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ENCODE cell lines, expression (Ernst 2011)

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Results for THRB

Z-value: 0.62

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.13 THRB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24207039_24207086,
hg19_v2_chr3_-_24536253_24536328		0.421.0e-01Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_-_21810765 2.79 ENST00000450584.1
ENST00000350669.1
 LDHB
 lactate dehydrogenase B
chr12_-_21810726 2.78 ENST00000396076.1
 LDHB
 lactate dehydrogenase B
chr20_+_37434329 2.29 ENST00000299824.1
ENST00000373331.2
 PPP1R16B
 protein phosphatase 1, regulatory subunit 16B
chr8_+_28174649 0.90 ENST00000301908.3
 PNOC
 prepronociceptin
chr10_+_60145155 0.89 ENST00000373895.3
 TFAM
 transcription factor A, mitochondrial
chr8_-_124037890 0.80 ENST00000519018.1
ENST00000523036.1
 DERL1
 derlin 1
chr6_-_99842041 0.80 ENST00000254759.3
ENST00000369242.1
 COQ3
 coenzyme Q3 methyltransferase
chr10_+_62538089 0.79 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
 CDK1
 cyclin-dependent kinase 1
chr10_+_62538248 0.76 ENST00000448257.2
 CDK1
 cyclin-dependent kinase 1
chr11_+_73498898 0.72 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
 MRPL48
 mitochondrial ribosomal protein L48
chr11_+_5617952 0.59 ENST00000354852.5
 TRIM6-TRIM34
 TRIM6-TRIM34 readthrough
chr10_+_35456444 0.55 ENST00000361599.4
 CREM
 cAMP responsive element modulator
chr16_-_69368774 0.43 ENST00000562949.1
 RP11-343C2.12
 Conserved oligomeric Golgi complex subunit 8
chr18_-_47808120 0.41 ENST00000587605.1
ENST00000591416.1
ENST00000382948.5
ENST00000269471.5
ENST00000269468.5
ENST00000347968.3
ENST00000436910.1
ENST00000349085.2
 MBD1
 methyl-CpG binding domain protein 1
chr8_-_100905925 0.38 ENST00000518171.1
 COX6C
 cytochrome c oxidase subunit VIc
chr6_+_151042224 0.36 ENST00000358517.2
 PLEKHG1
 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr1_-_207224307 0.35 ENST00000315927.4
 YOD1
 YOD1 deubiquitinase
chr8_-_100905850 0.33 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
 COX6C
 cytochrome c oxidase subunit VIc
chr18_-_47808050 0.31 ENST00000590208.1
 MBD1
 methyl-CpG binding domain protein 1
chr11_-_47399942 0.29 ENST00000227163.4
 SPI1
 spleen focus forming virus (SFFV) proviral integration oncogene
chr4_+_114214125 0.28 ENST00000509550.1
 ANK2
 ankyrin 2, neuronal
chrX_-_1511617 0.26 ENST00000381401.5
 SLC25A6
 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr8_+_28174496 0.25 ENST00000518479.1
 PNOC
 prepronociceptin
chr13_-_24007815 0.24 ENST00000382298.3
 SACS
 spastic ataxia of Charlevoix-Saguenay (sacsin)
chrY_-_1461617 0.22 ENSTR0000381401.5
 SLC25A6
 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chrX_+_101854096 0.22 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
 ARMCX5
 armadillo repeat containing, X-linked 5
chr18_-_47807829 0.21 ENST00000585672.1
ENST00000457839.2
ENST00000353909.3
ENST00000339998.6
ENST00000398493.1
 MBD1
 methyl-CpG binding domain protein 1
chr11_-_64014379 0.16 ENST00000309318.3
 PPP1R14B
 protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_47400078 0.15 ENST00000378538.3
 SPI1
 spleen focus forming virus (SFFV) proviral integration oncogene
chr8_-_100905363 0.15 ENST00000524245.1
 COX6C
 cytochrome c oxidase subunit VIc
chr8_+_22102626 0.14 ENST00000519237.1
ENST00000397802.4
 POLR3D
 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr8_+_22102611 0.14 ENST00000306433.4
 POLR3D
 polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr11_-_45307817 0.12 ENST00000020926.3
 SYT13
 synaptotagmin XIII
chr1_-_113498943 0.11 ENST00000369626.3
 SLC16A1
 solute carrier family 16 (monocarboxylate transporter), member 1
chr7_+_102937869 0.10 ENST00000249269.4
ENST00000428154.1
ENST00000420236.2
 PMPCB
 peptidase (mitochondrial processing) beta
chr11_+_46366918 0.07 ENST00000528615.1
ENST00000395574.3
 DGKZ
 diacylglycerol kinase, zeta
chr3_+_50606901 0.05 ENST00000455834.1
 HEMK1
 HemK methyltransferase family member 1
chr3_+_50606577 0.02 ENST00000434410.1
ENST00000232854.4
 HEMK1
 HemK methyltransferase family member 1
chr7_-_38394118 0.02 ENST00000390345.2
 TRGV4
 T cell receptor gamma variable 4
chr1_-_154164534 0.01 ENST00000271850.7
ENST00000368530.2
 TPM3
 tropomyosin 3
chr7_-_100253993 0.00 ENST00000461605.1
ENST00000160382.5
 ACTL6B
 actin-like 6B

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.2 0.8 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.0 0.5 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 5.6 GO:0043209 myelin sheath(GO:0043209)
0.0 0.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.1 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.7 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.1 1.6 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.0 0.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.4 5.6 GO:0006089 lactate metabolic process(GO:0006089)
0.3 1.6 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.2 0.9 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.2 0.5 GO:0052510 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
0.1 0.8 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1 0.4 GO:1990168 protein K33-linked deubiquitination(GO:1990168)
0.1 0.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.1 0.9 GO:0048712 negative regulation of astrocyte differentiation(GO:0048712)
0.1 0.8 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.0 0.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.0 0.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.0 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 1.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.6 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.2 0.9 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.2 1.1 GO:0001515 opioid peptide activity(GO:0001515)
0.1 0.5 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.1 0.4 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.9 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.1 1.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.8 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.8 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.9 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)