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ENCODE cell lines, expression (Ernst 2011)

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Results for TBX4

Z-value: 0.69

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Transcription factors associated with TBX4

Gene Symbol Gene ID Gene Info
TBX4
ENSG00000121075.5 TBX4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX4hg19_v2_chr17_+_59529743_59529798-0.184.9e-01Click!

Activity profile of TBX4 motif

Sorted Z-values of TBX4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_-_75567962 2.58 ENST00000297785.3
ENST00000376939.1
 ALDH1A1
 aldehyde dehydrogenase 1 family, member A1
chr2_-_175870085 2.34 ENST00000409156.3
 CHN1
 chimerin 1
chr2_-_175869936 2.21 ENST00000409900.3
 CHN1
 chimerin 1
chr4_-_186456652 1.66 ENST00000284767.5
ENST00000284770.5
 PDLIM3
 PDZ and LIM domain 3
chr4_-_186456766 1.65 ENST00000284771.6
 PDLIM3
 PDZ and LIM domain 3
chr10_+_31608054 1.46 ENST00000320985.10
ENST00000361642.5
ENST00000560721.2
ENST00000558440.1
ENST00000424869.1
ENST00000542815.3
 ZEB1
 zinc finger E-box binding homeobox 1
chr4_-_186732048 1.24 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
 SORBS2
 sorbin and SH3 domain containing 2
chr12_-_90024360 1.16 ENST00000393164.2
 ATP2B1
 ATPase, Ca++ transporting, plasma membrane 1
chr21_+_30502806 1.11 ENST00000399928.1
ENST00000399926.1
 MAP3K7CL
 MAP3K7 C-terminal like
chr5_-_172756506 1.05 ENST00000265087.4
 STC2
 stanniocalcin 2
chr5_+_82767284 0.92 ENST00000265077.3
 VCAN
 versican
chr5_+_82767487 0.85 ENST00000343200.5
ENST00000342785.4
 VCAN
 versican
chr6_+_39760129 0.73 ENST00000274867.4
 DAAM2
 dishevelled associated activator of morphogenesis 2
chr13_-_36429763 0.71 ENST00000379893.1
 DCLK1
 doublecortin-like kinase 1
chr16_+_85645007 0.64 ENST00000405402.2
 GSE1
 Gse1 coiled-coil protein
chr11_-_85779971 0.60 ENST00000393346.3
 PICALM
 phosphatidylinositol binding clathrin assembly protein
chr1_-_230561475 0.59 ENST00000391860.1
 PGBD5
 piggyBac transposable element derived 5
chrX_-_11445856 0.46 ENST00000380736.1
 ARHGAP6
 Rho GTPase activating protein 6
chr9_+_34990219 0.39 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
 DNAJB5
 DnaJ (Hsp40) homolog, subfamily B, member 5
chr18_-_53068911 0.38 ENST00000537856.3
 TCF4
 transcription factor 4
chr10_-_75226166 0.34 ENST00000544628.1
 PPP3CB
 protein phosphatase 3, catalytic subunit, beta isozyme
chr11_+_1940786 0.32 ENST00000278317.6
ENST00000381561.4
ENST00000381548.3
ENST00000360603.3
ENST00000381549.3
 TNNT3
 troponin T type 3 (skeletal, fast)
chr1_+_114471972 0.29 ENST00000369559.4
ENST00000369554.2
 HIPK1
 homeodomain interacting protein kinase 1
chr15_+_89402148 0.28 ENST00000560601.1
 ACAN
 aggrecan
chr11_+_61447845 0.28 ENST00000257215.5
 DAGLA
 diacylglycerol lipase, alpha
chr1_+_114472222 0.28 ENST00000369558.1
ENST00000369561.4
 HIPK1
 homeodomain interacting protein kinase 1
chr15_+_92937058 0.22 ENST00000268164.3
 ST8SIA2
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr6_-_31080336 0.19 ENST00000259870.3
 C6orf15
 chromosome 6 open reading frame 15
chr2_-_157189180 0.19 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
 NR4A2
 nuclear receptor subfamily 4, group A, member 2
chr15_+_92937144 0.18 ENST00000539113.1
ENST00000555434.1
 ST8SIA2
 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
chr1_+_114472481 0.17 ENST00000369555.2
 HIPK1
 homeodomain interacting protein kinase 1
chr5_-_114515734 0.16 ENST00000514154.1
ENST00000282369.3
 TRIM36
 tripartite motif containing 36
chr15_-_58357932 0.16 ENST00000347587.3
 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
chr11_+_4116054 0.16 ENST00000423050.2
 RRM1
 ribonucleotide reductase M1
chr10_+_94833642 0.15 ENST00000224356.4
ENST00000394139.1
 CYP26A1
 cytochrome P450, family 26, subfamily A, polypeptide 1
chr7_-_150675372 0.15 ENST00000262186.5
 KCNH2
 potassium voltage-gated channel, subfamily H (eag-related), member 2
chr17_-_8066843 0.15 ENST00000404970.3
 VAMP2
 vesicle-associated membrane protein 2 (synaptobrevin 2)
chr9_-_74979420 0.15 ENST00000343431.2
ENST00000376956.3
 ZFAND5
 zinc finger, AN1-type domain 5
chr5_-_60240858 0.15 ENST00000426742.2
ENST00000265038.5
ENST00000543101.1
ENST00000439176.1
 ERCC8
 excision repair cross-complementing rodent repair deficiency, complementation group 8
chr1_+_114471809 0.15 ENST00000426820.2
 HIPK1
 homeodomain interacting protein kinase 1
chr8_+_123793633 0.14 ENST00000314393.4
 ZHX2
 zinc fingers and homeoboxes 2
chr18_+_32073253 0.14 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
 DTNA
 dystrobrevin, alpha
chr5_-_54281407 0.14 ENST00000381403.4
 ESM1
 endothelial cell-specific molecule 1
chr11_+_73358594 0.13 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
 PLEKHB1
 pleckstrin homology domain containing, family B (evectins) member 1
chr17_-_61988556 0.13 ENST00000309894.5
ENST00000438387.2
ENST00000346606.6
ENST00000561003.1
ENST00000450719.3
ENST00000259003.10
 CSHL1
 chorionic somatomammotropin hormone-like 1
chr8_-_95907423 0.13 ENST00000396133.3
ENST00000308108.4
 CCNE2
 cyclin E2
chr17_-_26220366 0.13 ENST00000460380.2
ENST00000508862.1
ENST00000379102.3
ENST00000582441.1
 LYRM9
RP1-66C13.4
 LYR motif containing 9
Uncharacterized protein
chr1_-_1009683 0.12 ENST00000453464.2
 RNF223
 ring finger protein 223
chr2_-_85895295 0.12 ENST00000428225.1
ENST00000519937.2
 SFTPB
 surfactant protein B
chr16_+_2588012 0.12 ENST00000354836.5
ENST00000389224.3
 PDPK1
 3-phosphoinositide dependent protein kinase-1
chr11_-_5248294 0.09 ENST00000335295.4
 HBB
 hemoglobin, beta
chr7_+_143013198 0.09 ENST00000343257.2
 CLCN1
 chloride channel, voltage-sensitive 1
chr14_+_78870030 0.09 ENST00000553631.1
ENST00000554719.1
 NRXN3
 neurexin 3
chr20_-_22565101 0.09 ENST00000419308.2
 FOXA2
 forkhead box A2
chr1_+_145507587 0.09 ENST00000330165.8
ENST00000369307.3
 RBM8A
 RNA binding motif protein 8A
chr11_-_6502580 0.08 ENST00000423813.2
ENST00000396777.3
 ARFIP2
 ADP-ribosylation factor interacting protein 2
chr11_-_6502534 0.08 ENST00000254584.2
ENST00000525235.1
ENST00000445086.2
 ARFIP2
 ADP-ribosylation factor interacting protein 2
chr9_+_71986182 0.08 ENST00000303068.7
 FAM189A2
 family with sequence similarity 189, member A2
chr5_-_78809950 0.08 ENST00000334082.6
 HOMER1
 homer homolog 1 (Drosophila)
chr14_-_45603657 0.07 ENST00000396062.3
 FKBP3
 FK506 binding protein 3, 25kDa
chr11_-_128737259 0.07 ENST00000440599.2
ENST00000392666.1
ENST00000324036.3
 KCNJ1
 potassium inwardly-rectifying channel, subfamily J, member 1
chr16_+_2587965 0.07 ENST00000342085.4
ENST00000566659.1
 PDPK1
 3-phosphoinositide dependent protein kinase-1
chr1_+_95582881 0.07 ENST00000370203.4
ENST00000456991.1
 TMEM56
 transmembrane protein 56
chr3_-_49459865 0.07 ENST00000427987.1
 AMT
 aminomethyltransferase
chr2_-_111291587 0.07 ENST00000437167.1
 RGPD6
 RANBP2-like and GRIP domain containing 6
chr12_+_50451331 0.07 ENST00000228468.4
 ASIC1
 acid-sensing (proton-gated) ion channel 1
chr11_+_114271251 0.06 ENST00000375490.5
 RBM7
 RNA binding motif protein 7
chr11_+_74660278 0.06 ENST00000263672.6
ENST00000530257.1
ENST00000526361.1
ENST00000532972.1
 SPCS2
 signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr5_+_68788594 0.06 ENST00000396442.2
ENST00000380766.2
 OCLN
 occludin
chr17_-_39222131 0.06 ENST00000394015.2
 KRTAP2-4
 keratin associated protein 2-4
chr11_+_114270752 0.06 ENST00000540163.1
 RBM7
 RNA binding motif protein 7
chr12_+_57853918 0.06 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
 GLI1
 GLI family zinc finger 1
chr11_-_128737163 0.06 ENST00000324003.3
ENST00000392665.2
 KCNJ1
 potassium inwardly-rectifying channel, subfamily J, member 1
chr11_-_33913708 0.05 ENST00000257818.2
 LMO2
 LIM domain only 2 (rhombotin-like 1)
chr13_+_115047097 0.05 ENST00000351487.5
 UPF3A
 UPF3 regulator of nonsense transcripts homolog A (yeast)
chr1_-_111148241 0.05 ENST00000440270.1
 KCNA2
 potassium voltage-gated channel, shaker-related subfamily, member 2
chr17_-_61996160 0.05 ENST00000458650.2
ENST00000351388.4
ENST00000323322.5
 GH1
 growth hormone 1
chr2_+_37458776 0.05 ENST00000002125.4
ENST00000336237.6
ENST00000431821.1
 NDUFAF7
 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
chr5_+_113697983 0.05 ENST00000264773.3
 KCNN2
 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
chr17_+_30771279 0.05 ENST00000261712.3
ENST00000578213.1
ENST00000457654.2
ENST00000579451.1
 PSMD11
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
chr17_-_61996136 0.04 ENST00000342364.4
 GH1
 growth hormone 1
chr3_-_49459878 0.04 ENST00000546031.1
ENST00000458307.2
ENST00000430521.1
 AMT
 aminomethyltransferase
chrX_+_46771711 0.03 ENST00000424392.1
ENST00000397189.1
 PHF16
 jade family PHD finger 3
chr7_+_97361218 0.03 ENST00000319273.5
 TAC1
 tachykinin, precursor 1
chr5_-_74807418 0.03 ENST00000405807.4
ENST00000261415.7
 COL4A3BP
 collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr2_+_11696464 0.03 ENST00000234142.5
 GREB1
 growth regulation by estrogen in breast cancer 1
chr11_+_111749942 0.03 ENST00000260276.3
 C11orf1
 chromosome 11 open reading frame 1
chr17_-_61996192 0.03 ENST00000392824.4
 CSHL1
 chorionic somatomammotropin hormone-like 1
chr7_+_97361388 0.02 ENST00000350485.4
ENST00000346867.4
 TAC1
 tachykinin, precursor 1
chr9_-_74980113 0.02 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
 ZFAND5
 zinc finger, AN1-type domain 5
chr16_+_2587998 0.02 ENST00000441549.3
ENST00000268673.7
 PDPK1
 3-phosphoinositide dependent protein kinase-1
chr5_-_54281491 0.02 ENST00000381405.4
 ESM1
 endothelial cell-specific molecule 1
chr17_+_57970469 0.02 ENST00000443572.2
ENST00000406116.3
ENST00000225577.4
ENST00000393021.3
 RPS6KB1
 ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr17_-_61973929 0.02 ENST00000329882.8
ENST00000453363.3
ENST00000316193.8
 CSH1
 chorionic somatomammotropin hormone 1 (placental lactogen)
chrX_+_46771848 0.02 ENST00000218343.4
 PHF16
 jade family PHD finger 3
chr10_-_99531709 0.01 ENST00000266066.3
 SFRP5
 secreted frizzled-related protein 5
chr3_+_52811596 0.01 ENST00000542827.1
ENST00000273283.2
 ITIH1
 inter-alpha-trypsin inhibitor heavy chain 1
chr19_+_10131437 0.01 ENST00000587782.1
 RDH8
 retinol dehydrogenase 8 (all-trans)
chr3_+_120626919 0.00 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
 STXBP5L
 syntaxin binding protein 5-like
chr5_-_34043310 0.00 ENST00000231338.7
 C1QTNF3
 C1q and tumor necrosis factor related protein 3

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 1.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 5.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 0.4 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.5 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.1 1.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 0.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.2 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.2 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.0 0.1 GO:0070195 growth hormone receptor complex(GO:0070195)
0.0 0.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.0 3.8 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 2.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.1 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.3 GO:0005861 troponin complex(GO:0005861)
0.0 0.1 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.2 1.2 GO:1990034 calcium ion export from cell(GO:1990034)
0.2 1.5 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 1.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 4.3 GO:0008045 motor neuron axon guidance(GO:0008045)
0.1 0.9 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.1 0.6 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.1 1.8 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 0.3 GO:0099542 retrograde trans-synaptic signaling(GO:0098917) trans-synaptic signaling by lipid(GO:0099541) trans-synaptic signaling by endocannabinoid(GO:0099542)
0.1 0.2 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1 0.2 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.1 0.2 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
0.1 0.4 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.1 GO:0030185 nitric oxide transport(GO:0030185)
0.0 0.1 GO:2000543 carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) positive regulation of gastrulation(GO:2000543)
0.0 1.0 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.7 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.0 0.2 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0 0.2 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
0.0 0.2 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.1 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.0 0.2 GO:0035799 ureter maturation(GO:0035799)
0.0 0.5 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.0 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 1.1 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 0.3 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.1 GO:0007418 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0 0.1 GO:0010536 positive regulation of activation of Janus kinase activity(GO:0010536)
0.0 0.0 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.0 GO:0044333 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0 0.0 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.1 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 4.6 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.3 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.1 2.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.2 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.1 0.4 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.2 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.1 1.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.0 1.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0 0.3 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 3.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.4 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0005148 prolactin receptor binding(GO:0005148)
0.0 0.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 1.1 GO:0070888 E-box binding(GO:0070888)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0 0.2 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.0 0.1 GO:0030492 hemoglobin binding(GO:0030492)
0.0 0.1 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.0 0.0 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)