424.8 ENST00000503520.1	GUCY1B3	guanylate cyclase 1, soluble, beta 3

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Total log-likelihood	Term	Description
0.5	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
2.3	PID ATM PATHWAY	ATM pathway
3.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
2.5	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.7	ST G ALPHA S PATHWAY	G alpha s Pathway
1.3	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.7	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.5	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.9	PID RAS PATHWAY	Regulation of Ras family activation
0.7	PID BARD1 PATHWAY	BARD1 signaling events
1.7	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.4	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.3	PID ALK2 PATHWAY	ALK2 signaling events
0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.6	PID MYC PATHWAY	C-MYC pathway
1.3	PID CMYB PATHWAY	C-MYB transcription factor network

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0	0.2	GO:1990246	uniplex complex(GO:1990246)
0.0	0.4	GO:0000243	commitment complex(GO:0000243)
0.0	0.2	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.0	0.6	GO:0044295	axonal growth cone(GO:0044295)
0.0	2.3	GO:0000794	condensed nuclear chromosome(GO:0000794)
0.0	0.6	GO:0032040	small-subunit processome(GO:0032040)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.0	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.2	3.6	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.2	0.5	GO:0030895	apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.2	0.5	GO:0034680	integrin alpha10-beta1 complex(GO:0034680)
0.1	2.1	GO:0043020	NADPH oxidase complex(GO:0043020)
0.1	0.3	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	3.1	GO:0001533	cornified envelope(GO:0001533)
0.1	0.3	GO:0060200	clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.0	0.4	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0	0.4	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.2	GO:1990796	photoreceptor cell terminal bouton(GO:1990796)
0.0	0.4	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.6	GO:0030478	actin cap(GO:0030478)
0.0	0.2	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	0.1	GO:0097679	other organism cytoplasm(GO:0097679)
0.0	0.1	GO:1902636	kinociliary basal body(GO:1902636)
0.0	0.4	GO:0005577	fibrinogen complex(GO:0005577)
0.0	1.1	GO:0030673	axolemma(GO:0030673)
0.0	1.1	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.8	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.9	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.4	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0032311	angiogenin-PRI complex(GO:0032311)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.4	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0072536	interleukin-23 receptor complex(GO:0072536)
0.0	0.0	GO:0042627	chylomicron(GO:0042627)
0.0	0.2	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.4	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.0	GO:0033150	perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.0	1.0	GO:0034707	chloride channel complex(GO:0034707)
0.0	2.2	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0	0.1	GO:0005602	complement component C1 complex(GO:0005602)
0.0	0.0	GO:0044609	DBIRD complex(GO:0044609)
0.0	0.0	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.4	GO:0032420	stereocilium(GO:0032420)
0.0	0.1	GO:0097125	cyclin B1-CDK1 complex(GO:0097125)
0.0	0.4	GO:0005697	telomerase holoenzyme complex(GO:0005697)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.3	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.6	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	1.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.3	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.3	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.6	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.7	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.7	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.1	1.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1	1.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	1.1	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.9	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.8	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	0.5	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.4	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.7	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	1.6	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.3	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.4	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.3	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.7	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	1.6	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	0.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.1	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.0	0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.9	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.0	REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX	Genes involved in Association of licensing factors with the pre-replicative complex
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	3.1	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.4	2.2	GO:0005594	collagen type IX trimer(GO:0005594)
0.3	1.0	GO:0044611	nuclear pore inner ring(GO:0044611)
0.2	3.0	GO:0005577	fibrinogen complex(GO:0005577)
0.2	1.1	GO:0034457	Mpp10 complex(GO:0034457)
0.2	1.0	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.2	2.7	GO:0031089	platelet dense granule lumen(GO:0031089)
0.2	0.6	GO:0071001	U4/U6 snRNP(GO:0071001)
0.1	3.1	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	0.8	GO:0097209	epidermal lamellar body(GO:0097209)
0.1	0.8	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.1	0.6	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1	1.1	GO:0044666	MLL3/4 complex(GO:0044666)
0.1	1.8	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.8	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1	0.3	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1	1.4	GO:0032433	filopodium tip(GO:0032433)
0.1	0.5	GO:0070761	pre-snoRNP complex(GO:0070761)
0.1	2.9	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.1	0.5	GO:0005827	polar microtubule(GO:0005827)
0.1	0.6	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	0.6	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.1	0.6	GO:0000124	SAGA complex(GO:0000124)
0.1	0.4	GO:0042382	paraspeckles(GO:0042382)
0.0	0.0	GO:0097059	CNTFR-CLCF1 complex(GO:0097059)
0.0	4.8	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	0.3	GO:0044194	cytolytic granule(GO:0044194)
0.0	2.9	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	0.8	GO:0000974	Prp19 complex(GO:0000974)
0.0	1.3	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.0	0.4	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.5	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	1.1	GO:0030673	axolemma(GO:0030673)
0.0	0.2	GO:0043564	Ku70:Ku80 complex(GO:0043564)
0.0	0.9	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.3	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	2.3	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	1.6	GO:0031519	PcG protein complex(GO:0031519)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	3.1	GO:0031225	anchored component of membrane(GO:0031225)
0.0	0.1	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.2	GO:0033391	chromatoid body(GO:0033391)
0.0	2.3	GO:0016605	PML body(GO:0016605)
0.0	1.0	GO:0015030	Cajal body(GO:0015030)
0.0	0.2	GO:0042555	MCM complex(GO:0042555)
0.0	1.2	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.0	0.2	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.3	GO:0071141	SMAD protein complex(GO:0071141)
0.0	2.1	GO:0072562	blood microparticle(GO:0072562)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0	0.4	GO:0009925	basal plasma membrane(GO:0009925)
0.0	1.1	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	2.7	PID AURORA A PATHWAY	Aurora A signaling
0.0	0.8	PID ALK2 PATHWAY	ALK2 signaling events
0.0	1.7	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.5	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	1.0	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.4	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.3	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.5	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.2	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.2	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	1.1	PID E2F PATHWAY	E2F transcription factor network

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.3	GO:0035407	histone H3-T11 phosphorylation(GO:0035407)
0.2	1.4	GO:0032596	protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
0.2	0.7	GO:0050712	negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.2	0.6	GO:0034344	type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.1	10.9	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.1	0.6	GO:0046940	nucleoside monophosphate phosphorylation(GO:0046940)
0.1	0.2	GO:0032289	central nervous system myelin formation(GO:0032289) detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.1	1.0	GO:0010623	programmed cell death involved in cell development(GO:0010623)
0.1	0.6	GO:0003344	pericardium morphogenesis(GO:0003344)
0.1	0.4	GO:0061084	regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0	0.1	GO:0070171	negative regulation of tooth mineralization(GO:0070171)
0.0	0.1	GO:0044501	modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.0	0.2	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.0	0.3	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.6	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.4	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	0.2	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.6	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.2	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0048859	formation of anatomical boundary(GO:0048859)
0.0	0.1	GO:0035063	nuclear speck organization(GO:0035063)
0.0	0.5	GO:0010172	embryonic body morphogenesis(GO:0010172)
0.0	0.1	GO:0042427	serotonin biosynthetic process(GO:0042427)
0.0	0.3	GO:0036148	phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0	0.1	GO:1904425	negative regulation of GTP binding(GO:1904425)
0.0	0.3	GO:0006744	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.0	0.8	GO:0019731	antibacterial humoral response(GO:0019731)
0.0	0.1	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.2	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0	0.6	GO:0030490	maturation of SSU-rRNA(GO:0030490)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	4.2	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	3.3	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.9	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	2.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.0	0.8	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	1.6	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	1.0	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	2.1	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.2	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	3.3	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.5	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	3.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	2.2	PID E2F PATHWAY	E2F transcription factor network
0.0	1.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.0	0.5	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.0	0.6	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.5	PID ARF 3PATHWAY	Arf1 pathway
0.0	1.2	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	1.8	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	1.4	PID RAC1 PATHWAY	RAC1 signaling pathway
0.0	0.5	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	0.3	PID EPO PATHWAY	EPO signaling pathway
0.0	0.4	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.2	PID REELIN PATHWAY	Reelin signaling pathway
0.0	0.8	PID TNF PATHWAY	TNF receptor signaling pathway
0.0	1.3	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
0.0	1.1	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	1.2	PID P73PATHWAY	p73 transcription factor network
0.0	0.4	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.0	0.4	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	1.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	0.5	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.0	0.2	PID FGF PATHWAY	FGF signaling pathway

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.1	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.2	1.2	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.2	0.6	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.2	1.1	GO:0046979	TAP2 binding(GO:0046979)
0.2	0.5	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	6.6	GO:0003785	actin monomer binding(GO:0003785)
0.1	0.4	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.1	0.5	GO:0017089	glycolipid transporter activity(GO:0017089) ceramide binding(GO:0097001)
0.1	1.1	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1	0.9	GO:0035174	histone serine kinase activity(GO:0035174)
0.1	0.4	GO:0015180	L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1	0.3	GO:0050613	delta14-sterol reductase activity(GO:0050613)
0.1	0.6	GO:0052655	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1	1.7	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	0.5	GO:0004331	6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1	0.8	GO:0061578	Lys63-specific deubiquitinase activity(GO:0061578)
0.1	0.5	GO:0043426	MRF binding(GO:0043426)
0.1	1.2	GO:0038191	neuropilin binding(GO:0038191)
0.1	0.3	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.1	0.8	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	1.4	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.4	GO:0003910	DNA ligase (ATP) activity(GO:0003910)
0.0	0.9	GO:0070628	proteasome binding(GO:0070628)
0.0	0.6	GO:0097602	cullin family protein binding(GO:0097602)
0.0	1.0	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.6	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.9	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	3.5	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0	1.1	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.4	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.1	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.1	GO:0005502	11-cis retinal binding(GO:0005502)
0.0	0.5	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.3	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.6	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.2	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	1.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.4	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.0	0.5	GO:0005521	lamin binding(GO:0005521)
0.0	0.4	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.5	GO:0071889	14-3-3 protein binding(GO:0071889)
0.0	0.2	GO:0032395	MHC class II receptor activity(GO:0032395)
0.0	1.5	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.5	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.8	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.2	GO:0032393	MHC class I receptor activity(GO:0032393)
0.0	0.4	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0	0.6	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	0.3	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.3	GO:0000993	RNA polymerase II core binding(GO:0000993)
0.0	0.1	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0	0.5	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0035379	carbon dioxide transmembrane transporter activity(GO:0035379)
0.5	2.5	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.3	1.0	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.2	1.2	GO:0004647	phosphoserine phosphatase activity(GO:0004647)
0.2	0.6	GO:0017129	triglyceride binding(GO:0017129)
0.2	0.5	GO:0002113	interleukin-33 binding(GO:0002113)
0.2	0.5	GO:0033858	N-acetylgalactosamine kinase activity(GO:0033858)
0.1	0.9	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.1	0.5	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.1	0.4	GO:0005477	pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1	2.0	GO:0043395	heparan sulfate proteoglycan binding(GO:0043395)
0.1	0.5	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
0.1	0.3	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1	0.3	GO:0098639	collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1	0.3	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.1	0.3	GO:0001016	transcription factor activity, RNA polymerase III transcription factor binding(GO:0001007) RNA polymerase III regulatory region DNA binding(GO:0001016)
0.1	0.2	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1	0.5	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.1	0.5	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0034041	sterol-transporting ATPase activity(GO:0034041)
0.0	0.2	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.3	GO:0033038	bitter taste receptor activity(GO:0033038)
0.0	0.3	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.4	GO:0005112	Notch binding(GO:0005112)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	1.1	GO:0070888	E-box binding(GO:0070888)
0.0	0.2	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0	0.3	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.2	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.4	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.5	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.3	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0	0.4	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0	0.2	GO:0019864	IgG binding(GO:0019864)
0.0	0.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.6	GO:0042169	SH2 domain binding(GO:0042169)
0.0	1.2	GO:0004222	metalloendopeptidase activity(GO:0004222)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	5.8	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.5	1.4	GO:0072709	cellular response to sorbitol(GO:0072709)
0.3	0.9	GO:0044878	mitotic cytokinesis checkpoint(GO:0044878)
0.3	1.0	GO:2000620	positive regulation of histone H4-K16 acetylation(GO:2000620)
0.3	0.8	GO:0034146	B-1 B cell homeostasis(GO:0001922) negative regulation of toll-like receptor 2 signaling pathway(GO:0034136) toll-like receptor 5 signaling pathway(GO:0034146) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428) negative regulation of osteoclast proliferation(GO:0090291)
0.2	1.3	GO:0070294	renal sodium ion absorption(GO:0070294)
0.2	1.8	GO:1904424	regulation of GTP binding(GO:1904424)
0.2	1.7	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.2	0.5	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.2	0.5	GO:0035621	ER to Golgi ceramide transport(GO:0035621)
0.1	3.0	GO:0035855	megakaryocyte development(GO:0035855)
0.1	0.5	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1	0.5	GO:0031064	negative regulation of histone deacetylation(GO:0031064)
0.1	1.1	GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.1	0.4	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.1	0.8	GO:0002051	osteoblast fate commitment(GO:0002051)
0.1	0.3	GO:2001162	regulation of genetic imprinting(GO:2000653) regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
0.1	0.6	GO:0007386	compartment pattern specification(GO:0007386)
0.1	0.4	GO:0015808	L-alanine transport(GO:0015808)
0.1	0.3	GO:0036060	filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1	0.6	GO:0009082	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1	0.4	GO:0060623	regulation of chromosome condensation(GO:0060623)
0.1	0.5	GO:1904636	response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.1	1.1	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1	0.4	GO:0033567	DNA replication, Okazaki fragment processing(GO:0033567)
0.1	0.5	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1	0.2	GO:0043314	negative regulation of neutrophil degranulation(GO:0043314)
0.1	0.3	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1	1.0	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1	0.2	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.1	1.1	GO:0070307	lens fiber cell development(GO:0070307)
0.1	0.5	GO:0070236	regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1	0.2	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.1	1.0	GO:0007130	synaptonemal complex assembly(GO:0007130)
0.1	0.9	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.1	0.6	GO:0051601	exocyst localization(GO:0051601)
0.1	0.6	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1	0.3	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.0	1.1	GO:0009263	deoxyribonucleotide biosynthetic process(GO:0009263)
0.0	2.7	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0	0.6	GO:0031274	positive regulation of pseudopodium assembly(GO:0031274)
0.0	0.2	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.0	0.1	GO:0032696	negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-4 production(GO:0032713)
0.0	0.4	GO:0010265	SCF complex assembly(GO:0010265)
0.0	0.1	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.4	GO:0001865	NK T cell differentiation(GO:0001865)
0.0	0.7	GO:0032012	regulation of ARF protein signal transduction(GO:0032012)
0.0	1.2	GO:0045063	T-helper 1 cell differentiation(GO:0045063)
0.0	0.4	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.0	0.6	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	1.2	GO:0006298	mismatch repair(GO:0006298)
0.0	0.1	GO:0051866	general adaptation syndrome(GO:0051866)
0.0	1.1	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.2	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.4	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.5	GO:0034389	lipid particle organization(GO:0034389)
0.0	0.2	GO:0016198	axon choice point recognition(GO:0016198)
0.0	0.1	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.8	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.1	GO:0001970	positive regulation of activation of membrane attack complex(GO:0001970)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0072402	response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
0.0	0.2	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.3	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0001951	intestinal D-glucose absorption(GO:0001951)
0.0	0.3	GO:0016246	RNA interference(GO:0016246)
0.0	0.3	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	1.0	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.7	GO:0060113	inner ear receptor cell differentiation(GO:0060113)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.0	GO:0034686	integrin alphav-beta8 complex(GO:0034686)
0.4	3.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.2	1.6	GO:0000322	storage vacuole(GO:0000322)
0.2	0.6	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.2	1.8	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.2	1.1	GO:0033269	internode region of axon(GO:0033269)
0.2	2.6	GO:0043020	NADPH oxidase complex(GO:0043020)
0.2	2.0	GO:0000815	ESCRT III complex(GO:0000815)
0.1	0.6	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1	0.4	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.1	0.8	GO:0070436	Grb2-EGFR complex(GO:0070436)
0.1	0.7	GO:0005594	collagen type IX trimer(GO:0005594)
0.1	0.4	GO:0060187	cell pole(GO:0060187)
0.1	0.8	GO:0042382	paraspeckles(GO:0042382)
0.1	0.5	GO:0044530	supraspliceosomal complex(GO:0044530)
0.1	1.9	GO:0000780	condensed nuclear chromosome, centromeric region(GO:0000780)
0.1	0.9	GO:0031010	ISWI-type complex(GO:0031010)
0.1	0.7	GO:0016013	syntrophin complex(GO:0016013)
0.1	0.9	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.1	0.7	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	1.0	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.1	0.4	GO:0097165	nuclear stress granule(GO:0097165)
0.0	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.6	GO:0045120	pronucleus(GO:0045120)
0.0	2.5	GO:0005871	kinesin complex(GO:0005871)
0.0	2.3	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	2.3	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.5	GO:0002199	zona pellucida receptor complex(GO:0002199)
0.0	0.4	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	1.9	GO:0016235	aggresome(GO:0016235)
0.0	0.2	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.4	GO:0043073	germ cell nucleus(GO:0043073)
0.0	0.1	GO:0045177	apical part of cell(GO:0045177)
0.0	0.2	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.9	GO:0005859	muscle myosin complex(GO:0005859)
0.0	1.8	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	1.7	GO:0000794	condensed nuclear chromosome(GO:0000794)
0.0	0.6	GO:0032156	septin cytoskeleton(GO:0032156)
0.0	3.5	GO:0005923	bicellular tight junction(GO:0005923)
0.0	1.5	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.1	GO:0071565	nBAF complex(GO:0071565)
0.0	0.7	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.4	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.2	GO:0016460	myosin II complex(GO:0016460)
0.0	1.5	GO:0000777	condensed chromosome kinetochore(GO:0000777)
0.0	2.3	GO:0005882	intermediate filament(GO:0005882)
0.0	0.4	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	3.6	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.0	0.1	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.9	GO:0000786	nucleosome(GO:0000786)
0.0	2.0	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.7	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	0.2	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.3	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.2	GO:0097386	glial cell projection(GO:0097386)
0.0	0.3	GO:0005884	actin filament(GO:0005884)
0.0	0.2	GO:0005858	axonemal dynein complex(GO:0005858)
0.0	0.1	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.2	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.0	0.4	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	1.4	GO:0016363	nuclear matrix(GO:0016363)
0.0	0.5	GO:0043596	nuclear replication fork(GO:0043596)
0.0	0.5	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.7	GO:0005801	cis-Golgi network(GO:0005801)
0.0	1.1	GO:0005643	nuclear pore(GO:0005643)
0.0	0.2	GO:0032420	stereocilium(GO:0032420)
0.0	0.1	GO:0043190	ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0	0.1	GO:0044666	MLL3/4 complex(GO:0044666)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0006542	glutamine biosynthetic process(GO:0006542)
0.2	0.6	GO:0030185	nitric oxide transport(GO:0030185)
0.2	2.5	GO:0051639	actin filament network formation(GO:0051639)
0.1	0.4	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.1	0.7	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.1	4.3	GO:0050667	homocysteine metabolic process(GO:0050667)
0.1	0.6	GO:1902847	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.1	0.6	GO:0072143	mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
0.1	0.6	GO:0038110	interleukin-2-mediated signaling pathway(GO:0038110)
0.1	0.7	GO:0098532	histone H3-K27 trimethylation(GO:0098532)
0.1	0.5	GO:0098707	ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.1	0.3	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1	1.2	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.1	0.4	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1	0.5	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1	0.6	GO:0032790	ribosome disassembly(GO:0032790)
0.1	0.2	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.1	0.2	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.1	0.3	GO:0090625	mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.1	0.2	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1	0.3	GO:1903385	regulation of homophilic cell adhesion(GO:1903385)
0.1	2.1	GO:0050869	negative regulation of B cell activation(GO:0050869)
0.0	0.1	GO:0016260	selenocysteine biosynthetic process(GO:0016260)
0.0	0.5	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0	0.4	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.4	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0	0.2	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.0	0.3	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.2	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.1	GO:0005989	lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.0	0.3	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0	1.0	GO:0090022	regulation of neutrophil chemotaxis(GO:0090022)
0.0	0.2	GO:0060012	glycine transport(GO:0015816) synaptic transmission, glycinergic(GO:0060012)
0.0	0.1	GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0	0.3	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0090260	filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.0	0.2	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0	0.2	GO:2000628	regulation of miRNA metabolic process(GO:2000628)
0.0	0.1	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.2	GO:0040034	regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0	0.4	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.0	0.5	GO:0007158	neuron cell-cell adhesion(GO:0007158)
0.0	0.1	GO:0031118	rRNA pseudouridine synthesis(GO:0031118)
0.0	0.2	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.2	GO:0030238	male sex determination(GO:0030238)
0.0	0.1	GO:1904879	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0	0.6	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.1	GO:0052551	response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.0	0.4	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	0.3	GO:0008334	histone mRNA metabolic process(GO:0008334)
0.0	0.1	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.1	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.3	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.6	GO:0006730	one-carbon metabolic process(GO:0006730)
0.0	0.1	GO:1902455	negative regulation of stem cell population maintenance(GO:1902455)
0.0	0.2	GO:0016446	somatic diversification of immune receptors via somatic mutation(GO:0002566) somatic hypermutation of immunoglobulin genes(GO:0016446)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0001069	regulatory region RNA binding(GO:0001069)
0.3	2.0	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.3	1.3	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.3	2.1	GO:0008142	oxysterol binding(GO:0008142)
0.3	1.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.3	1.5	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
0.2	1.0	GO:0016211	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.2	0.7	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.2	0.6	GO:0043739	G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
0.2	3.2	GO:0030284	estrogen receptor activity(GO:0030284)
0.2	0.8	GO:0032038	myosin II heavy chain binding(GO:0032038)
0.2	1.0	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.2	2.0	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.1	0.6	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1	2.2	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.1	0.4	GO:0016435	rRNA (guanine) methyltransferase activity(GO:0016435)
0.1	0.7	GO:1990189	peptide-serine-N-acetyltransferase activity(GO:1990189)
0.1	2.6	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.1	1.4	GO:0015379	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1	1.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	0.8	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.1	0.8	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1	2.9	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.1	0.9	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1	1.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.1	0.7	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1	0.7	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1	0.4	GO:0005127	ciliary neurotrophic factor receptor binding(GO:0005127)
0.1	1.8	GO:0070628	proteasome binding(GO:0070628)
0.1	0.4	GO:0061665	SUMO ligase activity(GO:0061665)
0.1	0.3	GO:0031493	nucleosomal histone binding(GO:0031493)
0.1	0.2	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.1	2.3	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.1	3.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.1	2.6	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.1	0.4	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.1	0.4	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.1	0.6	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.1	0.2	GO:0000822	inositol hexakisphosphate binding(GO:0000822)
0.1	1.0	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1	0.2	GO:0005171	hepatocyte growth factor receptor binding(GO:0005171)
0.1	0.4	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.1	0.2	GO:0030350	iron-responsive element binding(GO:0030350)
0.1	0.8	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1	0.9	GO:0031996	thioesterase binding(GO:0031996)
0.1	0.8	GO:0042043	neurexin family protein binding(GO:0042043)
0.1	0.7	GO:0035497	cAMP response element binding(GO:0035497)
0.1	0.4	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	0.1	GO:0050211	procollagen galactosyltransferase activity(GO:0050211)
0.0	0.6	GO:0019534	toxin transporter activity(GO:0019534)
0.0	0.8	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.6	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.3	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	1.1	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.2	GO:0052591	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.0	0.2	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.4	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	1.0	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.4	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.2	GO:0008422	beta-glucosidase activity(GO:0008422)
0.0	4.2	GO:0033613	activating transcription factor binding(GO:0033613)
0.0	3.5	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0	0.4	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.9	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	1.0	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.3	GO:0003680	AT DNA binding(GO:0003680)
0.0	2.5	GO:0003777	microtubule motor activity(GO:0003777)
0.0	0.7	GO:0050998	nitric-oxide synthase binding(GO:0050998)
0.0	1.0	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	1.4	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.0	0.4	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.5	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.5	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.5	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
0.0	0.2	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.3	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.0	0.2	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.5	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	0.6	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.9	GO:0016279	lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0	0.2	GO:0000990	transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0	0.9	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.0	0.7	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.6	GO:0001046	core promoter sequence-specific DNA binding(GO:0001046)
0.0	0.1	GO:0019894	kinesin binding(GO:0019894)
0.0	0.3	GO:0050811	GABA receptor binding(GO:0050811)
0.0	1.1	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0	2.4	GO:0042393	histone binding(GO:0042393)
0.0	0.4	GO:0070034	telomerase RNA binding(GO:0070034)
0.0	0.5	GO:0001221	transcription cofactor binding(GO:0001221)
0.0	0.6	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.5	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.0	0.2	GO:0008417	fucosyltransferase activity(GO:0008417)
0.0	0.5	GO:0051393	alpha-actinin binding(GO:0051393)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	3.8	GO:0003713	transcription coactivator activity(GO:0003713)
0.0	0.4	GO:0002039	p53 binding(GO:0002039)
0.0	0.4	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.3	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.9	GO:0050661	NADP binding(GO:0050661)
0.0	0.4	GO:0005227	calcium activated cation channel activity(GO:0005227)
0.0	0.1	GO:0046935	phosphatidylinositol 3-kinase regulator activity(GO:0035014) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.4	GO:0005080	protein kinase C binding(GO:0005080)
0.0	2.4	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.0	0.3	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.0	GO:0035374	chondroitin sulfate binding(GO:0035374)

Gene overrepresentation in C2:CP category:

Total log-likelihood	Term	Description
3.9	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.7	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.0	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.7	PID AURORA A PATHWAY	Aurora A signaling
0.6	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.1	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.5	2.7	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.4	2.2	GO:0003796	lysozyme activity(GO:0003796)
0.3	2.2	GO:0030020	extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.3	1.9	GO:0019238	cyclohydrolase activity(GO:0019238)
0.3	1.3	GO:0010465	nerve growth factor receptor activity(GO:0010465)
0.2	0.9	GO:0052798	beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.2	0.8	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
0.2	0.6	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.2	0.8	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.2	2.6	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2	1.1	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.1	1.2	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.1	2.3	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.1	1.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1	1.4	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.1	0.6	GO:0032406	MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
0.1	0.8	GO:0072320	volume-sensitive chloride channel activity(GO:0072320)
0.1	1.9	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	0.4	GO:0004609	phosphatidylserine decarboxylase activity(GO:0004609)
0.1	0.5	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1	0.5	GO:0017040	ceramidase activity(GO:0017040)
0.1	0.3	GO:0033188	sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.1	1.2	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.1	1.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1	0.7	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1	0.3	GO:0004531	deoxyribonuclease II activity(GO:0004531)
0.1	0.3	GO:0004618	phosphoglycerate kinase activity(GO:0004618)
0.1	0.3	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1	1.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1	1.1	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1	2.0	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.1	0.4	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1	0.5	GO:0001165	RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.1	2.5	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.1	0.2	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.1	0.2	GO:0032089	NACHT domain binding(GO:0032089)
0.1	2.9	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	1.3	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.6	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.2	GO:0017159	pantetheine hydrolase activity(GO:0017159)
0.0	0.2	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.6	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0004914	interleukin-5 receptor activity(GO:0004914)
0.0	0.4	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.2	GO:0005332	gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0	0.5	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.3	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.9	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0052591	sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.0	0.7	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0071209	U7 snRNA binding(GO:0071209)
0.0	0.3	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.7	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	1.5	GO:0005548	phospholipid transporter activity(GO:0005548)
0.0	0.2	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	1.0	GO:0004532	exoribonuclease activity(GO:0004532)
0.0	0.3	GO:0016594	glycine binding(GO:0016594)
0.0	2.5	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	1.4	GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.9	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.5	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.6	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.2	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0030249	guanylate cyclase regulator activity(GO:0030249)
0.0	0.2	GO:0030280	structural constituent of epidermis(GO:0030280)
0.0	4.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	0.2	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.7	GO:0030507	spectrin binding(GO:0030507)
0.0	0.3	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.2	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.3	GO:0022829	wide pore channel activity(GO:0022829)
0.0	0.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0004647	phosphoserine phosphatase activity(GO:0004647)
0.0	0.8	GO:0004402	histone acetyltransferase activity(GO:0004402)
0.0	0.1	GO:0036374	glutathione hydrolase activity(GO:0036374)
0.0	1.3	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	0.2	GO:0004993	G-protein coupled serotonin receptor activity(GO:0004993)
0.0	0.2	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.3	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.3	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.7	PID IL1 PATHWAY	IL1-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	1.4	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	1.5	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
0.0	0.2	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	3.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	1.9	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.4	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.7	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.4	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.5	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.3	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.5	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis

Gene overrepresentation in C2:CP:REACTOME category:

Total log-likelihood	Term	Description
0.6	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.7	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.7	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.6	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.7	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.3	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.6	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.9	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.6	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.3	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.4	REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER	Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.1	GO:0010903	negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.6	1.9	GO:0051066	dihydrobiopterin metabolic process(GO:0051066)
0.4	2.2	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.4	1.3	GO:0070171	negative regulation of tooth mineralization(GO:0070171)
0.4	1.2	GO:0072428	signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.4	1.2	GO:0007290	spermatid nucleus elongation(GO:0007290)
0.4	4.2	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.3	1.3	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.3	1.3	GO:0002503	peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.3	1.4	GO:1902896	terminal web assembly(GO:1902896)
0.2	2.0	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.2	0.7	GO:0072092	ureteric bud invasion(GO:0072092)
0.2	0.7	GO:0021986	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2	0.8	GO:0035627	ceramide transport(GO:0035627)
0.2	0.8	GO:0031064	negative regulation of histone deacetylation(GO:0031064)
0.2	1.0	GO:0000973	posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
0.2	0.6	GO:0006711	estrogen catabolic process(GO:0006711)
0.2	1.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.2	0.8	GO:0048388	endosomal lumen acidification(GO:0048388)
0.2	0.5	GO:1903939	negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
0.2	1.2	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.1	0.6	GO:0034473	U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1	1.1	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.1	0.4	GO:0030033	microvillus assembly(GO:0030033)
0.1	1.8	GO:0051639	actin filament network formation(GO:0051639)
0.1	0.4	GO:0002370	natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.1	0.5	GO:0070301	cellular response to hydrogen peroxide(GO:0070301)
0.1	0.6	GO:0033490	cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
0.1	1.2	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1	1.1	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.1	1.4	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.1	0.7	GO:0036438	maintenance of lens transparency(GO:0036438)
0.1	0.5	GO:0070560	protein secretion by platelet(GO:0070560)
0.1	0.6	GO:0045007	depurination(GO:0045007)
0.1	0.2	GO:0006421	asparaginyl-tRNA aminoacylation(GO:0006421)
0.1	0.2	GO:1990502	dense core granule maturation(GO:1990502)
0.1	0.5	GO:0016926	protein desumoylation(GO:0016926)
0.1	0.7	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	0.5	GO:0034472	snRNA 3'-end processing(GO:0034472)
0.1	1.0	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.1	0.5	GO:0070995	NADPH oxidation(GO:0070995)
0.1	0.2	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.1	0.3	GO:0001880	Mullerian duct regression(GO:0001880)
0.1	0.4	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.8	GO:0001787	natural killer cell proliferation(GO:0001787)
0.0	2.9	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	3.1	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.0	0.5	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.0	0.3	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0038043	interleukin-5-mediated signaling pathway(GO:0038043)
0.0	0.3	GO:0002418	immune response to tumor cell(GO:0002418)
0.0	0.2	GO:0008065	establishment of blood-nerve barrier(GO:0008065)
0.0	0.3	GO:0070170	regulation of tooth mineralization(GO:0070170)
0.0	0.3	GO:0000712	resolution of meiotic recombination intermediates(GO:0000712)
0.0	0.3	GO:0035518	histone H2A monoubiquitination(GO:0035518)
0.0	0.9	GO:0006295	nucleotide-excision repair, preincision complex stabilization(GO:0006293) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	1.2	GO:0005980	glycogen catabolic process(GO:0005980)
0.0	0.8	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
0.0	0.2	GO:0071475	cellular hyperosmotic salinity response(GO:0071475)
0.0	0.1	GO:0021589	hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.0	0.1	GO:0072709	cellular response to sorbitol(GO:0072709)
0.0	0.7	GO:0030889	negative regulation of B cell proliferation(GO:0030889)
0.0	1.0	GO:0018146	keratan sulfate biosynthetic process(GO:0018146)
0.0	2.6	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	0.4	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.1	GO:0006127	glycerophosphate shuttle(GO:0006127)
0.0	0.3	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.5	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0071676	negative regulation of mononuclear cell migration(GO:0071676)
0.0	1.2	GO:0030490	maturation of SSU-rRNA(GO:0030490)
0.0	0.8	GO:0006505	GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.0	0.2	GO:1902525	regulation of protein monoubiquitination(GO:1902525)
0.0	0.2	GO:0015824	proline transport(GO:0015824)
0.0	2.6	GO:0006903	vesicle targeting(GO:0006903)
0.0	0.6	GO:0016578	histone deubiquitination(GO:0016578)
0.0	0.4	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.1	GO:1902310	positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.0	1.1	GO:1904837	beta-catenin-TCF complex assembly(GO:1904837)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.2	GO:0050713	negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0	0.3	GO:0035090	maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.0	2.1	GO:0008585	female gonad development(GO:0008585)
0.0	0.7	GO:0043029	T cell homeostasis(GO:0043029)
0.0	1.9	GO:0031295	T cell costimulation(GO:0031295)
0.0	0.0	GO:0032696	negative regulation of interleukin-13 production(GO:0032696)
0.0	0.6	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.0	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.0	0.3	GO:0051290	deoxyribonucleotide biosynthetic process(GO:0009263) protein heterotetramerization(GO:0051290)
0.0	0.6	GO:0042026	protein refolding(GO:0042026)
0.0	0.8	GO:0016445	somatic diversification of immunoglobulins(GO:0016445)
0.0	0.1	GO:0060041	retina development in camera-type eye(GO:0060041)
0.0	0.0	GO:0035482	gastric motility(GO:0035482) gastric emptying(GO:0035483)
0.0	0.1	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0	0.4	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0	0.3	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.2	GO:0015812	gamma-aminobutyric acid transport(GO:0015812)
0.0	0.1	GO:0015705	iodide transport(GO:0015705)
0.0	0.2	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	0.1	GO:0072584	caveolin-mediated endocytosis(GO:0072584)
0.0	0.9	GO:0006968	cellular defense response(GO:0006968)
0.0	0.1	GO:2000825	positive regulation of androgen receptor activity(GO:2000825)
0.0	1.4	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)
0.0	0.2	GO:0034308	primary alcohol metabolic process(GO:0034308)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	4.3	GO:0043020	NADPH oxidase complex(GO:0043020)
0.2	0.6	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.1	2.5	GO:0001891	phagocytic cup(GO:0001891)
0.1	0.4	GO:0071001	U4/U6 snRNP(GO:0071001)
0.1	0.5	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.1	0.4	GO:0042272	nuclear RNA export factor complex(GO:0042272)
0.1	0.3	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1	0.7	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.3	GO:0000322	storage vacuole(GO:0000322)
0.0	0.3	GO:0034715	U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.0	0.6	GO:0034366	spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.0	1.0	GO:0032420	stereocilium(GO:0032420)
0.0	0.7	GO:0097386	glial cell projection(GO:0097386)
0.0	0.3	GO:0035068	micro-ribonucleoprotein complex(GO:0035068)
0.0	0.2	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0005953	CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.0	0.2	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.1	GO:0097361	CIA complex(GO:0097361)
0.0	0.2	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0090661	box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0	0.2	GO:0000125	PCAF complex(GO:0000125)
0.0	0.5	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.3	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.7	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.2	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.2	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.5	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.3	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	1.0	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.2	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.0	0.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0097486	multivesicular body lumen(GO:0097486)
0.0	1.2	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.1	GO:1903440	calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0	0.1	GO:0005602	complement component C1 complex(GO:0005602)
0.0	0.5	GO:0042571	immunoglobulin complex, circulating(GO:0042571)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	1.7	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.1	0.8	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	0.8	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	0.5	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	1.4	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	6.6	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.7	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	1.1	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	1.1	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.9	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.7	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.4	REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND	Genes involved in Processive synthesis on the lagging strand
0.0	0.3	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	1.1	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	1.0	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.6	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.8	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.5	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.0	1.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.0	0.9	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	1.1	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	0.6	REACTOME MEIOSIS	Genes involved in Meiosis
0.0	0.3	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.3	GO:0035402	histone kinase activity (H3-T11 specific)(GO:0035402)
0.2	0.6	GO:0046899	nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1	0.7	GO:0004910	interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.1	0.3	GO:0050528	acyloxyacyl hydrolase activity(GO:0050528)
0.1	0.4	GO:0039552	RIG-I binding(GO:0039552)
0.1	0.6	GO:0003696	satellite DNA binding(GO:0003696)
0.1	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.6	GO:0030280	structural constituent of epidermis(GO:0030280)
0.0	0.4	GO:1990446	U1 snRNP binding(GO:1990446)
0.0	0.6	GO:0045499	chemorepellent activity(GO:0045499)
0.0	0.3	GO:0047144	2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0	0.2	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.3	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.6	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	2.0	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	1.0	GO:0004520	endodeoxyribonuclease activity(GO:0004520)
0.0	0.0	GO:0016296	oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.3	GO:0071949	FAD binding(GO:0071949)
0.0	0.8	GO:0004519	endonuclease activity(GO:0004519)
0.0	0.1	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.6	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.1	2.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	1.9	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.1	1.9	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.1	0.6	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.1	1.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	1.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.1	5.1	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.8	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.9	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	0.7	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	1.1	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.0	0.6	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	1.0	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.5	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.7	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	1.5	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.0	0.5	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0	0.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.4	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0	1.3	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	2.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.3	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.1	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.0	0.3	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.1	1.5	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	1.0	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.8	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	1.1	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	3.3	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	0.4	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	1.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	1.6	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.9	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.4	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.9	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.9	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.8	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.8	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.8	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	1.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.4	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	1.4	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.6	REACTOME G1 S SPECIFIC TRANSCRIPTION	Genes involved in G1/S-Specific Transcription
0.0	0.5	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.5	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0	0.5	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.2	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.2	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0	1.1	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.4	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.2	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.3	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.4	REACTOME EXTENSION OF TELOMERES	Genes involved in Extension of Telomeres
0.0	0.2	REACTOME PRE NOTCH EXPRESSION AND PROCESSING	Genes involved in Pre-NOTCH Expression and Processing
0.0	0.6	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.5	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.3	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.1	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.2	1.8	GO:0000322	storage vacuole(GO:0000322)
0.2	0.6	GO:0034991	nuclear meiotic cohesin complex(GO:0034991)
0.1	0.9	GO:0070852	cell body fiber(GO:0070852)
0.1	1.3	GO:0042612	MHC class I protein complex(GO:0042612)
0.1	0.9	GO:0032133	chromosome passenger complex(GO:0032133)
0.1	0.5	GO:0097129	cyclin D2-CDK4 complex(GO:0097129)
0.1	0.3	GO:0097179	protease inhibitor complex(GO:0097179)
0.1	0.8	GO:0043073	germ cell nucleus(GO:0043073)
0.1	0.5	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1	0.3	GO:0061689	tricellular tight junction(GO:0061689)
0.1	0.5	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.1	0.3	GO:0001740	Barr body(GO:0001740)
0.0	5.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	0.4	GO:0031467	Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0	1.1	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.8	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.3	GO:0042382	paraspeckles(GO:0042382)
0.0	0.3	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.6	GO:0000145	exocyst(GO:0000145)
0.0	3.0	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	0.4	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	0.1	GO:0005686	U2 snRNP(GO:0005686)
0.0	0.4	GO:0000795	synaptonemal complex(GO:0000795)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.2	GO:0031010	ISWI-type complex(GO:0031010)
0.0	1.0	GO:0031463	Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0030905	retromer, tubulation complex(GO:0030905)
0.0	0.8	GO:0030119	AP-type membrane coat adaptor complex(GO:0030119)
0.0	0.3	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.3	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.2	GO:0097440	apical dendrite(GO:0097440)
0.0	0.2	GO:0042611	MHC protein complex(GO:0042611) MHC class II protein complex(GO:0042613)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	2.4	GO:0002113	interleukin-33 binding(GO:0002113)
0.3	0.9	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.3	0.8	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2	1.2	GO:0004647	phosphoserine phosphatase activity(GO:0004647)
0.2	2.2	GO:0019826	oxygen sensor activity(GO:0019826)
0.2	0.7	GO:0033149	FFAT motif binding(GO:0033149)
0.2	0.9	GO:0004948	calcitonin receptor activity(GO:0004948)
0.2	1.1	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.2	1.0	GO:0031708	endothelin B receptor binding(GO:0031708)
0.2	1.2	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1	0.4	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1	0.4	GO:0034041	sterol-transporting ATPase activity(GO:0034041)
0.1	0.3	GO:0032089	NACHT domain binding(GO:0032089)
0.1	1.5	GO:0015643	toxic substance binding(GO:0015643)
0.1	0.5	GO:0098639	collagen binding involved in cell-matrix adhesion(GO:0098639)
0.1	0.7	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.1	0.8	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.1	1.7	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.1	0.7	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.1	0.7	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.1	0.9	GO:0030280	structural constituent of epidermis(GO:0030280)
0.1	0.4	GO:0050294	steroid sulfotransferase activity(GO:0050294)
0.1	0.4	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.1	0.3	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.1	0.3	GO:0030348	syntaxin-3 binding(GO:0030348)
0.1	2.0	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.0	0.2	GO:0052828	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0	0.1	GO:0047223	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.0	0.2	GO:0050544	icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567)
0.0	0.1	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
0.0	0.3	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.2	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	0.6	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0042056	chemoattractant activity(GO:0042056)
0.0	0.1	GO:0004756	selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.0	0.1	GO:0061513	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.4	GO:0008517	folic acid transporter activity(GO:0008517)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.8	GO:0005521	lamin binding(GO:0005521)
0.0	0.9	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.3	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.3	GO:0003720	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.2	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0	0.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	1.8	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	0.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.2	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0033823	procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.0	0.2	GO:0033038	bitter taste receptor activity(GO:0033038)
0.0	0.1	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.6	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.3	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.2	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0035671	enone reductase activity(GO:0035671)
0.0	0.1	GO:0042020	interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0	0.8	GO:0017080	sodium channel regulator activity(GO:0017080)
0.0	0.3	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0004307	ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.0	GO:0080101	phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.0	0.5	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	1.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.1	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.0	0.4	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.4	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.3	GO:0005112	Notch binding(GO:0005112)
0.0	0.1	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.0	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.0	GO:0033188	sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0	0.1	GO:0005152	interleukin-1 receptor antagonist activity(GO:0005152)
0.0	0.1	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	0.1	GO:0004522	ribonuclease A activity(GO:0004522)
0.0	0.2	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.0	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.0	0.1	GO:0030883	lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.0	1.1	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.3	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.3	GO:0016805	dipeptidase activity(GO:0016805)
0.0	0.1	GO:0033857	diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.3	GO:0019826	oxygen sensor activity(GO:0019826)
0.2	0.6	GO:0004913	interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917)
0.2	0.5	GO:0072510	ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.2	0.7	GO:0004356	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
0.1	0.6	GO:0030492	hemoglobin binding(GO:0030492)
0.1	0.4	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.1	0.4	GO:0001016	transcription factor activity, RNA polymerase III transcription factor binding(GO:0001007) RNA polymerase III regulatory region DNA binding(GO:0001016)
0.1	0.6	GO:0004064	arylesterase activity(GO:0004064)
0.1	0.6	GO:0090599	alpha-glucosidase activity(GO:0090599)
0.1	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.1	0.2	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.2	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0004756	selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.2	GO:0032296	ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.0	0.4	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.4	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	2.1	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.6	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.7	GO:0031489	myosin V binding(GO:0031489)
0.0	0.1	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.3	GO:0036310	annealing helicase activity(GO:0036310)
0.0	0.1	GO:0004662	CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.0	1.0	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.5	GO:0005112	Notch binding(GO:0005112)
0.0	0.2	GO:0032138	single base insertion or deletion binding(GO:0032138)
0.0	0.1	GO:0005277	acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.0	0.1	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.2	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.2	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.0	0.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.1	GO:0004565	beta-galactosidase activity(GO:0004565)
0.0	0.5	GO:0043015	gamma-tubulin binding(GO:0043015)
0.0	0.1	GO:0015185	gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0	0.1	GO:0035174	histone serine kinase activity(GO:0035174)
0.0	0.2	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.3	GO:0035198	miRNA binding(GO:0035198)
0.0	0.3	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0019836	hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.4	2.4	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
0.3	1.0	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2	0.7	GO:2000097	chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.2	1.1	GO:1903284	negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
0.2	0.7	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.2	0.9	GO:0032119	sequestering of zinc ion(GO:0032119)
0.2	2.0	GO:0052697	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1	1.5	GO:0001865	NK T cell differentiation(GO:0001865)
0.1	0.4	GO:1904328	regulation of myofibroblast contraction(GO:1904328) myofibroblast contraction(GO:1990764)
0.1	0.4	GO:0009726	detection of endogenous stimulus(GO:0009726)
0.1	0.3	GO:0052047	interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.1	0.4	GO:0021564	vagus nerve development(GO:0021564)
0.1	0.7	GO:0021842	directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1	3.9	GO:0060216	definitive hemopoiesis(GO:0060216)
0.1	0.4	GO:0072674	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.1	0.4	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1	0.3	GO:0098746	fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
0.1	0.4	GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1	1.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.1	0.4	GO:0034334	adherens junction maintenance(GO:0034334)
0.1	0.5	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1	0.9	GO:0034285	response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1	0.7	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.1	0.4	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1	0.4	GO:0045906	negative regulation of vasoconstriction(GO:0045906)
0.1	0.9	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1	0.6	GO:0038007	netrin-activated signaling pathway(GO:0038007)
0.1	0.6	GO:0098814	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1	0.2	GO:2001045	closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.1	0.4	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	0.2	GO:0006711	estrogen catabolic process(GO:0006711)
0.1	2.2	GO:0050667	homocysteine metabolic process(GO:0050667)
0.1	0.2	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.1	0.7	GO:0001778	plasma membrane repair(GO:0001778)
0.1	0.8	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.1	0.2	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.1	0.6	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1	3.1	GO:0018149	peptide cross-linking(GO:0018149)
0.0	0.3	GO:0010820	positive regulation of T cell chemotaxis(GO:0010820)
0.0	0.2	GO:0071461	cellular response to redox state(GO:0071461)
0.0	0.1	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	0.1	GO:1902396	protein localization to bicellular tight junction(GO:1902396)
0.0	0.1	GO:0010430	fatty acid omega-oxidation(GO:0010430)
0.0	0.1	GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.0	1.3	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.8	GO:0035855	megakaryocyte development(GO:0035855)
0.0	0.3	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.0	0.1	GO:0006788	heme oxidation(GO:0006788)
0.0	0.2	GO:0014886	transition between slow and fast fiber(GO:0014886)
0.0	1.7	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.7	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.4	GO:1902172	keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.0	0.3	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.3	GO:1902572	negative regulation of serine-type endopeptidase activity(GO:1900004) negative regulation of serine-type peptidase activity(GO:1902572)
0.0	0.1	GO:0042727	flavin-containing compound biosynthetic process(GO:0042727)
0.0	0.4	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.1	GO:0016260	selenocysteine biosynthetic process(GO:0016260)
0.0	0.2	GO:0098881	exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0	0.1	GO:1902019	negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0	0.1	GO:0032431	activation of phospholipase A2 activity(GO:0032431)
0.0	0.6	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.4	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.1	GO:0032203	telomere formation via telomerase(GO:0032203)
0.0	0.2	GO:0035881	amacrine cell differentiation(GO:0035881)
0.0	0.3	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.3	GO:0044387	negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.0	0.1	GO:0071409	cellular response to cycloheximide(GO:0071409)
0.0	0.1	GO:0002329	pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
0.0	0.1	GO:0010650	positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0	0.2	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.1	GO:0060671	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0	0.1	GO:1902775	mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.3	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.2	GO:0030421	defecation(GO:0030421)
0.0	0.4	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	1.0	GO:0046825	regulation of protein export from nucleus(GO:0046825)
0.0	0.1	GO:0016095	polyprenol catabolic process(GO:0016095)
0.0	0.4	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.2	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.3	GO:0045793	positive regulation of cell size(GO:0045793)
0.0	0.1	GO:0030323	respiratory tube development(GO:0030323) lung development(GO:0030324)
0.0	0.1	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.0	0.1	GO:0046947	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.0	0.1	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0042320	regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
0.0	0.2	GO:0042940	D-amino acid transport(GO:0042940)
0.0	0.1	GO:0002879	positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.0	0.1	GO:0031660	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
0.0	0.1	GO:0072023	thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0	0.3	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.1	GO:0038155	interleukin-23-mediated signaling pathway(GO:0038155)
0.0	0.2	GO:1903944	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0	0.8	GO:0006656	phosphatidylcholine biosynthetic process(GO:0006656)
0.0	0.1	GO:0044111	development involved in symbiotic interaction(GO:0044111)
0.0	0.1	GO:0060157	urinary bladder development(GO:0060157)
0.0	0.1	GO:0042330	chemotaxis(GO:0006935) taxis(GO:0042330)
0.0	0.1	GO:0010519	negative regulation of phospholipase activity(GO:0010519)
0.0	0.1	GO:0021997	response to chlorate(GO:0010157) neural plate axis specification(GO:0021997)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.3	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.0	GO:0042481	regulation of odontogenesis(GO:0042481)
0.0	0.1	GO:0070863	positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.0	0.2	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.9	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0	0.2	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.0	0.0	GO:0046533	negative regulation of photoreceptor cell differentiation(GO:0046533)
0.0	0.4	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.4	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.1	GO:0035752	lysosomal lumen pH elevation(GO:0035752)
0.0	0.0	GO:0042427	serotonin biosynthetic process(GO:0042427)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.3	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	1.0	GO:0030574	collagen catabolic process(GO:0030574)
0.0	0.2	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0	0.1	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.2	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.1	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:0072513	positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0	0.0	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.0	GO:0036269	swimming behavior(GO:0036269)
0.0	0.0	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.1	GO:0051026	chiasma assembly(GO:0051026)
0.0	0.1	GO:1902714	negative regulation of interferon-gamma secretion(GO:1902714)
0.0	0.1	GO:0001522	pseudouridine synthesis(GO:0001522)
0.0	0.2	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)

Gene overrepresentation in C2:CP category:

Total log-likelihood	Term	Description
3.5	PID NOTCH PATHWAY	Notch signaling pathway
2.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
2.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
2.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
1.4	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	PID IL23 PATHWAY	IL23-mediated signaling events
1.1	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.4	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.5	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.9	PID ENDOTHELIN PATHWAY	Endothelins
1.0	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.3	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.7	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.3	SIG CD40PATHWAYMAP	Genes related to CD40 signaling

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	3.2	GO:0071895	odontoblast differentiation(GO:0071895)
0.7	2.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.6	3.1	GO:0001834	trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.4	1.3	GO:0048203	vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.4	2.6	GO:1903758	regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.4	1.9	GO:0070842	aggresome assembly(GO:0070842)
0.4	1.1	GO:0002370	natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.4	1.1	GO:0045994	positive regulation of translational initiation by iron(GO:0045994)
0.3	2.0	GO:0051013	microtubule severing(GO:0051013)
0.3	1.6	GO:1904845	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.3	0.9	GO:0072709	cellular response to sorbitol(GO:0072709)
0.3	0.8	GO:1904425	negative regulation of GTP binding(GO:1904425)
0.3	1.5	GO:0035407	histone H3-T11 phosphorylation(GO:0035407)
0.3	0.8	GO:0098923	retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.2	1.0	GO:0006542	glutamine biosynthetic process(GO:0006542)
0.2	1.6	GO:1904424	regulation of GTP binding(GO:1904424)
0.2	1.4	GO:0061737	leukotriene signaling pathway(GO:0061737)
0.2	1.1	GO:1904209	regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.2	1.2	GO:0030421	defecation(GO:0030421)
0.2	0.6	GO:0036333	hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.2	0.6	GO:0090244	trachea cartilage morphogenesis(GO:0060535) Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.2	0.9	GO:0006740	NADPH regeneration(GO:0006740)
0.2	0.5	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.2	0.5	GO:0051086	chaperone mediated protein folding independent of cofactor(GO:0051086)
0.2	0.5	GO:0001544	initiation of primordial ovarian follicle growth(GO:0001544)
0.2	2.3	GO:0070307	lens fiber cell development(GO:0070307)
0.2	2.1	GO:0051382	kinetochore assembly(GO:0051382)
0.2	0.6	GO:1902544	oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
0.2	0.8	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.2	0.6	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.1	0.1	GO:0046833	positive regulation of RNA export from nucleus(GO:0046833)
0.1	0.7	GO:1904693	midbrain morphogenesis(GO:1904693)
0.1	0.4	GO:0036060	filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1	0.4	GO:0050902	leukocyte adhesive activation(GO:0050902)
0.1	0.4	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.1	0.4	GO:0032203	telomere formation via telomerase(GO:0032203)
0.1	0.8	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.1	0.4	GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1	2.2	GO:0021516	dorsal spinal cord development(GO:0021516)
0.1	1.2	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) negative regulation of chromatin silencing(GO:0031936) DNA replication-dependent nucleosome organization(GO:0034723)
0.1	1.4	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.1	0.5	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.1	0.7	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.1	1.2	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1	0.8	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.1	0.4	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.1	2.7	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1	0.3	GO:1901355	response to rapamycin(GO:1901355)
0.1	1.0	GO:1902414	protein localization to cell junction(GO:1902414)
0.1	0.9	GO:0090073	positive regulation of protein homodimerization activity(GO:0090073)
0.1	1.0	GO:0001573	ganglioside metabolic process(GO:0001573)
0.1	0.4	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.1	0.3	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.1	0.2	GO:0006286	base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.1	0.2	GO:0051097	negative regulation of helicase activity(GO:0051097)
0.1	0.4	GO:0048104	establishment of body hair or bristle planar orientation(GO:0048104) establishment of body hair planar orientation(GO:0048105)
0.1	0.2	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.1	1.2	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1	0.5	GO:0021764	amygdala development(GO:0021764)
0.1	0.3	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1	0.4	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.1	0.9	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.1	0.1	GO:0003358	noradrenergic neuron development(GO:0003358)
0.1	0.2	GO:0021571	rhombomere 5 development(GO:0021571)
0.1	0.5	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.1	0.3	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.1	0.9	GO:0045793	positive regulation of cell size(GO:0045793)
0.1	0.1	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.1	0.2	GO:0060926	atrioventricular node development(GO:0003162) cardiac pacemaker cell differentiation(GO:0060920) cardiac pacemaker cell development(GO:0060926)
0.1	1.8	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.1	0.4	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.1	0.2	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.1	2.4	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1	2.6	GO:0031122	cytoplasmic microtubule organization(GO:0031122)
0.1	0.1	GO:1903527	positive regulation of membrane tubulation(GO:1903527)
0.1	0.6	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.1	0.2	GO:0035616	histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.0	0.7	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0	0.9	GO:0035855	megakaryocyte development(GO:0035855)
0.0	0.2	GO:0072658	positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0	0.1	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.0	0.4	GO:0034128	negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128)
0.0	0.5	GO:0097034	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0	0.6	GO:0034378	chylomicron assembly(GO:0034378)
0.0	0.7	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.3	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.1	GO:1904247	modification by virus of host mRNA processing(GO:0046778) positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.0	2.5	GO:0048384	retinoic acid receptor signaling pathway(GO:0048384)
0.0	1.1	GO:0006825	copper ion transport(GO:0006825)
0.0	1.7	GO:0050873	brown fat cell differentiation(GO:0050873)
0.0	1.9	GO:0050775	positive regulation of dendrite morphogenesis(GO:0050775)
0.0	1.3	GO:2000785	regulation of autophagosome assembly(GO:2000785)
0.0	0.4	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	1.5	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.2	GO:0014724	regulation of twitch skeletal muscle contraction(GO:0014724)
0.0	0.4	GO:1903608	protein localization to cytoplasmic stress granule(GO:1903608)
0.0	1.0	GO:0003298	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0	0.5	GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0	0.5	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.0	1.1	GO:2000772	regulation of cellular senescence(GO:2000772)
0.0	0.1	GO:0021869	forebrain ventricular zone progenitor cell division(GO:0021869)
0.0	0.2	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0	0.2	GO:0006127	glycerophosphate shuttle(GO:0006127)
0.0	0.3	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	0.6	GO:0002227	innate immune response in mucosa(GO:0002227)
0.0	0.6	GO:0008340	determination of adult lifespan(GO:0008340)
0.0	0.5	GO:0098828	positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0	0.1	GO:0042539	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
0.0	1.0	GO:0050667	homocysteine metabolic process(GO:0050667)
0.0	0.1	GO:0035726	common myeloid progenitor cell proliferation(GO:0035726)
0.0	0.3	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.8	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.0	0.4	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.3	GO:0015868	purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.0	0.3	GO:0048298	positive regulation of isotype switching to IgA isotypes(GO:0048298)
0.0	0.2	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.4	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.2	GO:0030643	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	3.3	GO:0030183	B cell differentiation(GO:0030183)
0.0	0.7	GO:0032292	myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0	0.8	GO:0002026	regulation of the force of heart contraction(GO:0002026)
0.0	0.5	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	0.1	GO:0039656	modulation by virus of host transcription(GO:0019056) modulation by virus of host gene expression(GO:0039656) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.0	0.4	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.4	GO:1904886	beta-catenin destruction complex disassembly(GO:1904886)
0.0	0.4	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.0	0.4	GO:0031167	rRNA methylation(GO:0031167)
0.0	0.5	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0	0.2	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.2	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.1	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.0	0.5	GO:0032786	positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.0	0.0	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.4	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.4	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.1	GO:0034334	adherens junction maintenance(GO:0034334)
0.0	0.4	GO:0051560	mitochondrial calcium ion homeostasis(GO:0051560)
0.0	0.3	GO:0045109	intermediate filament organization(GO:0045109)
0.0	0.2	GO:0060285	cilium-dependent cell motility(GO:0060285)
0.0	0.2	GO:0060117	auditory receptor cell development(GO:0060117)
0.0	0.4	GO:0016048	detection of temperature stimulus(GO:0016048)
0.0	0.2	GO:0003382	epithelial cell morphogenesis(GO:0003382)
0.0	0.3	GO:0006379	mRNA cleavage(GO:0006379)
0.0	0.3	GO:0006895	Golgi to endosome transport(GO:0006895)
0.0	0.6	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.2	GO:0045725	positive regulation of glycogen biosynthetic process(GO:0045725)
0.0	0.5	GO:1901385	regulation of voltage-gated calcium channel activity(GO:1901385)
0.0	0.3	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.3	GO:0070262	peptidyl-serine dephosphorylation(GO:0070262)
0.0	0.9	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.3	GO:0035728	response to hepatocyte growth factor(GO:0035728)
0.0	0.2	GO:0003016	respiratory system process(GO:0003016)
0.0	0.1	GO:0014886	transition between slow and fast fiber(GO:0014886)
0.0	0.0	GO:0021781	glial cell fate commitment(GO:0021781)
0.0	1.2	GO:1902476	chloride transmembrane transport(GO:1902476)
0.0	0.3	GO:0018023	peptidyl-lysine trimethylation(GO:0018023)
0.0	0.1	GO:0038092	nodal signaling pathway(GO:0038092)
0.0	0.2	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.7	GO:0030218	erythrocyte differentiation(GO:0030218)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0035378	carbon dioxide transmembrane transport(GO:0035378)
0.5	2.5	GO:0051585	negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
0.2	1.0	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.2	2.3	GO:0001778	plasma membrane repair(GO:0001778)
0.2	0.9	GO:0003051	angiotensin-mediated drinking behavior(GO:0003051)
0.2	0.3	GO:0043405	regulation of MAP kinase activity(GO:0043405) negative regulation of MAP kinase activity(GO:0043407)
0.1	0.9	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1	0.4	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.1	1.0	GO:0009441	glycolate metabolic process(GO:0009441)
0.1	0.6	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1	0.5	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
0.1	1.2	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.1	0.6	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890) lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096)
0.1	2.0	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	0.4	GO:0007386	compartment pattern specification(GO:0007386)
0.1	0.3	GO:1902044	regulation of Fas signaling pathway(GO:1902044)
0.1	0.5	GO:0072733	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.1	0.3	GO:0001880	Mullerian duct regression(GO:0001880)
0.1	0.2	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.1	0.5	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.1	0.4	GO:0048014	Tie signaling pathway(GO:0048014)
0.1	0.5	GO:0016191	synaptic vesicle uncoating(GO:0016191)
0.1	0.5	GO:0015939	pantothenate metabolic process(GO:0015939)
0.1	0.2	GO:0006624	vacuolar protein processing(GO:0006624)
0.1	0.2	GO:0036215	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.4	GO:0006848	pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0009726	detection of endogenous stimulus(GO:0009726)
0.0	0.2	GO:0060133	somatotropin secreting cell development(GO:0060133)
0.0	0.3	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423) siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0	0.4	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.5	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.6	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.0	0.3	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.2	GO:0002353	regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0	0.6	GO:0071670	smooth muscle cell chemotaxis(GO:0071670)
0.0	0.2	GO:0055129	proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.0	0.1	GO:0006780	uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.5	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:1901377	mycotoxin catabolic process(GO:0043387) aflatoxin catabolic process(GO:0046223) organic heteropentacyclic compound catabolic process(GO:1901377) regulation of glutathione biosynthetic process(GO:1903786) positive regulation of glutathione biosynthetic process(GO:1903788)
0.0	0.5	GO:0006012	galactose metabolic process(GO:0006012)
0.0	1.1	GO:0030318	melanocyte differentiation(GO:0030318)
0.0	0.4	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0051012	microtubule sliding(GO:0051012)
0.0	0.2	GO:0060088	auditory receptor cell stereocilium organization(GO:0060088)
0.0	0.2	GO:0098814	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0	0.3	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:0072675	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.6	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	0.1	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.2	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0	0.3	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)

Gene overrepresentation in C2:CP category:

Total log-likelihood	Term	Description
2.5	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.3	PID ALK2 PATHWAY	ALK2 signaling events
1.0	NABA COLLAGENS	Genes encoding collagen proteins
1.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
2.3	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.3	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.5	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.3	GO:0034680	integrin alpha10-beta1 complex(GO:0034680)
0.1	0.4	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1	2.5	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	0.3	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.2	GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.0	0.6	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.0	3.0	GO:0005901	caveola(GO:0005901)
0.0	0.6	GO:0042627	chylomicron(GO:0042627)
0.0	1.0	GO:0005782	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.3	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.1	GO:0036128	CatSper complex(GO:0036128)
0.0	0.4	GO:0016328	lateral plasma membrane(GO:0016328)
0.0	1.0	GO:0035580	specific granule lumen(GO:0035580)

Results for SOX1

Z-value: 0.67

Motif logo

Transcription factors associated with SOX1

Activity-expression correlation:

Activity profile of SOX1 motif

Sorted Z-values of SOX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in cellular_component category: