ISMARA results: TBX2

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ENCODE cell lines, expression (Ernst 2011)

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Results for TBX2

Z-value: 0.74

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Transcription factors associated with TBX2

Gene Symbol	Gene ID	Gene Info
TBX2 Ensembl NCBI GeneCards UniProt	ENSG00000121068.9	TBX2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBX2	hg19_v2_chr17_+_59477233_59477263	0.19	4.7e-01	Click!

Activity profile of TBX2 motif

Sorted Z-values of TBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX2

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr1_+_100111580	1.70	ENST00000605497.1	PALMD	palmdelphin
chr1_-_79472365	1.62	ENST00000370742.3	ELTD1	EGF, latrophilin and seven transmembrane domain containing 1
chr2_-_175870085	1.44	ENST00000409156.3	CHN1	chimerin 1
chr1_+_100111479	1.41	ENST00000263174.4	PALMD	palmdelphin
chr2_-_175869936	1.40	ENST00000409900.3	CHN1	chimerin 1
chr12_+_75874984	1.37	ENST00000550491.1	GLIPR1	GLI pathogenesis-related 1
chrX_+_99899180	1.36	ENST00000373004.3	SRPX2	sushi-repeat containing protein, X-linked 2
chrY_+_2709527	1.34	ENST00000250784.8	RPS4Y1	ribosomal protein S4, Y-linked 1
chr3_-_120170052	1.30	ENST00000295633.3	FSTL1	follistatin-like 1
chr10_+_54074033	1.25	ENST00000373970.3	DKK1	dickkopf WNT signaling pathway inhibitor 1
chr1_+_101702417	1.25	ENST00000305352.6	S1PR1	sphingosine-1-phosphate receptor 1
chrY_+_2709906	1.18	ENST00000430575.1	RPS4Y1	ribosomal protein S4, Y-linked 1
chr18_-_52969844	1.18	ENST00000561831.3	TCF4	transcription factor 4
chr12_-_49318715	1.13	ENST00000444214.2	FKBP11	FK506 binding protein 11, 19 kDa
chrX_+_114795489	1.11	ENST00000355899.3 ENST00000537301.1 ENST00000289290.3	PLS3	plastin 3
chr8_-_27457494	1.10	ENST00000521770.1	CLU	clusterin
chrX_+_51636629	0.89	ENST00000375722.1 ENST00000326587.7 ENST00000375695.2	MAGED1	melanoma antigen family D, 1
chr6_+_121756809	0.87	ENST00000282561.3	GJA1	gap junction protein, alpha 1, 43kDa
chr2_+_33701286	0.86	ENST00000403687.3	RASGRP3	RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr15_+_25200074	0.84	ENST00000390687.4 ENST00000584968.1 ENST00000346403.6 ENST00000554227.2	SNRPN	small nuclear ribonucleoprotein polypeptide N
chr11_-_615570	0.77	ENST00000525445.1 ENST00000348655.6 ENST00000397566.1	IRF7	interferon regulatory factor 7
chr15_+_25200108	0.76	ENST00000577949.1 ENST00000338094.6 ENST00000338327.4 ENST00000579070.1 ENST00000577565.1	SNURF SNRPN	SNRPN upstream reading frame protein small nuclear ribonucleoprotein polypeptide N
chr3_-_66551397	0.75	ENST00000383703.3	LRIG1	leucine-rich repeats and immunoglobulin-like domains 1
chr9_+_124048864	0.73	ENST00000545652.1	GSN	gelsolin
chr2_+_201994042	0.72	ENST00000417748.1	CFLAR	CASP8 and FADD-like apoptosis regulator
chr21_+_30502806	0.71	ENST00000399928.1 ENST00000399926.1	MAP3K7CL	MAP3K7 C-terminal like
chr2_+_201994208	0.70	ENST00000440180.1	CFLAR	CASP8 and FADD-like apoptosis regulator
chr4_-_186732048	0.69	ENST00000448662.2 ENST00000439049.1 ENST00000420158.1 ENST00000431808.1 ENST00000319471.9	SORBS2	sorbin and SH3 domain containing 2
chr3_-_66551351	0.69	ENST00000273261.3	LRIG1	leucine-rich repeats and immunoglobulin-like domains 1
chr8_-_17533838	0.68	ENST00000400046.1	MTUS1	microtubule associated tumor suppressor 1
chr1_-_52456352	0.66	ENST00000371655.3	RAB3B	RAB3B, member RAS oncogene family
chr22_+_31003190	0.62	ENST00000407817.3	TCN2	transcobalamin II
chr22_+_35776828	0.62	ENST00000216117.8	HMOX1	heme oxygenase (decycling) 1
chr1_-_150780757	0.60	ENST00000271651.3	CTSK	cathepsin K
chr1_-_22263790	0.59	ENST00000374695.3	HSPG2	heparan sulfate proteoglycan 2
chr17_-_7590745	0.58	ENST00000514944.1 ENST00000503591.1 ENST00000455263.2 ENST00000420246.2 ENST00000445888.2 ENST00000509690.1 ENST00000604348.1 ENST00000269305.4	TP53	tumor protein p53
chr20_-_50385138	0.58	ENST00000338821.5	ATP9A	ATPase, class II, type 9A
chr5_-_55290773	0.56	ENST00000502326.3 ENST00000381298.2	IL6ST	interleukin 6 signal transducer (gp130, oncostatin M receptor)
chr8_+_82192501	0.55	ENST00000297258.6	FABP5	fatty acid binding protein 5 (psoriasis-associated)
chr17_+_26662730	0.53	ENST00000226225.2	TNFAIP1	tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr4_+_124317940	0.50	ENST00000505319.1 ENST00000339241.1	SPRY1	sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr3_-_105588231	0.47	ENST00000545639.1 ENST00000394027.3 ENST00000438603.1 ENST00000447441.1 ENST00000443752.1	CBLB	Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr22_+_31003133	0.46	ENST00000405742.3	TCN2	transcobalamin II
chr22_+_38597889	0.46	ENST00000338483.2 ENST00000538320.1 ENST00000538999.1 ENST00000441709.1	MAFF	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr4_-_186456766	0.44	ENST00000284771.6	PDLIM3	PDZ and LIM domain 3
chr1_+_38022572	0.44	ENST00000541606.1	DNALI1	dynein, axonemal, light intermediate chain 1
chr11_-_615942	0.44	ENST00000397562.3 ENST00000330243.5 ENST00000397570.1 ENST00000397574.2	IRF7	interferon regulatory factor 7
chr1_+_213123976	0.43	ENST00000366965.2 ENST00000366967.2	VASH2	vasohibin 2
chr3_-_49377499	0.43	ENST00000265560.4	USP4	ubiquitin specific peptidase 4 (proto-oncogene)
chrX_-_10645773	0.43	ENST00000453318.2	MID1	midline 1 (Opitz/BBB syndrome)
chr12_-_15104040	0.43	ENST00000541644.1 ENST00000545895.1	ARHGDIB	Rho GDP dissociation inhibitor (GDI) beta
chr7_-_99766191	0.42	ENST00000423751.1 ENST00000360039.4	GAL3ST4	galactose-3-O-sulfotransferase 4
chr17_-_39968406	0.41	ENST00000393928.1	LEPREL4	leprecan-like 4
chr4_-_186456652	0.41	ENST00000284767.5 ENST00000284770.5	PDLIM3	PDZ and LIM domain 3
chr7_+_114562172	0.41	ENST00000393486.1 ENST00000257724.3	MDFIC	MyoD family inhibitor domain containing
chr6_+_116692102	0.41	ENST00000359564.2	DSE	dermatan sulfate epimerase
chr19_-_44174330	0.40	ENST00000340093.3	PLAUR	plasminogen activator, urokinase receptor
chr15_-_22448819	0.40	ENST00000604066.1	IGHV1OR15-1	immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr2_+_219081817	0.40	ENST00000315717.5 ENST00000420104.1 ENST00000295685.10	ARPC2	actin related protein 2/3 complex, subunit 2, 34kDa
chr10_-_112678976	0.39	ENST00000448814.1	BBIP1	BBSome interacting protein 1
chr14_-_24664540	0.38	ENST00000530563.1 ENST00000528895.1 ENST00000528669.1 ENST00000532632.1	TM9SF1	transmembrane 9 superfamily member 1
chr19_-_44174305	0.38	ENST00000601723.1 ENST00000339082.3	PLAUR	plasminogen activator, urokinase receptor
chr15_-_35088340	0.38	ENST00000290378.4	ACTC1	actin, alpha, cardiac muscle 1
chr2_-_191878874	0.36	ENST00000392322.3 ENST00000392323.2 ENST00000424722.1 ENST00000361099.3	STAT1	signal transducer and activator of transcription 1, 91kDa
chr11_+_69455855	0.36	ENST00000227507.2 ENST00000536559.1	CCND1	cyclin D1
chr8_-_134584092	0.35	ENST00000522652.1	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr20_-_24973318	0.35	ENST00000447138.1	APMAP	adipocyte plasma membrane associated protein
chr8_-_134584152	0.34	ENST00000521180.1 ENST00000517668.1 ENST00000319914.5	ST3GAL1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr3_+_160117087	0.34	ENST00000357388.3	SMC4	structural maintenance of chromosomes 4
chr22_+_24823517	0.33	ENST00000496258.1 ENST00000337539.7	ADORA2A	adenosine A2a receptor
chr17_-_15165854	0.32	ENST00000395936.1 ENST00000395938.2	PMP22	peripheral myelin protein 22
chr17_-_39968855	0.32	ENST00000355468.3 ENST00000590496.1	LEPREL4	leprecan-like 4
chr19_-_39108568	0.31	ENST00000586296.1	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1
chr3_-_79068594	0.31	ENST00000436010.2	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr9_-_123676827	0.31	ENST00000546084.1	TRAF1	TNF receptor-associated factor 1
chr10_+_95256356	0.31	ENST00000371485.3	CEP55	centrosomal protein 55kDa
chr17_-_35969409	0.30	ENST00000394378.2 ENST00000585472.1 ENST00000591288.1 ENST00000502449.2 ENST00000345615.4 ENST00000346661.4 ENST00000585689.1 ENST00000339208.6	SYNRG	synergin, gamma
chr10_-_112678692	0.30	ENST00000605742.1	BBIP1	BBSome interacting protein 1
chr11_+_61447845	0.30	ENST00000257215.5	DAGLA	diacylglycerol lipase, alpha
chr10_-_112678904	0.30	ENST00000423273.1 ENST00000436562.1 ENST00000447005.1 ENST00000454061.1	BBIP1	BBSome interacting protein 1
chr6_+_26383404	0.30	ENST00000416795.2 ENST00000494184.1	BTN2A2	butyrophilin, subfamily 2, member A2
chr12_-_49351228	0.30	ENST00000541959.1 ENST00000447318.2	ARF3	ADP-ribosylation factor 3
chr1_+_32716840	0.29	ENST00000336890.5	LCK	lymphocyte-specific protein tyrosine kinase
chr5_+_35856951	0.29	ENST00000303115.3 ENST00000343305.4 ENST00000506850.1 ENST00000511982.1	IL7R	interleukin 7 receptor
chr11_-_58345569	0.29	ENST00000528954.1 ENST00000528489.1	LPXN	leupaxin
chr19_+_13049413	0.29	ENST00000316448.5 ENST00000588454.1	CALR	calreticulin
chr1_-_205290865	0.28	ENST00000367157.3	NUAK2	NUAK family, SNF1-like kinase, 2
chr5_+_140772381	0.28	ENST00000398604.2	PCDHGA8	protocadherin gamma subfamily A, 8
chr11_+_19138670	0.28	ENST00000446113.2 ENST00000399351.3	ZDHHC13	zinc finger, DHHC-type containing 13
chr1_+_32716857	0.28	ENST00000482949.1 ENST00000495610.2	LCK	lymphocyte-specific protein tyrosine kinase
chr3_+_101498269	0.27	ENST00000491511.2	NXPE3	neurexophilin and PC-esterase domain family, member 3
chr17_+_25958174	0.27	ENST00000313648.6 ENST00000577392.1 ENST00000584661.1 ENST00000413914.2	LGALS9	lectin, galactoside-binding, soluble, 9
chr14_-_45603657	0.27	ENST00000396062.3	FKBP3	FK506 binding protein 3, 25kDa
chr1_-_25256368	0.27	ENST00000308873.6	RUNX3	runt-related transcription factor 3
chr6_+_391739	0.27	ENST00000380956.4	IRF4	interferon regulatory factor 4
chrX_+_12885183	0.26	ENST00000380659.3	TLR7	toll-like receptor 7
chr9_+_134378289	0.25	ENST00000423007.1 ENST00000404875.2 ENST00000441334.1 ENST00000341012.7 ENST00000372228.3 ENST00000402686.3 ENST00000419118.2 ENST00000541219.1 ENST00000354713.4 ENST00000418774.1 ENST00000415075.1 ENST00000448212.1 ENST00000430619.1	POMT1	protein-O-mannosyltransferase 1
chr1_+_38022513	0.25	ENST00000296218.7	DNALI1	dynein, axonemal, light intermediate chain 1
chr19_-_51875523	0.25	ENST00000593572.1 ENST00000595157.1	NKG7	natural killer cell group 7 sequence
chr12_+_4714145	0.25	ENST00000545342.1	DYRK4	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr4_-_90756769	0.25	ENST00000345009.4 ENST00000505199.1 ENST00000502987.1	SNCA	synuclein, alpha (non A4 component of amyloid precursor)
chr6_+_80816342	0.24	ENST00000369760.4 ENST00000356489.5 ENST00000320393.6	BCKDHB	branched chain keto acid dehydrogenase E1, beta polypeptide
chr1_+_161736072	0.24	ENST00000367942.3	ATF6	activating transcription factor 6
chr14_+_90864504	0.24	ENST00000544280.2	CALM1	calmodulin 1 (phosphorylase kinase, delta)
chr9_+_90112117	0.24	ENST00000358077.5	DAPK1	death-associated protein kinase 1
chr11_-_6440624	0.24	ENST00000311051.3	APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr14_-_75643296	0.23	ENST00000303575.4	TMED10	transmembrane emp24-like trafficking protein 10 (yeast)
chr14_-_93651186	0.23	ENST00000556883.1 ENST00000298894.4	MOAP1	modulator of apoptosis 1
chr12_-_56120838	0.23	ENST00000548160.1	CD63	CD63 molecule
chr15_-_52483566	0.23	ENST00000261837.7	GNB5	guanine nucleotide binding protein (G protein), beta 5
chr15_-_75165651	0.22	ENST00000562363.1 ENST00000564529.1 ENST00000268099.9	SCAMP2	secretory carrier membrane protein 2
chr6_-_52705641	0.22	ENST00000370989.2	GSTA5	glutathione S-transferase alpha 5
chr3_-_125094093	0.22	ENST00000484491.1 ENST00000492394.1 ENST00000471196.1 ENST00000468369.1 ENST00000544464.1 ENST00000485866.1 ENST00000360647.4	ZNF148	zinc finger protein 148
chr5_-_68628543	0.22	ENST00000396496.2 ENST00000511257.1 ENST00000383374.2	CCDC125	coiled-coil domain containing 125
chr5_+_66124590	0.22	ENST00000490016.2 ENST00000403666.1 ENST00000450827.1	MAST4	microtubule associated serine/threonine kinase family member 4
chr19_-_39108643	0.22	ENST00000396857.2	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1
chr9_+_2157655	0.22	ENST00000452193.1	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr14_+_21249200	0.22	ENST00000304677.2	RNASE6	ribonuclease, RNase A family, k6
chr19_-_51875894	0.22	ENST00000600427.1 ENST00000595217.1 ENST00000221978.5	NKG7	natural killer cell group 7 sequence
chr17_-_8066843	0.21	ENST00000404970.3	VAMP2	vesicle-associated membrane protein 2 (synaptobrevin 2)
chr11_-_44972476	0.21	ENST00000527685.1 ENST00000308212.5	TP53I11	tumor protein p53 inducible protein 11
chr19_-_39108552	0.20	ENST00000591517.1	MAP4K1	mitogen-activated protein kinase kinase kinase kinase 1
chr1_-_207095212	0.20	ENST00000420007.2	FAIM3	Fas apoptotic inhibitory molecule 3
chr19_-_45982076	0.20	ENST00000423698.2	ERCC1	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr13_-_99630233	0.20	ENST00000376460.1 ENST00000442173.1	DOCK9	dedicator of cytokinesis 9
chrX_-_119709637	0.20	ENST00000404115.3	CUL4B	cullin 4B
chr6_+_26383318	0.20	ENST00000469230.1 ENST00000490025.1 ENST00000356709.4 ENST00000352867.2 ENST00000493275.1 ENST00000472507.1 ENST00000482536.1 ENST00000432533.2 ENST00000482842.1	BTN2A2	butyrophilin, subfamily 2, member A2
chr9_-_20622478	0.19	ENST00000355930.6 ENST00000380338.4	MLLT3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr8_-_19459993	0.19	ENST00000454498.2 ENST00000520003.1	CSGALNACT1	chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr1_-_113247543	0.19	ENST00000414971.1 ENST00000534717.1	RHOC	ras homolog family member C
chr19_-_43702231	0.19	ENST00000597374.1 ENST00000599371.1	PSG4	pregnancy specific beta-1-glycoprotein 4
chr6_-_31651817	0.19	ENST00000375863.3 ENST00000375860.2	LY6G5C	lymphocyte antigen 6 complex, locus G5C
chr22_+_38201114	0.18	ENST00000340857.2	H1F0	H1 histone family, member 0
chr4_-_90759440	0.18	ENST00000336904.3	SNCA	synuclein, alpha (non A4 component of amyloid precursor)
chr16_+_27413483	0.18	ENST00000337929.3 ENST00000564089.1	IL21R	interleukin 21 receptor
chr5_-_137514333	0.18	ENST00000411594.2 ENST00000430331.1	BRD8	bromodomain containing 8
chr3_+_25469802	0.18	ENST00000330688.4	RARB	retinoic acid receptor, beta
chr7_+_35840819	0.18	ENST00000399035.3	SEPT7	septin 7
chr9_+_34990219	0.18	ENST00000541010.1 ENST00000454002.2 ENST00000545841.1	DNAJB5	DnaJ (Hsp40) homolog, subfamily B, member 5
chr7_+_107220660	0.18	ENST00000465919.1 ENST00000445771.2 ENST00000479917.1 ENST00000421217.1 ENST00000457837.1	BCAP29	B-cell receptor-associated protein 29
chr16_+_12058961	0.18	ENST00000053243.1	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr11_-_14380664	0.18	ENST00000545643.1 ENST00000256196.4	RRAS2	related RAS viral (r-ras) oncogene homolog 2
chr7_-_87849340	0.17	ENST00000419179.1 ENST00000265729.2	SRI	sorcin
chr7_+_107220899	0.17	ENST00000379117.2 ENST00000473124.1	BCAP29	B-cell receptor-associated protein 29
chr13_-_46543805	0.17	ENST00000378921.2	ZC3H13	zinc finger CCCH-type containing 13
chr7_+_35840542	0.17	ENST00000435235.1 ENST00000399034.2 ENST00000350320.6 ENST00000469679.2	SEPT7	septin 7
chr19_+_55897297	0.17	ENST00000431533.2 ENST00000428193.2 ENST00000558815.1 ENST00000560583.1 ENST00000560055.1 ENST00000559463.1	RPL28	ribosomal protein L28
chr6_-_84937314	0.16	ENST00000257766.4 ENST00000403245.3	KIAA1009	KIAA1009
chr2_+_29338236	0.16	ENST00000320081.5	CLIP4	CAP-GLY domain containing linker protein family, member 4
chr16_+_12059050	0.16	ENST00000396495.3	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr12_-_56121612	0.16	ENST00000546939.1	CD63	CD63 molecule
chr7_+_872107	0.16	ENST00000405266.1 ENST00000401592.1 ENST00000403868.1 ENST00000425407.2	SUN1	Sad1 and UNC84 domain containing 1
chr1_-_146040968	0.16	ENST00000401010.3	NBPF11	neuroblastoma breakpoint family, member 11
chr12_-_56121580	0.16	ENST00000550776.1	CD63	CD63 molecule
chr11_+_62379194	0.16	ENST00000525801.1 ENST00000534093.1	ROM1	retinal outer segment membrane protein 1
chr6_+_30034966	0.16	ENST00000376769.2	PPP1R11	protein phosphatase 1, regulatory (inhibitor) subunit 11
chr1_+_16767167	0.15	ENST00000337132.5	NECAP2	NECAP endocytosis associated 2
chrX_+_70338366	0.15	ENST00000333646.6	MED12	mediator complex subunit 12
chr1_-_183387723	0.15	ENST00000287713.6	NMNAT2	nicotinamide nucleotide adenylyltransferase 2
chr12_-_12849073	0.15	ENST00000332427.2 ENST00000540796.1	GPR19	G protein-coupled receptor 19
chr1_+_16767195	0.15	ENST00000504551.2 ENST00000457722.2 ENST00000406746.1 ENST00000443980.2	NECAP2	NECAP endocytosis associated 2
chr1_+_155099927	0.15	ENST00000368407.3	EFNA1	ephrin-A1
chr22_-_42342733	0.15	ENST00000402420.1	CENPM	centromere protein M
chr9_+_17135016	0.15	ENST00000425824.1 ENST00000262360.5 ENST00000380641.4	CNTLN	centlein, centrosomal protein
chr11_-_6633799	0.15	ENST00000299424.4	TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr19_-_46000251	0.14	ENST00000590526.1 ENST00000344680.4 ENST00000245923.4	RTN2	reticulon 2
chr17_+_46184911	0.14	ENST00000580219.1 ENST00000452859.2 ENST00000393405.2 ENST00000439357.2 ENST00000359238.2	SNX11	sorting nexin 11
chr7_-_48019101	0.14	ENST00000432627.1 ENST00000258774.5 ENST00000432325.1 ENST00000446009.1	HUS1	HUS1 checkpoint homolog (S. pombe)
chr19_-_51192661	0.14	ENST00000391813.1	SHANK1	SH3 and multiple ankyrin repeat domains 1
chr6_+_292459	0.14	ENST00000419235.2 ENST00000605035.1 ENST00000605863.1	DUSP22	dual specificity phosphatase 22
chr3_+_32726774	0.14	ENST00000538368.1	CNOT10	CCR4-NOT transcription complex, subunit 10
chr6_+_30035307	0.14	ENST00000376765.2 ENST00000376763.1	PPP1R11	protein phosphatase 1, regulatory (inhibitor) subunit 11
chr13_+_27825706	0.14	ENST00000272274.4 ENST00000319826.4 ENST00000326092.4	RPL21	ribosomal protein L21
chr12_-_56120865	0.14	ENST00000548898.1 ENST00000552067.1	CD63	CD63 molecule
chr12_-_49351303	0.14	ENST00000256682.4	ARF3	ADP-ribosylation factor 3
chr12_-_56122220	0.14	ENST00000552692.1	CD63	CD63 molecule
chr14_-_55658323	0.13	ENST00000554067.1 ENST00000247191.2	DLGAP5	discs, large (Drosophila) homolog-associated protein 5
chr1_-_1009683	0.13	ENST00000453464.2	RNF223	ring finger protein 223
chr3_+_98250743	0.13	ENST00000284311.3	GPR15	G protein-coupled receptor 15
chr2_+_5832799	0.13	ENST00000322002.3	SOX11	SRY (sex determining region Y)-box 11
chrX_+_70338552	0.13	ENST00000374080.3 ENST00000429213.1	MED12	mediator complex subunit 12
chr9_+_17134980	0.13	ENST00000380647.3	CNTLN	centlein, centrosomal protein
chr12_+_124155652	0.12	ENST00000426174.2 ENST00000303372.5	TCTN2	tectonic family member 2
chr22_-_31688431	0.12	ENST00000402249.3 ENST00000443175.1 ENST00000215912.5 ENST00000441972.1	PIK3IP1	phosphoinositide-3-kinase interacting protein 1
chr12_-_57522813	0.12	ENST00000556155.1	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced
chr11_+_1940786	0.12	ENST00000278317.6 ENST00000381561.4 ENST00000381548.3 ENST00000360603.3 ENST00000381549.3	TNNT3	troponin T type 3 (skeletal, fast)
chr10_+_114135004	0.12	ENST00000393081.1	ACSL5	acyl-CoA synthetase long-chain family member 5
chr1_+_145507587	0.11	ENST00000330165.8 ENST00000369307.3	RBM8A	RNA binding motif protein 8A
chr2_-_85581701	0.11	ENST00000295802.4	RETSAT	retinol saturase (all-trans-retinol 13,14-reductase)
chr12_+_53443963	0.11	ENST00000546602.1 ENST00000552570.1 ENST00000549700.1	TENC1	tensin like C1 domain containing phosphatase (tensin 2)
chr2_+_102759199	0.11	ENST00000409288.1 ENST00000410023.1	IL1R1	interleukin 1 receptor, type I
chr4_-_90757364	0.11	ENST00000508895.1	SNCA	synuclein, alpha (non A4 component of amyloid precursor)
chr16_-_67493110	0.11	ENST00000602876.1	ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr17_+_58755184	0.11	ENST00000589222.1 ENST00000407086.3 ENST00000390652.5	BCAS3	breast carcinoma amplified sequence 3
chr16_+_31271274	0.11	ENST00000287497.8 ENST00000544665.3	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)
chr7_-_35077653	0.11	ENST00000310974.4	DPY19L1	dpy-19-like 1 (C. elegans)
chr12_-_56122761	0.11	ENST00000552164.1 ENST00000420846.3 ENST00000257857.4	CD63	CD63 molecule
chr7_+_5919458	0.11	ENST00000416608.1	OCM	oncomodulin
chr3_+_183967409	0.10	ENST00000324557.4 ENST00000402825.3	ECE2	endothelin converting enzyme 2
chr1_+_202995611	0.10	ENST00000367240.2	PPFIA4	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1	1.5	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.3	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.7	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.5	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.3	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	1.2	REACTOME ACTIVATION OF NF KAPPAB IN B CELLS	Genes involved in Activation of NF-kappaB in B Cells

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.7	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.6	1.7	GO:0043132	FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350) NAD transport(GO:0043132)
0.4	1.2	GO:0061010	gall bladder development(GO:0061010)
0.3	2.2	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.3	1.3	GO:1904845	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.2	0.7	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.2	1.5	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.2	0.7	GO:2000525	dendritic cell dendrite assembly(GO:0097026) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.2	0.6	GO:0070901	mitochondrial tRNA methylation(GO:0070901)
0.2	0.6	GO:1902303	regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.2	0.5	GO:0055073	cadmium ion homeostasis(GO:0055073)
0.2	0.5	GO:0021986	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2	1.1	GO:0097577	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.2	0.5	GO:0035621	ER to Golgi ceramide transport(GO:0035621)
0.1	0.7	GO:0010587	miRNA catabolic process(GO:0010587)
0.1	0.4	GO:0032831	regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
0.1	0.8	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.1	0.9	GO:1902962	regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1	1.3	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1	0.6	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1	0.6	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1	0.5	GO:0000255	allantoin metabolic process(GO:0000255)
0.1	0.5	GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.1	0.6	GO:1903588	negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1	0.8	GO:0031118	rRNA pseudouridine synthesis(GO:0031118)
0.1	0.6	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.1	0.3	GO:1901503	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1	0.3	GO:0044210	'de novo' CTP biosynthetic process(GO:0044210)
0.1	0.6	GO:2000503	positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1	0.9	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1	0.3	GO:1902523	positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1	0.5	GO:1903385	regulation of homophilic cell adhesion(GO:1903385)
0.1	0.3	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.1	0.8	GO:0001955	blood vessel maturation(GO:0001955)
0.1	0.5	GO:0006741	NADP biosynthetic process(GO:0006741)
0.1	0.2	GO:0045082	interleukin-4 biosynthetic process(GO:0042097) positive regulation of interleukin-10 biosynthetic process(GO:0045082) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1	0.4	GO:0007571	age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.1	0.8	GO:1903944	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1	0.4	GO:0061113	pancreas morphogenesis(GO:0061113)
0.1	0.2	GO:0071284	cellular response to lead ion(GO:0071284)
0.1	0.2	GO:1901189	arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.1	1.1	GO:0043248	proteasome assembly(GO:0043248)
0.1	0.8	GO:2000786	positive regulation of autophagosome assembly(GO:2000786)
0.1	0.2	GO:0043314	negative regulation of neutrophil degranulation(GO:0043314)
0.1	0.2	GO:0021938	ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.1	0.5	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.1	0.1	GO:0061394	regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1	0.7	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1	0.3	GO:0009149	pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
0.1	0.2	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1	0.2	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
0.1	0.9	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1	0.2	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.1	0.2	GO:0048859	formation of anatomical boundary(GO:0048859)
0.1	1.3	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.1	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.1	0.3	GO:1902766	skeletal muscle satellite cell migration(GO:1902766)
0.1	0.2	GO:0061030	axon target recognition(GO:0007412) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1	0.3	GO:0044806	G-quadruplex DNA unwinding(GO:0044806)
0.1	0.3	GO:0070537	histone H2A K63-linked deubiquitination(GO:0070537)
0.1	0.5	GO:0015889	cobalamin transport(GO:0015889)
0.1	0.1	GO:0014878	response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.0	0.1	GO:0098905	regulation of bundle of His cell action potential(GO:0098905)
0.0	0.4	GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.0	0.6	GO:0008228	opsonization(GO:0008228)
0.0	0.3	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	0.4	GO:0097646	calcitonin family receptor signaling pathway(GO:0097646) amylin receptor signaling pathway(GO:0097647)
0.0	0.2	GO:0014835	myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) positive regulation of interleukin-12 secretion(GO:2001184)
0.0	0.4	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0	1.9	GO:0002820	negative regulation of adaptive immune response(GO:0002820)
0.0	0.1	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.2	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.1	GO:1903464	signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) negative regulation of mitotic cell cycle DNA replication(GO:1903464) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.0	0.3	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.0	0.1	GO:0010793	regulation of mRNA export from nucleus(GO:0010793)
0.0	0.2	GO:1904098	regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0	0.2	GO:0007368	determination of left/right symmetry(GO:0007368)
0.0	0.1	GO:0002155	thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155) kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.0	2.1	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.0	0.3	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.4	GO:0072520	seminiferous tubule development(GO:0072520)
0.0	0.6	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.0	0.1	GO:0021633	optic nerve structural organization(GO:0021633)
0.0	0.1	GO:0006425	glutaminyl-tRNA aminoacylation(GO:0006425) valyl-tRNA aminoacylation(GO:0006438)
0.0	0.1	GO:0043449	olfactory learning(GO:0008355) cellular alkene metabolic process(GO:0043449)
0.0	0.1	GO:0072023	thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.0	0.1	GO:0035962	response to interleukin-13(GO:0035962)
0.0	0.1	GO:0036353	histone H2A-K119 monoubiquitination(GO:0036353)
0.0	0.2	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.0	0.2	GO:1902302	regulation of potassium ion export(GO:1902302)
0.0	0.7	GO:0006337	nucleosome disassembly(GO:0006337)
0.0	0.4	GO:0032516	positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.0	0.2	GO:0035934	corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.0	0.4	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.6	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.5	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.1	GO:0038188	cholecystokinin signaling pathway(GO:0038188)
0.0	0.1	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.0	0.2	GO:1902951	negative regulation of dendritic spine maintenance(GO:1902951)
0.0	0.1	GO:1990502	dense core granule maturation(GO:1990502)
0.0	1.2	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.2	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.2	GO:0051096	positive regulation of helicase activity(GO:0051096)
0.0	0.1	GO:0055009	atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.0	0.2	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.2	GO:0071285	cellular response to lithium ion(GO:0071285)
0.0	0.3	GO:0000380	alternative mRNA splicing, via spliceosome(GO:0000380)
0.0	0.1	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0	0.2	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.3	GO:0007096	regulation of exit from mitosis(GO:0007096)
0.0	0.3	GO:2000398	regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0	0.1	GO:0060718	chorionic trophoblast cell differentiation(GO:0060718)
0.0	0.0	GO:1905071	occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.0	0.6	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.1	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.0	0.2	GO:0060716	labyrinthine layer blood vessel development(GO:0060716)
0.0	0.0	GO:0015965	diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.0	0.2	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.0	GO:0018874	benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.0	0.1	GO:0034983	peptidyl-lysine deacetylation(GO:0034983)
0.0	0.1	GO:1903593	regulation of histamine secretion by mast cell(GO:1903593)
0.0	0.1	GO:0061668	mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.1	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.1	GO:0035356	cellular triglyceride homeostasis(GO:0035356)
0.0	0.1	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0030101	natural killer cell activation(GO:0030101)
0.0	0.1	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.0	0.3	GO:0002227	innate immune response in mucosa(GO:0002227)
0.0	0.4	GO:2001275	positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.0	0.1	GO:0045715	negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0	0.0	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
0.0	0.2	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.2	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.0	0.1	GO:0032688	negative regulation of interferon-beta production(GO:0032688)
0.0	0.3	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.2	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.1	GO:0032006	regulation of TOR signaling(GO:0032006)
0.0	0.1	GO:0045794	negative regulation of cell volume(GO:0045794)
0.0	0.1	GO:0090312	positive regulation of protein deacetylation(GO:0090312)
0.0	0.2	GO:0030422	production of siRNA involved in RNA interference(GO:0030422)
0.0	0.1	GO:0006657	CDP-choline pathway(GO:0006657)
0.0	0.4	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.1	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0	0.2	GO:0032060	bleb assembly(GO:0032060)
0.0	0.2	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	1.2	GO:0048010	vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0	0.1	GO:0045046	protein import into peroxisome membrane(GO:0045046)
0.0	0.4	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.0	GO:0015888	thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	GO:1990357	terminal web(GO:1990357)
0.1	1.2	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	1.2	GO:0044453	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.0	0.7	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.3	GO:0005680	anaphase-promoting complex(GO:0005680)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.4	GO:0032474	otolith morphogenesis(GO:0032474)
0.4	1.3	GO:0090244	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.4	1.2	GO:0003241	growth involved in heart morphogenesis(GO:0003241)
0.3	0.9	GO:0010645	regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.2	1.2	GO:0034124	regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
0.2	0.6	GO:0006788	heme oxidation(GO:0006788) smooth muscle hyperplasia(GO:0014806)
0.2	0.8	GO:0038195	urokinase plasminogen activator signaling pathway(GO:0038195)
0.2	0.6	GO:0051097	negative regulation of helicase activity(GO:0051097) oligodendrocyte apoptotic process(GO:0097252)
0.2	1.1	GO:1902998	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.2	0.5	GO:0060940	epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.1	0.7	GO:1903906	plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.1	1.4	GO:1903944	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1	0.6	GO:0048861	oncostatin-M-mediated signaling pathway(GO:0038165) leukemia inhibitory factor signaling pathway(GO:0048861)
0.1	1.4	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1	0.7	GO:0051582	peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.1	0.6	GO:0001957	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1	0.3	GO:0014057	positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.1	0.5	GO:0032227	negative regulation of synaptic transmission, dopaminergic(GO:0032227) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
0.1	0.4	GO:0071461	cellular response to redox state(GO:0071461)
0.1	1.1	GO:0015889	cobalamin transport(GO:0015889)
0.1	0.3	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.1	1.0	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
0.1	0.3	GO:0090245	axis elongation involved in somitogenesis(GO:0090245)
0.1	0.3	GO:0032829	regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.1	0.4	GO:2000697	negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.1	0.3	GO:0045082	interleukin-4 biosynthetic process(GO:0042097) positive regulation of interleukin-10 biosynthetic process(GO:0045082) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1	0.3	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
0.1	1.1	GO:0035826	rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.1	2.8	GO:0008045	motor neuron axon guidance(GO:0008045)
0.1	0.2	GO:0050760	negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
0.1	0.3	GO:0099541	retrograde trans-synaptic signaling(GO:0098917) trans-synaptic signaling by lipid(GO:0099541) trans-synaptic signaling by endocannabinoid(GO:0099542)
0.1	0.3	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.1	0.3	GO:0016476	regulation of embryonic cell shape(GO:0016476)
0.1	0.4	GO:0090131	mesenchyme migration(GO:0090131)
0.1	0.2	GO:0035964	COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.1	0.3	GO:1904098	regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.0	0.2	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0	0.2	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.0	0.3	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0	0.1	GO:0050894	determination of affect(GO:0050894)
0.0	0.1	GO:0061386	closure of optic fissure(GO:0061386)
0.0	0.3	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.0	0.2	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.2	GO:0097240	meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.0	0.3	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.5	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.1	GO:2000661	positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0	0.1	GO:0014028	notochord formation(GO:0014028)
0.0	0.1	GO:0018406	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.4	GO:0070141	response to UV-A(GO:0070141)
0.0	0.3	GO:0033089	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0	0.2	GO:1903593	regulation of histamine secretion by mast cell(GO:1903593)
0.0	0.6	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.9	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0	0.1	GO:0033313	meiotic cell cycle checkpoint(GO:0033313)
0.0	0.5	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.2	GO:0007079	mitotic chromosome movement towards spindle pole(GO:0007079)
0.0	0.1	GO:0043314	negative regulation of neutrophil degranulation(GO:0043314)
0.0	0.1	GO:0051039	histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.0	0.8	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.4	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	0.2	GO:1902766	skeletal muscle satellite cell migration(GO:1902766)
0.0	1.5	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.1	GO:0036378	calcitriol biosynthetic process from calciol(GO:0036378)
0.0	0.4	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.7	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.7	GO:0034204	lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0	0.1	GO:0061317	regulation of Wnt signaling pathway involved in heart development(GO:0003307) canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066)
0.0	0.2	GO:0097577	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0	0.1	GO:0061394	regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.0	0.1	GO:0035522	monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0	0.2	GO:0030101	natural killer cell activation(GO:0030101)
0.0	0.7	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0	0.1	GO:0071393	cellular response to progesterone stimulus(GO:0071393)
0.0	0.3	GO:1903830	magnesium ion transmembrane transport(GO:1903830)
0.0	0.1	GO:0006942	regulation of striated muscle contraction(GO:0006942)
0.0	0.2	GO:0070914	UV-damage excision repair(GO:0070914)
0.0	0.1	GO:0035965	cardiolipin acyl-chain remodeling(GO:0035965)
0.0	0.1	GO:0051710	regulation of cytolysis in other organism(GO:0051710)
0.0	0.5	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	2.9	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.5	GO:0007567	parturition(GO:0007567)
0.0	0.0	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.3	GO:0000920	cell separation after cytokinesis(GO:0000920)
0.0	0.1	GO:0010827	regulation of glucose transport(GO:0010827) regulation of glucose import(GO:0046324)
0.0	0.3	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0016050	vesicle organization(GO:0016050)
0.0	0.5	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.2	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.3	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0	0.4	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592)
0.0	0.1	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0	0.2	GO:0006531	aspartate metabolic process(GO:0006531)
0.0	0.3	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	0.0	GO:0006097	glyoxylate cycle(GO:0006097)
0.0	0.1	GO:0070365	hepatocyte differentiation(GO:0070365)
0.0	0.2	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0	0.2	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	2.9	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.1	GO:0061083	regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0	0.1	GO:0002829	negative regulation of type 2 immune response(GO:0002829)
0.0	0.0	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.6	GO:0019433	triglyceride catabolic process(GO:0019433)
0.0	0.4	GO:0007257	activation of JUN kinase activity(GO:0007257)
0.0	0.6	GO:0000186	activation of MAPKK activity(GO:0000186)
0.0	0.0	GO:0021633	optic nerve structural organization(GO:0021633)
0.0	0.3	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.1	GO:1901386	negative regulation of voltage-gated calcium channel activity(GO:1901386)
0.0	0.7	GO:0006027	glycosaminoglycan catabolic process(GO:0006027)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:2000538	regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.2	0.5	GO:0036058	filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1	0.7	GO:1902896	terminal web assembly(GO:1902896)
0.1	0.3	GO:0097068	response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.1	2.7	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
0.1	0.4	GO:0061143	alveolar primary septum development(GO:0061143)
0.1	1.2	GO:0032688	negative regulation of interferon-beta production(GO:0032688)
0.1	1.7	GO:0035338	long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1	0.2	GO:0038188	cholecystokinin signaling pathway(GO:0038188)
0.1	0.4	GO:0009134	nucleoside diphosphate catabolic process(GO:0009134)
0.1	0.3	GO:1902775	mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.2	GO:0019255	glucose 1-phosphate metabolic process(GO:0019255)
0.0	0.5	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.3	GO:0090129	positive regulation of synapse maturation(GO:0090129)
0.0	1.0	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.5	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.0	0.2	GO:0014051	gamma-aminobutyric acid secretion(GO:0014051)
0.0	0.1	GO:0070829	response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0030377	urokinase plasminogen activator receptor activity(GO:0030377)
0.2	0.6	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
0.2	0.6	GO:0019981	interleukin-6 receptor activity(GO:0004915) oncostatin-M receptor activity(GO:0004924) interleukin-6 binding(GO:0019981)
0.2	0.9	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.1	0.4	GO:0050698	proteoglycan sulfotransferase activity(GO:0050698)
0.1	0.4	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1	0.5	GO:0060961	phospholipase D inhibitor activity(GO:0060961)
0.1	0.4	GO:0031685	adenosine receptor binding(GO:0031685)
0.1	1.2	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036) sphingolipid binding(GO:0046625)
0.1	1.1	GO:0031419	cobalamin binding(GO:0031419)
0.1	0.6	GO:0042610	CD8 receptor binding(GO:0042610)
0.1	1.2	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1	1.3	GO:0048019	receptor antagonist activity(GO:0048019)
0.1	0.3	GO:0004917	interleukin-7 receptor activity(GO:0004917)
0.1	0.3	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.1	0.2	GO:0003863	alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.1	0.2	GO:0004515	nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1	3.1	GO:0046875	ephrin receptor binding(GO:0046875)
0.1	0.6	GO:0000990	transcription factor activity, core RNA polymerase binding(GO:0000990)
0.1	0.2	GO:0008955	peptidoglycan glycosyltransferase activity(GO:0008955)
0.1	0.7	GO:0045159	myosin II binding(GO:0045159)
0.1	0.3	GO:0070492	oligosaccharide binding(GO:0070492)
0.1	0.7	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	1.4	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.9	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0031877	somatostatin receptor binding(GO:0031877)
0.0	1.3	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	1.4	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.4	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.4	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.8	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.1	GO:0050528	acyloxyacyl hydrolase activity(GO:0050528)
0.0	0.3	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.3	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0010698	acetyltransferase activator activity(GO:0010698)
0.0	0.3	GO:0004865	protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0	0.2	GO:0008046	axon guidance receptor activity(GO:0008046)
0.0	0.7	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	2.5	GO:0019843	rRNA binding(GO:0019843)
0.0	0.5	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.4	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0070643	vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
0.0	0.7	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.2	GO:1990599	3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.0	0.1	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0004909	interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0	0.7	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:1901474	L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858) azole transmembrane transporter activity(GO:1901474)
0.0	0.6	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.6	GO:0001968	fibronectin binding(GO:0001968)
0.0	0.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.7	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.3	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.7	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	0.3	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.1	GO:0016019	peptidoglycan receptor activity(GO:0016019)
0.0	0.1	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0	0.1	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.3	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.3	GO:0035197	siRNA binding(GO:0035197)
0.0	0.3	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0016434	rRNA (cytosine) methyltransferase activity(GO:0016434)
0.0	0.1	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.0	0.5	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	1.7	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0	0.0	GO:0004450	isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0	0.1	GO:0015185	gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0	0.2	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0035497	cAMP response element binding(GO:0035497)
0.0	0.1	GO:0044547	DNA topoisomerase binding(GO:0044547)
0.0	0.4	GO:0060089	receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0	0.6	GO:0005504	fatty acid binding(GO:0005504)
0.0	0.1	GO:0001851	complement component C3b binding(GO:0001851)
0.0	0.2	GO:0102391	decanoate--CoA ligase activity(GO:0102391)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.1	1.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.1	0.6	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.1	0.9	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.9	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	1.1	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	1.3	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.5	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.7	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.7	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	1.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	2.5	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.5	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.6	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.0	0.7	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0	1.2	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.6	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.4	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.0	0.5	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	3.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.5	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.7	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.3	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.0	0.7	REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0	0.7	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.0	0.2	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	1.5	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	1.9	REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS	Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0	0.6	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.7	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.4	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.4	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.0	0.5	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.0	0.5	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.6	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.4	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.0	0.4	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.8	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane
0.0	1.5	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.6	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.4	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.8	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.5	REACTOME CD28 CO STIMULATION	Genes involved in CD28 co-stimulation
0.0	0.3	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	1.2	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.2	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.1	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.4	REACTOME KINESINS	Genes involved in Kinesins
0.0	1.0	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	0.1	REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT	Genes involved in p53-Independent G1/S DNA damage checkpoint
0.0	0.5	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.2	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.4	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.2	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.6	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.5	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.0	0.1	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.0	0.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.1	GO:0044326	dendritic spine neck(GO:0044326)
0.1	0.9	GO:0070381	endosome to plasma membrane transport vesicle(GO:0070381)
0.1	0.6	GO:0030678	mitochondrial ribonuclease P complex(GO:0030678)
0.1	2.3	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.1	0.6	GO:1902937	inward rectifier potassium channel complex(GO:1902937)
0.1	1.1	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1	0.6	GO:0031415	NatA complex(GO:0031415)
0.1	1.3	GO:0043020	NADPH oxidase complex(GO:0043020)
0.1	1.8	GO:0005779	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1	0.3	GO:0031510	SUMO activating enzyme complex(GO:0031510)
0.0	0.2	GO:0001405	presequence translocase-associated import motor(GO:0001405)
0.0	0.4	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.2	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.1	GO:1990622	CHOP-ATF3 complex(GO:1990622)
0.0	0.8	GO:0097342	ripoptosome(GO:0097342)
0.0	0.2	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.9	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.4	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.3	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.8	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.4	GO:1990023	kinetochore microtubule(GO:0005828) mitotic spindle midzone(GO:1990023)
0.0	0.3	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.3	GO:0097255	R2TP complex(GO:0097255)
0.0	0.2	GO:0070938	contractile ring(GO:0070938)
0.0	0.2	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.6	GO:0032982	myosin filament(GO:0032982)
0.0	0.2	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.3	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	2.3	GO:0035579	specific granule membrane(GO:0035579)
0.0	0.1	GO:0033010	paranodal junction(GO:0033010)
0.0	0.3	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.2	GO:0005655	nucleolar ribonuclease P complex(GO:0005655)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.2	GO:0000788	nuclear nucleosome(GO:0000788)
0.0	0.2	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0031931	TORC1 complex(GO:0031931)
0.0	1.2	GO:0034707	chloride channel complex(GO:0034707)
0.0	0.3	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.0	0.1	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	0.5	GO:0070821	tertiary granule membrane(GO:0070821)
0.0	0.2	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.1	GO:0000796	condensin complex(GO:0000796)
0.0	0.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.2	GO:0090543	Flemming body(GO:0090543)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.2	GO:0019774	proteasome core complex, beta-subunit complex(GO:0019774)
0.0	0.1	GO:0044294	dendritic growth cone(GO:0044294)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.7	GO:0051185	FAD transmembrane transporter activity(GO:0015230) coenzyme transporter activity(GO:0051185)
0.3	0.8	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.2	0.6	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.2	1.1	GO:0042610	CD8 receptor binding(GO:0042610)
0.2	0.5	GO:0051139	metal ion:proton antiporter activity(GO:0051139)
0.1	2.2	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1	0.5	GO:0097001	ceramide binding(GO:0097001)
0.1	0.3	GO:0003883	CTP synthase activity(GO:0003883)
0.1	0.3	GO:0099580	ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1	0.6	GO:0031726	CCR1 chemokine receptor binding(GO:0031726)
0.1	0.8	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.1	0.5	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.1	0.5	GO:0008948	malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
0.1	0.9	GO:0032050	clathrin heavy chain binding(GO:0032050)
0.1	0.4	GO:0051373	FATZ binding(GO:0051373)
0.1	1.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.1	0.2	GO:0032767	copper-dependent protein binding(GO:0032767)
0.1	0.2	GO:0047696	beta-adrenergic receptor kinase activity(GO:0047696)
0.1	1.3	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.1	0.7	GO:0002151	G-quadruplex RNA binding(GO:0002151)
0.1	0.6	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.1	0.2	GO:0034041	sterol-transporting ATPase activity(GO:0034041)
0.1	0.6	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1	0.4	GO:0070492	oligosaccharide binding(GO:0070492)
0.0	0.5	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.3	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.3	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.0	0.2	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.4	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.4	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.3	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	1.0	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.5	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.2	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.4	GO:0046935	1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.8	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	1.8	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.2	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.1	GO:0004307	diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.0	0.3	GO:0032552	deoxyribonucleotide binding(GO:0032552)
0.0	0.6	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0004819	glutamine-tRNA ligase activity(GO:0004819) valine-tRNA ligase activity(GO:0004832)
0.0	0.2	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.7	GO:0070412	R-SMAD binding(GO:0070412)
0.0	1.1	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	2.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.5	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	1.3	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.3	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.8	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.3	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.5	GO:0097493	muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.1	GO:0004447	iodide peroxidase activity(GO:0004447)
0.0	0.5	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.2	GO:0000150	recombinase activity(GO:0000150)
0.0	0.1	GO:0019828	aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.0	0.1	GO:0099529	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.0	0.1	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.0	0.3	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.1	GO:0017018	myosin phosphatase activity(GO:0017018)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.2	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.3	GO:0051400	BH domain binding(GO:0051400)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.3	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.0	0.1	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.0	0.1	GO:0031728	CCR3 chemokine receptor binding(GO:0031728)
0.0	1.5	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	0.4	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.8	GO:0035064	methylated histone binding(GO:0035064)
0.0	0.2	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.3	GO:0071949	FAD binding(GO:0071949)
0.0	0.0	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.2	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.2	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.3	GO:0005487	nucleocytoplasmic transporter activity(GO:0005487)
0.0	0.5	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.1	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.0	0.0	GO:0015234	thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2	0.5	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.1	1.0	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.1	1.2	GO:0004931	extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.1	1.7	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.1	1.5	GO:0045028	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1	0.2	GO:0003983	UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748)
0.1	0.2	GO:0004951	cholecystokinin receptor activity(GO:0004951)
0.1	0.3	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.4	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	1.2	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.5	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.1	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0	0.2	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.4	GO:0051183	vitamin transporter activity(GO:0051183)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.1	0.4	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1	1.0	GO:0034464	BBSome(GO:0034464)
0.1	1.5	GO:0005687	U4 snRNP(GO:0005687)
0.1	1.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.6	GO:0036021	endolysosome lumen(GO:0036021)
0.1	1.4	GO:0097342	ripoptosome(GO:0097342)
0.1	0.4	GO:0042643	actomyosin, actin portion(GO:0042643)
0.1	1.3	GO:0042583	chromaffin granule(GO:0042583)
0.1	0.9	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.1	0.8	GO:0071438	invadopodium membrane(GO:0071438)
0.1	0.9	GO:0005916	fascia adherens(GO:0005916)
0.1	0.2	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.2	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.7	GO:0030478	actin cap(GO:0030478)
0.0	0.3	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.3	GO:0043196	varicosity(GO:0043196)
0.0	2.5	GO:0005844	polysome(GO:0005844)
0.0	0.1	GO:0030896	checkpoint clamp complex(GO:0030896)
0.0	0.2	GO:1990812	growth cone filopodium(GO:1990812)
0.0	0.3	GO:0000796	condensin complex(GO:0000796)
0.0	0.2	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.0	0.6	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.3	GO:0032009	early phagosome(GO:0032009)
0.0	0.3	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.2	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.3	GO:0097227	sperm annulus(GO:0097227)
0.0	0.2	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.1	GO:1990622	CHOP-ATF3 complex(GO:1990622)
0.0	0.1	GO:0034688	integrin alphaM-beta2 complex(GO:0034688)
0.0	0.3	GO:0090543	Flemming body(GO:0090543)
0.0	1.3	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	0.7	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.1	GO:0014802	terminal cisterna(GO:0014802)
0.0	0.3	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.2	GO:0000788	nuclear nucleosome(GO:0000788)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.8	GO:0030286	dynein complex(GO:0030286)
0.0	0.3	GO:0000812	Swr1 complex(GO:0000812)
0.0	0.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	2.5	GO:0043197	dendritic spine(GO:0043197)
0.0	0.0	GO:0002139	stereocilia coupling link(GO:0002139)
0.0	1.8	GO:0031901	early endosome membrane(GO:0031901)
0.0	1.6	GO:0043202	lysosomal lumen(GO:0043202)
0.0	1.0	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.4	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.3	GO:0043218	compact myelin(GO:0043218)
0.0	0.3	GO:0030673	axolemma(GO:0030673)

Gene overrepresentation in C2:CP category:

Total log-likelihood	Term	Description
2.4	PID AURORA A PATHWAY	Aurora A signaling
0.6	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
1.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.5	PID IL5 PATHWAY	IL5-mediated signaling events
0.8	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
1.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.2	PID CXCR4 PATHWAY	CXCR4-mediated signaling events
2.1	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.2	PID IFNG PATHWAY	IFN-gamma pathway
0.3	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.7	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.3	PID EPO PATHWAY	EPO signaling pathway

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.7	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	1.4	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0	1.3	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	1.2	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.0	2.9	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	1.7	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.7	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	2.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.0	0.8	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0	0.4	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.7	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	1.9	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	0.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.0	1.2	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
0.0	0.2	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.6	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.4	PID RAS PATHWAY	Regulation of Ras family activation

Results for TBX2

Z-value: 0.74

Motif logo

Transcription factors associated with TBX2

Activity-expression correlation:

Activity profile of TBX2 motif

Sorted Z-values of TBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP category: