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ENCODE cell lines, expression (Ernst 2011)

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Results for SREBF2

Z-value: 1.19

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 SREBF2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_422291460.078.0e-01Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr6_+_151561085 5.65 ENST00000402676.2
 AKAP12
 A kinase (PRKA) anchor protein 12
chr2_-_56150184 5.15 ENST00000394554.1
 EFEMP1
 EGF containing fibulin-like extracellular matrix protein 1
chr8_+_26435359 4.77 ENST00000311151.5
 DPYSL2
 dihydropyrimidinase-like 2
chr5_-_149535421 2.66 ENST00000261799.4
 PDGFRB
 platelet-derived growth factor receptor, beta polypeptide
chr8_-_17579726 2.60 ENST00000381861.3
 MTUS1
 microtubule associated tumor suppressor 1
chr14_-_74960030 2.51 ENST00000553490.1
ENST00000557510.1
 NPC2
 Niemann-Pick disease, type C2
chr14_-_74959978 2.51 ENST00000541064.1
 NPC2
 Niemann-Pick disease, type C2
chr14_-_74959994 2.39 ENST00000238633.2
ENST00000434013.2
 NPC2
 Niemann-Pick disease, type C2
chr9_-_99381660 2.31 ENST00000375240.3
ENST00000463569.1
 CDC14B
 cell division cycle 14B
chr5_-_39425068 2.14 ENST00000515700.1
ENST00000339788.6
 DAB2
 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr6_-_52860171 2.12 ENST00000370963.4
 GSTA4
 glutathione S-transferase alpha 4
chr12_-_91505608 1.98 ENST00000266718.4
 LUM
 lumican
chr15_+_33010175 1.89 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
 GREM1
 gremlin 1, DAN family BMP antagonist
chr10_-_3827417 1.73 ENST00000497571.1
ENST00000542957.1
 KLF6
 Kruppel-like factor 6
chr17_-_15168624 1.57 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
 PMP22
 peripheral myelin protein 22
chr16_+_8736232 1.49 ENST00000562973.1
 METTL22
 methyltransferase like 22
chr10_-_74856608 1.15 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
 P4HA1
 prolyl 4-hydroxylase, alpha polypeptide I
chr11_+_2923499 1.07 ENST00000449793.2
 SLC22A18
 solute carrier family 22, member 18
chr11_+_2923423 1.05 ENST00000312221.5
 SLC22A18
 solute carrier family 22, member 18
chr2_-_26205340 1.03 ENST00000264712.3
 KIF3C
 kinesin family member 3C
chrX_-_153236819 0.99 ENST00000354233.3
 HCFC1
 host cell factor C1 (VP16-accessory protein)
chr11_+_2923619 0.92 ENST00000380574.1
 SLC22A18
 solute carrier family 22, member 18
chr3_-_98620500 0.86 ENST00000326840.6
 DCBLD2
 discoidin, CUB and LCCL domain containing 2
chr6_-_52859968 0.85 ENST00000370959.1
 GSTA4
 glutathione S-transferase alpha 4
chrX_-_153236620 0.83 ENST00000369984.4
 HCFC1
 host cell factor C1 (VP16-accessory protein)
chr1_+_39796810 0.74 ENST00000289893.4
 MACF1
 microtubule-actin crosslinking factor 1
chr16_+_66914264 0.68 ENST00000311765.2
ENST00000568869.1
ENST00000561704.1
ENST00000568398.1
ENST00000566776.1
 PDP2
 pyruvate dehyrogenase phosphatase catalytic subunit 2
chr18_-_21166841 0.65 ENST00000269228.5
 NPC1
 Niemann-Pick disease, type C1
chrX_-_153237258 0.63 ENST00000310441.7
 HCFC1
 host cell factor C1 (VP16-accessory protein)
chr12_-_48398104 0.60 ENST00000337299.6
ENST00000380518.3
 COL2A1
 collagen, type II, alpha 1
chr10_-_3827371 0.55 ENST00000469435.1
 KLF6
 Kruppel-like factor 6
chr15_-_73076030 0.52 ENST00000311669.8
 ADPGK
 ADP-dependent glucokinase
chr4_-_54930790 0.50 ENST00000263921.3
 CHIC2
 cysteine-rich hydrophobic domain 2
chr11_-_73309228 0.45 ENST00000356467.4
ENST00000064778.4
 FAM168A
 family with sequence similarity 168, member A
chr10_-_116444371 0.45 ENST00000533213.2
ENST00000369252.4
 ABLIM1
 actin binding LIM protein 1
chr8_+_104513086 0.42 ENST00000406091.3
 RIMS2
 regulating synaptic membrane exocytosis 2
chr19_+_36266417 0.35 ENST00000378944.5
ENST00000007510.4
 ARHGAP33
 Rho GTPase activating protein 33
chr19_+_36266433 0.32 ENST00000314737.5
 ARHGAP33
 Rho GTPase activating protein 33
chr19_+_55591743 0.27 ENST00000588359.1
ENST00000245618.5
 EPS8L1
 EPS8-like 1
chr5_+_137774706 0.26 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
 REEP2
 receptor accessory protein 2
chr3_-_171528227 0.23 ENST00000356327.5
ENST00000342215.6
ENST00000340989.4
ENST00000351298.4
 PLD1
 phospholipase D1, phosphatidylcholine-specific
chr19_-_18392422 0.19 ENST00000252818.3
 JUND
 jun D proto-oncogene
chr19_-_46285736 0.19 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
 DMPK
 dystrophia myotonica-protein kinase
chr7_-_44580861 0.17 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
 NPC1L1
 NPC1-like 1
chr17_-_56065484 0.15 ENST00000581208.1
 VEZF1
 vascular endothelial zinc finger 1
chrX_-_112084043 0.14 ENST00000304758.1
 AMOT
 angiomotin
chr19_-_46285646 0.13 ENST00000458663.2
 DMPK
 dystrophia myotonica-protein kinase
chr6_+_79577189 0.12 ENST00000369940.2
 IRAK1BP1
 interleukin-1 receptor-associated kinase 1 binding protein 1
chr19_+_11200038 0.11 ENST00000558518.1
ENST00000557933.1
ENST00000455727.2
ENST00000535915.1
ENST00000545707.1
ENST00000558013.1
 LDLR
 low density lipoprotein receptor
chr2_-_219925189 0.11 ENST00000295731.6
 IHH
 indian hedgehog
chr1_+_206643787 0.08 ENST00000367120.3
 IKBKE
 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr17_-_40075197 0.08 ENST00000590770.1
ENST00000590151.1
 ACLY
 ATP citrate lyase
chr17_-_40075219 0.08 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
 ACLY
 ATP citrate lyase
chr19_-_11308190 0.07 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
 KANK2
 KN motif and ankyrin repeat domains 2
chr2_+_27435734 0.04 ENST00000419744.1
 ATRAID
 all-trans retinoic acid-induced differentiation factor
chr13_+_24844819 0.04 ENST00000399949.2
 SPATA13
 spermatogenesis associated 13
chr1_-_155232221 0.03 ENST00000355379.3
 SCAMP3
 secretory carrier membrane protein 3

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.8 GO:0004157 dihydropyrimidinase activity(GO:0004157)
1.0 5.1 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.9 2.7 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.6 3.0 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.4 5.7 GO:0008179 adenylate cyclase binding(GO:0008179)
0.3 1.9 GO:0016015 morphogen activity(GO:0016015)
0.2 1.1 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.2 2.5 GO:0043996 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.1 8.1 GO:0015485 cholesterol binding(GO:0015485)
0.1 0.6 GO:0042289 MHC class II protein binding(GO:0042289)
0.1 0.7 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1 2.1 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1 3.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 2.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0 1.5 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.3 GO:0042608 T cell receptor binding(GO:0042608)
0.0 2.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 1.0 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 3.0 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 2.1 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.1 2.0 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 3.0 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.7 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.0 REACTOME KINESINS Genes involved in Kinesins
0.0 0.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 3.3 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 2.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.3 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.9 PID BMP PATHWAY BMP receptor signaling
0.0 2.1 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.6 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 5.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.6 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.0 0.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 7.4 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.9 2.7 GO:0060437 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) lung growth(GO:0060437) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.6 1.9 GO:1900158 negative regulation of osteoclast proliferation(GO:0090291) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.6 2.5 GO:0019046 release from viral latency(GO:0019046)
0.6 5.1 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.5 2.1 GO:0035026 leading edge cell differentiation(GO:0035026)
0.4 3.0 GO:0046618 drug export(GO:0046618)
0.4 5.7 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.2 2.0 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.2 2.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 1.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.1 0.3 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.1 3.0 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 0.6 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.1 1.6 GO:0032060 bleb assembly(GO:0032060)
0.1 0.6 GO:0060174 limb bud formation(GO:0060174)
0.0 0.4 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 5.5 GO:0030516 regulation of axon extension(GO:0030516)
0.0 0.7 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.1 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.0 0.3 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0 0.3 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.0 0.1 GO:0048073 regulation of eye pigmentation(GO:0048073)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.1 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.0 1.0 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.2 GO:0006085 acetyl-CoA biosynthetic process(GO:0006085)
0.0 2.3 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.1 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.0 0.5 GO:0061621 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.5 GO:0006893 Golgi to plasma membrane transport(GO:0006893)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.2 2.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.2 2.6 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 2.5 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.1 7.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 1.6 GO:0043218 compact myelin(GO:0043218)
0.0 1.0 GO:0097542 ciliary tip(GO:0097542)
0.0 0.2 GO:0035976 AP1 complex(GO:0035976)
0.0 2.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.7 GO:0043202 lysosomal lumen(GO:0043202)
0.0 7.8 GO:0005874 microtubule(GO:0005874)
0.0 6.3 GO:0005938 cell cortex(GO:0005938)
0.0 5.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)