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ENCODE cell lines, expression (Ernst 2011)

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Results for SOX30

Z-value: 0.68

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Transcription factors associated with SOX30

Gene Symbol Gene ID Gene Info
SOX30
ENSG00000039600.6 SOX30

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX30hg19_v2_chr5_-_157079372_157079395,
hg19_v2_chr5_-_157079428_157079452		0.341.9e-01Click!

Activity profile of SOX30 motif

Sorted Z-values of SOX30 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX30

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_12290586 1.66 ENST00000379375.5
 EDN1
 endothelin 1
chr11_-_89224638 1.40 ENST00000535633.1
ENST00000263317.4
 NOX4
 NADPH oxidase 4
chr11_+_46402744 1.01 ENST00000533952.1
 MDK
 midkine (neurite growth-promoting factor 2)
chr12_-_10251603 0.86 ENST00000457018.2
 CLEC1A
 C-type lectin domain family 1, member A
chr11_+_128563948 0.86 ENST00000534087.2
 FLI1
 Fli-1 proto-oncogene, ETS transcription factor
chr11_+_128563652 0.85 ENST00000527786.2
 FLI1
 Fli-1 proto-oncogene, ETS transcription factor
chr12_-_10251576 0.83 ENST00000315330.4
 CLEC1A
 C-type lectin domain family 1, member A
chr5_-_141338627 0.81 ENST00000231484.3
 PCDH12
 protocadherin 12
chr7_-_11871815 0.66 ENST00000423059.4
 THSD7A
 thrombospondin, type I, domain containing 7A
chr12_-_10251539 0.61 ENST00000420265.2
 CLEC1A
 C-type lectin domain family 1, member A
chr17_+_67498538 0.54 ENST00000589647.1
 MAP2K6
 mitogen-activated protein kinase kinase 6
chr11_-_75236867 0.53 ENST00000376282.3
ENST00000336898.3
 GDPD5
 glycerophosphodiester phosphodiesterase domain containing 5
chr20_-_45981138 0.44 ENST00000446994.2
 ZMYND8
 zinc finger, MYND-type containing 8
chr11_-_102323489 0.40 ENST00000361236.3
 TMEM123
 transmembrane protein 123
chr11_-_102323740 0.37 ENST00000398136.2
 TMEM123
 transmembrane protein 123
chr11_+_125365110 0.35 ENST00000527818.1
 AP000708.1
 AP000708.1
chr1_+_244998602 0.35 ENST00000411948.2
 COX20
 COX20 cytochrome C oxidase assembly factor
chr17_+_47448102 0.34 ENST00000576461.1
 RP11-81K2.1
 Uncharacterized protein
chr4_+_113152978 0.33 ENST00000309703.6
 AP1AR
 adaptor-related protein complex 1 associated regulatory protein
chr1_+_93913713 0.33 ENST00000604705.1
ENST00000370253.2
 FNBP1L
 formin binding protein 1-like
chrY_+_15016013 0.32 ENST00000360160.4
ENST00000454054.1
 DDX3Y
 DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr8_-_141810634 0.31 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
 PTK2
 protein tyrosine kinase 2
chrX_-_15872914 0.31 ENST00000380291.1
ENST00000545766.1
ENST00000421527.2
ENST00000329235.2
 AP1S2
 adaptor-related protein complex 1, sigma 2 subunit
chr2_+_143635067 0.25 ENST00000264170.4
 KYNU
 kynureninase
chr3_-_8686479 0.25 ENST00000544814.1
ENST00000427408.1
 SSUH2
 ssu-2 homolog (C. elegans)
chr2_+_232573222 0.24 ENST00000341369.7
ENST00000409683.1
 PTMA
 prothymosin, alpha
chr2_+_232573208 0.23 ENST00000409115.3
 PTMA
 prothymosin, alpha
chr2_-_169769787 0.21 ENST00000451987.1
 SPC25
 SPC25, NDC80 kinetochore complex component
chr10_+_35484793 0.21 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
 CREM
 cAMP responsive element modulator
chr9_+_103235365 0.20 ENST00000374879.4
 TMEFF1
 transmembrane protein with EGF-like and two follistatin-like domains 1
chr1_+_74701062 0.20 ENST00000326637.3
 TNNI3K
 TNNI3 interacting kinase
chr10_+_70480963 0.19 ENST00000265872.6
ENST00000535016.1
ENST00000538031.1
ENST00000543719.1
ENST00000539539.1
ENST00000543225.1
ENST00000536012.1
ENST00000494903.2
 CCAR1
 cell division cycle and apoptosis regulator 1
chr2_+_86669118 0.17 ENST00000427678.1
ENST00000542128.1
 KDM3A
 lysine (K)-specific demethylase 3A
chr8_-_82024290 0.17 ENST00000220597.4
 PAG1
 phosphoprotein associated with glycosphingolipid microdomains 1
chr6_+_22146851 0.16 ENST00000606197.1
 CASC15
 cancer susceptibility candidate 15 (non-protein coding)
chr13_-_41593425 0.15 ENST00000239882.3
 ELF1
 E74-like factor 1 (ets domain transcription factor)
chr1_-_243418344 0.15 ENST00000366542.1
 CEP170
 centrosomal protein 170kDa
chr22_-_43485381 0.15 ENST00000331018.7
ENST00000266254.7
ENST00000445824.1
 TTLL1
 tubulin tyrosine ligase-like family, member 1
chr7_+_100770328 0.15 ENST00000223095.4
ENST00000445463.2
 SERPINE1
 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr22_-_30970560 0.13 ENST00000402369.1
ENST00000406361.1
 GAL3ST1
 galactose-3-O-sulfotransferase 1
chr6_-_89927151 0.13 ENST00000454853.2
 GABRR1
 gamma-aminobutyric acid (GABA) A receptor, rho 1
chr1_+_185014496 0.12 ENST00000367510.3
 RNF2
 ring finger protein 2
chr1_-_243418621 0.12 ENST00000366544.1
ENST00000366543.1
 CEP170
 centrosomal protein 170kDa
chr10_+_35416090 0.12 ENST00000354759.3
 CREM
 cAMP responsive element modulator
chr1_-_156828810 0.11 ENST00000368195.3
 INSRR
 insulin receptor-related receptor
chr10_+_35415719 0.11 ENST00000474362.1
ENST00000374721.3
 CREM
 cAMP responsive element modulator
chr5_+_66254698 0.10 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
 MAST4
 microtubule associated serine/threonine kinase family member 4
chr2_-_157198860 0.10 ENST00000409572.1
 NR4A2
 nuclear receptor subfamily 4, group A, member 2
chr4_-_70725856 0.09 ENST00000226444.3
 SULT1E1
 sulfotransferase family 1E, estrogen-preferring, member 1
chr4_-_87028478 0.08 ENST00000515400.1
ENST00000395157.3
 MAPK10
 mitogen-activated protein kinase 10
chr17_-_10372875 0.06 ENST00000255381.2
 MYH4
 myosin, heavy chain 4, skeletal muscle
chr16_+_87636474 0.06 ENST00000284262.2
 JPH3
 junctophilin 3
chr5_-_160279207 0.06 ENST00000327245.5
 ATP10B
 ATPase, class V, type 10B
chr1_+_180897269 0.06 ENST00000367587.1
 KIAA1614
 KIAA1614
chrX_+_41192595 0.06 ENST00000399959.2
 DDX3X
 DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr10_+_35415978 0.05 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
 CREM
 cAMP responsive element modulator
chr5_+_170288856 0.05 ENST00000523189.1
 RANBP17
 RAN binding protein 17
chr11_-_102576537 0.05 ENST00000260229.4
 MMP27
 matrix metallopeptidase 27
chr12_-_10282742 0.05 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
 CLEC7A
 C-type lectin domain family 7, member A
chr10_+_35416223 0.05 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
 CREM
 cAMP responsive element modulator
chr12_-_11422739 0.05 ENST00000279573.7
 PRB3
 proline-rich protein BstNI subfamily 3
chr12_-_11036844 0.04 ENST00000428168.2
 PRH1
 proline-rich protein HaeIII subfamily 1
chr1_-_167883327 0.04 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
 ADCY10
 adenylate cyclase 10 (soluble)
chr14_-_90421028 0.04 ENST00000267544.9
ENST00000316738.7
ENST00000538485.2
ENST00000556609.1
 EFCAB11
 EF-hand calcium binding domain 11
chr1_+_228337553 0.03 ENST00000366714.2
 GJC2
 gap junction protein, gamma 2, 47kDa
chr18_+_32455201 0.03 ENST00000590831.2
 DTNA
 dystrobrevin, alpha
chr11_+_63137251 0.03 ENST00000310969.4
ENST00000279178.3
 SLC22A9
 solute carrier family 22 (organic anion transporter), member 9
chr14_+_101299520 0.02 ENST00000455531.1
 MEG3
 maternally expressed 3 (non-protein coding)
chr2_+_27719697 0.02 ENST00000264717.2
ENST00000424318.2
 GCKR
 glucokinase (hexokinase 4) regulator
chr3_-_167191814 0.01 ENST00000466903.1
ENST00000264677.4
 SERPINI2
 serpin peptidase inhibitor, clade I (pancpin), member 2
chr14_+_52456327 0.01 ENST00000556760.1
 C14orf166
 chromosome 14 open reading frame 166
chr6_+_126240442 0.00 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
 NCOA7
 nuclear receptor coactivator 7
chr14_-_90420862 0.00 ENST00000556005.1
ENST00000555872.1
 EFCAB11
 EF-hand calcium binding domain 11
chr12_-_11422630 0.00 ENST00000381842.3
ENST00000538488.1
 PRB3
 proline-rich protein BstNI subfamily 3
chr1_+_154401791 0.00 ENST00000476006.1
 IL6R
 interleukin 6 receptor

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 1.3 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.7 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.4 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 2.3 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 1.4 GO:0019826 oxygen sensor activity(GO:0019826)
0.1 0.5 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 0.3 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.3 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0070740 tubulin-glutamic acid ligase activity(GO:0070740)
0.0 0.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.6 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.2 GO:0031013 troponin I binding(GO:0031013)
0.0 0.1 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.0 0.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 1.4 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.2 0.5 GO:0072709 cellular response to sorbitol(GO:0072709)
0.2 1.0 GO:0030421 defecation(GO:0030421)
0.1 0.3 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.3 GO:0097052 tryptophan catabolic process to acetyl-CoA(GO:0019442) L-kynurenine metabolic process(GO:0097052)
0.1 1.7 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.4 GO:1903758 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 0.2 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 0.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.5 GO:0048505 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0 0.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
0.0 1.4 GO:0050667 homocysteine metabolic process(GO:0050667)
0.0 0.1 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0 0.3 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.0 0.1 GO:0006711 estrogen catabolic process(GO:0006711)
0.0 0.3 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.1 GO:0018095 protein polyglutamylation(GO:0018095)
0.0 0.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.1 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 0.1 GO:0042256 mature ribosome assembly(GO:0042256)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.3 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 1.4 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:0030314 junctional membrane complex(GO:0030314)