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ENCODE cell lines, expression (Ernst 2011)

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Results for TP73

Z-value: 0.63

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Transcription factors associated with TP73

Gene Symbol Gene ID Gene Info
TP73
ENSG00000078900.10 TP73

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP73hg19_v2_chr1_+_3614591_3614622-0.292.7e-01Click!

Activity profile of TP73 motif

Sorted Z-values of TP73 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of TP73

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_230135937 1.57 ENST00000392054.3
ENST00000409462.1
ENST00000392055.3
 PID1
 phosphotyrosine interaction domain containing 1
chr5_+_125758865 1.48 ENST00000542322.1
ENST00000544396.1
 GRAMD3
 GRAM domain containing 3
chr10_+_47746929 1.47 ENST00000340243.6
ENST00000374277.5
ENST00000449464.2
ENST00000538825.1
ENST00000335083.5
 ANXA8L2
AL603965.1
 annexin A8-like 2
Protein LOC100996760
chr5_+_125758813 1.47 ENST00000285689.3
ENST00000515200.1
 GRAMD3
 GRAM domain containing 3
chr10_-_47173994 1.37 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
 ANXA8L1
LINC00842
 annexin A8-like 1
long intergenic non-protein coding RNA 842
chr1_-_68698222 1.13 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
 WLS
 wntless Wnt ligand secretion mediator
chr17_+_73750699 1.04 ENST00000584939.1
 ITGB4
 integrin, beta 4
chr8_+_54764346 0.98 ENST00000297313.3
ENST00000344277.6
 RGS20
 regulator of G-protein signaling 20
chr8_-_145016692 0.97 ENST00000357649.2
 PLEC
 plectin
chr12_-_91573249 0.96 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
 DCN
 decorin
chr3_-_185538849 0.90 ENST00000421047.2
 IGF2BP2
 insulin-like growth factor 2 mRNA binding protein 2
chr11_+_65686952 0.85 ENST00000527119.1
 DRAP1
 DR1-associated protein 1 (negative cofactor 2 alpha)
chr14_+_75745477 0.80 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
 FOS
 FBJ murine osteosarcoma viral oncogene homolog
chr5_+_119799927 0.72 ENST00000407149.2
ENST00000379551.2
 PRR16
 proline rich 16
chr20_+_48807351 0.62 ENST00000303004.3
 CEBPB
 CCAAT/enhancer binding protein (C/EBP), beta
chr14_+_75746340 0.57 ENST00000555686.1
ENST00000555672.1
 FOS
 FBJ murine osteosarcoma viral oncogene homolog
chr11_+_65687158 0.57 ENST00000532933.1
 DRAP1
 DR1-associated protein 1 (negative cofactor 2 alpha)
chr6_-_46703069 0.56 ENST00000538237.1
ENST00000274793.7
 PLA2G7
 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr1_-_68698197 0.43 ENST00000370973.2
ENST00000370971.1
 WLS
 wntless Wnt ligand secretion mediator
chr8_+_37654693 0.43 ENST00000412232.2
 GPR124
 G protein-coupled receptor 124
chr10_-_79686284 0.41 ENST00000372391.2
ENST00000372388.2
 DLG5
 discs, large homolog 5 (Drosophila)
chr19_+_45281118 0.40 ENST00000270279.3
ENST00000341505.4
 CBLC
 Cbl proto-oncogene C, E3 ubiquitin protein ligase
chr15_+_41136216 0.38 ENST00000562057.1
ENST00000344051.4
 SPINT1
 serine peptidase inhibitor, Kunitz type 1
chr15_+_41136586 0.36 ENST00000431806.1
 SPINT1
 serine peptidase inhibitor, Kunitz type 1
chr6_-_46703430 0.35 ENST00000537365.1
 PLA2G7
 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr15_+_74466744 0.34 ENST00000560862.1
ENST00000395118.1
 ISLR
 immunoglobulin superfamily containing leucine-rich repeat
chr11_-_65686496 0.32 ENST00000449692.3
 C11orf68
 chromosome 11 open reading frame 68
chr7_-_2883928 0.30 ENST00000275364.3
 GNA12
 guanine nucleotide binding protein (G protein) alpha 12
chr1_-_203055129 0.24 ENST00000241651.4
 MYOG
 myogenin (myogenic factor 4)
chr6_-_122792919 0.24 ENST00000339697.4
 SERINC1
 serine incorporator 1
chr17_+_21191341 0.21 ENST00000526076.2
ENST00000361818.5
ENST00000316920.6
 MAP2K3
 mitogen-activated protein kinase kinase 3
chr14_-_25519317 0.19 ENST00000323944.5
 STXBP6
 syntaxin binding protein 6 (amisyn)
chr1_-_214724566 0.18 ENST00000366956.5
 PTPN14
 protein tyrosine phosphatase, non-receptor type 14
chr8_+_37654424 0.18 ENST00000315215.7
 GPR124
 G protein-coupled receptor 124
chr16_+_8891670 0.18 ENST00000268261.4
ENST00000539622.1
ENST00000569958.1
ENST00000537352.1
 PMM2
 phosphomannomutase 2
chr8_+_120885949 0.18 ENST00000523492.1
ENST00000286234.5
 DEPTOR
 DEP domain containing MTOR-interacting protein
chr17_-_79818354 0.17 ENST00000576541.1
ENST00000576380.1
ENST00000571617.1
ENST00000576052.1
ENST00000576390.1
ENST00000573778.2
ENST00000439918.2
ENST00000574914.1
ENST00000331483.4
 P4HB
 prolyl 4-hydroxylase, beta polypeptide
chr2_+_220283091 0.17 ENST00000373960.3
 DES
 desmin
chr14_-_25519095 0.17 ENST00000419632.2
ENST00000358326.2
ENST00000396700.1
ENST00000548724.1
 STXBP6
 syntaxin binding protein 6 (amisyn)
chr1_-_52344471 0.16 ENST00000352171.7
ENST00000354831.7
 NRD1
 nardilysin (N-arginine dibasic convertase)
chr9_-_128003606 0.15 ENST00000324460.6
 HSPA5
 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr12_-_57505121 0.15 ENST00000538913.2
ENST00000537215.2
ENST00000454075.3
ENST00000554825.1
ENST00000553275.1
ENST00000300134.3
 STAT6
 signal transducer and activator of transcription 6, interleukin-4 induced
chr22_+_39966758 0.14 ENST00000407673.1
ENST00000401624.1
ENST00000404898.1
ENST00000402142.3
ENST00000336649.4
ENST00000400164.3
 CACNA1I
 calcium channel, voltage-dependent, T type, alpha 1I subunit
chr16_+_84178874 0.11 ENST00000378553.5
 DNAAF1
 dynein, axonemal, assembly factor 1
chr18_-_28681950 0.11 ENST00000251081.6
 DSC2
 desmocollin 2
chr19_+_17326521 0.10 ENST00000593597.1
 USE1
 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
chr6_-_72130472 0.10 ENST00000426635.2
 LINC00472
 long intergenic non-protein coding RNA 472
chr15_+_64680003 0.10 ENST00000261884.3
 TRIP4
 thyroid hormone receptor interactor 4
chr14_-_105531759 0.09 ENST00000329797.3
ENST00000539291.2
ENST00000392585.2
 GPR132
 G protein-coupled receptor 132
chr3_+_48481658 0.08 ENST00000438607.2
 TMA7
 translation machinery associated 7 homolog (S. cerevisiae)
chr10_+_70661014 0.08 ENST00000373585.3
 DDX50
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr3_-_100120223 0.08 ENST00000284320.5
 TOMM70A
 translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
chr16_-_2581409 0.06 ENST00000567119.1
ENST00000565480.1
ENST00000382350.1
 CEMP1
 cementum protein 1
chr11_+_60197040 0.06 ENST00000300190.2
 MS4A5
 membrane-spanning 4-domains, subfamily A, member 5
chr11_+_60197069 0.05 ENST00000528905.1
ENST00000528093.1
 MS4A5
 membrane-spanning 4-domains, subfamily A, member 5
chr19_+_45254529 0.05 ENST00000444487.1
 BCL3
 B-cell CLL/lymphoma 3
chr20_-_52790055 0.04 ENST00000395955.3
 CYP24A1
 cytochrome P450, family 24, subfamily A, polypeptide 1
chr16_+_5008290 0.04 ENST00000251170.7
 SEC14L5
 SEC14-like 5 (S. cerevisiae)
chr10_-_105212059 0.03 ENST00000260743.5
 CALHM2
 calcium homeostasis modulator 2
chr3_-_48936272 0.03 ENST00000544097.1
ENST00000430379.1
ENST00000319017.4
 SLC25A20
 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
chr17_+_4835580 0.03 ENST00000329125.5
 GP1BA
 glycoprotein Ib (platelet), alpha polypeptide
chr11_+_65154070 0.03 ENST00000317568.5
ENST00000531296.1
ENST00000533782.1
ENST00000355991.5
ENST00000416776.2
ENST00000526201.1
 FRMD8
 FERM domain containing 8
chr19_+_41620335 0.03 ENST00000331105.2
 CYP2F1
 cytochrome P450, family 2, subfamily F, polypeptide 1
chr19_+_19627026 0.02 ENST00000608404.1
ENST00000555938.1
ENST00000503283.1
ENST00000512771.3
ENST00000428459.2
 YJEFN3
CTC-260F20.3
NDUFA13
 YjeF N-terminal domain containing 3
Uncharacterized protein
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
chr17_-_2614927 0.02 ENST00000435359.1
 CLUH
 clustered mitochondria (cluA/CLU1) homolog
chr18_-_4455260 0.02 ENST00000581527.1
 DLGAP1
 discs, large (Drosophila) homolog-associated protein 1
chr11_+_236959 0.02 ENST00000431206.2
ENST00000528906.1
 PSMD13
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
chr18_+_77623668 0.01 ENST00000316249.3
 KCNG2
 potassium voltage-gated channel, subfamily G, member 2
chr9_+_36169380 0.01 ENST00000335119.2
 CCIN
 calicin
chr7_+_116502527 0.01 ENST00000361183.3
 CAPZA2
 capping protein (actin filament) muscle Z-line, alpha 2
chr16_+_67197288 0.01 ENST00000264009.8
ENST00000421453.1
 HSF4
 heat shock transcription factor 4
chr12_+_44152740 0.00 ENST00000440781.2
ENST00000431837.1
ENST00000550616.1
ENST00000448290.2
ENST00000551736.1
 IRAK4
 interleukin-1 receptor-associated kinase 4
chr11_+_237016 0.00 ENST00000352303.5
 PSMD13
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:1901859 negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.5 1.6 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.2 1.4 GO:0001661 conditioned taste aversion(GO:0001661)
0.2 0.9 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.1 0.2 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.1 1.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 1.0 GO:0035878 nail development(GO:0035878)
0.1 0.8 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.1 0.4 GO:0071896 negative regulation of hippo signaling(GO:0035331) protein localization to adherens junction(GO:0071896)
0.0 0.2 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 1.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.7 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.4 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.0 0.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.0 0.5 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.2 GO:0035897 proteolysis in other organism(GO:0035897)
0.0 0.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.2 GO:0015825 L-serine transport(GO:0015825)
0.0 0.1 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.0 0.1 GO:0086073 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.0 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.0 0.2 GO:0045792 negative regulation of cell size(GO:0045792)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0035976 AP1 complex(GO:0035976)
0.1 2.0 GO:0030056 hemidesmosome(GO:0030056)
0.1 1.0 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 0.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1 1.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.9 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.0 0.4 GO:0000145 exocyst(GO:0000145)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 0.0 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 1.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.0 0.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 0.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.6 PID IL3 PATHWAY IL3-mediated signaling events
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 1.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 1.0 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 0.9 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.1 1.0 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.0 0.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 1.0 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 1.4 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.0 0.2 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 0.3 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.2 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0 0.1 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.0 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)