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ENCODE cell lines, expression (Ernst 2011)

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Results for TLX1_NFIC

Z-value: 2.44

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Transcription factors associated with TLX1_NFIC

Gene Symbol Gene ID Gene Info
TLX1
ENSG00000107807.8 TLX1
NFIC
ENSG00000141905.13 NFIC

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFIChg19_v2_chr19_+_3359561_33596810.774.8e-04Click!
TLX1hg19_v2_chr10_+_102891048_102891078-0.391.3e-01Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr7_+_116165038 11.91 ENST00000393470.1
 CAV1
 caveolin 1, caveolae protein, 22kDa
chr12_+_13349650 10.51 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
 EMP1
 epithelial membrane protein 1
chr8_-_42065187 9.02 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
 PLAT
 plasminogen activator, tissue
chr8_-_42065075 7.90 ENST00000429089.2
ENST00000519510.1
ENST00000429710.2
ENST00000524009.1
 PLAT
 plasminogen activator, tissue
chrX_+_102631844 7.28 ENST00000372634.1
ENST00000299872.7
 NGFRAP1
 nerve growth factor receptor (TNFRSF16) associated protein 1
chrX_+_102631248 7.01 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
 NGFRAP1
 nerve growth factor receptor (TNFRSF16) associated protein 1
chr7_+_102553430 6.87 ENST00000339431.4
ENST00000249377.4
 LRRC17
 leucine rich repeat containing 17
chr1_+_151512775 6.39 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
 TUFT1
 tuftelin 1
chr14_+_85996471 5.64 ENST00000330753.4
 FLRT2
 fibronectin leucine rich transmembrane protein 2
chr7_+_143079000 5.45 ENST00000392910.2
 ZYX
 zyxin
chr20_+_19867150 5.33 ENST00000255006.6
 RIN2
 Ras and Rab interactor 2
chr8_-_27468842 5.31 ENST00000523500.1
 CLU
 clusterin
chr14_+_105939276 5.23 ENST00000483017.3
 CRIP2
 cysteine-rich protein 2
chr12_-_56106060 5.04 ENST00000452168.2
 ITGA7
 integrin, alpha 7
chr8_-_27469196 5.04 ENST00000546343.1
ENST00000560566.1
 CLU
 clusterin
chr5_-_111092930 4.91 ENST00000257435.7
 NREP
 neuronal regeneration related protein
chr10_+_17272608 4.85 ENST00000421459.2
 VIM
 vimentin
chr7_+_143078652 4.79 ENST00000354434.4
ENST00000449423.2
 ZYX
 zyxin
chr8_-_27468945 4.75 ENST00000405140.3
 CLU
 clusterin
chr5_-_111093406 4.64 ENST00000379671.3
 NREP
 neuronal regeneration related protein
chr5_-_111093167 4.37 ENST00000446294.2
ENST00000419114.2
 NREP
 neuronal regeneration related protein
chr12_+_66217911 4.36 ENST00000403681.2
 HMGA2
 high mobility group AT-hook 2
chr12_-_54813229 4.27 ENST00000293379.4
 ITGA5
 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr5_-_111092873 4.24 ENST00000509025.1
ENST00000515855.1
 NREP
 neuronal regeneration related protein
chr5_-_111093081 4.06 ENST00000453526.2
ENST00000509427.1
 NREP
 neuronal regeneration related protein
chr11_-_111783919 3.91 ENST00000531198.1
ENST00000533879.1
 CRYAB
 crystallin, alpha B
chr8_-_18541603 3.71 ENST00000428502.2
 PSD3
 pleckstrin and Sec7 domain containing 3
chr20_-_60942361 3.48 ENST00000252999.3
 LAMA5
 laminin, alpha 5
chr14_+_85996507 3.46 ENST00000554746.1
 FLRT2
 fibronectin leucine rich transmembrane protein 2
chr1_-_153517473 3.46 ENST00000368715.1
 S100A4
 S100 calcium binding protein A4
chrX_-_102319092 3.45 ENST00000372728.3
 BEX1
 brain expressed, X-linked 1
chr5_+_92919043 3.41 ENST00000327111.3
 NR2F1
 nuclear receptor subfamily 2, group F, member 1
chr5_-_111093340 3.36 ENST00000508870.1
 NREP
 neuronal regeneration related protein
chr21_-_28217721 3.36 ENST00000284984.3
 ADAMTS1
 ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr9_-_130617029 3.35 ENST00000373203.4
 ENG
 endoglin
chr2_-_217560248 3.19 ENST00000233813.4
 IGFBP5
 insulin-like growth factor binding protein 5
chr11_-_111784005 3.12 ENST00000527899.1
 CRYAB
 crystallin, alpha B
chr9_-_130616915 3.11 ENST00000344849.3
 ENG
 endoglin
chr15_-_35088340 3.07 ENST00000290378.4
 ACTC1
 actin, alpha, cardiac muscle 1
chr9_+_139871948 3.06 ENST00000224167.2
ENST00000457950.1
ENST00000371625.3
ENST00000371623.3
 PTGDS
 prostaglandin D2 synthase 21kDa (brain)
chr1_-_173174681 2.92 ENST00000367718.1
 TNFSF4
 tumor necrosis factor (ligand) superfamily, member 4
chr7_+_22766766 2.88 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
 IL6
 interleukin 6 (interferon, beta 2)
chr1_-_153538292 2.87 ENST00000497140.1
ENST00000368708.3
 S100A2
 S100 calcium binding protein A2
chr10_+_17271266 2.83 ENST00000224237.5
 VIM
 vimentin
chr11_-_111781454 2.83 ENST00000533280.1
 CRYAB
 crystallin, alpha B
chr1_-_95392635 2.83 ENST00000538964.1
ENST00000394202.4
ENST00000370206.4
 CNN3
 calponin 3, acidic
chr8_-_13134045 2.82 ENST00000512044.2
 DLC1
 deleted in liver cancer 1
chr9_-_14180778 2.75 ENST00000380924.1
ENST00000543693.1
 NFIB
 nuclear factor I/B
chrX_+_99899180 2.73 ENST00000373004.3
 SRPX2
 sushi-repeat containing protein, X-linked 2
chr9_+_124030338 2.69 ENST00000449773.1
ENST00000432226.1
ENST00000436847.1
ENST00000394353.2
ENST00000449733.1
ENST00000412819.1
ENST00000341272.2
ENST00000373808.2
 GSN
 gelsolin
chr2_-_238322770 2.67 ENST00000472056.1
 COL6A3
 collagen, type VI, alpha 3
chr2_-_192711968 2.66 ENST00000304141.4
 SDPR
 serum deprivation response
chr2_-_238323007 2.64 ENST00000295550.4
 COL6A3
 collagen, type VI, alpha 3
chr17_+_38599693 2.64 ENST00000542955.1
ENST00000269593.4
 IGFBP4
 insulin-like growth factor binding protein 4
chr20_+_33759854 2.63 ENST00000216968.4
 PROCR
 protein C receptor, endothelial
chr2_-_238322800 2.62 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
 COL6A3
 collagen, type VI, alpha 3
chr17_-_76921459 2.44 ENST00000262768.7
 TIMP2
 TIMP metallopeptidase inhibitor 2
chr7_-_81399329 2.41 ENST00000453411.1
ENST00000444829.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr21_+_46875424 2.40 ENST00000359759.4
 COL18A1
 collagen, type XVIII, alpha 1
chr21_+_46875395 2.39 ENST00000355480.5
 COL18A1
 collagen, type XVIII, alpha 1
chr1_+_156095951 2.35 ENST00000448611.2
ENST00000368297.1
 LMNA
 lamin A/C
chr2_+_102721023 2.34 ENST00000409589.1
ENST00000409329.1
 IL1R1
 interleukin 1 receptor, type I
chr12_+_53491220 2.34 ENST00000548547.1
ENST00000301464.3
 IGFBP6
 insulin-like growth factor binding protein 6
chr14_+_24867992 2.25 ENST00000382554.3
 NYNRIN
 NYN domain and retroviral integrase containing
chr6_-_46922659 2.23 ENST00000265417.7
 GPR116
 G protein-coupled receptor 116
chr1_+_203595689 2.21 ENST00000357681.5
 ATP2B4
 ATPase, Ca++ transporting, plasma membrane 4
chr12_+_119616447 2.14 ENST00000281938.2
 HSPB8
 heat shock 22kDa protein 8
chr12_-_56122124 2.11 ENST00000552754.1
 CD63
 CD63 molecule
chr11_-_117186946 2.10 ENST00000313005.6
ENST00000528053.1
 BACE1
 beta-site APP-cleaving enzyme 1
chr3_-_52486841 2.09 ENST00000496590.1
 TNNC1
 troponin C type 1 (slow)
chr12_-_56122220 2.03 ENST00000552692.1
 CD63
 CD63 molecule
chr20_+_9049682 1.99 ENST00000334005.3
ENST00000378473.3
 PLCB4
 phospholipase C, beta 4
chr10_+_124320156 1.97 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
 DMBT1
 deleted in malignant brain tumors 1
chr15_-_40213080 1.92 ENST00000561100.1
 GPR176
 G protein-coupled receptor 176
chr9_+_470288 1.84 ENST00000382303.1
 KANK1
 KN motif and ankyrin repeat domains 1
chr15_-_77363441 1.81 ENST00000346495.2
ENST00000424443.3
ENST00000561277.1
 TSPAN3
 tetraspanin 3
chr10_+_124320195 1.77 ENST00000359586.6
 DMBT1
 deleted in malignant brain tumors 1
chr9_-_79520989 1.74 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
 PRUNE2
 prune homolog 2 (Drosophila)
chr15_-_77363375 1.69 ENST00000559494.1
 TSPAN3
 tetraspanin 3
chr9_-_13279589 1.69 ENST00000319217.7
 MPDZ
 multiple PDZ domain protein
chr9_-_13279563 1.66 ENST00000541718.1
 MPDZ
 multiple PDZ domain protein
chr13_+_113622757 1.63 ENST00000375604.2
 MCF2L
 MCF.2 cell line derived transforming sequence-like
chr1_-_153538011 1.61 ENST00000368707.4
 S100A2
 S100 calcium binding protein A2
chr1_+_156096336 1.56 ENST00000504687.1
ENST00000473598.2
 LMNA
 lamin A/C
chr1_+_203595903 1.55 ENST00000367218.3
ENST00000367219.3
ENST00000391954.2
 ATP2B4
 ATPase, Ca++ transporting, plasma membrane 4
chr7_-_151433393 1.54 ENST00000492843.1
 PRKAG2
 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr7_-_151433342 1.54 ENST00000433631.2
 PRKAG2
 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr7_+_128470431 1.49 ENST00000325888.8
ENST00000346177.6
 FLNC
 filamin C, gamma
chr11_-_65325664 1.44 ENST00000301873.5
 LTBP3
 latent transforming growth factor beta binding protein 3
chr16_-_19896220 1.43 ENST00000562469.1
ENST00000300571.2
 GPRC5B
 G protein-coupled receptor, family C, group 5, member B
chrX_-_154688276 1.42 ENST00000369445.2
 F8A3
 coagulation factor VIII-associated 3
chr11_+_67776012 1.40 ENST00000539229.1
 ALDH3B1
 aldehyde dehydrogenase 3 family, member B1
chr7_-_81399438 1.39 ENST00000222390.5
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr9_-_23821842 1.36 ENST00000544538.1
 ELAVL2
 ELAV like neuron-specific RNA binding protein 2
chr12_-_124457371 1.33 ENST00000238156.3
ENST00000545037.1
 CCDC92
 coiled-coil domain containing 92
chr6_+_132129151 1.32 ENST00000360971.2
 ENPP1
 ectonucleotide pyrophosphatase/phosphodiesterase 1
chr13_+_113622810 1.31 ENST00000397030.1
 MCF2L
 MCF.2 cell line derived transforming sequence-like
chr3_-_114866084 1.29 ENST00000357258.3
 ZBTB20
 zinc finger and BTB domain containing 20
chr3_+_8775466 1.28 ENST00000343849.2
ENST00000397368.2
 CAV3
 caveolin 3
chr16_+_30387141 1.24 ENST00000566955.1
 MYLPF
 myosin light chain, phosphorylatable, fast skeletal muscle
chr5_-_73937244 1.22 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
 ENC1
 ectodermal-neural cortex 1 (with BTB domain)
chr2_+_66662690 1.20 ENST00000488550.1
 MEIS1
 Meis homeobox 1
chr8_+_24772455 1.18 ENST00000433454.2
 NEFM
 neurofilament, medium polypeptide
chr12_-_56121612 1.17 ENST00000546939.1
 CD63
 CD63 molecule
chr2_+_66662510 1.15 ENST00000272369.9
ENST00000407092.2
 MEIS1
 Meis homeobox 1
chr12_-_56121580 1.14 ENST00000550776.1
 CD63
 CD63 molecule
chr16_+_57662419 1.11 ENST00000388812.4
ENST00000538815.1
ENST00000456916.1
ENST00000567154.1
ENST00000388813.5
ENST00000562558.1
ENST00000566271.2
 GPR56
 G protein-coupled receptor 56
chr13_-_96705624 1.10 ENST00000376747.3
ENST00000376712.4
ENST00000397618.3
ENST00000376714.3
 UGGT2
 UDP-glucose glycoprotein glucosyltransferase 2
chrX_+_154114635 1.10 ENST00000369446.2
 F8A1
 coagulation factor VIII-associated 1
chr1_-_229569834 1.09 ENST00000366684.3
ENST00000366683.2
 ACTA1
 actin, alpha 1, skeletal muscle
chr12_+_57522258 1.08 ENST00000553277.1
ENST00000243077.3
 LRP1
 low density lipoprotein receptor-related protein 1
chr11_-_65325430 1.06 ENST00000322147.4
 LTBP3
 latent transforming growth factor beta binding protein 3
chr5_-_176923846 1.04 ENST00000506537.1
 PDLIM7
 PDZ and LIM domain 7 (enigma)
chr7_-_81399411 1.04 ENST00000423064.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr16_+_57662138 1.03 ENST00000562414.1
ENST00000561969.1
ENST00000562631.1
ENST00000563445.1
ENST00000565338.1
ENST00000567702.1
 GPR56
 G protein-coupled receptor 56
chr5_-_176923803 1.03 ENST00000506161.1
 PDLIM7
 PDZ and LIM domain 7 (enigma)
chr2_-_37899323 1.02 ENST00000295324.3
ENST00000457889.1
 CDC42EP3
 CDC42 effector protein (Rho GTPase binding) 3
chr22_-_39640756 1.00 ENST00000331163.6
 PDGFB
 platelet-derived growth factor beta polypeptide
chr2_+_109237717 1.00 ENST00000409441.1
 LIMS1
 LIM and senescent cell antigen-like domains 1
chr1_-_243418621 0.96 ENST00000366544.1
ENST00000366543.1
 CEP170
 centrosomal protein 170kDa
chr14_+_73704201 0.95 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
 PAPLN
 papilin, proteoglycan-like sulfated glycoprotein
chr19_+_36606354 0.93 ENST00000589996.1
ENST00000591296.1
 TBCB
 tubulin folding cofactor B
chr17_-_48474828 0.88 ENST00000576448.1
ENST00000225972.7
 LRRC59
 leucine rich repeat containing 59
chr11_+_71938925 0.88 ENST00000538751.1
 INPPL1
 inositol polyphosphate phosphatase-like 1
chr1_-_151345159 0.88 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
 SELENBP1
 selenium binding protein 1
chrX_-_13956737 0.87 ENST00000454189.2
 GPM6B
 glycoprotein M6B
chr6_+_39760783 0.87 ENST00000398904.2
ENST00000538976.1
 DAAM2
 dishevelled associated activator of morphogenesis 2
chrX_+_154611749 0.87 ENST00000369505.3
 F8A2
 coagulation factor VIII-associated 2
chr8_+_120428546 0.85 ENST00000259526.3
 NOV
 nephroblastoma overexpressed
chr17_+_42429493 0.85 ENST00000586242.1
 GRN
 granulin
chr11_-_66313699 0.84 ENST00000526986.1
ENST00000310442.3
 ZDHHC24
 zinc finger, DHHC-type containing 24
chr20_-_34025999 0.83 ENST00000374369.3
 GDF5
 growth differentiation factor 5
chr2_-_219151487 0.83 ENST00000444881.1
 TMBIM1
 transmembrane BAX inhibitor motif containing 1
chr15_+_71228826 0.83 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
 LRRC49
 leucine rich repeat containing 49
chr16_+_57653854 0.81 ENST00000568908.1
ENST00000568909.1
ENST00000566778.1
ENST00000561988.1
 GPR56
 G protein-coupled receptor 56
chr2_-_47142884 0.79 ENST00000409105.1
ENST00000409973.1
ENST00000409913.1
ENST00000319466.4
 MCFD2
 multiple coagulation factor deficiency 2
chr14_-_50999307 0.79 ENST00000013125.4
 MAP4K5
 mitogen-activated protein kinase kinase kinase kinase 5
chr5_-_114880533 0.77 ENST00000274457.3
 FEM1C
 fem-1 homolog c (C. elegans)
chr17_-_42277203 0.75 ENST00000587097.1
 ATXN7L3
 ataxin 7-like 3
chr14_-_50999190 0.74 ENST00000557390.1
 MAP4K5
 mitogen-activated protein kinase kinase kinase kinase 5
chr1_+_110453203 0.73 ENST00000357302.4
ENST00000344188.5
ENST00000329608.6
 CSF1
 colony stimulating factor 1 (macrophage)
chr11_+_27062502 0.73 ENST00000263182.3
 BBOX1
 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr4_-_110723335 0.72 ENST00000394634.2
 CFI
 complement factor I
chr19_+_4304632 0.72 ENST00000597590.1
 FSD1
 fibronectin type III and SPRY domain containing 1
chr1_-_115300579 0.72 ENST00000358528.4
ENST00000525132.1
 CSDE1
 cold shock domain containing E1, RNA-binding
chr8_+_22022653 0.71 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
 BMP1
 bone morphogenetic protein 1
chr1_+_64059332 0.70 ENST00000540265.1
 PGM1
 phosphoglucomutase 1
chr4_-_120549163 0.70 ENST00000394439.1
ENST00000420633.1
 PDE5A
 phosphodiesterase 5A, cGMP-specific
chr4_-_110723194 0.68 ENST00000394635.3
 CFI
 complement factor I
chr4_-_110723134 0.67 ENST00000510800.1
ENST00000512148.1
 CFI
 complement factor I
chr15_-_59665062 0.66 ENST00000288235.4
 MYO1E
 myosin IE
chr7_-_81399355 0.65 ENST00000457544.2
 HGF
 hepatocyte growth factor (hepapoietin A; scatter factor)
chr19_+_45312347 0.65 ENST00000270233.6
ENST00000591520.1
 BCAM
 basal cell adhesion molecule (Lutheran blood group)
chr8_+_98881268 0.64 ENST00000254898.5
ENST00000524308.1
ENST00000522025.2
 MATN2
 matrilin 2
chr22_+_41763274 0.63 ENST00000406644.3
 TEF
 thyrotrophic embryonic factor
chr20_+_43343517 0.62 ENST00000372865.4
 WISP2
 WNT1 inducible signaling pathway protein 2
chr1_-_113247543 0.61 ENST00000414971.1
ENST00000534717.1
 RHOC
 ras homolog family member C
chr17_+_57642886 0.61 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
 DHX40
 DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr5_+_150020214 0.60 ENST00000307662.4
 SYNPO
 synaptopodin
chr20_+_43343886 0.59 ENST00000190983.4
 WISP2
 WNT1 inducible signaling pathway protein 2
chr11_+_1244288 0.59 ENST00000529681.1
ENST00000447027.1
 MUC5B
 mucin 5B, oligomeric mucus/gel-forming
chr8_-_82395461 0.58 ENST00000256104.4
 FABP4
 fatty acid binding protein 4, adipocyte
chr18_-_52989217 0.57 ENST00000570287.2
 TCF4
 transcription factor 4
chr3_-_58613323 0.57 ENST00000474531.1
ENST00000465970.1
 FAM107A
 family with sequence similarity 107, member A
chr1_-_32169761 0.57 ENST00000271069.6
 COL16A1
 collagen, type XVI, alpha 1
chr20_+_43343476 0.57 ENST00000372868.2
 WISP2
 WNT1 inducible signaling pathway protein 2
chr19_-_36247910 0.57 ENST00000587965.1
ENST00000004982.3
 HSPB6
 heat shock protein, alpha-crystallin-related, B6
chr2_-_47143160 0.55 ENST00000409800.1
ENST00000409218.1
 MCFD2
 multiple coagulation factor deficiency 2
chrX_+_153770421 0.55 ENST00000369609.5
ENST00000369607.1
 IKBKG
 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr1_-_32169920 0.54 ENST00000373672.3
ENST00000373668.3
 COL16A1
 collagen, type XVI, alpha 1
chr22_-_37213554 0.54 ENST00000443735.1
 PVALB
 parvalbumin
chrX_+_46937745 0.54 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
 RGN
 regucalcin
chr11_+_74862140 0.54 ENST00000525650.1
ENST00000454962.2
 SLCO2B1
 solute carrier organic anion transporter family, member 2B1
chr18_+_33877654 0.52 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
 FHOD3
 formin homology 2 domain containing 3
chr1_-_243418344 0.52 ENST00000366542.1
 CEP170
 centrosomal protein 170kDa
chr17_+_27369918 0.52 ENST00000323372.4
 PIPOX
 pipecolic acid oxidase
chrX_+_2746850 0.52 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
 GYG2
 glycogenin 2
chr1_-_115300592 0.52 ENST00000261443.5
ENST00000534699.1
ENST00000339438.6
ENST00000529046.1
ENST00000525970.1
ENST00000369530.1
ENST00000530886.1
 CSDE1
 cold shock domain containing E1, RNA-binding
chr9_-_132515302 0.51 ENST00000340607.4
 PTGES
 prostaglandin E synthase
chr3_-_98620500 0.50 ENST00000326840.6
 DCBLD2
 discoidin, CUB and LCCL domain containing 2
chr3_+_9791731 0.50 ENST00000449570.2
ENST00000302008.8
ENST00000383826.5
 OGG1
 8-oxoguanine DNA glycosylase
chr1_+_101185290 0.49 ENST00000370119.4
ENST00000347652.2
ENST00000294728.2
ENST00000370115.1
 VCAM1
 vascular cell adhesion molecule 1
chr22_-_30960876 0.47 ENST00000401975.1
ENST00000428682.1
ENST00000423299.1
 GAL3ST1
 galactose-3-O-sulfotransferase 1
chr16_-_2264779 0.47 ENST00000333503.7
 PGP
 phosphoglycolate phosphatase
chr18_-_52989525 0.45 ENST00000457482.3
 TCF4
 transcription factor 4
chr3_-_12200851 0.45 ENST00000287814.4
 TIMP4
 TIMP metallopeptidase inhibitor 4
chr6_-_28321971 0.44 ENST00000396838.2
ENST00000426434.1
ENST00000434036.1
ENST00000439628.1
 ZSCAN31
 zinc finger and SCAN domain containing 31
chr2_+_185463093 0.44 ENST00000302277.6
 ZNF804A
 zinc finger protein 804A
chr11_-_63536113 0.44 ENST00000433688.1
ENST00000546282.2
 C11orf95
RP11-466C23.4
 chromosome 11 open reading frame 95
RP11-466C23.4
chrX_-_54522558 0.43 ENST00000375135.3
 FGD1
 FYVE, RhoGEF and PH domain containing 1
chr1_-_231114542 0.43 ENST00000522821.1
ENST00000366661.4
ENST00000366662.4
ENST00000414259.1
ENST00000522399.1
 TTC13
 tetratricopeptide repeat domain 13
chr3_-_155572164 0.41 ENST00000392845.3
ENST00000359479.3
 SLC33A1
 solute carrier family 33 (acetyl-CoA transporter), member 1
chr19_+_42788172 0.40 ENST00000160740.3
 CIC
 capicua transcriptional repressor
chr2_+_10442993 0.40 ENST00000423674.1
ENST00000307845.3
 HPCAL1
 hippocalcin-like 1
chr7_+_75931861 0.40 ENST00000248553.6
 HSPB1
 heat shock 27kDa protein 1
chr1_+_110453462 0.39 ENST00000488198.1
 CSF1
 colony stimulating factor 1 (macrophage)
chr9_+_34646651 0.38 ENST00000378842.3
 GALT
 galactose-1-phosphate uridylyltransferase
chr9_+_34646624 0.38 ENST00000450095.2
ENST00000556278.1
 GALT
GALT
 galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr1_+_172422026 0.37 ENST00000367725.4
 C1orf105
 chromosome 1 open reading frame 105
chr17_+_48503603 0.37 ENST00000502667.1
 ACSF2
 acyl-CoA synthetase family member 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 11.9 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
2.5 15.1 GO:0061518 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
2.2 6.5 GO:0001300 chronological cell aging(GO:0001300)
1.5 9.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
1.5 4.5 GO:2000685 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
1.4 6.9 GO:0048539 bone marrow development(GO:0048539)
1.3 3.8 GO:0033241 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
1.1 3.2 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
1.0 2.9 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
1.0 2.9 GO:2000364 response to prolactin(GO:1990637) regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.8 3.9 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.8 2.3 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.7 7.7 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.7 4.2 GO:0090131 mesenchyme migration(GO:0090131)
0.7 5.5 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.6 16.9 GO:0031639 plasminogen activation(GO:0031639)
0.6 2.5 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.6 1.8 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.5 9.9 GO:0007021 tubulin complex assembly(GO:0007021)
0.5 2.7 GO:0044858 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.5 3.7 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.5 10.5 GO:0032060 bleb assembly(GO:0032060)
0.5 2.1 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.5 6.5 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.5 2.4 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.5 5.0 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.4 2.8 GO:2000795 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 1.2 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.4 1.1 GO:0097359 UDP-glucosylation(GO:0097359)
0.4 1.1 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.4 4.3 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.3 1.0 GO:1905064 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) phenotypic switching(GO:0036166) negative regulation of phospholipid biosynthetic process(GO:0071072) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of phenotypic switching(GO:1900239) negative regulation of vascular smooth muscle cell differentiation(GO:1905064) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.3 1.3 GO:0035995 detection of muscle stretch(GO:0035995)
0.3 1.5 GO:1904141 positive regulation of odontogenesis of dentin-containing tooth(GO:0042488) mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
0.3 0.8 GO:1990523 bone regeneration(GO:1990523)
0.3 2.7 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.3 0.8 GO:0006258 UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499)
0.2 1.0 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.2 3.4 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.2 3.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 0.8 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
0.2 2.8 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.2 1.3 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.2 1.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.2 2.2 GO:0015074 DNA integration(GO:0015074)
0.2 3.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 0.5 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853) negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.2 0.7 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.2 0.5 GO:0046440 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.2 0.5 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.2 0.6 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
0.2 3.1 GO:0006853 carnitine shuttle(GO:0006853)
0.1 2.8 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 2.4 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 1.4 GO:0046185 aldehyde catabolic process(GO:0046185)
0.1 3.5 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.1 2.6 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 1.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 0.3 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1 0.8 GO:0045007 depurination(GO:0045007)
0.1 7.9 GO:0030574 collagen catabolic process(GO:0030574)
0.1 14.9 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 0.6 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.1 1.4 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.1 0.4 GO:0099640 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033) axo-dendritic protein transport(GO:0099640)
0.1 0.5 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.7 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.1 0.4 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.1 0.9 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 0.6 GO:0099563 modification of synaptic structure(GO:0099563)
0.1 1.0 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 0.4 GO:0051182 coenzyme transport(GO:0051182)
0.1 0.2 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.1 0.4 GO:0071918 urea transmembrane transport(GO:0071918)
0.1 0.3 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.7 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.1 0.3 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.1 0.7 GO:0019388 galactose catabolic process(GO:0019388)
0.1 1.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 2.1 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 0.6 GO:0007160 cell-matrix adhesion(GO:0007160)
0.1 6.4 GO:0030282 bone mineralization(GO:0030282)
0.1 2.6 GO:0050819 negative regulation of coagulation(GO:0050819)
0.1 0.5 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.3 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.0 1.1 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.9 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.6 GO:0071285 cellular response to lithium ion(GO:0071285)
0.0 0.5 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 1.9 GO:0048512 circadian behavior(GO:0048512)
0.0 0.5 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.1 GO:0019605 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.0 2.0 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.2 GO:0034165 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0 1.5 GO:0048747 muscle fiber development(GO:0048747)
0.0 1.3 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 0.1 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.0 1.2 GO:0060548 negative regulation of cell death(GO:0060548)
0.0 3.5 GO:0043542 endothelial cell migration(GO:0043542)
0.0 1.9 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.6 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.2 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.7 GO:0043276 anoikis(GO:0043276)
0.0 0.3 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.0 0.6 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.1 GO:0042126 nitrate metabolic process(GO:0042126)
0.0 0.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.0 0.3 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.0 0.6 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 2.2 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 2.2 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.0 1.5 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.0 0.6 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.3 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.6 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 0.3 GO:0006884 cell volume homeostasis(GO:0006884)
0.0 1.3 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.0 GO:0048009 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567) insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 1.2 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 11.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
1.5 4.5 GO:0035501 MH1 domain binding(GO:0035501)
1.3 7.7 GO:1990254 keratin filament binding(GO:1990254)
1.3 3.8 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.9 6.4 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.8 6.5 GO:0005534 galactose binding(GO:0005534)
0.8 3.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.7 14.9 GO:0051787 misfolded protein binding(GO:0051787)
0.7 8.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.7 2.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.6 2.3 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.6 9.1 GO:0045499 chemorepellent activity(GO:0045499)
0.4 1.3 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.4 3.4 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 4.2 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.4 10.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.4 1.1 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.3 2.8 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.3 3.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.3 1.1 GO:0042954 apolipoprotein receptor activity(GO:0030226) lipoprotein transporter activity(GO:0042954)
0.2 1.5 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.2 2.7 GO:0045159 myosin II binding(GO:0045159)
0.2 2.5 GO:0050786 RAGE receptor binding(GO:0050786)
0.2 2.1 GO:0031013 troponin I binding(GO:0031013)
0.2 1.3 GO:0071253 connexin binding(GO:0071253)
0.2 0.7 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.2 6.8 GO:0042056 chemoattractant activity(GO:0042056)
0.2 0.5 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.2 0.5 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.2 0.6 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.1 3.7 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.6 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
0.1 3.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.4 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 0.4 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.1 1.4 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 0.5 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.1 15.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.7 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 2.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 2.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 2.8 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.6 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 5.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 0.4 GO:0015265 urea channel activity(GO:0015265)
0.1 0.8 GO:0036122 BMP binding(GO:0036122)
0.1 0.5 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.1 1.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.8 GO:0032357 oxidized purine DNA binding(GO:0032357)
0.1 0.3 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) aspartic-type endopeptidase inhibitor activity(GO:0019828) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.1 8.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.9 GO:0008430 selenium binding(GO:0008430)
0.1 0.8 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 0.2 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.1 1.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 2.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.8 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.5 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.3 GO:0004743 pyruvate kinase activity(GO:0004743)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 2.2 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.6 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.0 4.0 GO:0017022 myosin binding(GO:0017022)
0.0 0.4 GO:0001849 complement component C1q binding(GO:0001849)
0.0 2.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 1.2 GO:0030506 ankyrin binding(GO:0030506)
0.0 2.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.1 GO:0008940 nitrate reductase activity(GO:0008940)
0.0 0.3 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.8 GO:0005123 death receptor binding(GO:0005123)
0.0 3.4 GO:0008201 heparin binding(GO:0008201)
0.0 0.6 GO:0043236 laminin binding(GO:0043236)
0.0 0.7 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 2.5 GO:0019838 growth factor binding(GO:0019838)
0.0 0.3 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.7 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.0 1.6 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.6 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.0 0.3 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.0 0.6 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 1.0 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.3 GO:0000993 RNA polymerase II core binding(GO:0000993)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.5 GO:0072563 endothelial microparticle(GO:0072563)
1.1 4.3 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
1.0 2.1 GO:1990584 cardiac Troponin complex(GO:1990584)
1.0 16.3 GO:0097418 neurofibrillary tangle(GO:0097418)
0.9 3.5 GO:0043259 laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
0.9 11.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.7 2.8 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.6 9.9 GO:0097512 cardiac myofibril(GO:0097512)
0.6 3.1 GO:0042643 actomyosin, actin portion(GO:0042643)
0.6 7.9 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.6 5.5 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.5 6.5 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.4 3.9 GO:0005638 lamin filament(GO:0005638)
0.4 4.1 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 1.5 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 2.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 3.7 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 2.7 GO:0030478 actin cap(GO:0030478)
0.2 3.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.2 0.5 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.2 3.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.1 GO:0005593 FACIT collagen trimer(GO:0005593)
0.1 1.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 4.9 GO:0008305 integrin complex(GO:0008305)
0.1 14.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 3.0 GO:0097228 sperm principal piece(GO:0097228)
0.1 52.8 GO:0031012 extracellular matrix(GO:0031012)
0.1 0.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 8.4 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.5 GO:0043034 costamere(GO:0043034)
0.1 2.0 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 0.8 GO:0000124 SAGA complex(GO:0000124)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.4 GO:0035976 AP1 complex(GO:0035976)
0.0 1.9 GO:0005771 multivesicular body(GO:0005771)
0.0 0.6 GO:0043186 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.0 1.3 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.2 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 3.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 2.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 2.2 GO:0035579 specific granule membrane(GO:0035579)
0.0 1.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 1.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.0 1.9 GO:0005814 centriole(GO:0005814)
0.0 0.3 GO:0001726 ruffle(GO:0001726)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 17.5 GO:0005615 extracellular space(GO:0005615)
0.0 0.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.2 GO:0031932 TORC2 complex(GO:0031932)
0.0 1.1 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.1 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.6 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.3 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.7 GO:0043195 terminal bouton(GO:0043195)
0.0 0.9 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 18.5 PID ALK1 PATHWAY ALK1 signaling events
0.3 9.1 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.3 15.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.3 19.2 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.3 9.2 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.2 18.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.2 5.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1 7.7 PID AURORA B PATHWAY Aurora B signaling
0.1 19.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 13.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.0 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.1 4.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 5.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.0 PID IL1 PATHWAY IL1-mediated signaling events
0.1 1.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.1 1.4 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.9 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 2.0 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.0 PID S1P S1P3 PATHWAY S1P3 pathway
0.0 1.1 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.3 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.5 PID TNF PATHWAY TNF receptor signaling pathway
0.0 1.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.1 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 2.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 12.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3 8.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 10.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 4.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 3.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 2.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 3.2 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.2 13.0 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.2 21.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 24.1 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 2.0 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.1 2.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 2.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 2.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.1 0.4 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 4.1 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 1.1 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 0.3 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.1 3.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 1.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 0.5 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.0 1.8 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.0 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.9 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.1 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 0.6 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.3 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 1.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 0.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism