ENCODE cell lines, expression (Ernst 2011)

• Motif significance table
• Sample table
• Mean activities
• All promoters sorted by FOV

• Activity table
• Activity delta table
• Regulatory interactions
• Motifs sorted by significance
• Download the whole report

Gene Symbol	Gene ID	Gene Info
SRF Links Ensembl NCBI GeneCards UniProt	ENSG00000112658.6	SRF

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SRF	hg19_v2_chr6_+_43139037_43139094	-0.23	3.9e-01	Click!

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Promoter	Score	Transcript	Gene	Gene Info
chr20_+_35169885	31.81	ENST00000279022.2 ENST00000346786.2	MYL9	myosin, light chain 9, regulatory
chr15_-_35088340	22.47	ENST00000290378.4	ACTC1	actin, alpha, cardiac muscle 1
chr9_-_35691017	17.27	ENST00000378292.3	TPM2	tropomyosin 2 (beta)
chr2_+_74120094	15.97	ENST00000409731.3 ENST00000345517.3 ENST00000409918.1 ENST00000442912.1 ENST00000409624.1	ACTG2	actin, gamma 2, smooth muscle, enteric
chr12_+_75874460	13.20	ENST00000266659.3	GLIPR1	GLI pathogenesis-related 1
chr1_-_86043921	13.20	ENST00000535924.2	DDAH1	dimethylarginine dimethylaminohydrolase 1
chr12_+_75874580	12.83	ENST00000456650.3	GLIPR1	GLI pathogenesis-related 1
chr6_+_151561506	12.32	ENST00000253332.1	AKAP12	A kinase (PRKA) anchor protein 12
chr6_+_151561085	12.27	ENST00000402676.2	AKAP12	A kinase (PRKA) anchor protein 12
chr11_+_117070037	10.35	ENST00000392951.4 ENST00000525531.1 ENST00000278968.6	TAGLN	transgelin
chr2_-_106054952	9.91	ENST00000336660.5 ENST00000393352.3 ENST00000607522.1	FHL2	four and a half LIM domains 2
chr3_-_123339418	9.49	ENST00000583087.1	MYLK	myosin light chain kinase
chr7_-_94285402	9.25	ENST00000428696.2 ENST00000445866.2	SGCE	sarcoglycan, epsilon
chr7_-_94285472	9.20	ENST00000437425.2 ENST00000447873.1 ENST00000415788.2	SGCE	sarcoglycan, epsilon
chr3_-_123339343	9.15	ENST00000578202.1	MYLK	myosin light chain kinase
chr7_-_94285511	8.97	ENST00000265735.7	SGCE	sarcoglycan, epsilon
chr10_-_90712520	8.87	ENST00000224784.6	ACTA2	actin, alpha 2, smooth muscle, aorta
chr2_-_106015527	8.49	ENST00000344213.4 ENST00000358129.4	FHL2	four and a half LIM domains 2
chr15_+_74218787	8.39	ENST00000261921.7	LOXL1	lysyl oxidase-like 1
chr2_-_106015491	8.38	ENST00000408995.1 ENST00000393353.3 ENST00000322142.8	FHL2	four and a half LIM domains 2
chr3_-_99594948	8.16	ENST00000471562.1 ENST00000495625.2	FILIP1L	filamin A interacting protein 1-like
chr3_-_99595037	8.12	ENST00000383694.2	FILIP1L	filamin A interacting protein 1-like
chr1_-_89531041	7.84	ENST00000370473.4	GBP1	guanylate binding protein 1, interferon-inducible
chr16_+_30383613	6.91	ENST00000568749.1	MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle
chr9_-_79520989	6.87	ENST00000376713.3 ENST00000376718.3 ENST00000428286.1	PRUNE2	prune homolog 2 (Drosophila)
chr9_+_124088860	6.76	ENST00000373806.1	GSN	gelsolin
chr1_-_229569834	6.62	ENST00000366684.3 ENST00000366683.2	ACTA1	actin, alpha 1, skeletal muscle
chr10_-_17659357	6.57	ENST00000326961.6 ENST00000361271.3	PTPLA	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr2_-_161264385	6.46	ENST00000409972.1	RBMS1	RNA binding motif, single stranded interacting protein 1
chr8_+_97597148	6.42	ENST00000521590.1	SDC2	syndecan 2
chr19_+_16178317	6.32	ENST00000344824.6 ENST00000538887.1	TPM4	tropomyosin 4
chr1_+_223889285	6.18	ENST00000433674.2	CAPN2	calpain 2, (m/II) large subunit
chr17_-_10560619	6.00	ENST00000583535.1	MYH3	myosin, heavy chain 3, skeletal muscle, embryonic
chr17_+_42634844	5.97	ENST00000315323.3	FZD2	frizzled family receptor 2
chr19_-_45826125	5.89	ENST00000221476.3	CKM	creatine kinase, muscle
chr7_-_107643674	5.38	ENST00000222399.6	LAMB1	laminin, beta 1
chr10_+_31610064	5.26	ENST00000446923.2 ENST00000559476.1	ZEB1	zinc finger E-box binding homeobox 1
chr5_-_111093167	5.22	ENST00000446294.2 ENST00000419114.2	NREP	neuronal regeneration related protein
chr3_-_52486841	5.17	ENST00000496590.1	TNNC1	troponin C type 1 (slow)
chr5_+_92919043	5.09	ENST00000327111.3	NR2F1	nuclear receptor subfamily 2, group F, member 1
chr3_+_187930719	4.63	ENST00000312675.4	LPP	LIM domain containing preferred translocation partner in lipoma
chr9_+_92219919	4.45	ENST00000252506.6 ENST00000375769.1	GADD45G	growth arrest and DNA-damage-inducible, gamma
chr3_+_49027308	4.43	ENST00000383729.4 ENST00000343546.4	P4HTM	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr10_+_123922941	4.43	ENST00000360561.3	TACC2	transforming, acidic coiled-coil containing protein 2
chr22_-_36784035	4.42	ENST00000216181.5	MYH9	myosin, heavy chain 9, non-muscle
chr19_+_2476116	4.39	ENST00000215631.4 ENST00000587345.1	GADD45B	growth arrest and DNA-damage-inducible, beta
chr5_+_40679584	4.27	ENST00000302472.3	PTGER4	prostaglandin E receptor 4 (subtype EP4)
chr17_-_46671323	4.22	ENST00000239151.5	HOXB5	homeobox B5
chr22_-_36357671	4.22	ENST00000408983.2	RBFOX2	RNA binding protein, fox-1 homolog (C. elegans) 2
chr14_+_74034310	4.16	ENST00000538782.1	ACOT2	acyl-CoA thioesterase 2
chr10_-_17659234	4.05	ENST00000466335.1	PTPLA	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr7_-_27183263	3.72	ENST00000222726.3	HOXA5	homeobox A5
chr15_+_83776324	3.71	ENST00000379390.6 ENST00000379386.4 ENST00000565774.1 ENST00000565982.1	TM6SF1	transmembrane 6 superfamily member 1
chr19_-_36247910	3.65	ENST00000587965.1 ENST00000004982.3	HSPB6	heat shock protein, alpha-crystallin-related, B6
chr16_+_56965960	3.50	ENST00000439977.2 ENST00000344114.4 ENST00000300302.5 ENST00000379792.2	HERPUD1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr7_+_143078652	3.40	ENST00000354434.4 ENST00000449423.2	ZYX	zyxin
chr11_-_65667997	3.37	ENST00000312562.2 ENST00000534222.1	FOSL1	FOS-like antigen 1
chr1_-_89591749	3.25	ENST00000370466.3	GBP2	guanylate binding protein 2, interferon-inducible
chr12_-_50616382	3.11	ENST00000552783.1	LIMA1	LIM domain and actin binding 1
chr2_-_231989808	3.07	ENST00000258400.3	HTR2B	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr14_+_75745477	3.01	ENST00000303562.4 ENST00000554617.1 ENST00000554212.1 ENST00000535987.1 ENST00000555242.1	FOS	FBJ murine osteosarcoma viral oncogene homolog
chr12_-_50616122	3.01	ENST00000552823.1 ENST00000552909.1	LIMA1	LIM domain and actin binding 1
chr11_-_65667884	3.00	ENST00000448083.2 ENST00000531493.1 ENST00000532401.1	FOSL1	FOS-like antigen 1
chr11_-_65626753	2.98	ENST00000526975.1 ENST00000531413.1	CFL1	cofilin 1 (non-muscle)
chr10_-_16859442	2.89	ENST00000602389.1 ENST00000345264.5	RSU1	Ras suppressor protein 1
chr10_-_16859361	2.84	ENST00000377921.3	RSU1	Ras suppressor protein 1
chr2_-_128432639	2.74	ENST00000545738.2 ENST00000355119.4 ENST00000409808.2	LIMS2	LIM and senescent cell antigen-like domains 2
chr10_+_75757863	2.55	ENST00000372755.3 ENST00000211998.4 ENST00000417648.2	VCL	vinculin
chr11_-_2162468	2.32	ENST00000434045.2	IGF2	insulin-like growth factor 2 (somatomedin A)
chr4_-_10118469	2.29	ENST00000499869.2	WDR1	WD repeat domain 1
chr5_-_142000883	2.29	ENST00000359370.6	FGF1	fibroblast growth factor 1 (acidic)
chr17_-_79481666	2.27	ENST00000575659.1	ACTG1	actin, gamma 1
chr4_-_10118573	2.25	ENST00000382452.2 ENST00000382451.2	WDR1	WD repeat domain 1
chr5_-_176923803	2.24	ENST00000506161.1	PDLIM7	PDZ and LIM domain 7 (enigma)
chr15_+_96873921	2.24	ENST00000394166.3	NR2F2	nuclear receptor subfamily 2, group F, member 2
chr5_-_176923846	2.23	ENST00000506537.1	PDLIM7	PDZ and LIM domain 7 (enigma)
chr18_+_54318566	2.11	ENST00000589935.1 ENST00000357574.3	WDR7	WD repeat domain 7
chr2_-_208031943	2.10	ENST00000421199.1 ENST00000457962.1	KLF7	Kruppel-like factor 7 (ubiquitous)
chrX_-_153602991	2.07	ENST00000369850.3 ENST00000422373.1	FLNA	filamin A, alpha
chr4_-_54930790	1.92	ENST00000263921.3	CHIC2	cysteine-rich hydrophobic domain 2
chr7_+_94285637	1.88	ENST00000482108.1 ENST00000488574.1	PEG10	paternally expressed 10
chr10_+_112257596	1.84	ENST00000369583.3	DUSP5	dual specificity phosphatase 5
chr1_+_28099683	1.80	ENST00000373943.4	STX12	syntaxin 12
chr18_+_54318616	1.79	ENST00000254442.3	WDR7	WD repeat domain 7
chr10_+_88428206	1.78	ENST00000429277.2 ENST00000458213.2 ENST00000352360.5	LDB3	LIM domain binding 3
chr11_-_65626797	1.77	ENST00000525451.2	CFL1	cofilin 1 (non-muscle)
chr2_+_191792376	1.72	ENST00000409428.1 ENST00000409215.1	GLS	glutaminase
chr19_+_1026566	1.61	ENST00000348419.3 ENST00000565096.2 ENST00000562958.2 ENST00000562075.2 ENST00000607102.1	CNN2	calponin 2
chr10_+_96162242	1.55	ENST00000225235.4	TBC1D12	TBC1 domain family, member 12
chr1_+_11994715	1.54	ENST00000449038.1 ENST00000376369.3 ENST00000429000.2 ENST00000196061.4	PLOD1	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr11_-_2162162	1.52	ENST00000381389.1	IGF2	insulin-like growth factor 2 (somatomedin A)
chr12_-_6772303	1.46	ENST00000396807.4 ENST00000446105.2 ENST00000341550.4	ING4	inhibitor of growth family, member 4
chr6_-_111804905	1.44	ENST00000358835.3 ENST00000435970.1	REV3L	REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr12_+_59989791	1.40	ENST00000552432.1	SLC16A7	solute carrier family 16 (monocarboxylate transporter), member 7
chr19_+_1026298	1.28	ENST00000263097.4	CNN2	calponin 2
chr3_+_149192475	1.24	ENST00000465758.1	TM4SF4	transmembrane 4 L six family member 4
chr17_-_79479789	1.03	ENST00000571691.1 ENST00000571721.1 ENST00000573283.1 ENST00000575842.1 ENST00000575087.1 ENST00000570382.1 ENST00000331925.2	ACTG1	actin, gamma 1
chr7_-_5570229	0.89	ENST00000331789.5	ACTB	actin, beta
chr18_-_54318353	0.88	ENST00000590954.1 ENST00000540155.1	TXNL1	thioredoxin-like 1
chr19_-_15344243	0.85	ENST00000602233.1	EPHX3	epoxide hydrolase 3
chr19_+_13135386	0.83	ENST00000360105.4 ENST00000588228.1 ENST00000591028.1	NFIX	nuclear factor I/X (CCAAT-binding transcription factor)
chr17_-_4890919	0.81	ENST00000572543.1 ENST00000381311.5 ENST00000348066.3 ENST00000358183.4	CAMTA2	calmodulin binding transcription activator 2
chr13_+_27825706	0.81	ENST00000272274.4 ENST00000319826.4 ENST00000326092.4	RPL21	ribosomal protein L21
chr17_-_4890649	0.75	ENST00000361571.5	CAMTA2	calmodulin binding transcription activator 2
chr3_+_9834179	0.72	ENST00000498623.2	ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa
chr3_-_9834375	0.64	ENST00000343450.2 ENST00000301964.2	TADA3	transcriptional adaptor 3
chr12_-_125398850	0.61	ENST00000535859.1 ENST00000546271.1 ENST00000540700.1 ENST00000546120.1	UBC	ubiquitin C
chr3_+_9834758	0.60	ENST00000485273.1 ENST00000433034.1 ENST00000397256.1	ARPC4 ARPC4-TTLL3	actin related protein 2/3 complex, subunit 4, 20kDa ARPC4-TTLL3 readthrough
chr12_+_59989918	0.60	ENST00000547379.1 ENST00000549465.1	SLC16A7	solute carrier family 16 (monocarboxylate transporter), member 7
chr1_-_208084729	0.59	ENST00000310833.7 ENST00000356522.4	CD34	CD34 molecule
chr13_+_27825446	0.55	ENST00000311549.6	RPL21	ribosomal protein L21
chr17_+_7487146	0.54	ENST00000396501.4 ENST00000584378.1 ENST00000423172.2 ENST00000579445.1 ENST00000585217.1 ENST00000581380.1	MPDU1	mannose-P-dolichol utilization defect 1
chr1_-_168106536	0.53	ENST00000537209.1 ENST00000361697.2 ENST00000546300.1 ENST00000367835.1	GPR161	G protein-coupled receptor 161
chr19_+_45971246	0.47	ENST00000585836.1 ENST00000417353.2 ENST00000353609.3 ENST00000591858.1 ENST00000443841.2 ENST00000590335.1	FOSB	FBJ murine osteosarcoma viral oncogene homolog B
chr3_+_9834227	0.40	ENST00000287613.7 ENST00000397261.3	ARPC4	actin related protein 2/3 complex, subunit 4, 20kDa
chr17_+_73452695	0.38	ENST00000582186.1 ENST00000582455.1 ENST00000581252.1 ENST00000579208.1	KIAA0195	KIAA0195
chr5_+_137774706	0.38	ENST00000378339.2 ENST00000254901.5 ENST00000506158.1	REEP2	receptor accessory protein 2
chr8_+_1993152	0.36	ENST00000262113.4	MYOM2	myomesin 2
chr20_-_62258394	0.35	ENST00000370077.1	GMEB2	glucocorticoid modulatory element binding protein 2
chr22_+_38004832	0.30	ENST00000405147.3 ENST00000429218.1 ENST00000325180.8 ENST00000337437.4	GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr22_+_38004473	0.27	ENST00000414350.3 ENST00000343632.4	GGA1	golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr2_-_209118974	0.26	ENST00000415913.1 ENST00000415282.1 ENST00000446179.1	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble
chr10_+_88428370	0.24	ENST00000372066.3 ENST00000263066.6 ENST00000372056.4 ENST00000310944.6 ENST00000361373.4 ENST00000542786.1	LDB3	LIM domain binding 3
chr19_-_15343773	0.21	ENST00000435261.1 ENST00000594042.1	EPHX3	epoxide hydrolase 3
chr17_-_4871085	0.20	ENST00000575142.1 ENST00000206020.3	SPAG7	sperm associated antigen 7
chr8_+_1993173	0.15	ENST00000523438.1	MYOM2	myomesin 2
chr17_+_3379284	0.14	ENST00000263080.2	ASPA	aspartoacylase
chr11_+_34073195	0.13	ENST00000341394.4	CAPRIN1	cell cycle associated protein 1
chr5_+_66254698	0.11	ENST00000405643.1 ENST00000407621.1 ENST00000432426.1	MAST4	microtubule associated serine/threonine kinase family member 4
chr11_-_71823266	0.02	ENST00000538919.1 ENST00000539395.1 ENST00000542531.1	ANAPC15	anaphase promoting complex subunit 15

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.6	101.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.4	4.3	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.4	52.8	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.2	6.4	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.2	3.1	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.2	6.8	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	2.3	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.2	4.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	3.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	3.5	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.1	2.0	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	11.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	5.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	4.4	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	3.1	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.1	1.8	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.1	1.7	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.1	1.8	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	5.4	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
0.0	4.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	4.0	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	0.9	REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC	Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0	1.5	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	1.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	4.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.7	18.6	GO:0004687	myosin light chain kinase activity(GO:0004687)
2.6	13.2	GO:0016403	dimethylargininase activity(GO:0016403)
1.7	27.6	GO:0032036	myosin heavy chain binding(GO:0032036)
1.5	24.6	GO:0008179	adenylate cyclase binding(GO:0008179)
0.8	6.8	GO:0045159	myosin II binding(GO:0045159)
0.7	5.9	GO:0004111	creatine kinase activity(GO:0004111)
0.7	4.4	GO:0017018	myosin phosphatase activity(GO:0017018)
0.6	5.1	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.5	4.3	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.5	8.4	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.5	2.1	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.5	1.5	GO:0033823	procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.5	2.0	GO:0005477	pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.5	5.2	GO:0031013	troponin I binding(GO:0031013)
0.4	4.2	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.4	26.8	GO:0050681	androgen receptor binding(GO:0050681)
0.3	1.7	GO:0004359	glutaminase activity(GO:0004359)
0.3	22.9	GO:0017022	myosin binding(GO:0017022)
0.3	27.7	GO:0008307	structural constituent of muscle(GO:0008307)
0.3	6.0	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.3	3.1	GO:0051378	amine binding(GO:0043176) serotonin binding(GO:0051378)
0.2	4.4	GO:0043495	protein anchor(GO:0043495)
0.2	2.6	GO:0045294	alpha-catenin binding(GO:0045294)
0.2	4.4	GO:0031418	L-ascorbic acid binding(GO:0031418)
0.2	2.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.2	7.8	GO:0030507	spectrin binding(GO:0030507)
0.2	6.1	GO:0003785	actin monomer binding(GO:0003785)
0.2	0.6	GO:0070735	protein-glycine ligase activity(GO:0070735)
0.1	0.9	GO:0047134	protein-disulfide reductase activity(GO:0047134)
0.1	3.8	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1	3.7	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	0.9	GO:0030957	Tat protein binding(GO:0030957)
0.1	3.8	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.1	16.8	GO:0051015	actin filament binding(GO:0051015)
0.1	5.3	GO:0070888	E-box binding(GO:0070888)
0.1	0.3	GO:0004450	isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1	4.2	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1	2.3	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.1	3.0	GO:0070412	R-SMAD binding(GO:0070412)
0.1	6.4	GO:0030165	PDZ domain binding(GO:0030165)
0.1	2.2	GO:0001972	retinoic acid binding(GO:0001972)
0.1	0.6	GO:0043199	sulfate binding(GO:0043199)
0.1	5.4	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	1.4	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	6.5	GO:0003697	single-stranded DNA binding(GO:0003697)
0.0	0.6	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	1.8	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.6	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	3.3	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	3.9	GO:0035257	nuclear hormone receptor binding(GO:0035257)
0.0	1.5	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	1.2	GO:0042826	histone deacetylase binding(GO:0042826)
0.0	4.2	GO:0003714	transcription corepressor activity(GO:0003714)
0.0	2.2	GO:0044325	ion channel binding(GO:0044325)
0.0	0.2	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.5	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0	3.9	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0	17.6	GO:0005524	ATP binding(GO:0005524)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	26.8	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.8	44.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.5	41.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.2	5.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.2	8.8	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.2	11.9	PID RHOA PATHWAY	RhoA signaling pathway
0.2	6.0	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	10.7	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.2	6.8	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.2	4.5	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.2	3.8	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	6.4	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	6.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	19.3	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.1	3.8	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.1	2.3	PID FGF PATHWAY	FGF signaling pathway
0.0	1.8	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	2.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.0	7.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.9	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.2	PID RB 1PATHWAY	Regulation of retinoblastoma protein

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
9.0	53.9	GO:0090131	mesenchyme migration(GO:0090131)
5.4	26.8	GO:0055014	atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
2.3	18.6	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
1.9	11.2	GO:1900756	protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
1.7	8.4	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
1.6	24.6	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
1.4	4.3	GO:2000417	negative regulation of eosinophil migration(GO:2000417)
1.3	5.4	GO:0021812	neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.3	5.2	GO:0032972	diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
1.2	3.7	GO:0060535	trachea cartilage morphogenesis(GO:0060535)
1.1	4.5	GO:0042247	morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
1.1	13.2	GO:1900038	negative regulation of cellular response to hypoxia(GO:1900038)
1.1	6.4	GO:0007296	vitellogenesis(GO:0007296)
1.0	4.8	GO:2000771	regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
0.9	6.4	GO:0008218	bioluminescence(GO:0008218)
0.7	6.0	GO:0003150	muscular septum morphogenesis(GO:0003150)
0.7	4.2	GO:0060318	regulation of definitive erythrocyte differentiation(GO:0010724) definitive erythrocyte differentiation(GO:0060318)
0.6	3.1	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.6	5.3	GO:0045602	negative regulation of endothelial cell differentiation(GO:0045602)
0.6	2.3	GO:0060681	branch elongation involved in ureteric bud branching(GO:0060681)
0.6	2.2	GO:0060849	radial pattern formation(GO:0009956) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.5	5.9	GO:0006600	creatine metabolic process(GO:0006600)
0.5	1.5	GO:0046946	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.5	3.8	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.4	31.8	GO:0045652	regulation of megakaryocyte differentiation(GO:0045652)
0.4	8.8	GO:1900745	positive regulation of p38MAPK cascade(GO:1900745)
0.4	3.0	GO:0001661	conditioned taste aversion(GO:0001661)
0.4	1.5	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.3	2.1	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.3	1.7	GO:0006543	glutamine catabolic process(GO:0006543)
0.3	23.7	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.2	2.0	GO:0006848	pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.2	3.5	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.2	2.7	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.2	3.8	GO:0016540	protein autoprocessing(GO:0016540)
0.2	0.6	GO:0018094	protein polyglycylation(GO:0018094)
0.2	2.6	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.1	8.1	GO:0035904	aorta development(GO:0035904)
0.1	3.7	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1	0.4	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.1	1.8	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.1	4.2	GO:0000038	very long-chain fatty acid metabolic process(GO:0000038)
0.1	2.0	GO:0045214	sarcomere organization(GO:0045214)
0.1	6.1	GO:0031529	ruffle organization(GO:0031529)
0.1	0.6	GO:0090043	regulation of tubulin deacetylation(GO:0090043)
0.1	0.3	GO:0006097	glyoxylate cycle(GO:0006097)
0.1	4.4	GO:0045646	regulation of erythrocyte differentiation(GO:0045646)
0.1	23.7	GO:0007160	cell-matrix adhesion(GO:0007160)
0.1	4.1	GO:0010811	positive regulation of cell-substrate adhesion(GO:0010811)
0.1	2.1	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.1	4.2	GO:0070527	platelet aggregation(GO:0070527)
0.1	4.5	GO:0045669	positive regulation of osteoblast differentiation(GO:0045669)
0.1	0.5	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.1	1.6	GO:2000785	regulation of autophagosome assembly(GO:2000785)
0.0	4.2	GO:0048704	embryonic skeletal system morphogenesis(GO:0048704)
0.0	0.1	GO:0006533	aspartate catabolic process(GO:0006533)
0.0	2.9	GO:0035722	interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0	1.9	GO:0006893	Golgi to plasma membrane transport(GO:0006893)
0.0	1.9	GO:1903845	negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0	14.7	GO:0019216	regulation of lipid metabolic process(GO:0019216)
0.0	0.5	GO:0006488	dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0	5.1	GO:0010977	negative regulation of neuron projection development(GO:0010977)
0.0	1.8	GO:0000045	autophagosome assembly(GO:0000045)
0.0	3.2	GO:0060337	type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0	0.5	GO:0051412	response to corticosterone(GO:0051412)
0.0	1.1	GO:0034314	Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0	3.4	GO:0021987	cerebral cortex development(GO:0021987)
0.0	1.2	GO:0042246	tissue regeneration(GO:0042246)
0.0	2.2	GO:0048813	dendrite morphogenesis(GO:0048813)
0.0	0.6	GO:1901998	toxin transport(GO:1901998)
0.0	5.3	GO:0006260	DNA replication(GO:0006260)
0.0	2.0	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
0.0	0.9	GO:0045454	cell redox homeostasis(GO:0045454)
0.0	3.5	GO:0007517	muscle organ development(GO:0007517)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
5.4	27.0	GO:0042643	actomyosin, actin portion(GO:0042643)
3.4	27.4	GO:0016012	sarcoglycan complex(GO:0016012)
2.7	16.0	GO:0032982	myosin filament(GO:0032982)
2.2	8.9	GO:0030485	smooth muscle contractile fiber(GO:0030485)
1.8	5.4	GO:0005607	laminin-2 complex(GO:0005607)
1.5	4.4	GO:0005826	actomyosin contractile ring(GO:0005826)
1.2	23.6	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
1.0	36.0	GO:0005859	muscle myosin complex(GO:0005859)
0.9	5.2	GO:1990584	cardiac Troponin complex(GO:1990584)
0.7	2.1	GO:0031523	Myb complex(GO:0031523)
0.7	26.4	GO:0031430	M band(GO:0031430)
0.6	3.5	GO:1990037	Lewy body core(GO:1990037)
0.5	6.8	GO:0030478	actin cap(GO:0030478)
0.4	40.7	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.4	3.0	GO:0035976	AP1 complex(GO:0035976)
0.3	26.0	GO:0035577	azurophil granule membrane(GO:0035577)
0.3	4.2	GO:0097433	dense body(GO:0097433)
0.3	5.9	GO:0031143	pseudopodium(GO:0031143)
0.2	2.6	GO:0005916	fascia adherens(GO:0005916)
0.1	4.8	GO:0031258	lamellipodium membrane(GO:0031258)
0.1	1.4	GO:0042575	DNA polymerase complex(GO:0042575)
0.1	1.8	GO:0031083	BLOC-1 complex(GO:0031083)
0.1	1.7	GO:0005885	Arp2/3 protein complex(GO:0005885)
0.1	6.0	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1	25.2	GO:0005938	cell cortex(GO:0005938)
0.1	8.4	GO:0005604	basement membrane(GO:0005604)
0.1	6.4	GO:0042734	presynaptic membrane(GO:0042734)
0.1	1.5	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.1	6.4	GO:0005796	Golgi lumen(GO:0005796)
0.0	3.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	0.6	GO:0000124	SAGA complex(GO:0000124)
0.0	0.6	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	0.6	GO:0046930	pore complex(GO:0046930)
0.0	1.9	GO:0005798	Golgi-associated vesicle(GO:0005798)
0.0	4.2	GO:0001650	fibrillar center(GO:0001650)
0.0	3.9	GO:0008021	synaptic vesicle(GO:0008021)
0.0	1.4	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	10.4	GO:0005925	cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
0.0	0.6	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	3.7	GO:0005765	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0	1.6	GO:0005776	autophagosome(GO:0005776)
0.0	1.5	GO:0000123	histone acetyltransferase complex(GO:0000123)
0.0	11.1	GO:0000139	Golgi membrane(GO:0000139)
0.0	4.0	GO:0005667	transcription factor complex(GO:0005667)