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ENCODE cell lines, expression (Ernst 2011)

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Results for SOX4

Z-value: 1.50

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Transcription factors associated with SOX4

Gene Symbol Gene ID Gene Info
SOX4
ENSG00000124766.4 SOX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX4hg19_v2_chr6_+_21593972_215940710.467.0e-02Click!

Activity profile of SOX4 motif

Sorted Z-values of SOX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_1748214 6.87 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
 PXDN
 peroxidasin homolog (Drosophila)
chr13_-_110959478 6.19 ENST00000543140.1
ENST00000375820.4
 COL4A1
 collagen, type IV, alpha 1
chr5_-_39425222 4.65 ENST00000320816.6
 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr10_+_17272608 4.59 ENST00000421459.2
 VIM
 vimentin
chr5_-_39425290 4.54 ENST00000545653.1
 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chrX_+_12993336 4.11 ENST00000380635.1
 TMSB4X
 thymosin beta 4, X-linked
chr5_-_39425068 4.05 ENST00000515700.1
ENST00000339788.6
 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr2_+_33172221 3.86 ENST00000354476.3
 LTBP1
 latent transforming growth factor beta binding protein 1
chrX_+_12993202 3.67 ENST00000451311.2
ENST00000380636.1
 TMSB4X
 thymosin beta 4, X-linked
chr7_+_134551583 3.54 ENST00000435928.1
 CALD1
 caldesmon 1
chr3_+_159570722 3.47 ENST00000482804.1
 SCHIP1
 schwannomin interacting protein 1
chr9_-_16727978 2.93 ENST00000418777.1
ENST00000468187.2
 BNC2
 basonuclin 2
chr8_+_79428539 2.84 ENST00000352966.5
 PKIA
 protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr7_-_131241361 2.63 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
 PODXL
 podocalyxin-like
chr2_-_37899323 2.50 ENST00000295324.3
ENST00000457889.1
 CDC42EP3
 CDC42 effector protein (Rho GTPase binding) 3
chr2_+_33172012 2.45 ENST00000404816.2
 LTBP1
 latent transforming growth factor beta binding protein 1
chr6_+_139456226 2.42 ENST00000367658.2
 HECA
 headcase homolog (Drosophila)
chr12_-_10251576 2.34 ENST00000315330.4
 CLEC1A
 C-type lectin domain family 1, member A
chr15_+_63335899 2.34 ENST00000561266.1
 TPM1
 tropomyosin 1 (alpha)
chr10_+_11206925 2.32 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
 CELF2
 CUGBP, Elav-like family member 2
chr12_-_10251603 2.21 ENST00000457018.2
 CLEC1A
 C-type lectin domain family 1, member A
chr10_+_11047259 2.18 ENST00000379261.4
ENST00000416382.2
 CELF2
 CUGBP, Elav-like family member 2
chr10_+_11207438 2.09 ENST00000609692.1
ENST00000354897.3
 CELF2
 CUGBP, Elav-like family member 2
chr5_+_140739537 2.08 ENST00000522605.1
 PCDHGB2
 protocadherin gamma subfamily B, 2
chr5_+_102201509 2.06 ENST00000348126.2
ENST00000379787.4
 PAM
 peptidylglycine alpha-amidating monooxygenase
chr12_-_10251539 2.03 ENST00000420265.2
 CLEC1A
 C-type lectin domain family 1, member A
chr2_-_106015527 1.89 ENST00000344213.4
ENST00000358129.4
 FHL2
 four and a half LIM domains 2
chr18_+_56530794 1.81 ENST00000590285.1
ENST00000586085.1
ENST00000589288.1
 ZNF532
 zinc finger protein 532
chr9_-_14313641 1.75 ENST00000380953.1
 NFIB
 nuclear factor I/B
chr9_-_14313893 1.74 ENST00000380921.3
ENST00000380959.3
 NFIB
 nuclear factor I/B
chr7_+_134464414 1.72 ENST00000361901.2
 CALD1
 caldesmon 1
chr8_-_6420930 1.72 ENST00000325203.5
 ANGPT2
 angiopoietin 2
chr8_-_6420777 1.69 ENST00000415216.1
 ANGPT2
 angiopoietin 2
chr13_-_24007815 1.66 ENST00000382298.3
 SACS
 spastic ataxia of Charlevoix-Saguenay (sacsin)
chr5_+_102201430 1.59 ENST00000438793.3
ENST00000346918.2
 PAM
 peptidylglycine alpha-amidating monooxygenase
chr11_-_10830463 1.57 ENST00000527419.1
ENST00000530211.1
ENST00000530702.1
ENST00000524932.1
ENST00000532570.1
 EIF4G2
 eukaryotic translation initiation factor 4 gamma, 2
chr7_+_134464376 1.56 ENST00000454108.1
ENST00000361675.2
 CALD1
 caldesmon 1
chr7_-_27219849 1.55 ENST00000396344.4
 HOXA10
 homeobox A10
chr11_-_10829851 1.55 ENST00000532082.1
 EIF4G2
 eukaryotic translation initiation factor 4 gamma, 2
chr5_+_140749803 1.51 ENST00000576222.1
 PCDHGB3
 protocadherin gamma subfamily B, 3
chr8_+_9911778 1.41 ENST00000317173.4
ENST00000441698.2
 MSRA
 methionine sulfoxide reductase A
chr20_-_56284816 1.39 ENST00000395819.3
ENST00000341744.3
 PMEPA1
 prostate transmembrane protein, androgen induced 1
chr7_-_107643674 1.33 ENST00000222399.6
 LAMB1
 laminin, beta 1
chr2_-_85641162 1.33 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
 CAPG
 capping protein (actin filament), gelsolin-like
chr1_-_243418621 1.31 ENST00000366544.1
ENST00000366543.1
 CEP170
 centrosomal protein 170kDa
chr11_-_6677018 1.23 ENST00000299441.3
 DCHS1
 dachsous cadherin-related 1
chr1_+_81771806 1.19 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
 LPHN2
 latrophilin 2
chr1_-_243418344 1.16 ENST00000366542.1
 CEP170
 centrosomal protein 170kDa
chr11_-_64013663 1.13 ENST00000392210.2
 PPP1R14B
 protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_155880672 1.07 ENST00000609492.1
ENST00000368322.3
 RIT1
 Ras-like without CAAX 1
chr8_-_6420565 1.07 ENST00000338312.6
 ANGPT2
 angiopoietin 2
chr5_-_111091948 1.05 ENST00000447165.2
 NREP
 neuronal regeneration related protein
chr5_-_146833222 1.02 ENST00000534907.1
 DPYSL3
 dihydropyrimidinase-like 3
chr4_+_78078304 1.02 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
 CCNG2
 cyclin G2
chr20_-_4804244 0.98 ENST00000379400.3
 RASSF2
 Ras association (RalGDS/AF-6) domain family member 2
chr1_+_66458072 0.93 ENST00000423207.2
 PDE4B
 phosphodiesterase 4B, cAMP-specific
chr5_+_162930114 0.93 ENST00000280969.5
 MAT2B
 methionine adenosyltransferase II, beta
chr4_+_78079570 0.89 ENST00000509972.1
 CCNG2
 cyclin G2
chr7_-_150946015 0.89 ENST00000262188.8
 SMARCD3
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
chr1_-_203151933 0.88 ENST00000404436.2
 CHI3L1
 chitinase 3-like 1 (cartilage glycoprotein-39)
chr10_+_6244829 0.83 ENST00000317350.4
ENST00000379785.1
ENST00000379782.3
ENST00000360521.2
ENST00000379775.4
 PFKFB3
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
chr7_-_42276612 0.82 ENST00000395925.3
ENST00000437480.1
 GLI3
 GLI family zinc finger 3
chr5_+_140767452 0.79 ENST00000519479.1
 PCDHGB4
 protocadherin gamma subfamily B, 4
chr2_-_9143786 0.77 ENST00000462696.1
ENST00000305997.3
 MBOAT2
 membrane bound O-acyltransferase domain containing 2
chr22_-_36357671 0.77 ENST00000408983.2
 RBFOX2
 RNA binding protein, fox-1 homolog (C. elegans) 2
chr4_+_78079450 0.77 ENST00000395640.1
ENST00000512918.1
 CCNG2
 cyclin G2
chr12_+_93963590 0.77 ENST00000340600.2
 SOCS2
 suppressor of cytokine signaling 2
chr12_+_69004619 0.77 ENST00000250559.9
ENST00000393436.5
ENST00000425247.2
ENST00000489473.2
ENST00000422358.2
ENST00000541167.1
ENST00000538283.1
ENST00000341355.5
ENST00000537460.1
ENST00000450214.2
ENST00000545270.1
ENST00000538980.1
ENST00000542018.1
ENST00000543393.1
 RAP1B
 RAP1B, member of RAS oncogene family
chr7_+_23146271 0.76 ENST00000545771.1
 KLHL7
 kelch-like family member 7
chr1_+_156052354 0.75 ENST00000368301.2
 LMNA
 lamin A/C
chr2_+_172543967 0.75 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
 DYNC1I2
 dynein, cytoplasmic 1, intermediate chain 2
chr4_-_159080806 0.75 ENST00000590648.1
 FAM198B
 family with sequence similarity 198, member B
chr8_-_6420759 0.73 ENST00000523120.1
 ANGPT2
 angiopoietin 2
chr2_+_172543919 0.72 ENST00000452242.1
ENST00000340296.4
 DYNC1I2
 dynein, cytoplasmic 1, intermediate chain 2
chr22_+_31477296 0.71 ENST00000426927.1
ENST00000440425.1
ENST00000358743.1
ENST00000347557.2
ENST00000333137.7
 SMTN
 smoothelin
chr1_+_150039369 0.69 ENST00000369130.3
ENST00000369128.5
 VPS45
 vacuolar protein sorting 45 homolog (S. cerevisiae)
chr10_+_22605304 0.65 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
 COMMD3-BMI1
COMMD3
 COMMD3-BMI1 readthrough
COMM domain containing 3
chr2_+_172544294 0.63 ENST00000358002.6
ENST00000435234.1
ENST00000443458.1
ENST00000412370.1
 DYNC1I2
 dynein, cytoplasmic 1, intermediate chain 2
chr8_-_95908902 0.63 ENST00000520509.1
 CCNE2
 cyclin E2
chr5_-_141338627 0.62 ENST00000231484.3
 PCDH12
 protocadherin 12
chr14_+_101299520 0.60 ENST00000455531.1
 MEG3
 maternally expressed 3 (non-protein coding)
chr12_-_49582593 0.59 ENST00000295766.5
 TUBA1A
 tubulin, alpha 1a
chr10_+_22605374 0.59 ENST00000448361.1
 COMMD3
 COMM domain containing 3
chr15_+_25200108 0.57 ENST00000577949.1
ENST00000338094.6
ENST00000338327.4
ENST00000579070.1
ENST00000577565.1
 SNURF
SNRPN
 SNRPN upstream reading frame protein
small nuclear ribonucleoprotein polypeptide N
chr3_-_99833333 0.57 ENST00000354552.3
ENST00000331335.5
ENST00000398326.2
 FILIP1L
 filamin A interacting protein 1-like
chr7_+_99699280 0.56 ENST00000421755.1
 AP4M1
 adaptor-related protein complex 4, mu 1 subunit
chr8_+_79578282 0.54 ENST00000263849.4
 ZC2HC1A
 zinc finger, C2HC-type containing 1A
chr17_+_25621102 0.54 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
 WSB1
 WD repeat and SOCS box containing 1
chr1_-_26233423 0.53 ENST00000357865.2
 STMN1
 stathmin 1
chr14_+_69658194 0.53 ENST00000409018.3
ENST00000409014.1
ENST00000409675.1
 EXD2
 exonuclease 3'-5' domain containing 2
chr7_+_99699179 0.53 ENST00000438383.1
ENST00000429084.1
ENST00000359593.4
ENST00000439416.1
 AP4M1
 adaptor-related protein complex 4, mu 1 subunit
chr9_+_91003271 0.53 ENST00000375859.3
ENST00000541629.1
 SPIN1
 spindlin 1
chr9_+_101705893 0.51 ENST00000375001.3
 COL15A1
 collagen, type XV, alpha 1
chr1_+_25664408 0.51 ENST00000374358.4
 TMEM50A
 transmembrane protein 50A
chr15_+_25200074 0.51 ENST00000390687.4
ENST00000584968.1
ENST00000346403.6
ENST00000554227.2
 SNRPN
 small nuclear ribonucleoprotein polypeptide N
chr14_-_57960545 0.49 ENST00000526336.1
ENST00000216445.3
 C14orf105
 chromosome 14 open reading frame 105
chr4_-_139163491 0.48 ENST00000280612.5
 SLC7A11
 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr16_+_6069072 0.47 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
 RBFOX1
 RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_+_64239657 0.46 ENST00000371080.1
ENST00000371079.1
 ROR1
 receptor tyrosine kinase-like orphan receptor 1
chr20_+_45338126 0.45 ENST00000359271.2
 SLC2A10
 solute carrier family 2 (facilitated glucose transporter), member 10
chr22_-_31688431 0.44 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
 PIK3IP1
 phosphoinositide-3-kinase interacting protein 1
chr20_-_39317868 0.44 ENST00000373313.2
 MAFB
 v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr9_+_77230499 0.43 ENST00000396204.2
 RORB
 RAR-related orphan receptor B
chr4_-_164534657 0.42 ENST00000339875.5
 MARCH1
 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr16_+_6069586 0.40 ENST00000547372.1
 RBFOX1
 RNA binding protein, fox-1 homolog (C. elegans) 1
chr17_+_57642886 0.39 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
 DHX40
 DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr9_-_74979420 0.39 ENST00000343431.2
ENST00000376956.3
 ZFAND5
 zinc finger, AN1-type domain 5
chr14_+_91580357 0.39 ENST00000298858.4
ENST00000521081.1
ENST00000520328.1
ENST00000256324.10
ENST00000524232.1
ENST00000522170.1
ENST00000519950.1
ENST00000523879.1
ENST00000521077.2
ENST00000518665.2
 C14orf159
 chromosome 14 open reading frame 159
chr1_+_109419596 0.37 ENST00000435987.1
ENST00000264126.3
 GPSM2
 G-protein signaling modulator 2
chr20_-_17511962 0.36 ENST00000377873.3
 BFSP1
 beaded filament structural protein 1, filensin
chr6_-_132834184 0.36 ENST00000367941.2
ENST00000367937.4
 STX7
 syntaxin 7
chr8_-_17579726 0.35 ENST00000381861.3
 MTUS1
 microtubule associated tumor suppressor 1
chr12_+_32260085 0.34 ENST00000548411.1
ENST00000281474.5
ENST00000551086.1
 BICD1
 bicaudal D homolog 1 (Drosophila)
chr14_+_50234827 0.33 ENST00000554589.1
ENST00000557247.1
 KLHDC2
 kelch domain containing 2
chr14_+_91580708 0.32 ENST00000518868.1
 C14orf159
 chromosome 14 open reading frame 159
chr5_-_135701164 0.31 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
 TRPC7
 transient receptor potential cation channel, subfamily C, member 7
chr11_-_61560053 0.30 ENST00000537328.1
 TMEM258
 transmembrane protein 258
chr14_+_91580732 0.29 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
 C14orf159
 chromosome 14 open reading frame 159
chr14_+_91580777 0.29 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
 C14orf159
 chromosome 14 open reading frame 159
chr9_+_124088860 0.27 ENST00000373806.1
 GSN
 gelsolin
chr14_+_52456193 0.25 ENST00000261700.3
 C14orf166
 chromosome 14 open reading frame 166
chr5_+_140579162 0.24 ENST00000536699.1
ENST00000354757.3
 PCDHB11
 protocadherin beta 11
chrX_-_153599578 0.24 ENST00000360319.4
ENST00000344736.4
 FLNA
 filamin A, alpha
chr14_+_52456327 0.24 ENST00000556760.1
 C14orf166
 chromosome 14 open reading frame 166
chr6_-_133055815 0.22 ENST00000509351.1
ENST00000417437.2
ENST00000414302.2
ENST00000423615.2
ENST00000427187.2
ENST00000275223.3
ENST00000519686.2
 VNN3
 vanin 3
chr22_-_31688381 0.21 ENST00000487265.2
 PIK3IP1
 phosphoinositide-3-kinase interacting protein 1
chrX_+_65384052 0.21 ENST00000336279.5
ENST00000458621.1
 HEPH
 hephaestin
chr22_+_27017921 0.20 ENST00000354760.3
 CRYBA4
 crystallin, beta A4
chr14_+_91581011 0.17 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
 C14orf159
 chromosome 14 open reading frame 159
chr19_+_58095501 0.17 ENST00000536878.2
ENST00000597850.1
ENST00000597219.1
ENST00000598689.1
ENST00000599456.1
ENST00000307468.4
 ZIK1
 zinc finger protein interacting with K protein 1
chr18_+_7946941 0.17 ENST00000444013.1
 PTPRM
 protein tyrosine phosphatase, receptor type, M
chr12_+_70760056 0.16 ENST00000258111.4
 KCNMB4
 potassium large conductance calcium-activated channel, subfamily M, beta member 4
chr1_+_68150744 0.13 ENST00000370986.4
ENST00000370985.3
 GADD45A
 growth arrest and DNA-damage-inducible, alpha
chr7_+_116312411 0.13 ENST00000456159.1
ENST00000397752.3
ENST00000318493.6
 MET
 met proto-oncogene
chr18_+_6729725 0.13 ENST00000400091.2
ENST00000583410.1
ENST00000584387.1
 ARHGAP28
 Rho GTPase activating protein 28
chr16_+_54964740 0.13 ENST00000394636.4
 IRX5
 iroquois homeobox 5
chr19_+_49128209 0.11 ENST00000599748.1
ENST00000443164.1
ENST00000599029.1
 SPHK2
 sphingosine kinase 2
chr5_-_41213607 0.09 ENST00000337836.5
ENST00000433294.1
 C6
 complement component 6
chr10_+_51187938 0.08 ENST00000311663.5
 FAM21D
 family with sequence similarity 21, member D
chr14_+_22962898 0.08 ENST00000390492.1
 TRAJ45
 T cell receptor alpha joining 45
chr2_+_208423840 0.07 ENST00000539789.1
 CREB1
 cAMP responsive element binding protein 1
chr10_-_99052382 0.07 ENST00000453547.2
ENST00000316676.8
ENST00000358308.3
ENST00000466484.1
ENST00000358531.4
 ARHGAP19-SLIT1
ARHGAP19
 ARHGAP19-SLIT1 readthrough (NMD candidate)
Rho GTPase activating protein 19
chr2_-_136594740 0.06 ENST00000264162.2
 LCT
 lactase
chr14_-_61124977 0.06 ENST00000554986.1
 SIX1
 SIX homeobox 1
chr3_-_197025447 0.05 ENST00000346964.2
ENST00000357674.4
ENST00000314062.3
ENST00000448528.2
ENST00000419553.1
 DLG1
 discs, large homolog 1 (Drosophila)
chr4_-_106629796 0.04 ENST00000416543.1
ENST00000515819.1
ENST00000420368.2
ENST00000503746.1
ENST00000340139.5
ENST00000433009.1
 INTS12
 integrator complex subunit 12
chr1_+_28261621 0.03 ENST00000549094.1
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chr2_+_208423891 0.02 ENST00000448277.1
ENST00000457101.1
 CREB1
 cAMP responsive element binding protein 1
chr12_-_99288536 0.01 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
 ANKS1B
 ankyrin repeat and sterile alpha motif domain containing 1B
chrX_+_65384182 0.01 ENST00000441993.2
ENST00000419594.1
 HEPH
 hephaestin
chr6_+_43265992 0.01 ENST00000449231.1
ENST00000372589.3
ENST00000372585.5
 SLC22A7
 solute carrier family 22 (organic anion transporter), member 7
chr18_+_3449821 0.01 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
 TGIF1
 TGFB-induced factor homeobox 1
chr1_-_167883353 0.00 ENST00000545172.1
 ADCY10
 adenylate cyclase 10 (soluble)
chr13_+_111855414 0.00 ENST00000375737.5
 ARHGEF7
 Rho guanine nucleotide exchange factor (GEF) 7

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 13.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.8 6.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.5 7.1 GO:0030478 actin cap(GO:0030478)
0.4 1.3 GO:0005607 laminin-2 complex(GO:0005607)
0.3 2.6 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.3 0.9 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
0.3 3.5 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 6.3 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.3 0.5 GO:0098651 basement membrane collagen trimer(GO:0098651)
0.2 1.7 GO:0070852 cell body fiber(GO:0070852)
0.2 1.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.2 0.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.1 3.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 2.3 GO:0032059 bleb(GO:0032059)
0.1 1.3 GO:0090543 Flemming body(GO:0090543)
0.1 0.2 GO:0031523 Myb complex(GO:0031523)
0.1 2.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.5 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 0.3 GO:0045298 host cell cytoplasm(GO:0030430) host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648) host cell cytoplasm part(GO:0033655) tubulin complex(GO:0045298)
0.1 7.8 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.1 GO:0005687 U4 snRNP(GO:0005687)
0.0 1.9 GO:0031430 M band(GO:0031430)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 4.7 GO:0005882 intermediate filament(GO:0005882)
0.0 0.9 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.8 GO:0097542 ciliary tip(GO:0097542)
0.0 0.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 2.5 GO:0005814 centriole(GO:0005814)
0.0 3.6 GO:0043204 perikaryon(GO:0043204)
0.0 1.0 GO:0031941 filamentous actin(GO:0031941)
0.0 5.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.8 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.1 GO:0005579 membrane attack complex(GO:0005579)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 13.2 GO:0035026 leading edge cell differentiation(GO:0035026)
1.5 6.2 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
1.3 5.2 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
1.1 7.8 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.9 3.6 GO:0031179 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.7 6.3 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.7 2.6 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.5 3.5 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 4.6 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.4 1.2 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.4 1.9 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.3 1.3 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.3 2.3 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.3 0.8 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.2 0.9 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
0.2 0.7 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.2 2.5 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.2 2.1 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.2 0.9 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.2 2.8 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 6.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 0.7 GO:0070494 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.2 1.4 GO:0030091 protein repair(GO:0030091)
0.2 0.8 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 0.4 GO:0035283 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.1 5.1 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.1 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.1 0.8 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 1.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 1.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.1 1.0 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 0.4 GO:0031291 Ran protein signal transduction(GO:0031291)
0.1 2.9 GO:0003416 endochondral bone growth(GO:0003416)
0.1 0.9 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.1 0.9 GO:1901898 negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.4 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 0.3 GO:0010519 negative regulation of phospholipase activity(GO:0010519) minus-end-directed organelle transport along microtubule(GO:0072385)
0.1 1.3 GO:0051764 actin crosslink formation(GO:0051764)
0.1 1.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.3 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.1 1.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 0.4 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.0 1.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 1.1 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.8 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.5 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.8 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 3.1 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 0.1 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0 0.1 GO:2000729 positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.0 0.1 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.4 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.8 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.5 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.0 0.2 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.9 GO:0006536 glutamate metabolic process(GO:0006536)
0.0 0.5 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.6 GO:0007129 synapsis(GO:0007129)
0.0 2.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0 0.1 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.3 GO:0006828 manganese ion transport(GO:0006828)
0.0 0.5 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.1 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.4 GO:0003016 respiratory system process(GO:0003016)
0.0 6.4 GO:0006936 muscle contraction(GO:0006936)
0.0 0.5 GO:0014002 astrocyte development(GO:0014002)
0.0 0.7 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.2 GO:0005513 detection of calcium ion(GO:0005513)
0.0 0.2 GO:0006826 iron ion transport(GO:0006826)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 13.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 9.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 4.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 3.5 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.1 6.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1 7.8 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.1 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.0 1.0 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.8 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 3.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 2.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 0.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 0.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.5 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 1.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 6.9 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
1.3 6.3 GO:0050436 microfibril binding(GO:0050436)
0.9 3.6 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.8 6.2 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.8 4.6 GO:1990254 keratin filament binding(GO:1990254)
0.6 13.2 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 1.5 GO:0047820 D-glutamate cyclase activity(GO:0047820)
0.3 1.4 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.2 6.8 GO:0005523 tropomyosin binding(GO:0005523)
0.2 7.8 GO:0003785 actin monomer binding(GO:0003785)
0.1 6.6 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 2.8 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.8 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.1 0.8 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 1.0 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.1 2.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 0.8 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.1 0.5 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.1 0.5 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.1 0.3 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.1 0.9 GO:0008061 chitinase activity(GO:0004568) chitin binding(GO:0008061)
0.1 1.7 GO:0070628 proteasome binding(GO:0070628)
0.1 0.5 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.1 0.2 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 4.6 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.3 GO:0045159 myosin II binding(GO:0045159)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 3.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.4 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.5 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 0.9 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 2.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.9 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.1 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 0.1 GO:0005499 vitamin D binding(GO:0005499)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.8 GO:0050699 WW domain binding(GO:0050699)
0.0 0.1 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 3.1 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.8 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.7 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 13.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 3.4 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 5.1 PID AURORA B PATHWAY Aurora B signaling
0.1 13.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 2.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.9 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 3.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 1.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.6 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.3 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.4 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.