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ENCODE cell lines, expression (Ernst 2011)

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Results for TFAP2E

Z-value: 0.69

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Transcription factors associated with TFAP2E

Gene Symbol Gene ID Gene Info
TFAP2E
ENSG00000116819.6 TFAP2E

Activity profile of TFAP2E motif

Sorted Z-values of TFAP2E motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2E

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_116700614 2.29 ENST00000375345.1
 APOC3
 apolipoprotein C-III
chr11_+_116700600 2.28 ENST00000227667.3
 APOC3
 apolipoprotein C-III
chrX_+_115567767 1.62 ENST00000371900.4
 SLC6A14
 solute carrier family 6 (amino acid transporter), member 14
chr14_-_25519317 1.27 ENST00000323944.5
 STXBP6
 syntaxin binding protein 6 (amisyn)
chr2_+_75061108 1.24 ENST00000290573.2
 HK2
 hexokinase 2
chr14_-_25519095 1.24 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
 STXBP6
 syntaxin binding protein 6 (amisyn)
chr1_-_32801825 1.18 ENST00000329421.7
 MARCKSL1
 MARCKS-like 1
chr16_+_69599899 1.08 ENST00000567239.1
 NFAT5
 nuclear factor of activated T-cells 5, tonicity-responsive
chr16_+_69600058 1.08 ENST00000393742.2
 NFAT5
 nuclear factor of activated T-cells 5, tonicity-responsive
chr16_+_69599861 1.01 ENST00000354436.2
 NFAT5
 nuclear factor of activated T-cells 5, tonicity-responsive
chr2_+_38893047 0.86 ENST00000272252.5
 GALM
 galactose mutarotase (aldose 1-epimerase)
chr1_+_9599540 0.84 ENST00000302692.6
 SLC25A33
 solute carrier family 25 (pyrimidine nucleotide carrier), member 33
chr13_-_76056250 0.83 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
 TBC1D4
 TBC1 domain family, member 4
chrX_+_152990302 0.80 ENST00000218104.3
 ABCD1
 ATP-binding cassette, sub-family D (ALD), member 1
chr11_-_35440796 0.75 ENST00000278379.3
 SLC1A2
 solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_-_35441524 0.75 ENST00000395750.1
ENST00000449068.1
 SLC1A2
 solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr17_+_72428218 0.71 ENST00000392628.2
 GPRC5C
 G protein-coupled receptor, family C, group 5, member C
chr8_+_17780483 0.71 ENST00000517730.1
ENST00000518537.1
ENST00000523055.1
ENST00000519253.1
 PCM1
 pericentriolar material 1
chr8_+_17780346 0.66 ENST00000325083.8
 PCM1
 pericentriolar material 1
chr2_-_24149977 0.66 ENST00000238789.5
 ATAD2B
 ATPase family, AAA domain containing 2B
chr2_-_174828892 0.64 ENST00000418194.2
 SP3
 Sp3 transcription factor
chr5_-_115152651 0.61 ENST00000250535.4
 CDO1
 cysteine dioxygenase type 1
chr19_+_4969116 0.56 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
 KDM4B
 lysine (K)-specific demethylase 4B
chr11_-_47870019 0.55 ENST00000378460.2
 NUP160
 nucleoporin 160kDa
chr11_-_47869865 0.55 ENST00000530326.1
ENST00000532747.1
 NUP160
 nucleoporin 160kDa
chrX_+_131157290 0.52 ENST00000394334.2
 MST4
 Serine/threonine-protein kinase MST4
chrX_+_131157322 0.50 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
 MST4
 Serine/threonine-protein kinase MST4
chr1_+_211433275 0.47 ENST00000367005.4
 RCOR3
 REST corepressor 3
chr6_+_37787262 0.45 ENST00000287218.4
 ZFAND3
 zinc finger, AN1-type domain 3
chr17_+_3627185 0.45 ENST00000325418.4
 GSG2
 germ cell associated 2 (haspin)
chr3_+_4535025 0.44 ENST00000302640.8
ENST00000354582.6
ENST00000423119.2
ENST00000357086.4
ENST00000456211.2
 ITPR1
 inositol 1,4,5-trisphosphate receptor, type 1
chr3_+_171757346 0.43 ENST00000421757.1
ENST00000415807.2
ENST00000392699.1
 FNDC3B
 fibronectin type III domain containing 3B
chr3_+_52813932 0.43 ENST00000537050.1
 ITIH1
 inter-alpha-trypsin inhibitor heavy chain 1
chr6_+_7107999 0.42 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
 RREB1
 ras responsive element binding protein 1
chr6_+_292051 0.41 ENST00000344450.5
 DUSP22
 dual specificity phosphatase 22
chr6_+_13272904 0.40 ENST00000379335.3
ENST00000379329.1
 PHACTR1
 phosphatase and actin regulator 1
chr5_+_133984462 0.39 ENST00000398844.2
ENST00000322887.4
 SEC24A
 SEC24 family member A
chr6_+_42531798 0.34 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
 UBR2
 ubiquitin protein ligase E3 component n-recognin 2
chr17_-_47755436 0.33 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
 SPOP
 speckle-type POZ protein
chr1_-_114355083 0.31 ENST00000261441.5
 RSBN1
 round spermatid basic protein 1
chr7_-_140624499 0.28 ENST00000288602.6
 BRAF
 v-raf murine sarcoma viral oncogene homolog B
chr19_+_36195429 0.25 ENST00000392197.2
 ZBTB32
 zinc finger and BTB domain containing 32
chr1_+_17634689 0.24 ENST00000375453.1
ENST00000375448.4
 PADI4
 peptidyl arginine deiminase, type IV
chr17_+_74070853 0.24 ENST00000329003.3
 GALR2
 galanin receptor 2
chr12_-_15942309 0.24 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
 EPS8
 epidermal growth factor receptor pathway substrate 8
chr1_+_150122034 0.22 ENST00000025469.6
ENST00000369124.4
 PLEKHO1
 pleckstrin homology domain containing, family O member 1
chr1_-_11866034 0.21 ENST00000376590.3
 MTHFR
 methylenetetrahydrofolate reductase (NAD(P)H)
chr19_+_50936142 0.21 ENST00000357701.5
 MYBPC2
 myosin binding protein C, fast type
chr11_-_118305921 0.20 ENST00000532619.1
 RP11-770J1.4
 RP11-770J1.4
chr2_-_177502254 0.19 ENST00000339037.3
 AC017048.3
 long intergenic non-protein coding RNA 1116
chr17_-_47755338 0.18 ENST00000508805.1
ENST00000515508.2
ENST00000451526.2
ENST00000507970.1
 SPOP
 speckle-type POZ protein
chr12_+_53773944 0.18 ENST00000551969.1
ENST00000327443.4
 SP1
 Sp1 transcription factor
chr20_+_58508817 0.17 ENST00000358293.3
 FAM217B
 family with sequence similarity 217, member B
chrX_+_128872998 0.17 ENST00000371106.3
 XPNPEP2
 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
chr1_-_11865982 0.16 ENST00000418034.1
 MTHFR
 methylenetetrahydrofolate reductase (NAD(P)H)
chr22_+_29601840 0.15 ENST00000334018.6
ENST00000429226.1
ENST00000404755.3
ENST00000404820.3
ENST00000430127.1
 EMID1
 EMI domain containing 1
chr12_-_15942503 0.15 ENST00000281172.5
 EPS8
 epidermal growth factor receptor pathway substrate 8
chr2_+_232573208 0.14 ENST00000409115.3
 PTMA
 prothymosin, alpha
chr19_+_36195467 0.14 ENST00000426659.2
 ZBTB32
 zinc finger and BTB domain containing 32
chr9_+_136501478 0.14 ENST00000393056.2
ENST00000263611.2
 DBH
 dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr3_+_4535155 0.14 ENST00000544951.1
 ITPR1
 inositol 1,4,5-trisphosphate receptor, type 1
chr4_+_154387480 0.14 ENST00000409663.3
ENST00000440693.1
ENST00000409959.3
 KIAA0922
 KIAA0922
chr9_+_19230433 0.12 ENST00000434457.2
ENST00000602925.1
 DENND4C
 DENN/MADD domain containing 4C
chr3_+_155860751 0.12 ENST00000471742.1
 KCNAB1
 potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr19_-_11039188 0.12 ENST00000588347.1
 YIPF2
 Yip1 domain family, member 2
chr2_+_232572361 0.12 ENST00000409321.1
 PTMA
 prothymosin, alpha
chr3_+_49591881 0.11 ENST00000296452.4
 BSN
 bassoon presynaptic cytomatrix protein
chr4_-_82393009 0.11 ENST00000436139.2
 RASGEF1B
 RasGEF domain family, member 1B
chr9_-_34662651 0.10 ENST00000259631.4
 CCL27
 chemokine (C-C motif) ligand 27
chrX_+_51636629 0.10 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
 MAGED1
 melanoma antigen family D, 1
chr2_+_232573222 0.08 ENST00000341369.7
ENST00000409683.1
 PTMA
 prothymosin, alpha
chr11_+_64009072 0.08 ENST00000535135.1
ENST00000394540.3
 FKBP2
 FK506 binding protein 2, 13kDa
chr15_+_27112380 0.08 ENST00000554596.1
 GABRA5
 gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr15_+_77287426 0.08 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
 PSTPIP1
 proline-serine-threonine phosphatase interacting protein 1
chr1_-_11865351 0.08 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
 MTHFR
 methylenetetrahydrofolate reductase (NAD(P)H)
chr3_+_105086056 0.07 ENST00000472644.2
 ALCAM
 activated leukocyte cell adhesion molecule
chr19_-_46389359 0.07 ENST00000302165.3
 IRF2BP1
 interferon regulatory factor 2 binding protein 1
chr6_+_7107830 0.07 ENST00000379933.3
 RREB1
 ras responsive element binding protein 1
chr17_+_29158962 0.06 ENST00000321990.4
 ATAD5
 ATPase family, AAA domain containing 5
chr15_+_27112296 0.06 ENST00000554038.1
 GABRA5
 gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr1_-_201346761 0.06 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
 TNNT2
 troponin T type 2 (cardiac)
chr17_+_37824217 0.05 ENST00000394246.1
 PNMT
 phenylethanolamine N-methyltransferase
chr13_-_27334879 0.05 ENST00000405846.3
 GPR12
 G protein-coupled receptor 12
chr2_+_74741569 0.05 ENST00000233638.7
 TLX2
 T-cell leukemia homeobox 2
chr2_+_239335449 0.05 ENST00000264607.4
 ASB1
 ankyrin repeat and SOCS box containing 1
chr9_+_35605274 0.05 ENST00000336395.5
 TESK1
 testis-specific kinase 1
chr17_+_37824700 0.04 ENST00000581428.1
 PNMT
 phenylethanolamine N-methyltransferase
chr17_-_31620006 0.04 ENST00000225823.2
 ASIC2
 acid-sensing (proton-gated) ion channel 2
chr14_-_64010046 0.04 ENST00000337537.3
 PPP2R5E
 protein phosphatase 2, regulatory subunit B', epsilon isoform
chr11_-_65325430 0.04 ENST00000322147.4
 LTBP3
 latent transforming growth factor beta binding protein 3
chr11_-_113345995 0.03 ENST00000355319.2
ENST00000542616.1
 DRD2
 dopamine receptor D2
chr3_+_110790590 0.03 ENST00000485303.1
 PVRL3
 poliovirus receptor-related 3
chr16_+_56623433 0.02 ENST00000570176.1
 MT3
 metallothionein 3
chr9_-_21077939 0.02 ENST00000380232.2
 IFNB1
 interferon, beta 1, fibroblast
chr1_+_9005917 0.01 ENST00000549778.1
ENST00000480186.3
ENST00000377443.2
ENST00000377436.3
ENST00000377442.2
 CA6
 carbonic anhydrase VI
chr2_-_241831424 0.00 ENST00000402775.2
ENST00000307486.8
 C2orf54
 chromosome 2 open reading frame 54

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.0 0.4 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 1.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 1.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 0.6 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 1.4 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 1.0 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.6 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 2.5 GO:0000145 exocyst(GO:0000145)
0.1 0.2 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 1.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.6 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.4 GO:0000242 pericentriolar material(GO:0000242)
0.0 1.5 GO:0030673 axolemma(GO:0030673)
0.0 0.8 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.1 GO:1990635 proximal dendrite(GO:1990635)
0.0 1.1 GO:0031526 brush border membrane(GO:0031526)
0.0 0.1 GO:0032593 insulin-responsive compartment(GO:0032593)
0.0 0.1 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 1.3 GO:0017053 transcriptional repressor complex(GO:0017053)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 4.6 GO:0060621 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.4 0.8 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.3 1.4 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.3 0.9 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.3 0.8 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
0.3 2.5 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 0.8 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
0.2 1.5 GO:0070779 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.2 1.2 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.2 0.5 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.2 0.6 GO:0042412 taurine biosynthetic process(GO:0042412)
0.1 0.6 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.1 0.6 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.1 0.4 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.1 0.4 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.1 0.5 GO:2000676 positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.1 0.7 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 3.2 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 0.6 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 0.3 GO:0071233 cellular response to leucine(GO:0071233)
0.1 0.2 GO:1900239 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.1 0.3 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0 0.4 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.2 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0 0.4 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 1.6 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 0.1 GO:0042418 epinephrine biosynthetic process(GO:0042418)
0.0 1.1 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.0 0.4 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.2 GO:0051451 myoblast migration(GO:0051451)
0.0 0.2 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.1 GO:0032972 regulation of muscle filament sliding(GO:0032971) regulation of muscle filament sliding speed(GO:0032972)
0.0 0.2 GO:1901018 positive regulation of potassium ion transmembrane transporter activity(GO:1901018)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.6 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.3 0.8 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
0.2 1.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.2 0.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 1.2 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 0.6 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1 2.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.1 0.4 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.1 1.6 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 0.9 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 0.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.1 0.3 GO:0070728 leucine binding(GO:0070728)
0.1 0.2 GO:0004966 galanin receptor activity(GO:0004966)
0.0 0.4 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.2 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.0 1.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.0 0.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.0 0.6 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.0 0.1 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.1 GO:0004603 phenylethanolamine N-methyltransferase activity(GO:0004603)
0.0 0.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 1.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.0 0.8 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.0 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network